[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bladder-tumor\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bladder-tumor":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100635675","phase-1-calcium-electroporation-for-urinary-bladder-tumors-a-first-in-human-feasibility-safety-and-early-response-trial-100635675",false,"NCT07555769","Calcium Electroporation for Urinary Bladder Tumors: A First-in-Human Feasibility, Safety, and Early Response Trial","Calcium Electroporation for Urinary Bladder Tumors: A First-in-human Feasibility, Safety, and Early Response Trial - The CALCIFER Trial","CALCIFER","Inclusion Criteria:\n\n* Age ≥ 18 years and able to understand participant information and give informed consent\n* Histologically verified urothelial bladder tumor\n* Unfit for cystectomy and\u002For radiotherapy\n* Patients with recurrence after radiotherapy unfit for salvage cystectomy\n* Disease where other treatments are considered unsuitable or have been declined by the patient\n* The patient may receive simultaneous systemic treatment\n* Selected high-burden non-muscle-invasive bladder tumors after MDT assessment\n* Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤ 2\n* Life expectancy of ≥ 3 months\n* Patients must be deemed able to tolerate general anesthesia\n* Sexually active participants in the reproductive age must use contraception. Accepted contraception includes the use of intrauterine device (IUD), oral contraceptives, male or female condom, vasectomy or female sterilization\n* Patients must stop treatment with anticoagulants before surgery in accordance with national guidelines\n* Plasma ionized Ca2+ must be within the normal upper limit. Correction is allowed\n* Hematology\n\n  * Thrombocytes ≥ 50 billion\u002FL\n  * International normalized ratio (INR) ≤ 1.5. Correction is allowed\n\nExclusion Criteria:\n\n* Pregnancy (confirmed by a blood sample) or lactation\n* Allergy to calcium gluconate or any of its excipients\n* Any clinical condition or previous treatment, that in the investigators' opinion made the patient ineligible\n* Contraindications to treatment with calcium gluconate as described:\n\n  * Hypersensitivity to calcium gluconate or any of its excipients\n  * Hypercalcemia (e.g. due to hyperparathyroidism, hypervitaminosis D, decalcifying malignancies, renal insufficiency, immobilization osteoporosis, sarcoidosis, milk-alkali syndrome)","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","This phase I study evaluates intravesical calcium electroporation (CaEP) with a new transurethral electrode. The study is primarily designed to assess the safety of CaEP and secondarily, to preliminary explore the efficacy in patients with limited alternative therapies. The anticipated benefits and structured safety precautions justify the ethical conduct of the investigation.",[27,28,29,30],"Bladder Tumors","Bladder Tumor","Urothelial Carcinoma (UC)","Urothelial Carcinoma Bladder",[32,33,34,35,36],"calcium electroporation","electroporation","transurethral electroporation","bladder tumors","urothelial tumor","NOT_YET_RECRUITING","2026-04-21",{"date":40,"type":41},"2026-04-29","ACTUAL",{"date":43,"type":21},"2026-06",{"date":45,"type":21},"2030-04",{"name":47,"class":48},"Juan Luis Vásquez","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100592074","the-effect-of-perioperative-heated-sock-application-on-hypothermia-and-vital-signs-in-bladder-tumor-surgery-100592074","NCT06988696","The Effect of Perioperative Heated Sock Application on Hypothermia and Vital Signs in Bladder Tumor Surgery","The Effect of Perioperative Heated Sock Application on Hypothermia and Vital Signs in Bladder Tumor Surgery:A Randomized Controlled Trial","Inclusion Criteria:\n\n* The duration of surgical intervention is between 2 and 4 hours,\n* Ability to read, write, understand and communicate in Turkish,\n* Voluntary participation in the study,\n* Does not require follow-up in intensive care before or after surgery,\n* Dementia, alzheimer etc. absence of disease affecting cognitive functions,\n* Absence of a disease that may affect thermoregulation due to systemic effects such as chronic obstructive pulmonary disease (COPD), cancer, intracranial benign\u002Fmalignant tumor, epilepsy, multiple sclerosis, Parkinson's disease, and thyroid-related diseases,\n* Absence of drug use that may affect thermoregulation,\n* It is not uncomfortable to wear heat socks during application.\n\nExclusion Criteria:\n\n* Mental retardation and the presence of any psychiatric disorder,\n* Being addicted to alcohol and drugs,\n* Dementia, alzheimer etc. have a disease that affects cognitive functions,\n* Having drug use that may affect thermoregulation,\n* Discomfort from wearing heat socks during application,\n* Having any disease that affects tissue perfusion,\n* Presence of any peripheral arterial and venous disease,\n* The need for intensive care before or after surgery","20 Years","90 Years",{"count":59,"type":21},90,[61],"NA","The aim of this study is to evaluate the effect of perioperative use of heated socks on the prevention of hypothermia and its impact on vital signs in patients undergoing bladder tumor surgery. It is anticipated that the data obtained from the study will provide evidence that the use of perioperative heated socks can help prevent hypothermia and positively influence vital signs in patients undergoing bladder tumor surgery.",[28],"RECRUITING","2025-05-21",{"date":67,"type":41},"2025-05-25",{"date":69,"type":41},"2024-11-01",{"date":71,"type":21},"2025-06-30",{"name":73,"class":48},"Istanbul University - Cerrahpasa",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":74},"100552534","ai-detection-of-bladder-tumors-under-endoscopy-100552534","NCT06474338","AI Detection of Bladder Tumors Under Endoscopy","Artificial Intelligence Detection of Bladder Tumors Under Endoscopy","Inclusion Criteria:\n\nThe patient who receives cystoscopy and the cystoscopy video is available, and one or multiple bladder lesions can be observed in the cystoscopy.\n\nExclusion Criteria:\n\nThe patient whose cystoscopy is not clear enough to analyze.","100 Years",{"count":84,"type":21},1000,"OBSERVATIONAL","The goal of this clinical trial is to learn if the AI algorithm can detect bladder tumors better than urologists under cystoscopy. It will also train the AI algorithm for bladder tumor detection. The main question it aims to answer is:\n\nCan AI algorithm achieve IOU value, precision, recall, false negative rate of bladder tumor detection similar to that of urologists? The cystoscopy video will be annotated by AI and urologists. Researchers will compare AI algorithm to urologists to see if Al algorithm has a similar capability as urologists do.",[28],"2024-06-19",{"date":90,"type":41},"2024-06-25",{"date":92,"type":41},"2024-01-01",{"date":94,"type":21},"2034-12-31",{"name":96,"class":48},"Peking Union Medical College Hospital"]