[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"blood-flow-restriction-bfr-training-effects\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:blood-flow-restriction-bfr-training-effects":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100640906","feasibility-and-effects-of-inspiratory-muscle-training-combined-with-blood-flow-restriction-for-frail-older-adults-100640906",false,"NCT07573995","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Community-dwelling adults aged 65 years and older who are classified as at least \"vulnerable\" using the Clinical Frailty Scale (score ≥4).\n* Participants must have no cognitive impairment and be able to follow commands, as assessed by the Mini-Mental State Examination (MMSE).\n\nExclusion Criteria:\n\n* (1) are unable to participate in exercise (e.g., due to severe musculoskeletal disorders)\n* (2) have high-risk factors for exercise, such as uncontrolled hypertension (\\>150 mmHg systolic blood pressure (SBP) \u002F \\>90 mmHg diastolic blood pressure (DBP), coagulation disorders, and deep venous thrombosis\n* (3) have hematological disorders or are using hematology related-medications\n* (4) have significant comorbidities, including a history of stroke, diabetes with severe complications, or cardiovascular diseases\n* (5) chronic lung conditions (e.g., obstructive pulmonary disease, asthma), and\n* (6) have participated in a structured exercise training program within the past 3 months at a frequency exceeding three sessions per week.","ALL","65 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","This randomized controlled trial study aims to evaluate the feasibility and preliminary efficacy of a combined inspiratory muscle training (IMT) and blood flow restriction (BFR) intervention in frail older adults. Outcomes of interest include feasibility, physical function, respiratory muscle strength, handgrip strength, five-times sit-to-stand performance, body composition, frailty level, fall efficacy, blood pressure, and adverse events.",[26,27,28,29],"Frailty Syndrome","Older Adults","Blood Flow Restriction (BFR) Training Effects","Inspiratory Muscle Training",[31,32,33,34],"frailty","older adults","blood flow restriction","inspiratory muscle training","NOT_YET_RECRUITING","2026-05-01",{"date":38,"type":39},"2026-05-07","ACTUAL",{"date":41,"type":20},"2026-05",{"date":43,"type":20},"2026-10",{"name":45,"class":46},"Taipei Medical University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":17,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100616855","effect-of-blood-flow-restriction-rraining-on-rehabilitation-after-anterior-cruciate-ligament-reconstruction-100616855","NCT07311031","Effect of Blood Flow Restriction Rraining on Rehabilitation After Anterior Cruciate Ligament Reconstruction","Effect of Blood Flow Restriction Training on Quadriceps Muscle Strength, Knee Biomechanics and Rehabilitation After Anterior Cruciate Ligament Reconstruction in Active Workers","Inclusion Criteria:\n\n* Male or female (18-65 years of age); must be skeletally mature with closed physes\n* Worker active\n* Diagnosis of acute (\\\u003C8 weeks), unilateral ACL tear with planned surgery confirmed via clinical examination and MRI\n* No previous ACL injury or reconstruction on the involved limb\n* Planned graft: autologous ipsilateral hamstring graft for ACL reconstruction\n* Planned fixation: suspensory cortical femoral device and tibial interference screw\n\nExclusion Criteria:\n\n* Completed knee dislocation or multiligament injury (PCL, MCL, LCL)\n* ACL Graft diameter \\\u003C 8mm\n* Meniscal suture or meniscal root reattachment\n* Post-surgical immobilization\n* Any current or previous conditions or surgeries that might affect gait\n* Pregnant\n* Spinal fusion\n* Any implanted medical device or other contraindications for MRI\n* History of deep vein thrombosis and\u002For varicose veins or familiy history of deep vein thrombosis\n* Taking anti-coagulant drugs for any blood, cardiac or congenital disease that may cause coagulation disorders\n* Taking bone and muscle metabolism-modulation drugs or muscle supplements (e.g., creatine, amino acids, whey protein,…)\n* Recent inflammation, bleeding disorders, active bleeding, or infection within the lower limbs\n* Diabetic or have uncontrolled hypertension\n* Diminished capacity to provide informed consent\n* Unfeasible to attend regular physical therapy and study visits","18 Years",{"count":57,"type":20},60,[23],"Importance: Following anterior cruciate ligament reconstruction (ACLR), patients often experience quadriceps muscle weakness and atrophy, frequently leading to long-term complications. A promising rehabilitation program based on blood flow restriction training (BFRT) seems to be particularly valuable for patients who may be unable to train with heavy loads due recent surgery. Previous studies have demonstrated that BFRT promotes strength gains and muscle mass increases, with adaptations comparable to traditional high-intensity training, despite using low-load resistance exercises.\n\nObjective: to evaluate the effect of blood flow restriction training on quadriceps strength and knee biomechanics in a 4-month rehabilitation program of patients who have had an ACL reconstruction.\n\nDesign: The study will be a two-arm superiority randomized controlled clinical trial.\n\nSetting: The trial will be conducted at a work-related injuries specialised hospital, MAZ Hospital, Zaragoza, Spain.\n\nParticipants: Participants will be active workers who have suffered an acute ACL tear and they have undergone ACL reconstruction (n=60).\n\nIntervention: Patients will recieve a 14-16-week supervised accelerated early rehabilitation protocol; one group will complete it applying blood flow restriction training and the other will not.\n\nMain Outcome and Measure: The primary outcomes will be peak quadriceps strength and rate of torque development measured both isometrically and isokinetcally with a Isokinetic Dynamometer CON-TREX MG.\n\nLimitations: Potential limitations include patients and physiotherapists are not blinded.\n\nConclusions: The focus of the research will examine the impact of blood flow restriction rehabilitation on patients who have undergone ACLR.\n\nRelevance: The study has potential to restore quadriceps strength to a greater extent than standard rehabilitation protocol. Moreover, patients will spend less time in the rehabilitation process to return to work compared to standard care.",[61,28],"Anterior Cruciate Ligament Reconstruction Rehabilitation",[63,64,65],"KAATSU","Knee injury","ACL rehabilitation","2025-12-30",{"date":68,"type":39},"2026-01-05",{"date":70,"type":20},"2025-12-20",{"date":72,"type":20},"2027-09-01",{"name":74,"class":46},"Hospital MAZ",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":47},"100599037","comparing-vascular-responses-to-aerobic-exercise-with-and-without-blood-flow-restriction-in-young-and-older-adults-100599037","NCT07079280","Comparing Vascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults","Comparison of Acute Micro- and Macrovascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults: A Randomized Crossover Trial.","UNDER PRESSURE","Inclusion Criteria:\n\n* Aged between 18-30 years and those over 60 years.\n\nExclusion Criteria:\n\n* Past or current history of coronary heart disease, stroke, oncological disease, or major cardiovascular events.\n* Individuals who had undergone surgery within the last two months\n* Body mass index (BMI) greater than 30 kg\u002Fm²\n* Declared sleep apnea\n* Active kidney or liver disease\n* Active tobacco smokers\n* Sensory impairments\n* Neurological or orthopedic functional impairments, musculoskeletal pathologies affecting exercise capacity\n* Physically active for more than six months with a weekly activity level of 1,000 MET\u002Fmin.",true,{"count":85,"type":20},52,[23],"Aging is a major risk factor for cardiovascular disease (CVD), contributing to progressive macrovascular and microvascular dysfunction. Macrovascular impairments, such as arterial stiffening and endothelial dysfunction, reduce nitric oxide (NO) bioavailability, leading to hypertension and impaired blood flow regulation. Microvascular dysfunction exacerbates cardiovascular decline by compromising capillary perfusion and tissue oxygenation, increasing susceptibility to ischemic events. Preserving vascular function is essential for maintaining cardiovascular health in aging populations.\n\nLow-intensity aerobic exercise (LIAE) improves cardiovascular health and mobility, particularly in populations unable to perform high-intensity exercise. However, LIAE alone often fails to induce significant vascular adaptations, such as improved arterial compliance or endothelial function, highlighting the need for optimized interventions.\n\nBlood Flow Restriction (BFR) enhances vascular adaptations during low-intensity exercise by inducing localized hypoxia, stimulating endothelial function and arterial remodeling. While BFR may transiently increase blood pressure and arterial stiffness, its vascular benefits resemble those of high-intensity exercise at lower workloads. However, research on BFR's acute vascular effects during aerobic exercise in older adults remains limited.\n\nCurrent studies have focused on perceptual and hemodynamic responses to LIAE+BFR but lack direct assessments of macrovascular (e.g., flow-mediated slowing) and microvascular function. Older adults may exhibit distinct vascular responses, yet data are scarce. This study examines acute vascular responses to LIAE+BFR and high-intensity interval exercise (HIIE) in young and older adults.\n\nHypothesis:\n\n1. BFR combined with LIAE will elicit greater acute microvascular and macrovascular responses in older adults than in younger adults.\n2. These responses will be comparable to HIIE without BFR, suggesting BFR enhances LIAE's efficacy to high-intensity levels.\n3. Any transient vascular dysfunction (e.g., increased arterial stiffness) will normalize within 30 minutes post-exercise, supporting safety in aging populations.",[89,28],"Ageing",[91,92,93,94,95,96,97,27],"Aerobic Exercise","Blood Flow Restriction","Microvascular Function","Flow mediated Slowing","Arterial Stiffness","Central Blood Pressure","Young Adults","2025-07-13",{"date":100,"type":39},"2025-07-23",{"date":102,"type":20},"2025-10-06",{"date":104,"type":20},"2026-07-31",{"name":106,"class":46},"Egas Moniz - Cooperativa de Ensino Superior, CRL"]