[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"blood-flow-restriction-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:blood-flow-restriction-therapy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,71,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100627636","evaluating-the-efficacy-of-blood-flow-restriction-therapy-in-a-randomized-clinical-trial-for-postoperative-rehabilitation-following-ankle-ligament-reconstruction-100627636",false,"NCT07451210","Evaluating the Efficacy of Blood Flow Restriction Therapy in a Randomized Clinical Trial for Postoperative Rehabilitation Following Ankle Ligament Reconstruction","BFRankle recon","Inclusion Criteria:\n\n1. Age 18-65 years.\n2. Post ankle ligament reconstruction surgery (medial or lateral, with or without ankle scope).\n3. Capability of paying for physical therapy or having insurance coverage for at least 6 weeks of therapy.\n\nExclusion Criteria:\n\n1. Major cardiac or connective tissue disorders (e.g., Ehlers-Danlos syndrome, Marfan syndrome).\n2. Autoimmune disorders.\n3. History of stroke or deep vein thrombosis (DVT).\n4. Bleeding or coagulation disorders.\n5. Congenital or developmental musculoskeletal disorders (e.g., cerebral palsy, Parkinson's disease).\n6. Pregnancy (current or planning to become pregnant in the next 4 months)\n7. Malignancy (cancer).\n8. Professional athletes.\n9. Workers compensation insurance status as worker's compensation often does not cover the necessary duration of physical therapy (minimum of 4 weeks).\n10. Be currently enrolled or have been enrolled in another interventional clinical research study within the past 30 days (at time of consent); or\n11. Be deemed unsuitable for inclusion in the study at the discretion of the Investigators\n12. Cognitively not able to consent or participate in research (dementia; severe developmental delay; language\u002Fcommunication limitations; brain injury; etc.)","ALL","18 Years","65 Years",{"count":20,"type":21},105,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this single blinded clinical trial is to investigate blood flow restriction (BFR) for rehabilitation of patients after ankle ligament reconstruction surgery. Outcome measures will be compared between the standard of care (SoC) and BFR groups at the end of the study intervention.\n\nFollowing standard surgical procedures, both groups will undergo physical therapy by a certified physical therapist for a minimum of 6 weeks. The SOC group will receive standard physical therapy without use of BFR. The BFR group will receive physical therapy with BFR. Outcome measures of interest will be taken at the start of physical therapy (time 0) and at the end of physical therapy (minimum of 6 weeks of PT) for both groups.\n\nOutcome measures of interest include:\n\n* muscle atrophy;\n* ankle function;\n* fatigability\u002Fmanual muscle testing;\n* pain scores;\n* cardiovascular effects (heart rate, blood pressure).",[27,28,29],"Ankle Reconstruction","Blood Flow Restriction Therapy","Physical Therapy",[31,32,33,34],"ankle reconstruction","physical therapy","blood flow restriction therapy","BFR","RECRUITING","2026-03-13",{"date":38,"type":39},"2026-03-17","ACTUAL",{"date":41,"type":21},"2026-03-01",{"date":43,"type":21},"2027-12-31",{"name":45,"class":46},"Texas Tech University Health Sciences Center","OTHER",5,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100603074","optimizing-rehabilitation-after-achilles-tendon-rupture-repair-the-role-of-blood-flow-restriction-training-in-tendon-and-muscle-recovery-100603074","NCT07131787","Optimizing Rehabilitation After Achilles Tendon Rupture Repair: The Role of Blood Flow Restriction Training in Tendon and Muscle Recovery","TENDON-BFR","Inclusion Criteria:\n\n* patients with total midrupture Achilles tendon rupture\n* surgical treatment\n* \\> 18 years old\n* able to understand and speak Dutch\n\nExclusion Criteria:\n\n* Bilateral Achilles tendon rupture\n* Previous Achilles tendon rupture\n* Previous treatment with fluoroquinolones or cortisone\n* other condition in either leg that would limit the ability to perform the exercises or evaluations\n* Diabetes or rheumatic diseases\n* History of deep venous thrombosis\n* severe cardiovascular disease",{"count":56,"type":21},82,[24],"The goal of this clinical trial is to investigate whether rehabilitation with blood flow restriction (BFR) offers added value compared to conventional rehabilitation in patients undergoing surgical repair for Achilles tendon rupture. The study will include adult patients of all sexes who have undergone surgical treatment at two selected hospitals.\n\nThe main questions it aims to answer are:\n\nDoes BFR-enhanced rehabilitation improve functional recovery compared to conventional rehabilitation? What are the effects of BFR on muscle strength and tendon recovery?\n\nResearchers will compare blood flow restriction (BFR) therapy with conventional rehabilitation to determine whether BFR leads to improved clinical, muscular, and tendon-related outcomes.\n\nParticipants will:\n\n1. Undergo standard surgical repair of the Achilles tendon\n2. Be randomly assigned to a 24-week exercise therapy program-either with or without blood flow restriction (BFR)-starting four weeks post-surgery\n3. Take part in follow-up assessments at weeks 4, 8, 12, 18, 24, and 52, which will include:\n\n   * Questionnaires on pain, quality of life, fear of movement, and return to sport\n   * Medical imaging techniques such as ultrasound, MRI, shear wave elastography, and power Doppler\n   * Muscle strength testing\n   * Blood sample collection, along with a tendon tissue sample taken during surgery",[60,28],"Achilles Tendon Rupture","2025-09-17",{"date":63,"type":39},"2025-09-23",{"date":65,"type":39},"2025-08-20",{"date":67,"type":21},"2028-11",{"name":69,"class":46},"University Hospital, Ghent",2,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100606208","blood-flow-restriction-training-for-the-treatment-of-lateral-epicondylopathy-100606208","NCT07172568","Blood Flow Restriction Training For The Treatment Of Lateral Epicondylopathy","Randomisierte, Kontrollierte Untersuchung Der Wirksamkeit Von Blood Flow Restriction (BFR)-Training Zur Behandlung Der Epicondylopathia Humeri Radialis","EPIC-BFR","Inclusion Criteria:\n\n* diagnosis of lateral epicondylitis\n* duration of symptoms \\> 6 weeks\n* failed physical therapy\n* absence of x-ray abnormalities\n* written and informed consent\n\nExclusion Criteria:\n\n* prior joint infiltrations\n* duration of symptoms \\> 12 months\n* concomitant rheumatoid diseases\n* concomitant elbow pathologies, including medial epicondylitis\n* concomitant radicular symptoms of the cervical spine, shoulder or hand\n* traumatic etiology of symptoms",{"count":80,"type":21},40,[24],"The study aims to evaluate the effectiveness of Blood Flow Restriction Training for the treatment of lateral elbow epicondylopathy.",[84,85,86,87,28,34],"Elbow Tendinopathy","Elbow, Tennis","Lateral Epicondylitis","Epicondylitis of the Elbow",[89,90,91,34,92,93,94],"Randomised controlled Trial","RCT","Interventional study","Blood-Flow-Restriction-Therapy","lateral Epicondylopathy","Epicondylitis","2025-09-11",{"date":97,"type":39},"2025-09-15",{"date":99,"type":39},"2021-08-25",{"date":101,"type":21},"2026-02",{"name":103,"class":46},"Technical University of Munich",1,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":16,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":123,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":104},"100572890","the-enhancement-effect-of-low-level-laser-therapy-for-muscle-training-with-combined-nmes-and-bfr-100572890","NCT06739148","The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined NMES and BFR","The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined Neuromuscular Electrical Stimulation and Blood Flow Restriction","Inclusion Criteria:\n\n1. Healthy adults aged 20-40, without a diagnosis of cardiovascular or neuromusculoskeletal diseases.\n2. Normal vision range after visual correction.\n\nExclusion Criteria:\n\n1. Exclude students who have a teacher-student relationship with the principal investigator to ensure the participants\\' autonomy.\n2. History of brain injury, stroke, spinal cord injury, or other neuromuscular-related conditions.\n3. Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleeding areas, and photosensitive skin regions.\n4. Presence of any contraindications for blood flow restriction training, such as a history of injury or strain in the non-dominant arm\\'s biceps, deep vein thrombosis or venous occlusion in the non-dominant arm, acute unstable fractures in the non-dominant arm, acute regional infections in the non-dominant arm, severe peripheral arterial occlusive disease in the non-dominant arm, complete lymphatic obstruction in the non-dominant arm, and edema due to acute pulmonary edema or congestive heart failure in the non-dominant arm.",true,"20 Years","40 Years",{"count":116,"type":21},44,[24],"Blood flow restriction training (BFR) with neuromuscular stimulation (NMES) is employed for individuals with limited mobility and joint issues. However, this approach is highly susceptible to muscle fatigue, despite its potential beneficial effects on muscle strength. Recently, there has been growing interest in using low-level laser therapy (LLLT) to address muscle fatigue. LLLT, known for improving microcirculation and mitochondrial function, shows promise in alleviating enhanced muscle fatigue associated with combined BFR and NMES training. Despite these positive effects, there is limited knowledge about the short-term training impact of combined BFR and NMES with LLLT preconditioning. This project aims to investigate whether the photobiomodulation effects of LLLT could further enhance the training benefits of combined BFR and NMES. The study will employ an integrated analysis of decomposition surface EMG, EEG, and mechanomyogram to explore the behavior and neuromuscular mechanisms underlying the training benefits. If additional benefits are identified, LLLT pre-conditioning is recommended to enhance the use of combined BFR and NMES.",[28,120,121,122],"Neuromuscular Electrical Stimulation (NMES)","Laser Therapy, Low-Level","Muscle Strength",[124,125,126,127,128],"Muscle strength","Training","Low-level laser Therapy","Blood flow restriction","Neuromuscular electrical stimulation","2024-12-16",{"date":131,"type":39},"2024-12-18",{"date":133,"type":39},"2024-10-01",{"date":135,"type":21},"2025-07-31",{"name":137,"class":46},"National Cheng-Kung University Hospital"]