[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"blood-flow-restriction-training-bfrt\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:blood-flow-restriction-training-bfrt":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644047","acute-muscular-and-vascular-responses-to-a-single-session-of-exercise-with-bfr-in-copd-100644047",false,"NCT07668921","Acute Muscular and Vascular Responses to a Single Session of Exercise With BFR in COPD","Blood Flow Restriction (BFR): a Novel Approach to Potentiate the Effects of Rehabilitative Exercise Training in COPD? Study of Acute - Muscular, and Vascular - Responses to a Single Session of Exercise With BFR","2BFREE_aigu","Inclusion Criteria:\n\n* Negative pregnancy test and use of an acceptable contraceptive method throughout the study duration for women of childbearing potential\n* Established COPD defined as obstructive ventilatory defect (FEV1\u002FFVC \\\u003C 0.70 or below the 5th percentile)\n* Resting lung hyperinflation defined as functional residual capacity \\> 2.5 z-scores according to the Global Lung Function Initiative (GLI)\n* Clinical stability of COPD for at least 3 months, with no recent exacerbation requiring treatment modification\n* Covered by a national health insurance system\n* Able and willing to provide written informed consent\n\nNon-inclusion Criteria:\n\n* Presence of a medical device incompatible with magnetic stimulation\n* Inability to perform an exercise test on a cycle ergometer\n* Any usual contraindication to exercise testing, including:\n\n  * Recent myocardial infarction (3-5 days)\n  * Unstable coronary insufficiency\n  * Severe stenotic valvular disease\n  * Uncontrolled arrhythmia with hemodynamic instability\n  * Recent unexplained syncope\n  * Uncontrolled heart failure\n  * Uncontrolled arterial hypertension (systolic blood pressure ≥200 mmHg and\u002For diastolic blood pressure ≥110 mmHg at rest)\n  * Acute thromboembolic disease and\u002For pulmonary edema\n* Conditions contraindicating the use of blood flow restriction (BFR), including:\n\n  * Coagulation disorder\n  * Peripheral neuropathy\n  * Uncontrolled hypertension (\\>160\u002F100 mmHg)\n  * Peripheral arterial disease\n  * History of venous thrombosis\n  * Intensive care unit stay within the last 3 months\n* Participation in another study during an exclusion period\n* Inability to be contacted in case of emergency\n* Individuals covered under Articles L1121-5 to L1121-8 of the French Public Health Code (protected populations, including pregnant or breastfeeding women, prisoners, minors, individuals under legal protection, psychiatric inpatients, etc.)\n* Staff members with a hierarchical relationship with the principal investigator","ALL","45 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Exercise training is a cornerstone of pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary disease (COPD). However, some patients derive limited benefits from conventional exercise programs. Previous studies suggest that the magnitude of exercise-induced muscle fatigue is associated with training effectiveness, with patients unable to develop significant muscle fatigue (\"non-fatiguers\") showing smaller improvements in functional capacity and quality of life.\n\nBlood flow restriction (BFR) exercise consists in performing physical exercise while applying external pressure to the proximal part of the exercising limb, thereby reducing oxygen delivery to the muscles and limiting metabolite clearance. This approach has been shown to induce significant muscular adaptations despite the use of low exercise intensities. Because exercise intensity in COPD patients is often constrained by ventilatory limitations, BFR training may enhance muscle adaptations while reducing respiratory stress, potentially improving the effectiveness of PR.\n\nThe primary objective of this monocentric randomized crossover study is to compare lower-limb muscle fatigue induced by a single exercise session performed with BFR versus a standard exercise session in patients with COPD.",[27,28,29],"Control Condition","Pulmonary Disease (COPD), Chronic Obstructive","Blood Flow Restriction Training (BFRT)",[31,32,33,34,35],"Muscle Fatigue","COPD","Aerobic exercise","Resistance exercise","Blood Flow Restriction Training","NOT_YET_RECRUITING","2026-06-25",{"date":39,"type":40},"2026-06-30","ACTUAL",{"date":42,"type":21},"2026-11",{"date":44,"type":21},"2028-12",{"name":46,"class":47},"University Hospital, Grenoble","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":48},"100629012","effects-of-low-load-blood-flow-restriction-training-of-the-upper-extremity-in-patients-with-chronic-obstructive-pulmonary-disease-100629012","NCT07469111","Effects Of Low-Load Blood Flow Restriction Training Of The Upper Extremity In Patients With Chronic Obstructive Pulmonary Disease","Inclusion Criteria:\n\n* Individuals aged 40-80 years with stage 2 and 3 COPD diagnosed according to GOLD criteria\n\n  * Clinically stable COPD (no exacerbation in the last 6 weeks)\n  * Stable medical treatment for at least 4 weeks\n  * No orthopedic or neurological problems that would prevent them from performing upper extremity exercises\n  * Resting SpO2 ≥ 88%\n  * Able to understand and follow verbal instructions in Turkish\n  * Individuals with a Montreal Cognitive Assessment Scale (MoCa) score ≥ 24 will be included.\n\nExclusion Criteria:\n\n* Uncontrolled hypertension\n\n  * Severe arrhythmia\n  * Recent MI\n  * Deep vein thrombosis\n  * Peripheral vascular disease\n  * Presence of infection or open wound\n  * Having undergone upper extremity surgery within the last 6 months\n  * Cognitive impairment or cooperation problems will be among the exclusion criteria","40 Years","80 Years",{"count":58,"type":21},36,[24],"Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airflow limitation, progressive dyspnea, and peripheral muscle dysfunction, significantly impairing functional capacity and quality of life. Although the combined implementation of aerobic and resistance exercises is recommended in pulmonary rehabilitation programs, early-onset ventilatory limitation in individuals with COPD often hinders tolerance to high exercise intensities. This limitation increases the need for alternative exercise approaches targeting peripheral muscle adaptations. Low-load blood flow restriction training (LL-BFRT), which enables improvements in muscle strength with low mechanical loads, has emerged as a potential option for this patient population. However, evidence regarding the effects of LL-BFRT in individuals with COPD-particularly on upper extremity muscles-remains limited.\n\nThe aim of this study is to comparatively investigate the effects of LL-BFRT and sham-BFRT, both administered in addition to an aerobic exercise program in individuals diagnosed with stage II and III COPD, on upper extremity muscle strength, upper extremity functional capacity, activities of daily living performance, quality of life, functional exercise capacity, muscle oxygenation, and respiratory parameters. The study is designed as a randomized controlled, single-blind, quasi-experimental interventional trial.\n\nThe expected outcomes are that LL-BFRT may enhance upper extremity muscle strength and functional capacity, improve activities of daily living and quality of life, and increase exercise tolerance due to its applicability at low mechanical loads. Furthermore, findings related to muscle oxygenation and respiratory parameters are anticipated to provide clinical evidence regarding the physiological effects of LL-BFRT on peripheral muscle adaptations. These results are expected to guide the integration of LL-BFRT as an alternative and safe approach in upper extremity exercise prescription within pulmonary rehabilitation programs, support clinical decision-making processes, and establish a scientific foundation for future research.",[62,29],"Chronic Obstructive Pulmonary Disease (COPD)",[62,64,65,66,29],"Los Load Resistance Exercise","Upper Extremity Function","Muscle Strength","RECRUITING","2026-03-09",{"date":70,"type":40},"2026-03-13",{"date":72,"type":21},"2026-02-15",{"date":74,"type":21},"2026-12-25",{"name":76,"class":47},"Inonu University"]