[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"blood-flow\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:blood-flow":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,69,106,132,160,190],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100630289","the-relationship-between-blood-flow-readings-during-surgery-and-how-well-the-graft-stays-open-and-how-patients-recover-afterward-in-coronary-artery-bypass-graft-surgery-100630289",false,"NCT07485738","The Relationship Between Blood Flow Readings During Surgery and How Well the Graft Stays Open and How Patients Recover Afterward in Coronary Artery Bypass Graft Surgery","Surgical Measurement for Accurate Revascularization Using Transit-time FLOW (SMARTFLOW):Patency","SMARTFLOW","Inclusion Criteria:\n\n1. Age \\>18 years\n2. First-time, non-emergent isolated multivessel CABG through median sternotomy\n3. Willing and able to provide written informed consent and comply with all study procedures, including QOL questionnaires\n\nExclusion Criteria:\n\n1. Reoperation\n2. Emergency procedures\n3. Combined CABG + other cardiac or non-cardiac surgery\n4. Isolated single vessel CABG\n5. Minimally invasive CABG\n6. Inability to undergo coronary computed tomographic angiography (CCTA)\n7. Unable to provide written informed consent or comply with all the study procedures.","ALL","18 Years",{"count":20,"type":21},1242,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to learn more about a tool called Transit-Time Flow Measurement (TTFM). TTFM uses sound waves during surgery to check how well blood is flowing through blood vessels. This helps doctors see if the blood flow is good during coronary artery bypass grafting (CABG), which is a type of heart surgery",[27,28,29,30,31],"CABG Graft Integrity","CABG","Blood Flow","Transit-time Flow Measurement","Heart Disease",[15],"RECRUITING","2026-04-20",{"date":36,"type":37},"2026-04-22","ACTUAL",{"date":39,"type":37},"2026-03-30",{"date":41,"type":21},"2032-03",{"name":43,"class":44},"Weill Medical College of Cornell University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100559522","microvascular-blood-flow-during-passive-heating-100559522","NCT06565221","Microvascular Blood Flow During Passive Heating","Inclusion Criteria:\n\n* between 18 and 50 years\n\nExclusion Criteria:\n\n* Diagnosis of peripheral neuropathy\n* open wounds on feet",true,"50 Years",{"count":55,"type":21},50,[24],"Determine whether passive heating intervention effects microvascular blood flow as measured with near-infrared spectroscopy",[29],"NOT_YET_RECRUITING","2026-03-11",{"date":62,"type":37},"2026-03-13",{"date":64,"type":21},"2026-08",{"date":66,"type":21},"2026-12",{"name":68,"class":44},"San Diego State University",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":86,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":45},"100567804","dose-response-impact-of-glucosyl-hesperidin-citrapeak-on-exercise-performance-blood-flow-stress-cognition-and-other-perceptual-indicators-100567804","NCT06672952","Dose-Response Impact of Glucosyl-Hesperidin (CitraPeak) on Exercise Performance, Blood Flow, Stress, Cognition, and Other Perceptual Indicators","HES","Inclusion Criteria:\n\n1. Participants who are between 18 - 50 years of age\n2. Body mass index values will range from \\>25.0 \\\u003C 30.0 kg\u002Fm2\n3. The average body mass index for entire study cohort will be less than 27.0 kg\u002Fm2. As such an ongoing calculation of the recruited cohort's mean body mass index will be maintained and people will only be randomized into the study if the average cohort body mass index value does not exceed 27.0 kg\u002Fm2\n4. Free-living and independent\n5. In good health absent of being overweight or mildly obese with no other signs or symptoms of cardiovascular, respiratory, metabolic, immune, psychiatric, or musculoskeletal disease or disorders\n6. Willingness to maintain consistent sleep duration the evening before study visits\n7. Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, and carry out all study-related procedures\n8. Regular completion of at least 180 minutes of moderate to vigorous exercise per week for the past 6 months\n\nExclusion Criteria:\n\n1. Not currently completing at least 180 minutes of moderate to vigorous exercise per week for the past 6 months\n2. Positive medical history and\u002For is currently being treated for some form of heart disease, cardiovascular disease\n3. Currently being treated for kidney disease, renal failure, or has dialysis performed on regular intervals\n4. Has liver disease or some form of clinically diagnosed hepatic impairment\n5. Diagnosed with having Type I or Type II diabetes (determined as fasting blood glucose \\> 126 mg\u002FdL)\n6. Diagnosed with or is being treated for some form of thyroid disease\n7. Diagnosed with major affective disorder or other psychiatric disorder that required hospitalization in the prior year\n8. Diagnosed with some form of immune disorder (i.e., HIV\u002FAIDS)\n9. History of cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit).\n10. Participant has an abnormality or obstruction of the gastrointestinal tract precluding swallowing (e.g., dysphagia) and digestion (e.g., known intestinal malabsorption, celiac disease, inflammatory bowel disease, chronic pancreatitis, steatorrhea)\n11. Positive medical history for any neurological condition or neurological disease\n12. Currently prescribed a statin drugs (i.e., Lipitor, Livalo, Crestor, Zocor, etc.) or any hypertension medications (i.e., Beta-blockers, ACE Inhibitors, Alpha blockers, Vasodilators, etc.)\n13. Current smoker (average of \\> 1 pack per day within the past 3 months) has quit within the past six months. This includes all forms of nicotine\n14. Intake of any drugs (prescribed or over the counter) or dietary supplements that are known or are purported to weight loss such as thermogenics, hydroxycitric acid, ephedra, capsaicin, etc.\n15. Participants who are lactating, pregnant or planning to become pregnant\n16. Have a known sensitivity or allergy to any of the study products\n17. History of alcohol or substance abuse in the 12 months prior to screening\n18. Receipt or use of an investigational product in another research study within 30 days of beginning the study protocol\n19. Any orthopedic limitation that would prevent participation in a general fitness program\n20. Any condition or abnormality that, in the opinion of the investigator, would compromise the safety of the participant or the quality of the study data",{"count":77,"type":21},60,[24],"The purpose of this study is to evaluate the dose-dependent effects of glucosyl-hesperidin (CITRAPEAK) supplementation on exercise performance, recovery indicators, blood flow, cognitive function, mood, sleep, and fuel utilization in recreationally active adults.",[81,82,83,84,29,85],"Exercise Performance","Exercise Recovery","Cognitive Function","Nitric Oxide","Endurance Exercise",[87,88,89,90,91,92,93,94,95,96],"exercise performance","aerobic capacity","anaerobic power","mood","nitric oxide","cognitive function","glucosyl-hesperidin","training readiness","fuel utilization","endothelial function","2025-12-05",{"date":99,"type":37},"2025-12-12",{"date":101,"type":37},"2025-04-15",{"date":103,"type":21},"2026-01-01",{"name":105,"class":44},"Lindenwood University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":52,"sex":112,"minAge":18,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":45},"100556122","early-phase-1-early-neurovascular-adaptations-in-aging-women-100556122","NCT06520982","Early Neurovascular Adaptations in Aging Women","Inclusion Criteria:\n\n* Assigned female at birth (AFAB)\n* 18-70 years of age\n\nExclusion Criteria:\n\n* Assigned male at birth (AMAB)\n* Pregnancy, breastfeeding\n* Body mass index ≥30 kg\u002Fm2\n* Taking medications known to affect metabolic, autonomic, and\u002For respiratory function\n* Oral hormonal contraception in last 6 month\n* History of hormone replacement therapy\n* History of hyster- or oophor-ectomy\n* Current smoking\u002FNicotine use\n* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy\n* Chronic disease\n* Blood pressure ≥140\u002F90 mmHg\n* Communication barriers","FEMALE","70 Years",{"count":115,"type":21},64,[117],"EARLY_PHASE1","Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.",[120,121,122,29],"Women","Sympathetic Nervous System","Aging","2025-11-20",{"date":125,"type":37},"2025-11-26",{"date":127,"type":37},"2024-09-20",{"date":129,"type":21},"2028-06-30",{"name":131,"class":44},"University of Missouri-Columbia",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":147,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":45},"100583930","the-immediate-effect-of-applying-transcutaneous-electrical-nerve-stimulation-tens-on-sympathetic-ganglion-and-gastrocnemius-for-popliteal-blood-flow-100583930","NCT06882733","The Immediate Effect of Applying Transcutaneous Electrical Nerve Stimulation (TENS) on Sympathetic Ganglion and Gastrocnemius for Popliteal Blood Flow","TENS","Inclusion Criteria:\n\n1. Healthy people\n2. Age: 18 years and above (inclusive)\n3. Body mass index (BMI) between 18.5 and 24\n\nExclusion Criteria:\n\n1. Unable to complete two interventions within a week\n2. Have contraindications to electrotherapy (for example: metal implants in the body, open wounds, pregnancy, sensory loss)\n3. Obvious varicose veins 4. Unable to lie down for about 1 to 2 hours 5. Taking drugs or nutritional supplements that affect autonomic nervous activity or vasodilation (for example: Ginkgo biloba) 6. Smoking 7. Ankle and Ankle Index (ABI) less than 0.9 or greater than 1.3",{"count":140,"type":21},43,[24],"This study aims to evaluate the immediate hemodynamic effects of transcutaneous electrical nerve stimulation (TENS) on the popliteal artery and vein. Vascular issues like PAOD and DVT are common in patients with diabetes, obesity, or immobility due to increased resistance and reduced blood flow. Traditional treatments (medication or surgery) are not always feasible, prompting interest in TENS as an alternative. Although primarily used for pain relief, TENS may enhance blood flow. This research compares different stimulation frequencies (80 Hz vs. 4 Hz) and sites (gastrocnemius muscle vs. thoracolumbar sympathetic ganglia) to identify the most effective configuration.",[144,145,29,146],"Transcutaneous Electrical Nerve Stimulation (TENS)","Popliteal","Sympathetic Ganglia",[148,149,150],"transcutaneous electrical nerve stimulation (TENS)","blood flow","sympathetic ganglia","2025-07-16",{"date":153,"type":37},"2025-07-18",{"date":155,"type":37},"2024-12-03",{"date":157,"type":21},"2025-12-01",{"name":159,"class":44},"Kaohsiung Medical University",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":17,"minAge":168,"maxAge":169,"enrollmentInfo":170,"targetDuration":4,"studyType":172,"phases":4,"briefSummary":173,"conditions":174,"keywords":177,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":186,"leadSponsor":188,"locationsCount":45},"100584235","mri-assesment-of-cerebral-blood-flow-in-anesthetized-children-100584235","NCT06886698","MRI Assesment of Cerebral Blood Flow in Anesthetized Children","Arterial Spin Label Assessment of Cerebral Blood Flow in Anesthetized Children","BAMBI","Inclusion Criteria:\n\n* children aged 6 months to 12 years\n* Planned to undergo MRI brain\n* Exclusion Criteria:\n* known brain tumor\n* vascular malformation in the brain\n* hydrocephalus","6 Months","12 Years",{"count":171,"type":21},30,"OBSERVATIONAL","Children undergoing magnetic resonance imaging (MRI) of the brain often need to be sedated to complete the examination, as it is difficult to remain still for a long period, which is required to obtain usable images. During sedation, most patients typically experience a drop in blood pressure, including children. Maintaining an adequate blood pressure under anesthesia is important, as blood pressure is routinely used as a measure to ensure sufficient blood circulation to the body's organs, including the brain. Ensuring adequate blood flow to the brain is one of the cornerstones of all anesthesia, including in children. Therefore, low blood pressure during anesthesia is often treated with standardized interventions, such as blood pressure-raising interventions. These treatments generally restore blood pressure to normal, but how this affects blood flow to the brain in children is not fully known.\n\nWith the help of modern MRI technology (so-called Arterial Spin Labeling, ASL), blood flow in the brain can be measured quickly and completely safely with high precision.\n\nIn similar situations with adult patients, it has been observed that while blood pressure-raising interventions successfully normalize low blood pressure, MRI scans show that blood flow to the brain paradoxically decreases despite the increase in blood pressure. It is believed that this may be due to the brain's blood vessels constricting.\n\nThe investigators now wish to examine this relationship in sedated children undergoing planned brain MRI for certain diagnoses. The investigators hypothesis is that standardized measures intended to raise blood pressure (i.e., the routine treatment used regardless of whether a patient participates in the study or not) normalizes low blood pressure (when deemed necessary to treat according to routine) but does not necessarily lead to improved blood flow to the brain.\n\nPrimary research question: How does routine treatment of low blood pressure affect cerebral blood flow in sedated children?",[29,175,176],"Cerebral Oxygenation","Blood Pressure",[178,179,180,181],"anesthesia","bloodflow","brain","children","2025-03-24",{"date":184,"type":37},"2025-03-25",{"date":101,"type":21},{"date":187,"type":21},"2026-09-15",{"name":189,"class":44},"Karolinska Institutet",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":198,"briefSummary":199,"conditions":200,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":45},"100530915","regional-blood-flow-during-peripheral-heating-100530915","NCT06192992","Regional Blood Flow During Peripheral Heating","Inclusion Criteria:\n\n* between 18 and 65 years\n\nExclusion Criteria:\n\n* open wounds on feet or legs","65 Years",{"count":171,"type":21},[24],"Blood flow through the popliteal, brachial, and carotid arteries during peripheral heating of the feet",[29],"2024-07-09",{"date":203,"type":37},"2024-07-10",{"date":205,"type":37},"2022-05-31",{"date":207,"type":21},"2025-05-31",{"name":68,"class":44}]