[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"blood-pressure-variability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:blood-pressure-variability":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,54,77,98,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100639968","cf-pwv-and-tyg-index-study-100639968",false,"NCT07589374","Cf-PWV and TyG Index Study","Correlation Between Carotid-Femoral Pulse Wave Velocity and Triglyceride-Glucose Index and Its Derived Metrics","RIGID-TyG","Inclusion Criteria:\n\n* Adults aged 18 to 65 years;\n* Both sexes;\n* Referred for ambulatory blood pressure monitoring (ABPM) as part of routine clinical evaluation;\n* Not receiving antihypertensive medication at the time of assessment;\n* Availability of valid 24-hour ABPM data;\n* Availability of carotid-femoral pulse wave velocity (cf-PWV) measurement;\n* Availability of fasting laboratory data, including glucose and triglycerides, for calculation of the triglyceride-glucose (TyG) index;\n* Ability and willingness to provide written informed consent (for prospectively recruited participants).\n\nExclusion Criteria:\n\n* Use of antihypertensive medication at the time of evaluation;\n* Cardiac arrhythmias that may interfere with accurate blood pressure or pulse wave velocity measurements;\n* Invalid or poor-quality ambulatory blood pressure monitoring (ABPM) recordings;\n* Inability to obtain reliable carotid-femoral pulse wave velocity (cf-PWV) measurements;\n* Presence of severe vascular disease or conditions affecting arterial waveform assessment;\n* Missing essential clinical, laboratory, or hemodynamic data required for the primary analysis;\n* Pregnancy;\n* Refusal or inability to provide informed consent (for prospectively recruited participants).",true,"ALL","18 Years","65 Years",{"count":22,"type":23},800,"ESTIMATED","OBSERVATIONAL","This study aims to investigate how metabolic health is related to arterial stiffness and daily blood pressure patterns. High blood pressure is one of the leading causes of heart disease worldwide, but cardiovascular risk is not determined only by average blood pressure values. Changes in blood vessel structure and metabolic function also play an important role in the development of cardiovascular disease.\n\nArterial stiffness reflects how flexible or rigid the arteries are. It can be measured using carotid-femoral pulse wave velocity (cf-PWV), which is considered a reliable and widely used method to assess vascular health. Increased arterial stiffness is associated with aging and higher cardiovascular risk.\n\nAt the same time, metabolic factors such as insulin resistance and central obesity are strongly linked to vascular damage. The triglyceride-glucose (TyG) index is a simple measure derived from routine blood tests and has been shown to reflect insulin resistance. Additional derived indices that combine TyG with body measurements (such as waist circumference and body mass index) may provide an even more comprehensive evaluation of metabolic risk.\n\nAnother important aspect of cardiovascular regulation is how blood pressure changes throughout the day. Blood pressure naturally rises in the morning after waking, a phenomenon known as the morning blood pressure surge. When this increase is excessive, it has been associated with a higher risk of cardiovascular events such as stroke and heart attack.\n\nThis study will evaluate the relationship between metabolic indices, arterial stiffness, and morning blood pressure patterns in adults undergoing ambulatory blood pressure monitoring as part of routine clinical care. The study will include both previously collected data and new participants evaluated using standardized methods.\n\nNo additional interventions will be performed, and all data will be collected as part of routine clinical evaluation. The results of this study may help improve cardiovascular risk assessment by integrating simple metabolic markers with vascular measurements and daily blood pressure behavior, potentially allowing earlier identification of individuals at higher risk.",[27,28,29,30,31],"Hypertension","Insulin Resistance Syndrome","Arterial Stiffness","Cardiovascular Risk","Blood Pressure Variability",[33,34,35,36,37,38,39,40],"Arterial stiffness","Pulse wave velocity","Triglyceride-glucose index","Insulin resistance","Ambulatory blood pressure monitoring","Morning blood pressure surge","Blood pressure variability","Cardiovascular risk","NOT_YET_RECRUITING","2026-05-19",{"date":44,"type":45},"2026-05-22","ACTUAL",{"date":47,"type":23},"2026-07-01",{"date":49,"type":23},"2028-07-01",{"name":51,"class":52},"Hospital de Base","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100497362","blood-pressure-variability-and-ischemic-stroke-outcome-100497362","NCT05756257","Blood Pressure Variability and Ischemic Stroke Outcome","BP-VISO","Inclusion Criteria:\n\n* Ischemic stroke according to the American Heart Association (AHA) definition and either:\n\n  1. CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or\n  2. Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)\n\n     Onset of ischemic stroke within 48 hours and able to get baseline pMRI within 72 hours of arrival\n\n     4\\) NIH Stroke Scale ≥ 4 at time of enrollment\n\n     Exclusion Criteria:\n* Pre-morbid mRS ≥3\n* Predicted hospital system admission \\\u003C72 hours\n* Pacemaker or other MRI contraindications per American College of Radiology guidelines",{"count":62,"type":23},150,"The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are:\n\n1. To determine the association of BPV with functional\u002Fcognitive outcome after ischemic stroke.\n2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome.\n3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.",[65,31],"Acute Ischemic Stroke","RECRUITING","2026-05-18",{"date":69,"type":45},"2026-05-20",{"date":71,"type":45},"2024-07-15",{"date":73,"type":23},"2026-07-30",{"name":75,"class":52},"Yale University",3,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":83,"targetDuration":85,"studyType":24,"phases":4,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100629925","association-between-intraoperative-mean-arterial-pressure-variability-and-postoperative-fatigue-in-patients-undergoing-laparoscopic-abdominal-surgery-100629925","NCT07481006","Association Between Intraoperative Mean Arterial Pressure Variability and Postoperative Fatigue in Patients Undergoing Laparoscopic Abdominal Surgery","Inclusion Criteria:\n\n1. Age ≥ 18 years;\n2. ASA physical status I-III;\n3. Scheduled for elective laparoscopic abdominal surgery under general anesthesia.\n\nExclusion Criteria:\n\n1. Severe cardiac, hepatic, or renal insufficiency, or major neurological or psychiatric disorders;\n2. Known allergy to drugs used during the study;\n3. Participation in other clinical trials within the past 3 months;\n4. Unable to complete the required questionnaires or assessments;\n5. Surgery duration \\\u003C 60 minutes.",{"count":84,"type":23},353,"7 Days","This prospective cohort study aims to investigate the relationship between intraoperative mean arterial pressure (MAP) variability and postoperative fatigue syndrome (POFS) in elderly patients (≥18 years) undergoing laparoscopic abdominal surgery. The main research question is:\n\nDoes the degree of intraoperative MAP fluctuation correlate with postoperative fatigue in elderly patients?\n\nEligible patients scheduled for elective laparoscopic abdominal surgery under general anesthesia will have their intraoperative blood pressure variability recorded (generalized average real variability, G-ARV), and postoperative fatigue and recovery will be assessed on postoperative days 1, 3, and 7 using the Christensen fatigue scale.",[88,31],"Fatigue Symptom","2026-03-20",{"date":91,"type":45},"2026-03-24",{"date":93,"type":23},"2026-04-15",{"date":95,"type":23},"2026-12-31",{"name":97,"class":52},"The First People's Hospital of Lianyungang",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":106,"phases":107,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":117,"locationsCount":4},"100517049","phase-1-correlates-and-control-of-blood-pressure-variability-100517049","NCT06012487","Correlates and Control of Blood Pressure Variability","Inclusion Criteria:\n\n* Individuals 18 years old or older are included.\n* Patients followed continuously at Cedars-Sinai for at least 5 years, defined as at least 1 outpatient visit with a Cedars-Sinai physician at which a blood pressure was measured each of the last 2 calendar years\n* Patients with a PCP in the Cedars-Sinai Medical Group or faculty practice\n* Patients on antihypertensive therapy other than a DPH-CCB or thiazide-like diuretic\n* Patients in the highest decile of BPV based on extracted BP data from the EHR\n\nExclusion Criteria:\n\n* Any records flagged \"break the glass\" or \"research opt out.\"\n* Pregnant or breastfeeding patients (due to guideline recommendations for specific medications for the treatment of hypertension during pregnancy and breastfeeding).",{"count":105,"type":23},10,"INTERVENTIONAL",[108],"PHASE1","The purpose the research is to prospectively demonstrate agreement between EHR and ambulatory blood pressure monitor (ABPM) derived blood pressure variability (BPV), as well as the feasibility of reducing BPV using a data-driven pharmacotherapeutic approach. To this end, this is a feasibility study that will make use of the Cedars-Sinai Health System including the Medical Delivery Network and the clinics of all practitioners who use the same EHR.",[31],"2025-02-17",{"date":113,"type":45},"2025-02-19",{"date":115,"type":23},"2026-05-01",{"date":95,"type":23},{"name":118,"class":52},"Cedars-Sinai Medical Center",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":128,"conditions":129,"keywords":131,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":53},"100457103","blood-pressure-variability-in-non-hypertensive-patients-with-ischemic-cerebrovascular-disease-100457103","NCT05232240","Blood Pressure Variability in Non-hypertensive Patients With Ischemic Cerebrovascular Disease","BPV-NhICVD","Inclusion Criteria:\n\n1. Diagnosed as ischemic stroke or transient ischemic attack (TIA), with confirmation of computed tomography or magnetic resonance imaging.\n2. Less than 90 days after onset of ischemic stroke or TIA symptoms.\n3. The blood pressure measured 5\\~90 days after the ICVD onset without any anti-hypertension treatment is less than 140\u002F90 mmHg (an average of ≥2 readings obtained on ≥ 2 occasions after emptying bladder, relaxing for more than 5 min, and avoiding caffeine, exercise, or smoking for at least 30 min before measurement).\n4. Consent to participate in the study.\n\nExclusion Criteria:\n\n1. A definite diagnosis of hypertension.\n2. Under anti-hypertension treatment.\n3. Worsening neurological conditions.\n4. With a National Institute of Health Stroke Scale score more than 5 points.\n5. Intracranial hemorrhage.\n6. Autonomic failure.\n7. With malignant tumors or poor organ functions or hematologic diseases, whose estimated life expectancy is less than 3 years.\n8. With contraindications to ambulatory 24-hour blood pressure monitoring or fail to finish the examination at baseline.\n9. Mental disease.\n10. Pregnant.",{"count":127,"type":23},300,"This study is a single-center prospective cohort of patients with ischemic cerebrovascular disease (ICVD) who have not met the diagnostic criteria for hypertension. Ambulatory 24-hour blood pressure monitoring (ABPM) will be performed at baseline and one year after the enrollment. The primary purpose of the study is to delineate the relationship of blood pressure variability (BPV) with the risk of composite vascular events in non-hypertensive patients with ICVD. The factors related to BPV, as well as the potential modulators of the associations between BPV and vascular risk, will be further explored among these patients.",[130,31],"Ischemic Cerebrovascular Disease",[132,133,134,135,136],"ischemic stroke","transient ischemic attack","non-hypertensive","blood pressure variability","vascular risk","2022-02-26",{"date":139,"type":45},"2022-03-14",{"date":141,"type":45},"2022-02-14",{"date":143,"type":23},"2028-02",{"name":145,"class":52},"Xuanwu Hospital, Beijing"]