[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"blood-purification\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:blood-purification":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,58,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100625220","oxiclear-oxiris-cytokines-and-endotoxin-adsorption-rate-study-100625220",false,"NCT07419802","OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study","Endotoxin and Cytokine Adsorption Properties of the Oxiris Hemofilter in Septic Shock: Evaluation of Saturation Phenomena and Inflammatory Mediators' Clearance Capacity","OxiCLEAR","Inclusion Criteria (should meet all the criteria mentioned below):\n\n* Septic shock patient with a Dynamic scoring system of 6-8 points \u002FSeptic shock definition based on Sepsis-3: a vasopressor requirement to maintain a mean arterial pressure of 65 mmHg or greater and serum lactate greater than 2mmol\u002FL despite optimal (30ml\u002Fkg body weight) bolus fluid resuscitation\u002F\n* CVVH with AN69-polyethylenimine (Oxiris) membrane for at least 24 hours\n* Age \\>18 years\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Pregnancy\n* Known contraindications to citrate anticoagulation\n* High likelihood of death within 24 hours due to irreversible comorbidities (e.g., end-stage cardiac, pulmonary, or hepatic disease; hepatorenal syndrome; advanced uncontrolled malignancy)\n* Simultaneous treatment with another adsorption device during the study period","ALL","18 Years",{"count":20,"type":21},29,"ESTIMATED","OBSERVATIONAL","This study examines how well the Oxiris® hemofilter works over time in adults with septic shock who require continuous kidney support in the intensive care unit (ICU).\n\nSeptic shock is a severe form of infection that leads to organ failure, including acute kidney injury. Many people with septic shock require continuous renal replacement therapy (CRRT), a form of dialysis that runs continuously to support the kidneys. The Oxiris® hemofilter is a special type of CRRT filter designed not only to replace kidney function but also to remove harmful substances from the blood, including endotoxins from bacteria and inflammatory proteins (cytokines).\n\nAlthough Oxiris® is widely used, it is not known how long the filter continues to remove these substances effectively. Over time, the membrane of the filter may become filled with endotoxins and cytokines, which could reduce its ability to clean the blood. This study aims to determine whether and when this loss of adsorption occurs during a standard twenty-four-hour treatment period.\n\nAdults with septic shock who receive Oxiris® as part of routine ICU care will take part in this observational study. No experimental treatment will be given. Blood samples will be taken before and after the filter, and fluid leaving the filter will be collected, to measure how endotoxins and cytokines are removed over time.\n\nThe study will also assess how changes in filter performance relate to clinical markers such as blood pressure support, blood lactate levels, organ function scores, kidney recovery, and twenty-eight-day survival.\n\nThe results will help define the optimal timing for Oxiris® filter replacement and support more effective use of blood purification therapy in patients with septic shock.",[25,26,27,28],"Sepsis","Septic Shock","Blood Purification","Hemoadsorption",[30,31,32,33,34,35,36,37,38,39,40,41,42,43,44],"Oxiris","blood purification","hemoadsorption","septic shock","saturation phenomena","Continuous renal replacement therapy (CRRT)","AN69-polyethylenimine membrane","Endotoxin adsorption","Cytokine adsorption","Membrane saturation","Mass balance","Inlet-outlet concentration gradient","Membrane fouling","Precision blood purification","Endotoxemia","RECRUITING","2026-02-16",{"date":48,"type":49},"2026-02-19","ACTUAL",{"date":51,"type":21},"2026-03-01",{"date":53,"type":21},"2027-09-01",{"name":55,"class":56},"Pauls Stradins Clinical University Hospital","OTHER",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":4,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":65,"maxAge":18,"enrollmentInfo":66,"targetDuration":4,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":57},"100484990","blood-purification-in-septic-children-100484990","NCT05595239","Blood Purification in Septic Children","The Efficacy of Different Mode of Blood Purification in Septic Children","Inclusion Criteria:\n\n* Meet the 2005 diagnostic criteria for sepsis\n* Age 29 days - 18 years old\n* Sepsis-induced dysfunction of more than one organ or abnormal tissue perfusion, or septic shock\n* Diagnosis \\\u003C 48 hours\n\nExclusion Criteria:\n\n* Inability to obtain an informed consent from the subject, family member or an authorized surrogate\n* Subject has end-stage renal disease and requires chronic dialysis\n* There is clinical support for non-septic shock\n* Subject has had chest compressions as part of cardiopulmonary resuscitation this hospitalization without immediate return to communicative state\n* Subject has uncontrolled hemorrhage\n* Subject has immunodeficiency diseases\n* Subject has received chemoradiotherapy or immunosuppressive therapy in the 14 days before enrollment\n* HIV infection in association with a last known or suspected CD4 count of \\\u003C50\u002Fmm3\n* Subject has sustained extensive third-degree burns within the past 7 days\n* Subject has known sensitivity or allergy to heparin or has a history of heparin associated thrombocytopenia\n* Subject is currently enrolled in an investigational drug or device trial\n* Subject has been previously enrolled in the current trial\n* Any other condition, that in the opinion of the investigator, would preclude the subject from being a suitable candidate for enrollment, such as end stage chronic illness with no reasonable expectation of survival to hospital discharge\n* Known hypersensitivity to hemofilter\n* Subject has received organ transplantation\n* Subject is expected to die within 24 hours","29 Days",{"count":67,"type":21},120,"INTERVENTIONAL",[70],"NA","In septic shock, dysregulated host responses to pathogens lead to cytokine storms that damage host tissues and organs, further contributing to the development of organ dysfunction and increased mortality. For sepsis, blood purification can remove inflammatory factors in sepsis by filtration or adsorption, so as to achieve the purpose of reducing inflammatory mediators in the body. However, there are few prospective randomized controlled studies in children. Therefore, this study intends to compare the efficacy and prognosis of different blood purifications on children with sepsis through randomized controlled studies, so as to provide a corresponding basis for the treatment of children with sepsis blood purification.",[25,27],"NOT_YET_RECRUITING","2026-02-12",{"date":76,"type":49},"2026-02-17",{"date":78,"type":21},"2026-07-01",{"date":80,"type":21},"2026-12-31",{"name":82,"class":56},"Children's Hospital of Fudan University",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":68,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":57},"100554840","oxiris-for-abdominal-septic-shock-oases-study-100554840","NCT06504316","OXiris for Abdominal SEptic Shock (OASES Study)","A Multicenter, Randomized Control Clinical Trial on the Effect of Adsorptive Filter oXiris on Hemodynamics of Abdominal Septic Shock Patients","OASES","Inclusion Criteria:\n\n1. Age ≥18 years;\n2. Weight ≥30 kg;\n3. Intra-abdominal infection (blood or abdominal drainage fluid culture positive for Gram-negative bacteria or suspected to be caused by a Gram-negative agent);\n4. Diagnostic septic shock (Sepsis 3.0): Sepsis was defined as \"life-threatening organ dysfunction caused by a dysregulated host response to infection\" with organ dysfunction defined as an increase in qSOFA ⩾2 points. Septic shock was defined as sepsis requiring vasoactive therapy to maintain mean arterial pressure (MAP) ⩾ 65 mmHg and lactate elevation to \\>2 mmol\u002FL despite adequate volume resuscitation;\n5. The dose of norepinephrine⩾0.4ug\u002Fkg\u002Fmin;\n6. PCT⩾50ug\u002FL, and\u002For IL-6⩾1000pg\u002Fml;\n7. AKI stage II\u002FIII (Kidney Disease Improving Global Outcomes, KDIGO grade);\n8. Duration of septic shock ≤48 hours.\n\nExclusion Criteria:\n\n1. Patients with highly contagious infectious diseases, such as tuberculosis;\n2. Pregnant and lying-in woman or lactation period;\n3. Infection of other sites (no abdominal infection like pneumonia, central nervous system infection and so on);\n4. CRRT cannot be performed for various reasons;\n5. Death is expected within 48 hours of admission to the ICU;\n6. Previous renal replacement therapy;\n7. Patients that underwent cardio-pulmonary resuscitation (CPR);\n8. Patients who will not sign the informed consent form.",{"count":92,"type":21},192,[70],"This study innovatively utilizes multi-modal hemodynamic monitoring (Norepinephrine equivalence, NEE+Pulse indicator Continuous Cariac output, PiCCO) to investigate the optimal timing of initiation of oXiris in abdominal infection-associated septic shock patients and to investigate prognosis on sepsis phenotypes undergoing oXiris therapy.",[26,96,97,27,98],"Abdominal Sepsis","Multi Organ Failure","AKI - Acute Kidney Injury","2024-07-10",{"date":101,"type":49},"2024-07-16",{"date":103,"type":21},"2024-08-15",{"date":105,"type":21},"2027-05-31",{"name":107,"class":56},"RenJi Hospital"]