[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"blood-transfusion-associated-adverse-reactions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:blood-transfusion-associated-adverse-reactions":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100634166","phase-4-antihistamine-for-prevention-of-htr-after-blood-primed-cpb-100634166",false,"NCT07536152","Antihistamine for Prevention of HTR After Blood Primed CPB","Prophylactic Antihistamine for Prevention of Hypotensive Transfusion Reaction After Blood Primed Cardiopulmonary Bypass in Pediatric Cardiac Surgery: a Randomized-controlled Study","HTR - CPB","Inclusion Criteria:\n\n* Acyanotic congenital heart disease.\n* Age :1 -7 years.\n* Genre: both.\n\nExclusion Criteria:\n\n* Redo patient.\n* History of allergy to antihistamines.\n* Bleeding disorders with INR \\> 1.5 and\u002For platelets \\\u003C 50,000.\n* Emergency procedure.","ALL","1 Year","7 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.",[28],"Blood Transfusion Associated Adverse Reactions",[30],"prevention of hypotensive transfusion reaction","RECRUITING","2026-04-16",{"date":34,"type":35},"2026-04-21","ACTUAL",{"date":37,"type":35},"2026-03-01",{"date":39,"type":22},"2026-12",{"name":41,"class":42},"Kasr El Aini Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100550164","respiratory-trends-during-blood-transfusions-in-newborns-100550164","NCT06443515","Respiratory Trends During Blood Transfusions in Newborns.","Evaluation of Respiratory Trends During Blood Transfusions in Newborns.","ARTE","Inclusion Criteria:\n\n* admitted newborns requiring blood transfusions as per local practice and\u002For international guidelines\n\nExclusion Criteria:\n\n* newborns with major malformations\n* need for palliative care\n* lack of informed consent","1 Month",{"count":54,"type":22},71,[56],"NA","The prevalence of transfusion reactions is between 1 and 11% of transfusions. Most reactions are mild and do not pose a life-threatening risk to the patient. More serious problems may be the only manifestations that lead to suspicion of a transfusion reaction.\n\nMost noninfectious transfusion reactions are immune-mediated. Two main types of reactions can be distinguished: TACO (transfusion associated cardiac overload, which is a cardiogenic pulmonary edema) and TRALI (transfusion related acute lung injury, non-cardiogenic pulmonary edema).\n\nAlthough TRALI are diagnoses of exclusion, the presence of noncardiogenic pulmonary edema and respiratory problems in the vicinity of blood product transfusions should raise suspicion. Other signs of TRALI are hypotension and tachycardia, while in TACO arterial hypertension with positive water balance can be observed.\n\nAccording to previous reports, the prevalence of transfusion reactions in the neonatal population is approximately 8%. Factors associated with these reactions are low birth weight and low gestational age. However, diagnostic criteria of respiratory transfusion reactions are not uniform across studies, and often the generic terms \"acute lung injury\" have been used.\n\nTherefore, the primary objective of this study is to evaluate the respiratory trend during blood transfusions; secondary objectives are the study of risk factors for the development of respiratory worsening and the possible association with complications.",[59,28,60,61],"Blood Transfusion Complication","Respiratory Complication","Respiratory Morbidity","2024-09-23",{"date":64,"type":35},"2024-09-24",{"date":66,"type":35},"2024-07-01",{"date":68,"type":22},"2026-01-15",{"name":70,"class":42},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS"]