[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"blood-transfusion-complication\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:blood-transfusion-complication":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,57,86,112,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":33,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100616764","hip-fracture-surgery-timing-and-blood-transfusion-risk-in-patients-on-doacs-100616764",false,"NCT07309848","Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs","Blood Transfusion Risk After Early vs. Delayed Surgery in Hip Fracture Patients on Direct Oral Anticoagulants: A Natural Experiment","OPTIMIZEDOAC","Inclusion Criteria:\n\n* Isolated hip fracture classified as AO\u002FOTA 31A or 31B requiring surgical intervention.\n* Current DOAC use with the last dose taken ≤24 hours before emergency department (ED) presentation\n\nExclusion Criteria:\n\n* Pathologic or periprosthetic hip fractures.\n* Fracture sustained \\>24 hours before ED presentation.\n* Inter-hospital transfer.\n* Hematologic disorders (e.g., thalassemia, sickle cell disease, aplastic anemia, myelodysplastic syndromes, leukemia).\n* Use of a non-EMA-approved DOAC (e.g., betrixaban).","ALL",{"count":19,"type":20},374,"ESTIMATED","OBSERVATIONAL","This study looks at patients with hip fractures who are taking direct oral anticoagulants (DOACs), a type of blood thinner. In many hospitals, surgery for these patients is delayed because of concerns about bleeding, but waiting longer can also increase risks such as complications and longer hospital stays. The purpose of this study is to find out whether operating within 24 hours is as safe as delaying surgery beyond 24 hours. Specifically, the investigators want to know if early surgery does not lead to a higher need for blood transfusions compared to delayed surgery.",[24,25,26,27,28,29,30,31,32],"Blood Transfusion","Hip Fracture Surgeries","Geriatric","Bleeding Complications","Bleeding as Surgical Complication (Treatment)","Bleeding","Blood Transfusions","Blood Transfusion Complication","Direct Oral Anticoagulants (DOACs)",[34,35,36,37,38,39,40,41,42,43],"natural experiment","doac","direct oral anticoagulant","hip fracture","geriatric","surgery","bleeding","blood transfusion","early","delayed","RECRUITING","2025-12-15",{"date":47,"type":48},"2025-12-30","ACTUAL",{"date":50,"type":48},"2025-11-01",{"date":52,"type":20},"2027-12-31",{"name":54,"class":55},"St. Antonius Hospital","OTHER",7,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":17,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100452371","blood-warming-in-preterm-infants-to-decrease-hypothermia-100452371","NCT05170633","Blood Warming in Preterm Infants to Decrease Hypothermia","Evaluation of a Blood Warming Device for Packed Red Blood Cell Transfusions to Decrease Hypothermia in Very Preterm Infants","Inclusion Criteria:\n\n* Any infant born at PRISMA Health Richland hospital\n* less than 32 weeks gestational age by obstetrical dating as indicated in the electronic medical chart\n* admitted to the neonatal intensive care unit receiving one PRBC transfusion within the first month of life.\n\nExclusion Criteria:\n\n* Infants having neurological anatomical abnormalities or major brain hemorrhage (Grade III or IV), because neurological damage can interfere with thermal control.",true,"24 Weeks","32 Weeks",{"count":68,"type":20},140,"INTERVENTIONAL",[71],"NA","Background\u002Fsignificance: Over 100,000 early preterm infants are born annually in the United States and suffer morbidity and mortality during hospitalization in a neonatal intensive care unit. One such condition is hypothermia. Hypothermia has been defined as a contributor of neonatal morbidity by The World Health Organization. Another acute morbidity is anemia in preterm infants due to the prematurity and frequent laboratory testing. Anemia requires correction with a packed red blood cells (PRBC) transfusion.\n\nResearchers have previous noted hypothermia during PRBC transfusions in preterm infants. Objective: To use a commercial blood warmer in the neonatal intensive care setting to prevent hypothermic body temperatures (\\\u003C36.5°C) in very preterm infants during PRBC transfusions.\n\nProcess: Based on a completed national survey of neonatal intensive care nurses and PRBC transfusion practices and personal NICU experience, we designed this randomized control trial in 140 very preterm infants in a Southeastern, level III neonatal intensive care unit.\n\nOutcomes: Very preterm infants (\\\u003C32 weeks gestational age) receiving PRBC transfusions warmed by the commercial blood warmer will have a lower incidence of central body hypothermia post transfusion (temperatures \\\u003C36.5C), compared to infants receiving PRBC transfusions by standard of care. Very preterm infants (\\\u003C32 weeks gestational age) receiving PRBC transfusions warmed by the commercial blood warmer will have a higher post transfusion mean abdominal skin body temperature when compared to infants receiving PRBC transfusions by standard of care.\n\nHypothesis : The results of this trial could show that very preterm infants experience hypothermia during PRBC transfusions, and thus provide the evidence to support the need for warmed PRBC transfusions in very preterm infants nationwide.",[74,31,75],"Preterm Birth","Hypothermia","2024-12-05",{"date":78,"type":48},"2024-12-11",{"date":80,"type":48},"2022-01-01",{"date":82,"type":20},"2026-01-01",{"name":84,"class":55},"University of South Carolina",1,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":69,"phases":97,"briefSummary":98,"conditions":99,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":85},"100550164","respiratory-trends-during-blood-transfusions-in-newborns-100550164","NCT06443515","Respiratory Trends During Blood Transfusions in Newborns.","Evaluation of Respiratory Trends During Blood Transfusions in Newborns.","ARTE","Inclusion Criteria:\n\n* admitted newborns requiring blood transfusions as per local practice and\u002For international guidelines\n\nExclusion Criteria:\n\n* newborns with major malformations\n* need for palliative care\n* lack of informed consent","1 Month",{"count":96,"type":20},71,[71],"The prevalence of transfusion reactions is between 1 and 11% of transfusions. Most reactions are mild and do not pose a life-threatening risk to the patient. More serious problems may be the only manifestations that lead to suspicion of a transfusion reaction.\n\nMost noninfectious transfusion reactions are immune-mediated. Two main types of reactions can be distinguished: TACO (transfusion associated cardiac overload, which is a cardiogenic pulmonary edema) and TRALI (transfusion related acute lung injury, non-cardiogenic pulmonary edema).\n\nAlthough TRALI are diagnoses of exclusion, the presence of noncardiogenic pulmonary edema and respiratory problems in the vicinity of blood product transfusions should raise suspicion. Other signs of TRALI are hypotension and tachycardia, while in TACO arterial hypertension with positive water balance can be observed.\n\nAccording to previous reports, the prevalence of transfusion reactions in the neonatal population is approximately 8%. Factors associated with these reactions are low birth weight and low gestational age. However, diagnostic criteria of respiratory transfusion reactions are not uniform across studies, and often the generic terms \"acute lung injury\" have been used.\n\nTherefore, the primary objective of this study is to evaluate the respiratory trend during blood transfusions; secondary objectives are the study of risk factors for the development of respiratory worsening and the possible association with complications.",[31,100,101,102],"Blood Transfusion Associated Adverse Reactions","Respiratory Complication","Respiratory Morbidity","2024-09-23",{"date":105,"type":48},"2024-09-24",{"date":107,"type":48},"2024-07-01",{"date":109,"type":20},"2026-01-15",{"name":111,"class":55},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":119,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":69,"phases":123,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":136,"locationsCount":85},"100534856","the-safety-and-efficacy-of-autologous-transfusion-in-spinal-surgery-for-lung-cancer-with-spinal-metastasis-100534856","NCT06244264","The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis","A Single-center, Prospective, Randomized Controlled Study of the Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis","Inclusion Criteria:\n\n* The age range is 18-75 years old;\n* The pathological diagnosis was lung cancer and spinal metastatic tumor;\n* Expected survival \\> 3 months, can tolerate surgery;\n* Unstable spine; And\u002For spinal cord nerve compression, nerve function; Progressive decline, palliative spinal open decompression surgery\n* Patients with intraoperative\u002Fpostoperative Hb\\\u003C90 g\u002FL or other conditions requiring blood transfusion\n\nExclusion Criteria:\n\n* Serious heart dysfunction or heart failure, diagnosed blood system diseases, coagulation disorders;\n* Severe renal insufficiency or need hemodialysis treatment;\n* Sepsis or septicemia;\n* Unable to obtain consent from the patient or family.","18 Years","75 Years",{"count":122,"type":20},118,[71],"The goal of this single-center prospective randomized controlled trial is to test and compare the safety and effectiveness of autologous blood transfusion in spinal surgery for lung cancer spinal metastases. The main questions it aims to answer are:\n\n* Does autologous blood transfusion increase the incidence of new metastases?\n* Does autologous blood transfusion affect postoperative hemoglobin levels and the number of circulating tumor cells in the blood?\n* Can autologous blood transfusion reduce the rate of allogeneic transfusion during and after surgery for spinal metastases?",[126,31,127,128,129],"Spinal Metastases","Lung Cancer","Surgery","Autologous Blood Transfusion","2024-07-11",{"date":132,"type":48},"2024-07-12",{"date":134,"type":48},"2024-03-15",{"date":52,"type":20},{"name":137,"class":55},"Guangdong Provincial People's Hospital",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":64,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":145,"targetDuration":147,"studyType":21,"phases":4,"briefSummary":148,"conditions":149,"keywords":154,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":85},"100517862","hepatitis-b-vaccination-after-neonatal-surgery-100517862","NCT06023056","Hepatitis B Vaccination After Neonatal Surgery","Influence of Delayed Vaccination of Hepatitis B Vaccine on Vaccination Safety and Immune Response of Newborns After Gastrointestinal Surgery","Inclusion Criteria:\n\n1\\. Term neonates; 2. Underwent staged gastrointestinal surgery; 3. HBsAg-; 4. No immune system disease; 5.no serious defect of heart, brain, liver, kidney and other organs.\n\nExclusion Criteria:\n\n1\\. Premature; 2. HBsAg+; 3. Having immune system diseases; 4. Having serious defect of heart, brain, liver, kidney and other organs; 5. Lost patients.",{"count":146,"type":20},180,"2 Years","At present, whether the hepatitis B vaccine (HBV) can be vaccinated on time after neonatal surgery has become a common problem for children's families, neonatal surgeons, and vaccination departments, but there are few relevant studies at home and abroad, and there is no corresponding guide or consensus. In the early stage, our research team investigated the vaccination plans of the vaccination units in the main urban areas of Chongqing for such children through telephone follow-up, and found that the practices of each unit were different, all based on their own experience, and there was no clear evidence to support the vaccination or should not be vaccinated, which may cause some children to miss the best vaccination time or increase the risk of vaccination. The center is a relatively large neonatal surgery center in southwest China. The diagnosis and treatment of neonatal digestive tract malformations is at the leading level in China. It can carry out various neonatal operations such as neonatal necrotizing enterocolitis, congenital anorectal malformations, and congenital megacolon. On average, it carries out more than 30 third and fourth grade neonatal gastrointestinal operations every month. It has accumulated a lot of experience in the follow-up of newborns, There is a large amount of clinical data support for children who need to be vaccinated after surgery, so it is planned to follow up the second and third doses of hepatitis B vaccine and whether there are adverse reactions related to vaccination for children who need to be vaccinated after gastrointestinal surgery in the neonatal period, and at the same time check the production of HBsAb after vaccination, The immune response and adverse reactions of hepatitis B vaccine at different time points after surgery were studied to increase clinical evidence for the determination of hepatitis B vaccine vaccination program for newborns after surgery.",[150,151,152,31,153],"Vaccination Reaction","Hepatitis B Virus Infection","Digestive System Disorders of Fetus and Newborn","Hepatitis B Vaccine Adverse Reaction",[155,153,156,157],"Hepatitis B Vaccination Reaction","Neonatal surgery","Gastrointestinal Surgery","2023-09-07",{"date":160,"type":48},"2023-09-11",{"date":162,"type":48},"2022-11-01",{"date":164,"type":20},"2030-11-01",{"name":166,"class":55},"Children's Hospital of Chongqing Medical University"]