[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"blunt-chest-trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:blunt-chest-trauma":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100626162","non-invasive-dynamic-monitoring-guided-oscillation-and-lung-expansion-for-airway-clearance-in-severe-blunt-chest-trauma-a-clinical-study-100626162",false,"NCT07432048","Non-Invasive Dynamic Monitoring-Guided Oscillation and Lung Expansion for Airway Clearance in Severe Blunt Chest Trauma: A Clinical Study","Inclusion Criteria:\n\n* Severe blunt chest trauma, defined as injury caused by blunt force such as chest impact or compression, with an Abbreviated Injury Scale (AIS) score of the chest ≥ 3\n* Age 18 to 70 years\n* Time from injury to enrollment \\\u003C 48 hours\n* Receiving invasive mechanical ventilation, with duration of mechanical ventilation \\\u003C 24 hours\n* Written informed consent signed by the patient or his\u002Fher legal representative\n\nExclusion Criteria:\n\n* Combined penetrating chest trauma\n* Perinatal women\n* Inability of the patient to cooperate with examinations and treatment\n* Contraindications to EIT monitoring, including implanted cardiac pacemaker, unhealed local skin wound after thoracic surgery, extensive subcutaneous emphysema of the chest, etc\n* Contraindications to OLE therapy:\n\nHemodynamic instability (heart rate \\\u003C 60 beats\u002Fmin or \\> 130 beats\u002Fmin; systolic blood pressure \\\u003C 90 mmHg or \\> 180 mmHg; or mean arterial pressure \\\u003C 60 mmHg or \\> 100 mmHg)\n\n* Unstable angina pectoris or cardiac arrhythmia\n* Intracranial pressure \\> 20 mmHg\n* Active bleeding\n* Suspected or active hemoptysis\n* Undrained pneumothorax\n* Unstable deep vein thrombosis or pulmonary embolism\n* Unstable spinal or long bone fractures\n* Unstable head and neck injury","ALL","18 Years","70 Years",{"count":19,"type":20},80,"ESTIMATED","OBSERVATIONAL","In our previous study, the investigators analyzed more than 30,000 cases from the National Trauma Center Database and found that 66.4% of patients with severe blunt chest trauma had concurrent rib fractures, 55.87% had multiple fractures (≥4 ribs), and 37.4% had combined pulmonary contusion. In a further prospective observational cohort study evaluating the efficacy of EIT-guided OLE in such patients, results demonstrated that this protocol improved the ventilation-perfusion ratio and oxygenation index and shortened total mechanical ventilation duration. Based on literature review and preliminary findings, the investigators propose the following hypothesis: the application of EIT-noninvasively monitored OLE airway clearance in patients with severe blunt chest trauma can improve the ventilation-perfusion ratio, shorten mechanical ventilation time, reduce the incidence of complications such as pulmonary infection and mortality, and decrease medical resource consumption.\n\nThis study will verify this hypothesis through a prospective randomized controlled trial and further refine the specific implementation protocol of OLE to enhance its scientific validity and clinical applicability.",[24],"Blunt Chest Trauma",[26,27,28,29],"blunt chest trauma","pulmonary contusion","oscillation and lung expansion","electrical Impedance Tomography","NOT_YET_RECRUITING","2026-02-24",{"date":33,"type":34},"2026-02-25","ACTUAL",{"date":36,"type":20},"2026-03",{"date":38,"type":20},"2027-11",{"name":40,"class":41},"Peking University People's Hospital","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100611284","effectiveness-of-an-innovative-chest-stabilizer-in-rib-fracture-treatment-impact-on-respiratory-function-complications-and-clinical-outcomes-100611284","NCT07238582","Effectiveness of an Innovative Chest Stabilizer in Rib Fracture Treatment: Impact on Respiratory Function, Complications, and Clinical Outcomes","Effectiveness of an Innovative Chest Stabilizer in the Treatment of Rib Fractures: Impact on Respiratory Function, Complications, and Clinical Outcomes","Inclusion Criteria:\n\nAdults aged 18 to 80 years. Blunt chest trauma with at least three rib fractures confirmed by imaging. Numeric Rating Scale (NRS) pain score ≥ 5 at rest, during deep inspiration, or with movement.\n\nAble to perform spirometry reliably (FVC, FEV1, PEF). Hemodynamically stable and medically suitable for participation. Able and willing to provide informed consent.\n\nExclusion Criteria:\n\nAge younger than 18 or older than 80 years. Penetrating chest trauma. Patients who have undergone surgical rib fixation. Active pneumonia, clinically significant atelectasis, or severe pulmonary infection at admission.\n\nUncontrolled cardiovascular, renal, or hepatic disease. Severe cognitive impairment, psychiatric disorders, or inability to comply with study procedures.\n\nSevere respiratory failure requiring invasive mechanical ventilation. Skin infection, open wounds, or dermatologic conditions preventing stabilizer application.\n\nCoagulopathy or contraindications to external chest compression. Pregnancy. Refusal or inability to give informed consent.","80 Years",{"count":51,"type":20},74,"INTERVENTIONAL",[54],"NA","This study aims to evaluate the effectiveness of an innovative, non-invasive chest stabilizer in patients with multiple rib fractures caused by blunt chest trauma. Rib fractures often lead to severe pain, breathing difficulties, and complications such as pneumonia or atelectasis. Participants will be randomly assigned to one of two groups: standard pain management or the new chest stabilizer, which will be used for 10 days.\n\nThe study will assess improvements in pain levels, breathing function (including FVC, FEV1, and PEF), and the occurrence of lung-related complications. Additional outcomes such as hospital stay, patient comfort, and skin reactions related to the device will also be evaluated. The goal of this research is to determine whether the innovative stabilizer can provide safer, more comfortable, and more effective treatment compared with current standard care for rib fracture patients.",[57,24,58,59],"Rib Fractures","Thoracic Injuries","Pulmonary Complications","2025-11-16",{"date":62,"type":34},"2025-11-20",{"date":64,"type":20},"2025-12-01",{"date":66,"type":20},"2027-12-01",{"name":68,"class":41},"Caner İşevi, MD",1]