[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bone-disease-metabolic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bone-disease-metabolic":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100530274","elucidating-the-minimal-effective-dose-of-prunes-for-bone-health-in-postmenopausal-women-100530274",false,"NCT06184646","Elucidating the Minimal Effective Dose of Prunes for Bone Health in Postmenopausal Women","Effect of Calcium and Vitamin D Supplements and\u002For Prunes on Bone Health","Inclusion Criteria:\n\n* Postmenopausal\n* BMD t-score is between 0.5 and 2 SD below the mean\n* Not on hormone replacement therapy (HRT) and\u002For other pharmacological agents known to affect bone for at least three months prior to initiation of the study\n\nExclusion Criteria:\n\n* Women whose BMD t-score at any site falls below 2.5 SD of the mean\n* Subjects receiving endocrine (e.g., prednisone, other glucocorticoids) or neuroactive (e.g., dilantin, phenobarbital) drugs or any drugs known to influence bone and calcium metabolism\n* Subjects who smoke cigarettes or vape\n* Regular consumption of dried plum or prune juice","FEMALE",{"count":18,"type":19},200,"ESTIMATED","INTERVENTIONAL",[22],"NA","The objective of this study is to examine if calcium and vitamin D supplements and\u002For prune can prevent bone loss in postmenopausal women.",[25],"Bone Disease, Metabolic",[27,28,29],"Osteopenia","Prune","Functional food","RECRUITING","2026-06-29",{"date":33,"type":34},"2026-07-01","ACTUAL",{"date":36,"type":34},"2024-03-15",{"date":38,"type":19},"2028-12",{"name":40,"class":41},"San Diego State University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":20,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":42},"100576817","glucose-dependent-insulinotropic-polypeptide-effect-on-bone-remodelling-and-cell-activity-ginebra-100576817","NCT06790225","Glucose-dependent INsulinotropic Polypeptide: Effect on Bone Remodelling and Cell Activity (GINEBRA)","GINEBRA","Inclusion Criteria:\n\n* healthy volunteers\n\nExclusion Criteria:\n\n* pre-diabetes or diabetes (HbA1c \\>42mmol\u002Fmol)\n* BMI \\>28\n* fractures with \\\u003C 6months\n* comorbidities\u002Ftreatments that may influence bone metabolism or procedures - -- pregnancy\n* inability to provide informed concent",true,"ALL","18 Years","40 Years",{"count":55,"type":19},12,[22],"Glucose-dependent insulinotropic polypeptide (GIP) is released by the intestines in response to food intake and increases insulin secretion. Although short-term (\\\u003C 3 hours) stimulation with GIP decreases bone resorption in humans, the effect may vanish following continuous administration within 24 hours, at least in patients with type 1 diabetes. Whether the anti-resorptive effect of GIP can be maintained if the hormone is non-continuously administrated is unclear. As the first GIP receptor (GIPR) agonist, tirzepatide was recently approved for the treatment of obesity and type 2 diabetes in the USA and type 2 diabetes alone in the EU, there is a need to establish knowledge about the long-term effects of GIP on bone health, including if different exposure times to GIP have different skeletal effects.\n\nThis project will investigate whether GIP maintains its anti-resorptive potential if given as intermittent compared to continuous infusion in healthy men and women aged 18-40 years. Administration cycles involve intermittent (8 hours daily) and continuous (24 hours daily) injection of GIP for three days each. The effect of GIP will be measured by bone markers in blood samples, as well as in vitro activity and genetic alterations of bone cells (osteoclasts and osteoblasts) using bone marrow aspirates and bone marrow biopsies. Each participant will receive both administration cycles using a crossover design with a 14-28 days washout period between administrations of GIP.",[25,59,60],"Diabetes Mellitus, Type 2","Obesity and Obesity-related Medical Conditions",[62,63,64,65,66],"GIP","CTX","P1NP","Glucose-dependent insulinotropic polypeptide","Bone remodelling","2025-12-29",{"date":69,"type":34},"2026-01-02",{"date":71,"type":34},"2025-11-10",{"date":73,"type":19},"2027-11-30",{"name":75,"class":41},"Esbjerg Hospital - University Hospital of Southern Denmark",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":42},"100315473","metabolic-profile-of-bone-in-professional-athletes-100315473","NCT03386981","Metabolic Profile of Bone in Professional Athletes","Study of the Metabolic Profile of Bone in Professional Athletes as a Function of the Kind of Physical Activity Performed","SportMarkers","Inclusion Criteria:\n\n* \\>\u002F= 18 yo\n* healthy status\n* caucasians\n\nExclusion Criteria:\n\n* \\\u003C 18 yo\n* pregnancy status\n* ongoing or previous (\\\u003C5 years) neoplasia\n* acute or chronic inflammatory pathologies\n* primary metabolic diseases of bone\n* recent bone fractures (\\\u003C 6 months)\n* chronic drugs\n* recent drugs administration (\\\u003C 2 months) for non steroidal anti-inflammatory drugs (NSAIDs) and steroids\n* anxious-depressive conditions\n* inability to understand the information given by the recruiting physician",{"count":18,"type":19},"OBSERVATIONAL","Physical activity is a key stimulus for bone metabolism through both direct mechanisms (e.g., as a result of the applied load and\u002For impact) and indirect mechanisms (e.g., the activation of several metabolic pathways and the production of several mediators and effectors that have systemic effects). However, different kinds of physical activity exert different effects on bone and endocrine system.\n\nAim of the study is to investigate the effects of different kinds of physical activity on bone metabolism and on the relationships existing between bone metabolism, energy metabolism, hormone profile, and organ functionality.",[25,88],"Physical Activity",[90,91,92],"Energy metabolism","Homeostasis","Bone turnover markers","2025-09-04",{"date":95,"type":34},"2025-09-11",{"date":97,"type":34},"2016-02-04",{"date":99,"type":19},"2027-02-04",{"name":101,"class":41},"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio"]