[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bone-graft\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bone-graft":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,40,67,89,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100626351","comparison-of-iliac-crest-marrow-vs-proximal-tibia-avitus-bone-graft-100626351",false,"NCT07434505","Comparison of Iliac Crest Marrow vs. Proximal Tibia Avitus® Bone Graft","Inclusion Criteria:\n\n* Patient must be 18 years of age or older.\n* Patient must be able and willing to sign the IRB approved informed consent.\n* Patient must consent to preoperative knee and pelvis radiographs to confirm no issue at harvest location.\n* Patient has indication for autograft bone harvest (undergoing any ankle or hindfoot fusion, complex mid and forefoot fusions requiring graft supplementation, treatment of fuse and fracture nonunions)\n* Patient is indicated for proximal tibia autograft harvest and iliac crest BMA (e.g. no hx bilateral TKAs or previous iliac wing trauma bilaterally).\n* Patient is skeletally \"mature\" and presents with no concern for osteopenia\u002Fosteoporosis.\n* Patient has sufficient volume of harvest material for study inclusion (minimum of 10 ml of cancellous bone graft plus 10 ml fluid pressed out from cancellous bone portion)\n* Patient must speak English or have access to sufficient translator.\n\nExclusion Criteria:\n\n* Patient is 70 yrs of age or older.\n* Patient is unwilling or unable to give consent or comply with study protocol.\n* Patient has any condition, which in the judgement of the Investigator, places the patient at undue risk or interferes with the study.\n* Patient has mental or neurological disorder that will not allow for proper informed consent.\n* Patient is known to be pregnant or breastfeeding.\n* Patient is a vulnerable subject (prisoner, mentally incompetent or unable to understand what participation to the study entails, a known alcohol or drug abuser, and\u002For anticipated to be non-compliant).\n* Patient has any condition, which in the judgement of the Investigator, may chemically skew bone marrow. This may include but is not limited to the following:\n\n  * Cancer\n  * Undergoing chemotherapy radiation,\n  * Bone marrow transplant\n  * Infection at the donor sites\n  * Organ transplant on antirejection meds\n  * Usage of anti-rheumatologic drugs\n  * Chronic steroid usage\n  * Anemia\n  * Myelodysplastic Syndromes\n* Patient presents with arthritis of the knee and may require knee replacement within the next 12 months.","ALL","18 Years","70 Years",{"count":19,"type":20},12,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this research is to provide comparative data about the Avitus product and its equivalence to other Bone Marrow Aspirate (BMA) harvesting techniques.",[26],"Bone Graft","RECRUITING","2026-02-20",{"date":30,"type":31},"2026-02-25","ACTUAL",{"date":33,"type":31},"2025-11-06",{"date":35,"type":20},"2026-12",{"name":37,"class":38},"Mayo Clinic","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":39},"100583085","acellular-collagen-matrix-as-a-tool-to-obtain-wound-closure-following-a-guided-bone-regeneration-procedure-100583085","NCT06871735","Acellular Collagen Matrix as a Tool to Obtain Wound Closure Following a Guided Bone Regeneration Procedure","Acellular Collagen Matrix (Mucograft) as a Tool to Obtain Wound Closure Following GBR Procedures","Inclusion Criteria:\n\n* Have a missing tooth or teeth which are planned to be replaced with an implant\n* Need for guided bone regeneration procedure to increase the bone available for implant placement\n* Systemically healthy with no contraindications for bone grafting and\u002For implant surgery\n* No chronic sinus problems\n* Non-smoker\n* No need for removable temporary restorations during wound healing.\n\nExclusion Criteria:\n\n* Patients that have sufficient bone volume to perform implant placement through conventional drilling protocol without any pre-implant GBR procedure\n* Indications for pre-implant\u002Fpre-GBR soft tissue grafting procedure to increase existing soft tissue contours\n* The need to wear a removable temporary restoration during healing","21 Years","75 Years",{"count":50,"type":20},30,"OBSERVATIONAL","Guided bone regeneration (GBR) is a procedure used to increase the amount of bone volume in the jaw before placing a dental implant. It is needed when a lot of bone has been lost around the spot where a tooth has been lost or extracted.\n\nAn incision is made, bone grafting material is placed in that spot, there is a membrane put over it as a barrier, then gum tissue has to be pulled back over it. Usually, this is enough to cover the whole wound, but sometimes the barrier membrane can't be covered with tissue the whole way without too much pulling, and the barrier membrane is still exposed.\n\nIn that case, one thing that can be done is to place another material, an acellular collagen matrix, over the barrier membrane and secure it there. This material has been shown to help with the healing in these cases.\n\nParticipants in this study will be clinic patients who have been determined to need a GBR procedure. Participants will get the GBR. If the barrier membrane is still exposed, then the acellular matrix material will be placed. This study will compare the healing outcomes and the success of the GBR depending on whether the acellular matrix material was used. The procedure itself is not part of the study. The only people in the study are patients who are already planning to have this procedure done as part of their dental care.\n\nIt is important to note that the research study will not affect the care that the patient is given, or whether or not the acellular matrix material is used. That will be decided by the dental surgeon who is treating them, based on their clinical judgement. The research study will only observe and compare the outcomes.\n\nFor the study, participants will have some additional clinical measurements made, besides the ones that are done as part of the follow-up care, and will be asked questions about their experience.",[26],[55,56,57],"GBR","Bone graft","dental implant","2026-02-11",{"date":60,"type":31},"2026-02-13",{"date":62,"type":31},"2023-04-13",{"date":64,"type":20},"2026-10",{"name":66,"class":38},"Ohio State University",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":21,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":39},"100537281","mix-of-demineralized-freeze-dried-bone-allograft-and-deproteinized-bovine-bone-mineral-a-possible-solution-for-alveolar-ridge-preservation-100537281","NCT06275789","Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?","Inclusion Criteria:\n\n* Patients in good health\n* Require the extraction of at least one premolar or molar with future implant placement\n* Sufficient keratinized gingiva (equal or more than 2mm prior to extraction),\n* No more than 3mm of buccal bone loss\n* Flapless extraction possible\n* Full mouth plaque index of less than 25%\n\nExclusion Criteria:\n\n* Nicotine consumption equivalent to or more than 10 cigarettes per day\n* Electronic cigarette usage\n* A history of irradiation of head and neck area\n* Immunodeficiency disease\n* Uncontrolled systemic health problems (hypertension crisis 180\u002F120, hyperthyroidism, diabetes with HbA1c over 7, recent history of stroke, cancer) History of medications that affect bone remodeling process (bisphosphonates, RANK-L inhibitors)\n* Previous adverse reaction to the biomaterials used\n* Pregnancy\u002Flactation, or those who are trying to become pregnant.\n* Active uncontrolled or untreated periodontal disease\n* Periapical lesions greater than 1 cm and soft tissue pathology",true,{"count":50,"type":20},[23],"The purpose of the study is to compare a new grafting material for alveolar ridge preservation to a commonly used and well studied material. Alveolar ridge dimensions as well as histology will be compared.",[78,79,26],"Alveolar Ridge Preservation","Dental Extraction","2025-09-05",{"date":82,"type":31},"2025-09-12",{"date":84,"type":31},"2024-01-26",{"date":86,"type":20},"2026-06",{"name":88,"class":38},"Nova Southeastern University",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":21,"phases":97,"briefSummary":98,"conditions":99,"keywords":103,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":115,"locationsCount":118},"100572683","study-on-safety-and-performance-of-advancore-bone-void-filler-100572683","NCT06736457","Study on Safety and Performance of AdvanCore Bone Void Filler","Inclusion Criteria:\n\n* Adult subjects ≥ 18 years old, male or female.\n* Subjects who are eligible for a bone grafting\u002Fbone void filler procedure.\n* Subjects with bone lesions beyond the limits of the bone's self-healing ability.\n* Subjects, and\u002For an authorized representative, who are willing and capable of providing informed consent, participating in all testing associated with this clinical investigation at an approved clinical investigational center.\n* Subjects with only one fracture susceptible to treatment with an AdvanCore implant.\n\nExclusion Criteria:\n\n* Subjects with any AdvanCore contraindication for implantation or use.\n* Subjects with hypersensitivity to any of the AdvanCore components.\n* Subjects with infections or soft\u002Fgranulation tissue in the area to place bone graft.\n* Subjects who are currently enrolled in another investigational study or registry that would directly interfere with the current study.\n* Women who are breastfeeding or of childbearing potential who are, or plan to become, pregnant during the time of the study (method of assessment upon physician's discretion).",{"count":96,"type":20},190,[23],"The objective of this study is to evaluate the safety and performance of AdvanCore implantable bone graft through a 12-month follow-up period in a prospective, parallel-group design, non-controlled, open label, multi-center and real-world setting study. This study is intended to satisfy post-market clinical follow-up requirements of CE Mark in Europe.",[100,101,102,26],"Bone Fractures","Bone Defects","Bone Loss",[56,104,105,106,107,108],"Bone substitute","Bone regeneration","AdvanCore","Beta-Tricalcium Phosphate","Synthetic bone graft","2025-05-30",{"date":111,"type":31},"2025-05-31",{"date":113,"type":31},"2025-05-29",{"date":64,"type":20},{"name":116,"class":117},"Artur Salgado SA","INDUSTRY",4,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":21,"phases":128,"briefSummary":129,"conditions":130,"keywords":134,"overallStatus":140,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":39},"100409325","prospective-i-factortm-analysis-fusion-rate-and-quality-of-life-100409325","NCT04610021","Prospective i-FactorTM Analysis Fusion Rate and Quality of Life","Prospective Analysis of the i-FactorTM Bone Graft on the Fusion Rate and Quality of Life of Patients With Adult Spine Deformity","Inclusion Criteria:\n\n* Patients of legal age.\n* Patients diagnosed with adult deformity, whether due to scoliosis, imbalance, thoracolumbar curves, etc. In which the minimum number of levels to be instrumented is 5, that is, 4 intervertebral discs.\n* Patients who provide their informed consent in writing. (In the event that the patient's circumstances do not allow him to grant consent, this may be provided by the legal representative).\n* Present radiological tests, computed tomography and \u002F or magnetic resonance imaging prior to surgery.\n* The implants used in the surgery are Cobalt Chrome bars and Titanium screws and interbody cages.\n\nExclusion Criteria:\n\n* Patients who are expected to be unavailable for follow-up.\n* Patients with mental disabilities that make it difficult for them to fill in the questionnaires.\n* Patients who have had other types of implants placed, other than Cobalt Chrome bars and Titanium screws and interbody cages.\n* Patients who are going to have cemented and \u002F or expansive screws, Peek boxes or another type of material other than Titanium.\n* Underlying neurological or neuromuscular disease.\n* Underlying inflammatory or tumor disease.",{"count":127,"type":20},128,[23],"Adult spinal deformity surgery is a complex procedure that involves many risks and complications. Bone grafts and bone substitutes are essential to achieve fusion and manage stability in spinal surgery.\n\nAutologous bone has been considered the \"gold-standard\" for obtaining a spinal fusion. However, the source from which to obtain it is limited. Furthermore, the problems of bone quality in patients with osteoporosis and the morbidity have forced the orthopedic community to seek other options.\n\nI-Factor ™ Bone Graft (Cerapedics, Inc., Westminster, CO) is a compound formed by peptide P-15 bound to an anorganic bone mineral of bovine origin that is composed of porous and smooth hydroxyapatite (ABM) particles.\n\nIn the literature there are no articles which identify bone formation with the i-Factor ™ graft in more than 4 instrumented levels, therefore the development of this study will allow assessing the fusion rate and quality of life of patients, which could lead to an improvement in the management and decision-making of surgical procedures, as well as better control of healthcare spending",[131,26,132,133],"Spinal Deformity","Fusion Rate","Quality of Life",[135,56,136,137,138,139],"Adult Spinal deformity","Fusion rate","Quality of life","Spinal Surgery","Functional limitations","NOT_YET_RECRUITING","2021-02-05",{"date":143,"type":31},"2021-02-09",{"date":145,"type":20},"2021-03",{"date":147,"type":20},"2027-03",{"name":149,"class":38},"Complejo Asistencial Universitario de León Urgencias"]