[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bone-grafting\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bone-grafting":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,70,93,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100638724","influence-of-alveolar-bone-drilling-and-anatomical-position-on-integration-100638724",false,"NCT07589140","Influence of Alveolar Bone Drilling and Anatomical Position on Integration","Influence of Alveolar Bone Drilling and Anatomical Position on the Primary Stability, Osseointegration and Functioning of Immediately Placed Dental Implants","Inclusion Criteria:\n\n* ≥ 18 years old.\n* healthy patients without medical contraindications for dental implantation surgery.\n* removable and non-molar teeth indicated for extraction in both jaws\n* healthy soft tissues (bleeding on probing \\\u003C 20%, plaque index \\\u003C 25%);\n* intact alveolar bone walls post-extraction\n* signed informed consent form and permission to use the obtained data for research purposes.\n\nExclusion Criteria:\n\n* Smokers (≥ 10 cigarettes per day);\n* history of uncontrolled periodontitis;\n* uncontrolled diabetes\u002Falcoholism;\n* use of drugs that may affect healing;\n* persons who, due to health status, cannot be considered capable of reasonably assessing their interests;","ALL","18 Years",{"count":19,"type":20},124,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn if alveolar bone drilling and anatomical position of an immediately placed dental implant has influence on the primary stability, osseointegration and function. It aims to answer these questions:\n\n* Does absence of alveolar drilling before implant placement give the same result as traditional osteotomy with apical drilling?\n* Is palatinal root position of implant as succesful as central position?\n\nResearchers will compare crestal bone levels and primary stability of the implant after insertion in the groups. Subjects will be assigned to groups, acoording to clinical situation. Study groups:\n\n1. Dental implants will be placed in the extraction socket with an apical osteotomy.\n2. Dental implants will be placed in the extraction socket without performing an osteotomy.\n3. Dental implants will be placed in the centre of the extracted maxillary molar socket.\n4. Dental implants will be placed into the palatal root socket of the extracted maxillary molar.",[26,27,28],"Dental Implant","Bone Grafting","Immediate Dental Implant Placement",[30],"dental implant","NOT_YET_RECRUITING","2026-06-01",{"date":34,"type":35},"2026-06-03","ACTUAL",{"date":37,"type":20},"2026-07",{"date":39,"type":20},"2028-05",{"name":41,"class":42},"Lithuanian University of Health Sciences","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100638981","evaluating-the-barrier-function-regenerative-capacity-and-soft-tissue-outcomes-of-acellular-dermal-matrix-100638981","NCT07613047","Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix","A Prospective, Double-Arm, Randomized Controlled Trial Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix Compared to Resorbable Collagen Membranes in Edentulous Ridge Augmentation","Inclusion Criteria:\n\n* English speaking\n* At least 18 years old\n* Must be a patient of the UAB Dental School\n* Able to read and understand informed consent document\n* Patients presenting with a diagnosed need horizontal ridge augmentation with GBR without simultaneous implant placement, to allow for future dental implant placement.\n* Presence of periodontally healthy, non-carious neighboring teeth and\u002For healthy restored dental implants on either side of the edentulous span planned for GBR, or unhealthy adjacent teeth to be extracted during the same visit.\n* ≤4 mm ridge width in a Seibert Class I Edentulous span19\n* No anticipated need for surgical and\u002For endodontic care at planned teeth adjacent to the proposed surgical site during the study period.\n\nExclusion Criteria:\n\n* Non-English speaking\n* Less than 18 years old\n* Smokers\u002Fnicotine users (defined as currently reporting use of any form of tobacco\u002Fnicotine products)\n* Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing, including:\n\n  * Uncontrolled diabetes (HbA1c \\> 7%)\n  * Untreated periodontal disease\n  * History of head\u002Fneck radiation\n  * IV bisphosphonates\n  * Immunocompromised state\n  * Pregnancy\n  * Acute infection at site\n* Documented or suspected allergy or sensitivity to any study product",true,"85 Years",{"count":54,"type":20},70,[23],"This investigator-initiated study will compare ADM and resorbable cross-linked collagen membrane barriers for guided bone regeneration at atrophic lateral ridge augmentation sites.",[58,27,59],"Acellular Dermal Matrix","Soft Tissue Grafting",[61],"soft tissue graft","2026-05-28",{"date":32,"type":35},{"date":65,"type":20},"2026-10",{"date":67,"type":20},"2028-10",{"name":69,"class":42},"University of Alabama at Birmingham",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":43},"100632309","outcomes-of-different-bone-graft-combinations-for-maxillary-sinus-augmentation-procedure-100632309","NCT07512011","Outcomes of Different Bone Graft Combinations for Maxillary Sinus Augmentation Procedure","Maxillary Sinus Augmentation Through Lateral Window Technique: Outcomes of Different Bone Graft Combinations (MSA-BGC STUDY)","MSA-BGC","Inclusion Criteria:\n\n* Indication of bilateral sinus augmentation through lateral window technique to prepare maxillary right and left posterior edentulous sites for a single or multiple unit implant supported restorations.\n* Systemically healthy with controlled conditions\n* Periodontally healthy\u002Fcontrolled dentition\n* No known chronic and\u002For seasonal sinusitis\n* No previous ear, nose, throat, and sinus surgeries\n* Non-smokers\n* Willing to be treated with allograft, xenograft and\u002For synthetic bone graft materials\n\nExclusion Criteria:\n\n* 1\\. Indication of sinus augmentation through indirect techniques (≥5 mm initial alveolar ridge height from crest to maxillary sinus floor)\n* Implant placement surgery planned somewhere else\n* Implant placement planned at the time of sinus augmentation\n* Cases requiring major alveolar ridge augmentation concurrent with sinus augmentation\n* Cases requiring the use of a partial denture with buccal flange extension during the post-operative period\n* History of previously failed implant and\u002Fsinus augmentation procedures\n* History of tumors and\u002For radiation and\u002For chemotherapy\n* Uncontrolled systemic health problems and ENT\u002Fsinus concerns\n* Uncontrolled periodontal\u002Fdental problems\n* Intake of medications affecting wound or bone healing (e.g., corticosteroids, immunosuppressants, etc.)\n* Alcohol or drug abuse\n* Active smokers (patient should be a non-smoker for at least 1 year prior to sinus augmentation procedure)\n* Unable\u002Funwilling to follow post-operative instructions, rejecting to be treated with allograft, xenograft and\u002For synthetic bone graft materials\n* Unable\u002Funwilling to attend scheduled study visits\n* Participation in another clinical trial within 3 months prior to planned study entry",{"count":79,"type":20},10,"OBSERVATIONAL","This study investigates the outcomes of a surgical procedure that is performed to increase bone support at a future implant site on the upper back jaw area. This procedure requires placing bone graft material and\u002For substitutes into the maxillary sinus. The average healing time for the graft is about 6 months. Then, the site will be ready for dental implant. The study will compare healing outcomes of two types of bone graft mixtures used on the same patient (right and left upper jaw regions). The outcomes will be evaluated through clinical examination but also by studying the quality of the tissue through tissue biopsies obtained from grafted sites.",[27,83],"Sinus Lifting","2026-04-03",{"date":86,"type":35},"2026-04-06",{"date":88,"type":20},"2026-06",{"date":90,"type":20},"2027-06",{"name":92,"class":42},"Ohio State University",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":105,"conditions":106,"keywords":109,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":43},"100615722","antibiotic-prophylaxis-versus-placebo-in-alveolar-bone-grafting-a-randomized-controlled-trial-100615722","NCT07296302","Antibiotic Prophylaxis Versus Placebo in Alveolar Bone Grafting: A Randomized Controlled Trial","Randomized Clinical Trial Comparing Prophylactic Antibiotic Therapy and Placebo in Intraoral Alveolar Bone Grafting Procedures.","ABXGRAFT","Inclusion Criteria:\n\n* Age between 18 and 65 years.\n\nGenerally healthy individuals classified as American Society of Anesthesiologists (ASA) physical status I or II ( ASA I or ASA II).\n\nIndication for tooth extraction followed by alveolar bone grafting in a fresh socket.\n\nAbsence of active infection at the surgical site.\n\nWillingness to take amoxicillin or, in cases of β-lactam antibiotic allergy, azithromycin.\n\nNo use of antibiotics in the previous 30 days.\n\nAgreement to participate and signature of the informed consent form (ICF).\n\nExclusion Criteria:\n\n* Presence of uncontrolled systemic diseases or chronic use of immunosuppressive medications.\n\nPregnancy or breastfeeding.\n\nSevere liver disease.\n\nSmoking more than 10 cigarettes per day.\n\nKnown allergy to macrolides (azithromycin).\n\nPrior use of antibiotics within the last 30 days.\n\nConcomitant use of medications with known risk of QT interval prolongation.\n\nSigns of acute infection at the extraction site.","65 Years",{"count":103,"type":20},150,[23],"Tooth extraction sites often require alveolar bone grafting to preserve ridge dimensions and improve conditions for future implant placement. Although systemic antibiotic prophylaxis is commonly prescribed after grafting procedures, there is limited evidence supporting its necessity in healthy patients undergoing intraoral bone grafting. This randomized, double-blind, placebo-controlled clinical trial aims to compare the effects of prophylactic amoxicillin versus placebo on postoperative outcomes in alveolar bone graft procedures using Plenum® Oss HP biomaterial, a synthetic biphasic bioceramic composed of hydroxyapatite and beta-tricalcium phosphate (HA\u002Fβ-TCP; 70:30 ratio).\n\nParticipants will be randomly assigned to receive either amoxicillin 500 mg every 8 hours for 7 days or a matching placebo. Clinical parameters, postoperative complications, and patient-reported outcomes will be assessed. The study seeks to determine whether antibiotic prophylaxis provides measurable clinical benefits or whether placebo yields comparable results, contributing to more rational antibiotic use and supporting antimicrobial stewardship in oral surgery.",[107,27,108],"Alveolar Ridge Augmentation","Antibiotic Prophylaxis",[110,111,108,112,113],"Ridge Preservation","Alveolar Bone Graft","Synthetic Bone Graft","Biphasic Calcium Phosphate","2025-12-20",{"date":116,"type":35},"2025-12-29",{"date":118,"type":20},"2026-02",{"date":120,"type":20},"2027-08",{"name":122,"class":42},"Agnaldo Rocha de Souza Junior",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":4},"100604720","creos-xenoprotect-pmcf-100604720","NCT07153185","Creos Xenoprotect PMCF","A Retrospective Multi-center, PMCF Study to Assess the Safety and Performance of a Biodegradable Dental Barrier Membrane (Creos Xenoprotect)","Inclusion Criteria:\n\n* Participant was treated before December 2023 (creos xenoprotect placement)\n\n  * Participant signed informed consent form and data protection consent form1\n  * Participant was at least 18 years old at the time of treatment\n  * Participant received guided bone regeneration combined with the use of creos xenoprotect according to one of the four indications\n  * Participant was treated according to instructions for use (IFU)\n  * Participant should have follow-up time of \\>9 months after placement of the investigational device\n\nExclusion Criteria:\n\n* In Group 3: Sinus floor augmentation (lateral approach): usage of creos xenoprotect to replace a ruptured Schneiderian Membrane",{"count":131,"type":20},200,"The goal of this retrospective PMCF study is to assess safety and performance of creos xenoprotect in all indications functioning as dental barrier membrane.\n\nThe primary endpoint of the study is the occurrence of major complications during 6 months after creos xenoprotect placement whereas the hypothesis is that these major complications occur in less than 5% within this timeframe.\n\nThis is a retrospective, multicenter clinical investigation with consecutive cases. Data will be collected on consecutive data cases from patient files, given that these patients were treated within a defined indication with creos xenoprotect in the past. Patients participating in this study do not have any obligations or need to come back for any intervention. A total of 11 centers are planned to be included. Sample size is n=200 patients and is distributed equally in four indication groups:\n\nGroup 1: Ridge augmentation (vertical and horizontal) Group 2: Alveolar ridge preservation Group 3: Sinus floor augmentation Group 4: Augmentation around implant or teeth",[134,135,27],"Bone Regeneration","Dental Implants",[137,138,139],"Dental Barrier Membrane","PMCF Study","Retrospective","2025-08-25",{"date":142,"type":35},"2025-09-03",{"date":144,"type":20},"2025-11-01",{"date":146,"type":20},"2026-07-31",{"name":148,"class":149},"Nobel Biocare","INDUSTRY"]