[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bone-loss-alveolar\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bone-loss-alveolar":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,78,99],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100644159","outcomes-of-ridge-splitting-versus-sausage-technique-100644159",false,"NCT07664605","Outcomes of Ridge Splitting Versus Sausage Technique","Outcomes Of Ridge Splitting Versus Sausage Technique With Simultaneous Implant Placement For Augmenting Mandibular Horizontal Bone Defects.","Inclusion Criteria:\n\n1. Patients with deficient bone volume between (2 : 3.5 ) mm\n2. Patients must have installed functional implant for no less than 3 months- enough time to allow for bone augmentation changes.\n3. Patients with no defect in the gingival tissues.\n4. Patients with un-remarkable medical compromising conditions\n5. Patients with good oral hygiene at time of the examination\n\nExclusion Criteria:\n\n1. Patients with compromising medical condition.\n2. Patients with severe bone resorption.\n3. Patients with D1 or D2 bone.\n4. Bone height \\\u003C10mm",true,"ALL","20 Years","75 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","The current study aims to increase the width of the alveolar bone in defective mandibular ridge with simultaneous implant placement and enhance the implant stability",[28],"Bone Loss, Alveolar","RECRUITING","2026-06-20",{"date":32,"type":33},"2026-06-24","ACTUAL",{"date":35,"type":22},"2026-06-01",{"date":37,"type":22},"2026-12-01",{"name":39,"class":40},"Beni-Suef University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":16,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":51,"briefSummary":54,"conditions":55,"keywords":60,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":41},"100439112","phase-1-autogenous-mesenchymal-stem-cell-culture-derived-signalling-molecules-as-enhancers-of-bone-formation-in-bone-grafting-100439112","NCT04998058","Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting","Inclusion Criteria:\n\n* patients \\>35 years-old.\n* presenting highly atrophic fully edentulous maxilla (residual bone height \\\u003C5 mm).\n* In need of bilateral sinus floor augmentation aiming full mouth implant-supported rehabilitation.\n* having teeth extraction at least 8 weeks prior to bone augmentation.\n\nExclusion Criteria:\n\n* smokers, illicit drug users and alcohol daily consumers.\n* patients with metabolic and\u002For systemic diseases leading to impaired healing (e.g. decompensated diabetes, leukocyte or coagulation disorders, immunosuppression).\n* history of radiotherapy in the head or neck region.\n* bisphosphonate-based therapy recipients.\n* intolerant to general\u002Flocal anesthesia.","35 Years",{"count":50,"type":22},20,[52,53],"PHASE1","PHASE2","This study aims to evaluate bone formation in grafts in terms of its quality (density), quantity (volume) and maturation obtained with the application of a tissue-engineered bone grafting compound containing concentrated autogenous cell-culture medium (CM) and a synthetic bone substitute. The present study was designed as an experimental prospective split-mouth randomized controlled clinical trial. After protocol approval by the Research Ethics Committee, a total of 20 consecutive participants in need of maxillary reconstruction aiming implant-supported oral rehabilitation will be invited to join the study. To collect autogenous adipose tissue-derived mesenchymal stem cells (hASCs), an outpatient lipoplasty procedure at the abdominal area of each patient will be performed. To isolate and expand hASCs from the lipoaspirate, specific cell culture protocols will be followed, resulting in cultured viable cells and their conditioned medium (CM). Cells and CM will be then separated by a sequence of filters and centrifugation, and isolated CM will be frozen. ELISA will analyze the presence of chemokines and their concentration in CM before grafting. Following pre-op surgical planning, both maxillary sinuses of each patient will be grafted internally applying a lateral window to each sinus. The bony floor of the test maxillary sinus will be augmented with synthetic bone substitute (BoneCeramic™ 1-2 mm) mixed with 10 to 15 ml of CM (test). The control site will receive bone substitute with saline. Lateral windows in both sinuses will be then closed with a collagen membrane (Bio-Gide™). After 6 months, first-stage implant surgery will be performed placing 6 implants in each patient. Registration of implant stability by manual torque wrench will be performed. Also, bone biopsies from each drilled implant site will be collected for histology, histomorphometry and immunohistochemistry (RT-PCR). Tomographic evaluation of the bone formation will include cone beam computed tomographies (CBCTs) at pre-operative \\[Baseline\\], 90 \\[T1\\] and 180 \\[T2 = implant placement\\] days for bone 3D image analysis.",[56,28,57,58,59],"Bone Loss, Osteoclastic","Alveolar Bone Loss","Alveolar Bone Atrophy","Grafting Bone",[61,62,63,64,65,66,67],"bone","bone formation","bone graft","tissue engineering","stem cell","exosome","cell-free therapy","NOT_YET_RECRUITING","2025-06-02",{"date":71,"type":33},"2025-06-05",{"date":73,"type":22},"2025-12-15",{"date":75,"type":22},"2026-12-30",{"name":77,"class":40},"Pontificia Universidade Católica do Rio Grande do Sul",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},"100566337","grafting-of-the-peri-implant-bony-defects-around-immediate-implants-using-xenogenic-versus-alloplastic-sticky-grafts-randomized-controlled-clinical-trial-100566337","NCT06653868","Grafting of the Peri-implant Bony Defects Around Immediate Implants Using Xenogenic Versus Alloplastic Sticky Grafts: Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Patients with healthy systemic condition (Mazzotti et al., 2023).\n2. Age from 20-50 years old\n3. Patients must be free of any systemic disease which could influence the surgical procedure.\n4. Tooth involved in the esthetic zone.\n5. Sufficient hard and soft tissue volume in vertical and buccolingual direction\n6. Natural teeth adjacent to the involved tooth will be required to be free from infection.\n7. Controlled oral hygiene.\n8. Indication for tooth extraction included (Degidi et al., 2012);\n\n   * Endodontic failures\n   * Untreatable caries\n   * Non- restorable teeth\n   * Vertical root fracture\n   * Remaining roots\n\nExclusion Criteria:\n\n\\- 1.Pregnant females 2.Smokers (Khuller, 2009) 3.Unmotivated and uncooperative patients with poor oral hygiene 4.Patients with habits that may compromise the longevity and affect the result of the study as alcoholism or parafunctional habits.\n\n5.Presence of acute dento-alveolar infection.","50 Years",{"count":50,"type":22},[25],"In patients with a single non restorable tooth, does filling the peri-implant buccal gap with alloplastic sticky grafts result comparable results compared to xenogenic sticky grafts?",[28],"2024-10-21",{"date":91,"type":33},"2024-10-22",{"date":93,"type":22},"2024-10-20",{"date":95,"type":22},"2026-03-20",{"name":97,"class":40},"Cairo University",2,{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":109,"briefSummary":110,"conditions":111,"keywords":112,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":41},"100559090","evaluation-of-bone-gain-using-customized-3d-zirconia-barrier-versus-titanium-mesh-100559090","NCT06559605","Evaluation of Bone Gain Using Customized 3D Zirconia Barrier Versus Titanium Mesh","Clinical and Radiographic Evaluation of Bone Gain Using Customized 3D Printed Zirconia Barrier Versus Titanium Mesh in Combined Ridge Defects in The Aesthetic Zone: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age: 20-70 years.\n* Bone width less than 4mm\n* Vertical bone height less than 9mm\n* Periodontally sound neighboring teeth\n* Patients with sound vertical occlusal bite dimension\n* Good oral hygiene (full mouth plaque control record \\[PCR\\] \\\u003C 25%,full mouth bleeding on probing (BOP) \\\u003C 25% .\n* Patients demonstrating understanding and commitment to the post-operative care regime and the study follow up timeline.\n* Good general health (including participants with well-controlled systemic disease)\n\nExclusion Criteria:\n\n1. Pathological lesions (abscess-cyst-acute infection) in the defect site\n2. Systemic diseases that would interfere with bone metabolism\n3. Uncontrolled diabetic patients\n4. Ongoing treatment or a history of recent chemotherapy or radiotherapy\n5. Poor oral hygiene after hygienic phase (Plaque control record over 30%) or Active periodontal disease","70 Years",{"count":108,"type":22},26,[25],"Evaluation of clinical and radiographical amount of bone gained using customized 3D printed zirconia barrier compared to titanium mesh in combined ridge defect at the esthetic zone.",[28],[113,114,115],"zirconia membrane","titanium membrane","combined bone defect","2024-08-16",{"date":118,"type":33},"2024-08-20",{"date":120,"type":33},"2024-05-22",{"date":122,"type":22},"2026-11-22",{"name":97,"class":40}]