[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bone-loss-in-jaw\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bone-loss-in-jaw":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100603516","mandibular-overdentures-vs-all-on-4-with-peek-100603516",false,"NCT07137533","Mandibular Overdentures vs All-on-4 With PEEK","Long-Term Peri-Implant Outcomes of Mandibular Overdentures and All-on-4 Prostheses With PEEK Frameworks","Inclusion Criteria:\n\nAdults aged ≥40 years.\n\nCompletely edentulous mandible for at least 6 months prior to implant placement.\n\nTreated with either:\n\nFour-implant-retained mandibular overdenture with a PEEK framework, or\n\nMandibular All-on-4 fixed prosthesis with a PEEK framework.\n\nAll implants placed in the lateral incisor and first premolar regions (per respective protocol).\n\nRestorations fabricated via CAD\u002FCAM-milled PEEK framework with acrylic denture teeth.\n\nProsthesis delivered with a delayed loading protocol.\n\nMinimum clinical and radiographic follow-up of 4 years.\n\nAvailability of standardized baseline and follow-up periapical radiographs for marginal bone level assessment.\n\nTreated by the same surgical and prosthodontic team.\n\nExclusion Criteria:\n\nHistory of uncontrolled systemic diseases that could affect bone healing (e.g., uncontrolled diabetes, osteoporosis under bisphosphonate therapy).\n\nHistory of head and neck radiotherapy.\n\nActive periodontal or peri-implant infection at the time of implant placement.\n\nInsufficient bone volume in the interforaminal region requiring grafting beyond minor augmentation.\n\nHeavy smoking habit (\\>10 cigarettes\u002Fday) at the time of treatment.\n\nParafunctional habits (e.g., severe bruxism or clenching) documented in patient records.\n\nUse of medications known to affect bone metabolism (e.g., high-dose corticosteroids, antiresorptive drugs).\n\nPregnancy at the time of implant placement.\n\nIncomplete clinical or radiographic records.\n\nFollow-up period of less than 4 years.","ALL","40 Years","70 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","This study compares long-term peri-implant outcomes between two mandibular full-arch rehabilitation approaches-four-implant-retained overdentures and All-on-4 fixed prostheses-when both are fabricated with polyetheretherketone (PEEK) frameworks. While overdentures and All-on-4 prostheses are widely used, evidence on the clinical performance of PEEK frameworks in these modalities is scarce. By evaluating marginal bone loss and other peri-implant parameters, the research aims to clarify whether prosthetic design influences biological outcomes when using this high-performance polymer.",[25],"Bone Loss in Jaw","RECRUITING","2025-08-15",{"date":29,"type":30},"2025-08-22","ACTUAL",{"date":32,"type":30},"2025-08-01",{"date":34,"type":21},"2025-10-25",{"name":36,"class":37},"Menoufia University","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":38},"100600843","l-prf-vs-connective-tissue-with-customized-healing-abutment-in-immediate-implant-placement-100600843","NCT07102758","L-PRF vs Connective Tissue With Customized Healing Abutment in Immediate Implant Placement","Evaluation of Soft and Hard Tissue Augmentation by Connective Tissue Graft or Leukocyte-Platelet Rich Fibrin in Immediate Implant Placement With Customized Healing Abutment: A Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* Intact labial\u002Fbuccal bone plate\n* The presence of non-restorable single-rooted maxillary centrals, canines or premolars.\n* Sufficient bone volume.\n* Good oral hygiene.\n* Nonsmokers.\n* Sufficient bone width (≥ 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).\n\nExclusion Criteria:\n\n* Insufficient bone volume.\n* Active infection.\n* Patients on chemotherapy or radiotherapy.\n* Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, …etc},\n* Pregnant patients,\n* Patients with bone diseases\n* Presence of periapical pathology.",true,"21 Years","45 Years",{"count":50,"type":21},16,"INTERVENTIONAL",[53],"NA","comparison between L-prf and connective tissue with dental implant",[56,25],"Recession, Gingival",[58,59,60,61],"L-prf","connective tissue","customized healing abutment","implant","2025-08-10",{"date":64,"type":30},"2025-08-14",{"date":66,"type":21},"2025-08-05",{"date":68,"type":21},"2027-08-20",{"name":70,"class":37},"Kafrelsheikh University"]