[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bone-marrow-aspirate-concentrate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bone-marrow-aspirate-concentrate":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,90,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100622663","biologic-injection-for-adults-with-lumbar-disc-herniation-100622663",false,"NCT07386548","Biologic Injection For Adults With Lumbar Disc Herniation","Bone Marrow Aspirate Concentrate Injection With MRI's - A Prospective Randomized Control Trial","BMAC","Inclusion Criteria:\n\n* Male or female patients ≥ 18 years of age\n* Clinically and\u002For radiographically (MRI) confirmed diagnosis of degenerative disc disease of the lumbar spine, lumbar disc herniation, and indication for lumbar microdiscectomy surgery\n* Unresponsive to conservative\u002Fnon-operative treatment for \\>3 months\n* Psychosocial, mental and physical ability to understand and to adhere to this protocol, especially adhering to the visit schedule follow-ups and observe the treatment plan\n\nExclusion Criteria:\n\n* Prisoners\n* Individuals who are not yet adults (infants, children, teenagers)\n* Individuals who are not able to clearly understand English\n* Adults with diminished capacity to consent\n* Major cognitive impairment causing to inability to understand and provide informed consent\n* Active malignancy\n* Active chronic or acute infection\n* Autoimmune disorder that impacts the lumbar spine (ankylosing spondylitis, lupus e.g.)\n* Bone marrow-derived or non-bone marrow-derived cancer\n* Low platelet count or clotting disorders\n* Prior surgery at the level to be treated or the adjacent level","ALL","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation.\n\nThe main questions it aims to answer are:\n\n* Does the BMAC injection lead to better disc tissue health after surgery (as seen on MRI scans)?\n* Does the BMAC injection lead to greater improvement in pain and disability compared to surgery alone?\n\nParticipants will be adults aged 18 and older who are scheduled for lumbar microdiscectomy surgery.\n\nResearchers will compare one group of participants receiving the standard-of-care surgery plus the BMAC injection with another group receiving the same surgery without the injection to see if the injection offers added benefit.\n\nParticipants will:\n\n* Have surgery (microdiscectomy) with or without the injection.\n* Complete pain and disability questionnaires at several times over 2 years.\n* Undergo MRI scans at baseline and follow-up to assess disc structure and tissue health.\n* Provide samples of leftover disc or bone-marrow tissue (as applicable) from surgery for analysis.",[27,28,29,30,31,32,33,34,35,36,37],"Degenerative Disc Disease","DDD","Degenerative Disc Disease Lumbar","Degenerative Disc Disease, Lumbar","Lumbar Disc Herniation","Disc Herniation, Lumbar","Bone Marrow Aspirate Concentrate","Intervertebral Disc Displacement","Low Back Pain","Chronic Low Back Pain (CLBP)","CLBP - Chronic Low Back Pain",[39,40,41,42,43],"degenerative disc disease","lumbar disc herniation","bone marrow aspirate concentrate","intervertebral disc displacement","low back pain","NOT_YET_RECRUITING","2026-04-14",{"date":47,"type":48},"2026-04-16","ACTUAL",{"date":50,"type":21},"2026-05-01",{"date":52,"type":21},"2030-12",{"name":54,"class":55},"Weill Medical College of Cornell University","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":89},"100540028","phase-4-concentrated-bone-marrow-aspirate-in-revision-acl-reconstruction-100540028","NCT06311513","Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction","Multi-Center Pilot Study to Evaluate Concentrated Bone Marrow Aspirate (cBMA) as a Treatment to Modify Post-Traumatic Osteoarthritis (PTOA) Following Revision Anterior Cruciate Ligament Reconstruction (ACLR)","Inclusion Criteria:\n\n* Males and Females\n* Age 18 to 55\n* Previous unilateral ACLR (Anterior Cruciate Ligament Reconstruction) within the last 5 years, and identified as having experienced failure of the primary ACLR\n* Scheduled to have a revision ACLR surgery, with any graft type (including patellar tendon, hamstring, quad or allograft)\n* Able to complete all study procedures and participate in a standardized physical therapy program\n\nExclusion Criteria:\n\n* History of inflammatory arthritis or joint sepsis\n* Prior or concurrent total or sub-total meniscectomy\n* Prior or present avascular necrosis of the index knee\n* Oral or intra-articular corticosteroid injection within 3 months\n* Hyaluronic acid or PRP (Platelet-Rich Plasma) injection within 6 months\n* Use of duloxetine, doxycycline, indomethacin, glucosamine and\u002For chondroitin (ongoing or within 2 months)\n* Any clinical or laboratory abnormality greater than grade 3 CTCAE, which in the view of the investigator, will compromise the participant's safety.\n* Planned arthroplasty in the index knee","55 Years",{"count":66,"type":21},40,[68],"PHASE4","The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior cruciate ligament reconstruction surgery. The main questions it aims to answer are whether clinical outcomes, such as pain, are improved in patients who get cBMA with surgery, if there is a change in circulating markers of inflammation and what part of the cellular and molecular composition of cBMA may explain its effects.",[71,72,33,73],"Anterior Cruciate Ligament Injuries","Post-Traumatic Osteoarthritis of Knee","ACL Injury",[75,76,77,78],"Regenerative Medicine","Orthobiologics","Concentrated Bone Marrow Aspirate","Revision ACLR","RECRUITING","2025-11-19",{"date":82,"type":48},"2025-11-20",{"date":84,"type":48},"2024-01-22",{"date":86,"type":21},"2028-12",{"name":88,"class":55},"Hospital for Special Surgery, New York",2,{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":99,"phases":4,"briefSummary":100,"conditions":101,"keywords":106,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":56},"100355529","use-of-bmac-with-hip-arthroscopy-treatment-of-fai-and-labral-tear-100355529","NCT03909139","Use of BMAC With Hip Arthroscopy Treatment of FAI and Labral Tear","Prospective PROMs Outcomes in Arthroscopic Acetabular Labral Repair With and Without Application of Platelet-Rich Plasma (PRP) Harvested From the Body of the Ilium","Inclusion Criteria and Rationale:\n\n1. Age 18 or older: patients of any age have the capacity to potentially benefit from labral repair\n2. Symptoms consistent with a tear of the acetabular labrum (i.e., catching, clicking, popping, pain with sitting, episodic pain, pain with hip flexion, adduction, and\u002For internal rotation): asymptomatic labral tears do exist in the general population however there is not definitive evidence to suggest treatment of asymptomatic tears is beneficial.\n3. Symptoms not due to some other acute process in or around the hip (including septic arthritis, osteonecrosis, hemarthrosis, iliotibial band syndrome, fractures of the femoral neck or head, fractures of the acetabulum, greater trochanteric pain syndrome, sacroiliac joint pain, piriformis syndrome, low back pain associated with hip pain and not knee nor acute low back injury): certain conditions are not treatable by either arthroscopy or physical therapy. Some of these conditions can be managed with physical therapy but not arthroscopy.\n4. Availability of hip radiographs and magnetic resonance imaging (MRI and\u002For MRA): needed to assess eligibility\n5. Evidence of labral tear on MRI and\u002For MRA: documentation of acetabular labrum tear\n6. Willingness to participate and ability to understand and sign informed consent document: ability to understand study and consent willingly\n7. Returning subjects enrolled in protocol 2017P001391\u002FPHS\n\nExclusion Criteria and Rationale:\n\n1. Non-English speaking subjects: PROMs are only validated in English.\n2. Systemic infection: surgery is generally contraindicated when systemic infection is present.\n3. Systemic heparinization: the vascularity of the bone and adjacent tissues is significant, posing a potential problem for bleeding when the patient is anti-coagulated.\n4. Pregnant women\u002Ffetuses: although surgery can be performed on pregnant women, pregnant women are excluded under federal regulations.",{"count":98,"type":21},400,"OBSERVATIONAL","Femoro-acetabular impingement is a well known cause of damage to the acetabular labrum and chondrolabral junction. Additionally, it has been proposed that disruption of hip biomechanics resulting from a labral tear causes a faster progression towards osteoarthritis (OA). This progression has been observed to begin with breakdown of the chondrolabral junction with later development of diffuse osteoarthritis. Use of hip arthroscopy has increased dramatically in recent years to treat symptomatic labral tears and potentially avoid the morbidity and cost associated with hip osteoarthritis.\n\nCorrection of labral pathology presents a technical challenge and many techniques currently exist. Increased understanding of the structure-functional relationship dictated by labral anatomy has led to the development of methods aimed at restoring functional anatomy by re-establishing the labrum's native position and contour on the rim of the acetabulum. Therefore, akin to repairing a torn meniscus in the knee, restoring the anatomic footprint of a torn labrum will reconstitute normal joint biomechanics.\n\nDespite the advances in techniques for labral repair, strategies for mitigating or repairing damage to the chondrolabral junction do not yet exist. This area has been shown to consist of hyaline and fibro cartilage. Many techniques for cartilage repair exist, although most are not feasible due to technical challenges specific to the hip joint.\n\nThe management of articular cartilage defects is one of the most challenging clinical problems for orthopaedic surgeons. Articular cartilage has a limited intrinsic healing capacity, and pathology frequently results in gradual tissue deterioration. Currently, the standard surgical intervention for end-stage degenerative joint pathology is total joint replacement. Early surgical interventions for symptomatic cartilage lesions including cell based therapies such as autologous chondrocyte implantation (ACI), bone marrow aspirate concentrate (BMAC) implantation, or microfracture have been suggested to restore normal joint congruity and minimize further joint deterioration. Techniques such as ACI, which have been successfully used in the knee joint, have limited application in the hip due to the technical difficulties of open procedures.",[102,103,104,33,105],"Acetabular Labrum Tear","Femoro Acetabular Impingement","Chondral Defect","Mesenchymal Stromal Cell",[102,103,104,33,105,107,108,109,110,15],"Chondrolabral Junction","Osteoarthritis","Femoroacetabuloplasty","Hip Arthroscopy","2025-10-24",{"date":113,"type":48},"2025-10-27",{"date":115,"type":48},"2019-09-06",{"date":117,"type":21},"2027-06-30",{"name":119,"class":55},"Massachusetts General Hospital",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":132,"conditions":133,"keywords":134,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":56},"100516329","phase-3-effect-of-prp-ppp--bmac-on-functional-outcomes-following-hip-arthroscopy-for-acetabular-labral-pathologies-100516329","NCT06003101","Effect of PRP, PPP, & BMAC on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies","Effect of Platelet-Rich Plasma, Platelet-Poor Plasma, & Bone Marrow Aspirate Concentrate Application on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies: A Prospective Randomized Controlled Trial","PRP; PPP; BMAC","Inclusion Criteria:\n\n* Age: \\> or equal to 18 years\n* Clinically indicated for hip arthroscopy (by the study PI) to address a labral pathology\n* Willingness to participate, amenable to randomization into either treatment arm of the research study, and the ability to understand \\& sign the informed consent document\n\nExclusion Criteria:\n\n* Non-English speaking (PROM surveys are only validated in English)\n* Prior same site (i.e., ipsilateral hip) surgery, including but not limited to previous hip arthroscopy, core decompression, or periacetabular osteotomies",{"count":129,"type":21},160,[131],"PHASE3","The goal of this clinical trial is to assess the effect of PRP\u002FPPP\u002FBMAC application on functional outcomes after hip arthroscopy to address acetabular labral pathologies. The main questions it aims to answer are:\n\n1. Does PRP\u002FPPP\u002FBMAC application improve functional outcomes after hip arthroscopy to address acetabular labral pathologies?\n2. Does PRP\u002FPPP\u002FBMAC application reduce the arthritic burden as measured by functional outcomes following hip arthroscopy to address labral pathologies with concomitant PRP\u002FPPP\u002FBMAC application?",[102,103,104,33],[102,103,104,33,107,108,110,15],"2024-11-18",{"date":137,"type":48},"2024-11-20",{"date":139,"type":48},"2023-08-30",{"date":141,"type":21},"2045-08-30",{"name":119,"class":55}]