[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bone-substitutes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bone-substitutes":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644469","bone-substitutes-and-nipsa-in-intrabony-periodontal-defects-a-randomized-controlled-trial-100644469",false,"NCT07671963","Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial","Regenerative Therapy of Intrabony Periodontal Defects Using Bone Substitutes and a Minimally Invasive Nonincised Papilla Surgical Approach - A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of Stage III periodontitis\n* At least one intrabony periodontal defect with probing depth \\> 5 mm following completion of non-surgical periodontal therapy\n* Full-mouth plaque score (FMPS) \\\u003C 20%\n* Full-mouth bleeding score (FMBS) \\\u003C 20%\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Systemic medical contraindications to periodontal surgery\n* History of head and neck radiotherapy\n* Poor oral hygiene or lack of motivation\u002Fcompliance\n* Uncontrolled diabetes mellitus\n* Pregnancy or lactation\n* Treatment with antiresorptive medications or other drugs affecting bone remodeling\n* Heavy smoking (\\>20 cigarettes\u002Fday)",true,"ALL","18 Years","80 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with the Non-Incised Papilla Surgical Approach (NIPSA) for the treatment of intrabony periodontal defects. The study will evaluate whether differences exist between the two biomaterials with respect to clinical attachment gain, defect resolution, wound healing and biological markers of regeneration.",[28,29,30],"Periodontitis (Stage 3)","Minimally Invasive Surgical Procedures","Bone Substitutes",[32,33,34,35],"periodontitis","regenerative treatment","NIPSA","bone substitutes","RECRUITING","2026-06-22",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":22},"2026-07-01",{"date":44,"type":22},"2027-03-01",{"name":46,"class":47},"University of Belgrade","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100566920","bone-augmentation-techniques-in-the-mandible-posterior-region-100566920","NCT06661447","Bone Augmentation Techniques in the Mandible Posterior Region","Comparison of Bone Augmentation Techniques in the Mandibular Posterior Region: A Randomized Clinical Trial","Inclusion Criteria:\n\nPosterior mandibular edentulism requiring horizontal ridge augmentation (Cawood \\& Howell Classes IV-VI).\n\nOne or two eligible posterior mandibular sites suitable for cortical shell augmentation.\n\nAdequate residual bone height to allow safe fixation above the mandibular canal.\n\nGood general health (ASA I or II). Plaque index \\\u003C 20% and absence of active periodontal infection. Ability and willingness to attend scheduled follow-up visits (up to 12 months). Written informed consent provided prior to any study-related procedure.\n\nExclusion Criteria:\n\nUncontrolled systemic diseases affecting bone healing (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders).\n\nCurrent heavy smoking (\\>5 cigarettes\u002Fday). Pregnancy or lactation. Current use of medications known to affect bone metabolism or healing (e.g., bisphosphonates, long-term corticosteroids, anticoagulants).\n\nActive periodontal disease or untreated oral infection. History of chemotherapy or radiotherapy to the head and neck region.","64 Years",{"count":58,"type":22},78,[25],"This study will compare three methods to rebuild lost bone in the back part of the lower jaw (posterior mandible) before dental implant placement. Seventy-eight adults will be randomly assigned to receive one of three \"cortical shell\" techniques using either the patient's own bone (autogenous) or prefabricated bone plates from animal (xenogeneic) or human donors (allogeneic). In all groups, the space inside the shell will be filled with a mixture of small bone chips and bone substitute material. The main outcome is the increase in jawbone width measured on 3D cone-beam CT scans at 6 months after surgery. Additional scans and clinical assessments up to 12 months will evaluate healing, bone stability, and postoperative recovery.",[30,62],"Alveolar Bone Grafting",[64,30,65],"Alveolar Bone Atrophy","Bone Resorption","NOT_YET_RECRUITING","2026-02-18",{"date":69,"type":40},"2026-02-20",{"date":71,"type":22},"2026-04-01",{"date":73,"type":22},"2027-04-01",{"name":75,"class":47},"Universidad de Especialidades Espiritu Santo",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":76},"100564748","adjunctive-use-of-polynucleotide-and-hyaluronic-acid-based-gel-in-alveolar-preservation-after-tooth-extraction-100564748","NCT06633211","Adjunctive Use of Polynucleotide and Hyaluronic Acid-based Gel in Alveolar Preservation After Tooth Extraction","Clinical and Histological Effects of the Adjunctive Use of Polynucleotide and Hyaluronic Acid-based Gel in Alveolar Preservation After Tooth Extraction: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults (\\>18 years) who need the extraction of a single non-molar tooth in the mandible or maxilla.\n* ASA I or II\n* Intact post-extraction socket or with only one wall dehiscence (buccal or lingual) of no more than 50% of the socket.\n* The treatment plan must include the replacement of the tooth to be extracted by placing an implant and an implant-supported prosthesis.\n\nExclusion Criteria:\n\n* Mandibular incisors and molars.\n* Acute infection associated with the tooth that needs to be extracted.\n* Uncontrolled systemic disease.\n* Pregnant patient.\n* Patient under treatment with antiresorptives drugs (bisphosphonates or Receptor Activator of Nuclear Factor Kappa-B Ligand (i.e., Denosumab)) or antiangiogenics.\n* Smokers (\\>10 cigarettes a day).",{"count":85,"type":22},20,[25],"Alveolar ridge resorption after tooth extraction is a physiological process that continues throughout the patient's life due to the loss of the periodontal ligament and lack of mechanical stimulation. Alveolar ridge preservation (ARP) techniques aim to minimize dimensional changes in the ridge after tooth extraction. These techniques involve grafting the socket to fill the bed and\u002For sealing it with a biomaterial. Currently, there is a polynucleotide and hyaluronic acid-based gel (Regenfast®) on the market that has proven useful in treating residual periodontal defects. Hyaluronic acid-based gels also appear to enhance the regenerative potential of critical bone defects in both in-vitro studies on rats and clinical studies. Therefore, this study aims to evaluate the clinical and histological effects of polynucleotide and hyaluronic acid-based gel in alveolar preservation procedures.",[30,89],"Tooth Extraction Status Nos",[91,92],"Alveolar Ridge preservation","Guided bone regeneration","2024-10-07",{"date":95,"type":40},"2024-10-09",{"date":97,"type":22},"2024-10-15",{"date":99,"type":22},"2025-10-15",{"name":101,"class":47},"Adrià Jorba García"]