[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bowel-endometriosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bowel-endometriosis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100633178","efficacy-and-safety-of-intra-operative-dual-laparoscopy-and-neo-rectoscopy-for-bowel-endometriosis-the-lumen-01-trial-100633178",false,"NCT07523308","Efficacy and Safety of Intra-operative Dual Laparoscopy and Neo-rectoscopy for Bowel Endometriosis: The LUMEN-01 Trial","Efficacy and Safety of Intra-operative Dual Laparoscopy and Neo-rectoscopy (IDLnR) Versus Conventional Laparoscopic Surgery for Bowel Endometriosis: A Multicenter, Open-Label, Randomized Controlled Trial (LUMEN-01)","LUMEN-01","Inclusion Criteria:\n\n* Premenopausal women aged 18 to 55 years.\n* Preoperative pelvic contrast-enhanced MRI and\u002For transrectal endosonography confirmed bowel endometriosis (BE) lesions involving the muscular layer of the intestinal wall, located in the rectum and\u002For sigmoid colon. Postoperative pathological diagnosis serves as the gold standard.\n* Pre-treatment LARS score \\> 20.\n* Eligible for laparoscopic surgery.\n* Voluntarily participated in this study and signed written informed consent\n\nExclusion Criteria:\n\n* Pregnancy or lactation.\n* Presence of active inflammatory bowel disease, irritable bowel syndrome, or other similar conditions with disease flare-ups within the past 1 year.\n* Acute or severe infectious disease within 4 weeks prior to surgery.\n* History of malignant tumor, or highly suspected gynecological\u002Fgastrointestinal malignancy based on preoperative imaging or tumor marker tests.\n* American Society of Anesthesiologists (ASA) physical status classification ≥ Grade Ⅲ, or severe cardiac, pulmonary, hepatic, renal, or coagulation dysfunction that precludes general anesthesia and elective laparoscopic surgery.\n* Undergoing robot-assisted laparoscopic surgery or open laparotomy.\n* Currently participating in other clinical trials that may affect the outcome assessment of this study.\n* Previous participation in other interventional clinical trials that may affect the outcome assessment of this study.\n* History of colorectal resection and anastomosis or stoma surgery.\n* History of pelvic radiotherapy.","FEMALE","18 Years","55 Years",{"count":21,"type":22},192,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this prospective, multicenter, randomized controlled trial is to compare the clinical efficacy and safety of intra-operative dual laparoscopy and neo-rectoscopy (IDLnR) versus conventional laparoscopy (CL) in patients with bowel endometriosis (BE) undergoing surgery. The primary objective is to assess differences in postoperative bowel function improvement at 6 months between the two groups.\n\nThe main questions it aims to answer are:\n\nIs there a significant difference in postoperative bowel function (primary endpoint) at 6 months postoperatively between IDLnR and CL groups? Do the two groups differ in secondary outcomes, including efficacy indicators (LARS score\u002Fcure rate\u002Fimprovement rate, CRADI-8, Wexner score, GIQLI, EHP-30, VAS pain reduction) and safety indicators (30-day severe complications, antibiotic use intensity, hospital stay \\>7 days)? Researchers will randomize BE surgical patients to IDLnR or CL groups, then compare the above primary and secondary endpoints to evaluate IDLnR's clinical value.\n\nParticipants will undergo either IDLnR or CL surgery for BE lesions, and be followed up to assess bowel function, quality of life, pain, and safety outcomes as specified.\n\nThis study will fill evidence gaps for IDLnR in BE surgery, support its standardized application, optimize BE treatment strategies, and aim for complete lesion resection, preserved intestinal function, and improved long-term patient quality of life.",[28,29,30],"Bowel Endometriosis","Endometriosis","Intestinal Endometriosis",[28,32,33,34,35],"Intra-operative Dual Laparoscopy and Neo-rectoscopy (IDLnR)","Efficacy","Safety","LARS","RECRUITING","2026-05-16",{"date":39,"type":40},"2026-05-19","ACTUAL",{"date":42,"type":40},"2026-04-13",{"date":44,"type":22},"2028-05-31",{"name":46,"class":47},"Obstetrics & Gynecology Hospital of Fudan University","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100622654","the-association-between-deep-endometriosis-and-the-occurrence-of-colorectal-carcinoma-100622654","NCT07386431","The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma","Inclusion Criteria:\n\nFemale patients aged 18 and over, treated at the Department of Reproduction for diagnosed deep endometriosis, including bowel endometriosis, for whom surgical treatment is indicated.\n\nExclusion Criteria:\n\n* Patients with known inflammatory bowel disease (IBD), patients with a personal history of gynecological or gastrointestinal malignancy",{"count":55,"type":22},30,"OBSERVATIONAL","The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma. The study will include patients for whom surgical treatment of bowel endometriosis is clinically indicated.\n\nThis research would represent a significant advancement in evaluating the necessity of surgical intervention in asymptomatic patients or those with mild symptoms. Furthermore, it would provide a broader insight into the systemic impact of endometriosis on other organ systems, ultimately improving risk assessment and preventive measures.",[29,59,28,60,61,62,63,64,65,66],"Deep Endometriosis","Colorectal Carcinoma","Colon Resection","Endometriosis Pelvic","Endometriosis Rectum","Carcinogenesis","Genetic Change","Infertility","NOT_YET_RECRUITING","2026-02-05",{"date":70,"type":40},"2026-02-06",{"date":72,"type":22},"2026-02",{"date":74,"type":22},"2029-05",{"name":76,"class":47},"University Medical Centre Ljubljana",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":107},"100575765","evaluation-of-rectal-infiltration-depth-and-length-in-bowel-involvement-of-deep-infiltrative-endometriosis-die-using-intraoperative-transrectal-ultrasound-trus-100575765","NCT06776536","Evaluation of Rectal Infiltration Depth and Length in Bowel Involvement of Deep Infiltrative Endometriosis (DIE) Using Intraoperative Transrectal Ultrasound (TRUS)","DIE IO TRUS","Inclusion Criteria:\n\n* The study will include a minimum of 15 female patients aged 18-55 with bowel involvement due to deep infiltrative endometriosis, requiring bowel resection.\n\nExclusion Criteria:\n\nPatients with bowel endometriosis who does not require bowel resection, patients who have other bowel diseases, such as rectal tumors, Crohn's disease, or ulcerative colitis, will be excluded.\n\n\\-",{"count":85,"type":22},15,[25],"we aim to evaluate the success of intraoperative transrectal ultrasound in measuring the depth and extent of bowel involvement in patients preoperatively diagnosed with intestinal endometriosis using transvaginal ultrasound and MRI, and who are planned for bowel resection",[89,90,28,91],"Deep Infiltrating Endometriosis (DIE)","Transrectal Ultrasound","Bowel Resection",[93,94,95,96],"Deeply infiltrating endometriosis","bowel endometriosis","transrectal ultrasound","bowel resection","2025-01-10",{"date":99,"type":40},"2025-01-15",{"date":101,"type":22},"2025-01-07",{"date":103,"type":22},"2026-04-07",{"name":105,"class":106},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV",1]