[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bowel-obstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bowel-obstruction":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100576570","resection-of-the-primary-tumor-vs-systemic-treatment-alone-for-patients-with-small-intestinal-neuroendocrine-tumors-and-unresectable-metastases-a-europe-wide-study-100576570",false,"NCT06787014","Resection of the Primary Tumor vs. Systemic Treatment Alone for Patients With Small Intestinal Neuroendocrine Tumors and Unresectable Metastases: a Europe-wide Study","Resection of the Primary Tumor vs. Systemic Treatment Alone for Patients With Small Intestinal Neuroendocrine Tumors and Unresectable Metastases: a Retrospective, Europe-wide, Pooled Cohort Study (ENETS-SurgSmInt)","ENETSSurgSmInt","Inclusion Criteria:\n\n\\- All patients with siNET and non-curative metastatic disease between 01.01.2005 and 31.12.2021 will be included.\n\nExclusion Criteria:\n\n\\- All patients with siNET G3, resectable metastatic disease and\u002For non-resectable primary tumor at initial diagnosis will be excluded. Furthermore, symptomatic patients (small intestinal obstruction, bleeding) or when imaging suggests that obstruction will probably occur (bowel dilatation, mesenteric fibrosis) at initial diagnosis will be excluded. Patients with diarrhea, flushing, or abdominal pain will not be excluded.\n\nPatients with a documented rejection for a further use of their data for scientific purposes will also be excluded.","ALL",{"count":19,"type":20},3200,"ESTIMATED","OBSERVATIONAL","When possible, surgery to completely remove small intestinal neuroendocrine tumors (siNETs) is always recommended. However, in cases where the tumor has spread and cannot be cured completely, it is unclear whether a surgical removal of the primary tumor only is reasonable. In this situation, current guidelines from the European Neuroendocrine Tumor Society (ENETS) recommend surgery only for patients who have symptoms like intestinal blockage or bleeding, or are at risk of such complications. For patients without symptoms, it is still unclear whether removing the main tumor improves overall outcomes and prevents future problems.\n\nStudies evaluating this type of surgery on survival show conflicting results. These studies often do not separate patients with symptoms from those without, and they overlook other important factors like the amount of cancer in the liver and nearby tissues. Due to these uncertainties, the rarity of siNETs and many factors that can affect outcomes, like age, overall health, or other current treatments, conducting a high-quality study to answer this question is challenging. To address this, the present Europe-wide study is being planned.\n\nThis study aims to determine if resecting the main tumor improves the 10-year overall survival and reduces risks like intestinal blockages or blood flow issues compared to no surgery in patients without symptoms. The study will also assess other outcomes, such as how long patients stay free from disease progression, the risks of surgery, and prognostic factors for long-term survival. This international collaboration among neuroendocrine tumor referral centers will provide robust evidence to guide clinical practice and update treatment guidelines for siNETs.",[24,25,26],"Neuroendocrine (NE) Tumors","Metastasis","Bowel Obstruction","RECRUITING","2026-03-17",{"date":30,"type":31},"2026-03-18","ACTUAL",{"date":33,"type":31},"2026-03-09",{"date":35,"type":20},"2028-12-31",{"name":37,"class":38},"Insel Gruppe AG, University Hospital Bern","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":17,"minAge":47,"maxAge":4,"enrollmentInfo":48,"targetDuration":50,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":69},"100587450","magdi-us-registry-100587450","NCT06928545","MagDI U.S. Registry","Post-Market Assessment of the Incidence and Severity of Internal Hernia and Bowel Obstruction at One Year Following Use of the MagDI System to Create Side-to-Side Duodeno-Ileal Magnetic Compression Anastomoses (MagDI US Registry)","Inclusion Criteria:\n\n1. \\>21 years of age, at the time of informed consent.\n2. Body Mass Index (BMI) between 30-50 kg\u002Fm2.\n3. Indicated for a side-to-side duodeno-ileal anastomosis and is treated with the MagDI System at a U.S. registry center.\n4. Participant has been informed of the nature of the registry.\n\nExclusion Criteria:\n\n1\\. Participant does not provide informed consent to be enrolled and followed in the registry.","22 Years",{"count":49,"type":20},106,"12 Months","Assess the incidence and severity of internal hernia and bowel obstruction at one year in a U.S. population following use of the MagDI System to create side-to-side duodeno-ileal anastomoses.",[53,54,26],"Anastomosis, Surgical","Internal Hernia",[56,57,58],"GT Metabolic","MagDI System","Magnetic Anastomosis","2026-02-19",{"date":61,"type":31},"2026-02-20",{"date":63,"type":31},"2025-03-28",{"date":65,"type":20},"2027-04",{"name":67,"class":68},"GT Metabolic Solutions, Inc.","INDUSTRY",5,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":81,"studyType":21,"phases":4,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100599014","adhesion-prevention-in-asbo-surgery-using-4dryfield-ph-100599014","NCT07078981","Adhesion Prevention in ASBO Surgery Using 4DryField® PH","Assessing Determinants of Headway in Evaluating Risk of Adhesion: the ADHERE Study","ADHERE","Inclusion Criteria:\n\nAge ≥ 18 years\n\n* Undergoing surgical treatment for adhesive small bowel obstruction (ASBO)\n* Ability and willingness to provide informed consent\n* Willingness to adhere to follow-up visits\n\nExclusion Criteria:\n\n* Presence of peritonitis\n* Intra-abdominal active malignancy\n* Pregnancy or breastfeeding","18 Years",{"count":80,"type":20},189,"1 Year","Post-surgical adhesions occur in up to 90% of abdominal surgeries, often leading to complications like adhesive small bowel obstruction (ASBO) and chronic pain. They result from imbalanced healing processes influenced by growth factors, fibroblast activity, and genetic predispositions. While surgery can relieve ASBO, it frequently causes new adhesions, with recurrence rates up to 40%. Anti-adhesion barriers, such as the starch-based 4DryField® PH, form a temporary gel barrier to support healing. Though promising, its role in preventing ASBO recurrence is not well studied. This study evaluates whether intra-operative use of 4DryField® PH reduces ASBO recurrence over 12 months and compares perioperative outcomes in treated vs. untreated patients.",[84,85,26,86],"Adhesive Small Bowel Obstruction","Postoperative Abdominal Adhesions","Abdominal Surgery Complications",[88,89,90,91,92,93,94,95,96,97],"adhesion","obstruction","acute abdomen","emergency surgery","4DryField","adhesiolysis","antiadhesion barrier","ASBO","abdominal surgery","peritoneal adhesion","NOT_YET_RECRUITING","2025-07-14",{"date":101,"type":31},"2025-07-22",{"date":103,"type":20},"2025-07-15",{"date":105,"type":20},"2027-07-15",{"name":107,"class":38},"Alessio Giordano"]