[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bowel-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bowel-surgery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100626336","phase-3-use-of-dexmedetomidine-to-improve-pain-control-and-recovery-after-laparocopic-assisted-bowel-surgery-in-adults-100626336",false,"NCT07434310","Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults","Postoperative Dexmedetomidine (PODEX) for Enhanced Recovery in Bowel Surgery: A Double-Blinded, Randomized Controlled Trial","PODEX","Inclusion Criteria:\n\n1. Adults aged 18-70 years.\n2. Undergoing elective or semi-elective laparoscopic-assisted bowel surgery (e.g., bowel resection, colectomy, ileostomy reversal).\n3. ASA physical status I-III.\n\nExclusion Criteria:\n\n1. Known allergy or hypersensitivity to dexmedetomidine.\n2. Cardiac impairment defined as:\n\n   1. Moderate or severe systolic dysfunction\n   2. Moderate or severe valvulopathy (as per American Society of Echocardiography criteria)\n   3. Significant bradycardia (baseline heart rate \\\u003C 60) or\n   4. Heart block without a pacemaker.\n3. Active infection or sepsis at the time of surgery.\n4. Use of medications with significant interactions with dexmedetomidine (e.g., MAO inhibitors).\n5. Pregnant or breastfeeding individuals.\n6. Current opioid use (\\> 30 mg daily oral morphine equivalent) or history of opioid use disorder.\n7. Current clonidine use.\n8. Patients undergoing thoracic epidurals.\n9. Patients with liver impairment with a Child-Pugh class of B (moderate) or C (severe).","ALL","18 Years","70 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","This study is testing whether continuing a medication called dexmedetomidine after surgery can improve quality of recovery for adults undergoing laparoscopic-assisted bowel surgery.\n\nAfter bowel surgery, many patients experience significant pain and slow recovery. Pain is often treated with strong opioid medications, which can cause side effects such as nausea, vomiting, constipation, sedation, and delayed return of bowel function. Other pain control options, such as epidurals or nerve blocks, are not always suitable for laparoscopic bowel surgery and may have their own risks or limitations. As a result, there are few effective non-opioid options for managing pain in this patient group.\n\nDexmedetomidine is a medication that can reduce pain and the need for opioids while providing sedation without affecting breathing. It is commonly used during surgery, but it is not known whether continuing dexmedetomidine after surgery improves pain control and overall recovery in bowel surgery patients. This study aims to answer that question.\n\nThe PODEX study is a single-centre, randomized, double-blind, placebo-controlled trial. Adults aged 18 to 70 years who are having elective or semi-elective laparoscopic-assisted bowel surgery will be invited to take part. About 94 participants will be enrolled. After surgery, participants will be randomly assigned (by chance) to receive either a continuous dexmedetomidine infusion or a placebo (salt water) infusion for 48 hours. Neither the participants nor the study team will know which treatment a participant receives during the study. All participants will receive the same standard surgical care, anesthesia, and postoperative pain medications.\n\nThe main outcome of the study is quality of recovery, measured 48 hours after surgery using a short questionnaire (QoR-15) that asks about comfort, pain, physical well-being, and emotional state. Other outcomes include recovery scores at additional time points, pain levels, opioid use, nausea and vomiting, return of bowel function, length of hospital stay, and side effects such as low blood pressure or slow heart rate.\n\nThe results of this study may help determine whether postoperative dexmedetomidine is a safe and effective way to improve recovery and reduce opioid use after bowel surgery.",[28,29,30],"Bowel Diseases, Inflammatory","Bowel Surgery","Laparoscopic Abdominal Surgeries",[32,33,34,35,36,37,38,39,40,41],"bowel surgery","pain after surgery","quality of recovery","recovery after surgery","laparoscopic surgery","postoperative pain","bowel surgery pain","laparoscopy surgery pain","abdominal pain","laparoscopy","NOT_YET_RECRUITING","2026-06-19",{"date":45,"type":46},"2026-06-24","ACTUAL",{"date":48,"type":22},"2026-07-01",{"date":50,"type":22},"2027-12-01",{"name":52,"class":53},"Dr. Naveed Siddiqui","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":54},"100596612","comparative-outcome-of-early-and-standard-oral-feeding-after-emergency-bowel-surgery-100596612","NCT07047729","COMPARATIVE OUTCOME OF EARLY AND STANDARD ORAL FEEDING AFTER EMERGENCY BOWEL SURGERY","Inclusion Criteria:\n\n* Either Gender\n* Requiring emergency surgery due to conditions such as obstructive bowel disease, GI perforation, colorectal surgery, blunt abdominal trauma (resulting from falls or roadside accidents), and penetrating abdominal trauma (involving firearm injuries and stab wounds).\n\nExclusion Criteria:\n\n* Patients with terminal cancer need palliative surgery (as their focus is on comfort care rather than surgical intervention).\n* Patients who had undergone surgery within the past 30 days (to avoid potential complications associated with recent surgical procedures).\n* Patients receive regular renal replacement therapy (to prevent additional stress on their medical condition).\n* Pregnant women (as surgical interventions may pose risks to both the mother and the unborn child).",{"count":62,"type":22},60,[64],"NA","Informed consent will be obtained from patients or their legal representatives in cases where the patient is unconscious. Patient information, including names, ages, gender, smoking history, comorbidities, and the indication for emergency surgical procedures, will be documented. All surgical procedures will follow standard protocols and will be conducted by a single surgical team led by at least two consultants, each with more than five years of experience. All 60 patients will be randomly allocated into two groups using a random number table: Group A (early oral feeding), consisting of 30 patients, and Group B (standard oral feeding), consisting of 30 patients. In Group A, a liquid diet will be initiated within 24 hours after surgery and, if well-tolerated without vomiting, will transition to a regular diet over the subsequent 24 hours. On the other hand, in Group B, a standard diet (late feeding), including liquid filtrates, will only be introduced after the resolution of the ileus, during which these patients will remain NPO (nothing by mouth).",[29,67,68],"Emergency Abdominal Surgery","ERAS","RECRUITING","2025-06-24",{"date":72,"type":46},"2025-07-02",{"date":74,"type":46},"2025-03-06",{"date":76,"type":22},"2025-09-06",{"name":78,"class":53},"Dr Hamail Khanum"]