[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bowens-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bowens-disease":54},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":5},"100622473","high-intensity-focused-ultrasound-vs-cryotherapy-in-the-treatment-of-basal-cell-carcinomas-and-bowens-disease-in-adults-100622473",false,"NCT07384078","High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease in Adults","HIFU vs. CRYO - High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease - a Randomized Controlled Trial","HIFUvsCRYO","Inclusion Criteria:\n\n* age 18 years or older at the time of informed consent\n* ability to give informed consent and comply with the treatment protocol and follow-up plan\n* study lesion located between neck and knees\n* one of following histologically confirmed diagnosis: Superficial BCC with maximum diameter of 2.0 cm \u002F Nodular BCC with max. diameter of 1.5 cm \u002F BD with max. diameter of 2.0 cm\n\nExclusion Criteria:\n\n* Study lesion location in face, head, genitals, hands, or below the knee\n* Clinical\u002Fdermoscopical\u002Fhistological feature for high-risk\u002Faggressive BCC\n* Clinical\u002Fhistological sign for hypertrophic BD\n* Clinical\u002Fdermoscopical\u002Fhistological feature for Squamous cell carcinoma\n* Gorlin Golz syndrome\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":20,"type":21},294,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, randomized, controlled, and single-blinded non-inferiority clinical trial compare the efficacy and tolerability of high intensity focused ultrasound (HIFU) to standard cryotherapy in the treatment of low-risk basal cell carcinomas (BCCs) and Bowen's disease (BD) in adults. The main questions it aims to answer are:\n\n* Is HIFU an efficient treatment option for BCCs and BD?\n* What medical problems do participants get after HIFU?\n\nResearchers will compare HIFU to standard cryotherapy with liquid nitrogen to see if the ultrasound works to treat these local and low-risk non-melanosytic skin cancers.\n\nParticipants will:\n\n* Be treated either with HIFU (intervention) or cryotherapy (control).\n* Visit the clinic 4 weeks, 1-, 3- and 5 years after the treatment for check-ups, tests and survey questions.",[27,28,29,30,31],"Superficial Basal Cell Carcinoma","Nodular Basal Cell Carcinoma","Bowen's Disease","BCC","BD",[33,34,35,36,37,38,39,40,41],"HIFU","cryo","cryotherapy","high intensity focused ultrasound","basal cell carcinoma","Bowen's disease","superficial basal cell carcinoma","nodular basal cell carcinoma","non-surgical treatment","NOT_YET_RECRUITING","2026-01-26",{"date":45,"type":46},"2026-02-03","ACTUAL",{"date":48,"type":21},"2026-04-01",{"date":50,"type":21},"2032-12-31",{"name":52,"class":53},"Jussi Salonen","OTHER","Bowens Disease"]