[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bph-with-urinary-obstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bph-with-urinary-obstruction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,76,105,133,157],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100489354","noninvasive-ultrasound-assessment-of-detrusor-dysfunction-100489354",false,"NCT05652023","Noninvasive Ultrasound Assessment of Detrusor Dysfunction","NUADD","Inclusion Criteria:\n\n* Aim1:\n\nAge \\>18 scheduled to undergo UDS for their clinical care for one of the included diagnoses.\n\n-Aim2: Inclusions: Age \\>45 scheduled to undergo selective photovaporization of the prostate.\n\nExclusion Criteria:\n\n* Aim1:Obesity (BMI \\>35kg\u002Fm2), known neurologic disease impacting bladder function (e.g. spinal cord injury, multiple sclerosis, Parkinson's, prior cerebrovascular accident), previous pelvic radiation therapy, previous radical pelvic surgery (such as for uterine or colorectal cancer), prior bladder surgery (including prostate resection), and pregnant or breast-feeding women.\n* Aim2:Obesity (BMI \\>35kg\u002Fm2), known neurologic disease impacting bladder function (e.g. spinal cord injury, multiple sclerosis, Parkinson's, prior cerebrovascular accident), previous pelvic radiation therapy, previous radical pelvic surgery (such as colorectal cancer).","ALL","18 Years","90 Years",{"count":20,"type":21},2023,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to test a new ultrasound method called Quantitative Ultrasound Bladder Vibrometry to detect abnormal bladder function.",[25,26,27],"Bladder Dysfunction","Overactive Bladder","BPH With Urinary Obstruction",[29,30,31,32],"Detrusor Pressure","Bladder Compliance","Ultrasound","Ultrasound Vibrometery","RECRUITING","2026-03-23",{"date":36,"type":37},"2026-03-27","ACTUAL",{"date":39,"type":37},"2023-04-20",{"date":41,"type":21},"2028-12-20",{"name":43,"class":44},"Mayo Clinic","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100609022","phase-3-randomized-controlled-trial-of-different-antibiotic-duration-prior-to-prostate-enucleation-surgery-100609022","NCT07209150","Randomized Controlled Trial of Different Antibiotic Duration Prior to Prostate Enucleation Surgery","Randomized Controlled Trial of 3 vs 7 Days for Perioperative Antibiotic Prophylaxis for Patients With an Indwelling Catheter Prior to Holmium Laser Enucleation of the Prostate","Inclusion Criteria:\n\n* 1\\. Candidate for HoLEP surgery 2. Must be 18 years or older. 3. The patient must be able to understand and willing to provide informed consent as described in this study protocol.\n\nExclusion Criteria:\n\n* 1\\. Under the age of 18 2. Refuse to provide informed consent 3. Anticipated need for perineal urethrostomy 4. History of multi-drug resistant organism on urine culture that is not susceptible to any oral agents","MALE",{"count":55,"type":21},250,"INTERVENTIONAL",[58],"PHASE3","To compare the risk of infectious complications (UTI, pyelonephritis, sepsis, hospital admission, ED visits) for patients with an indwelling urinary catheter (urethral or suprapubic) or CIC receiving 3 or 7 days of peri-operative antibiotic prophylaxis at time of Holmium Laser Enucleation of the Prostate",[27,61],"Antibiotic Prophylaxis",[63,64,65],"bph","urinary retention","antibiotic prophylaxis","NOT_YET_RECRUITING","2025-09-30",{"date":69,"type":37},"2025-10-06",{"date":71,"type":21},"2026-01-01",{"date":73,"type":21},"2028-07-15",{"name":75,"class":44},"Ohio State University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":53,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":56,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":45},"100607332","evaluating-the-clinical-efficacy-of-thulio-vs-holmium-laser-enucleation-of-the-prostate-100607332","NCT07187180","Evaluating the Clinical Efficacy of Thulio vs. Holmium Laser Enucleation of the Prostate","Inclusion Criteria:\n\n* Understand and voluntarily sign an informed consent form.\n* Patients must be males with a prostate, at least 18 years of age\n* No prior prostate surgery\n\nExclusion Criteria:\n\n* Unable\u002Frefuse to provide informed consent\n* Prior prostate surgery\n* Bladder stones that requiring lasering (small stone that can be removed whole is ok)\n* Unable to hold anticoagulants or antiplatelets per standard protocols for surgery and up to 1 week postop.",true,{"count":84,"type":21},50,[86],"NA","Many consider laser enucleation of the prostate the new 'gold standard' for the surgical treatment of benign prostatic hyperplasia (BPH) due to its excellent outcomes, high success rates, and long-term efficacy. Holmium laser enucleation of the prostate (HoLEP) was the earliest form of prostate enucleation and is recommended by the American Urological Association (AUA), along with thulium laser enucleation of the prostate (ThuLEP), as size-independent techniques for the management of BPH with fewer complications than transurethral resection of the prostate (TURP). Further development of laser technology has additionally led to enucleation using pulsed-modulated (e.g. \"Virtual Basket™\" mode or MOSES™ mode) holmium lasers as well as the thulium fiber laser.",[89,27],"BPH With Symptomatic Lower Urinary Tract Symptoms",[91,92,93,94,95],"BPH","Enlarged prostate","Thulio laser","Prostate enucleation","male urinary retention","2025-09-16",{"date":98,"type":37},"2025-09-22",{"date":100,"type":37},"2025-06-02",{"date":102,"type":21},"2026-09",{"name":104,"class":44},"Smita De",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":53,"minAge":113,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":56,"phases":116,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":45},"100518962","pul-vs-turp-in-bph-patients-with-urinary-retention-100518962","NCT06037356","PUL vs TURP in BPH Patients With Urinary Retention","Prostatic Urethral Lift Versus Transurethral Resection of Prostate in Benign Prostatic Hyperplasia Patients With Urinary Retention","PULTUR","Inclusion Criteria:\n\n* Male patients\n* age \\>40 years old\n* urinary retention who failed trial without catheter\n\nExclusion Criteria:\n\n* Inability to provide consent OR no guardians or relatives to help provide consent on patient's behalf\n* Active urinary tract infection\n* Previous surgical treatment for benign prostatic hyperplasia (i.e., TURP, prostatic urethral lift, etc.)\n* Bladder stones\n* Urethral strictures or bladder neck contractures\n* Prostate size \\>100mL\n* Solely obstructing median lobe\n* Urinary retention not due to obstruction (i.e., Bladder outflow obstruction index \\\u003C20 on urodynamic studies)\n* Poor detrusor contractility (maximum detrusor pressure \\\u003C20cmH2O during voiding phase)\n* Anticoagulant or antiplatelet agents that cannot be stopped","40 Years",{"count":115,"type":21},100,[86],"The study will be a prospective, randomized controlled trial comparing prostatic urethral lift (PUL) versus transurethral resection of prostate (TURP) in benign prostate hyperplasia (BPH) patients with urinary retention. The primary objective of this study is to compare the catheter-free rates of PUL vs TURP. Secondary objectives include comparison of complications rates, cost effectiveness, patient satisfactory, symptom scores, quality of life measures and urodynamic parameters.",[27],[91,120,121,122,123],"Urinary retention","prostatic urethral lift","PUL","TURP","2025-07-21",{"date":126,"type":37},"2025-07-24",{"date":128,"type":37},"2025-01-01",{"date":130,"type":21},"2035-05-30",{"name":132,"class":44},"Queen Mary Hospital, Hong Kong",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":82,"sex":53,"minAge":17,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":56,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":45},"100486954","phase-3-intra-operative-loop-diuretics-to-improve-same-day-discharge-rates-after-holep-100486954","NCT05620784","Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP","Loop Diuretics During Morcellation to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP)","Inclusion Criteria:\n\n* Males 18 -89 undergoing HoLEP\n* Willing to sign the Informed Consent Form\n* Able to read, understand, and complete patient questionnaires.\n\nExclusion Criteria:\n\n* Allergy or hypersensitivity to furosemide or other loop diuretic\n* Anuric patients or patients with liver failure\n* Patients having a concurrent ureteroscopy +\u002F- laser lithotripsy, percutaneous nephrolithotomy, or non-urologic surgery at the time of their HoLEP\n* Anticipated need for perineal urethrostomy at the time of HoLEP\n* Patient not undergoing catheter removal and voiding trial at Northwestern Memorial Hospital","89 Years",{"count":142,"type":21},138,[58],"Holmium Laser Enucleation of the Prostate (HoLEP) is a size-independent treatment option for benign prostatic hypertrophy (BPH) as recommended by the American Urological Association (AUA) Guidelines. Loop diuretics (furosemide) have been given historically during the morcellation portion of HoLEP to promote urine production in the post-operative setting and to minimize the impact of fluid absorption during long periods of morcellation. The intra-operative use of 20mg IV furosemide in perioperative HoLEP pathways has been propagated with the dissemination of HoLEP across North America without evidence to support its routine administration. With increasing surgical efficiency from improvements in laser and morcellator technology, the role of intra-operative furosemide is unknown. This study is designed to assess if there is a significant difference in same day discharge rates after Holmium Laser Enucleation of the Prostate (HoLEP) with and without IV furosemide. .",[27,91,146,147],"Hematuria","Same Day Discharge","2023-09-11",{"date":150,"type":37},"2023-09-13",{"date":152,"type":37},"2023-03-01",{"date":154,"type":21},"2024-08-01",{"name":156,"class":44},"Northwestern University",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":82,"sex":53,"minAge":17,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":56,"phases":164,"briefSummary":166,"conditions":167,"keywords":170,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":45},"100370378","phase-4-optimizing-pain-control-in-transurethral-resection-of-the-prostate-100370378","NCT04102566","Optimizing Pain Control in Transurethral Resection of the Prostate","Inclusion Criteria:\n\n* Are identified as candidates for TURP\n* Are 18 years of age or greater\n* Are proficient in English\n\nExclusion Criteria:\n\n* Have filled an opioid prescription in the last 2 months\n* Have an allergy to a medication included in the protocol\n* Have a history of pelvic radiation\n* Have renal failure (Serum Cr \\> 2.0 mg\u002Fdl), peptic ulcer disease, history of gastric bypass, cirrhosis, or other contraindication precluding use of NSAID's\n* Have liver failure, hepatitis, or alcohol abuse which precludes use of acetaminophen",{"count":84,"type":21},[165],"PHASE4","The purpose of this study is to develop a multi-modal protocol for pain management after TURP that minimizes opioid use. The investigators hypothesize this approach will provide non-inferior pain control to the current standard of care which includes opioids as the primary agent. The investigators believe this is an important step in reducing the opioid epidemic in surgical patients.",[168,27,169],"Pain","BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms",[171,172,173],"postoperative pain","Transurethral resection of the prostate","Multimodal pain control","2019-09-25",{"date":176,"type":37},"2019-09-27",{"date":178,"type":37},"2017-12-08",{"date":180,"type":21},"2019-12-01",{"name":182,"class":44},"Benaroya Research Institute"]