[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brachial-artery-flow-mediated-dilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brachial-artery-flow-mediated-dilation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100601380","dose-response-effects-of-inspiratory-muscle-strength-training-on-blood-pressure-and-vascular-function-100601380",false,"NCT07109739","Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function","Inclusion Criteria:\n\n* Age ≥18 years\n* Resting SBP ≥120 mmHg as measured during screening 1 \\& 2\n* Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis.\n* No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax)\n* Language: English-speaking, with ability to comprehend study materials and instructions.\n* Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit.\n* Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year).\n\nExclusion Criteria:\n\n* Self-report of history of cardiovascular disease, or conditions affecting the ear (e.g., ruptured eardrum).\n* Recent abdominal surgery or presence of an abdominal hernia.\n* Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of dyspnea.\n* Ruptured eardrum or any other condition of the ear.\n* Markedly elevated left ventricular end-diastolic volume and pressure.\n* Current respiratory conditions such as a cold, sinusitis, or respiratory tract infection (participants may be included once they recover from the respiratory condition).\n* Female-Specific: Pregnant or planning to become pregnant during the study period.\n* Compliance: Unable or unwilling to comply with pre-visit restrictions (e.g., avoiding caffeine, alcohol, and exercise within specified hours before visits).","ALL","18 Years",{"count":18,"type":19},144,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.",[25,26],"Systolic Hypertension","Brachial Artery Flow-mediated Dilation","RECRUITING","2025-11-24",{"date":30,"type":31},"2025-11-25","ACTUAL",{"date":33,"type":31},"2025-10-24",{"date":35,"type":19},"2027-03-31",{"name":37,"class":38},"University of Minnesota","OTHER"]