[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brachial-plexus-blockade\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brachial-plexus-blockade":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100637162","nociception-level-index-after-brachial-plexus-block-in-upper-extremity-surgery-100637162",false,"NCT07620002","Nociception Level Index After Brachial Plexus Block In Upper Extremity Surgery","Nociception Level Index After Brachial Plexus Block In Upper Extremity Surgery: Prospective Comparison Trial","Inclusion Criteria:\n\n* Age \\>18\n* Upper extremity surgery\n* Provision of signed and dated informed consent forms\n\nExclusion Criteria:\n\n* Pregnant women\n* Known allergic reaction to bupivacaine or other anesthetic medicine: Midazolam, Fentanyl, Propofol, Rocuronium, Remifentanil, Sevoflurane)\n* Known coagulopathy resulting in bleeding tendency\n* Thrombocytopenia\n* Abnormal laboratory coagulation tests in the previous week = Anticoagulation therapy Participation in other study",true,"ALL","18 Years",{"count":20,"type":21},45,"ESTIMATED","1 Day","OBSERVATIONAL","The present prospective within-subject observational study will evaluate whether unilateral brachial plexus block (BPB) induces measurable lateralized autonomic modulation, assesses using bilateral Nociception Level (NoL) monitoring during standardized intraoperative stimuli under general anesthesia. Regional anesthesia efficacy is traditionally assessed through sensory and motor examination. However, objective physiologic markers reflecting sympathetic modulation remain limited. Forty five adults undergoing upper extremity surgery with BPB and general anesthesia, bilateral NoL monitoring will be performed during local anesthetic injection, endotracheal intubation, and nasogastric tube placement. The primary aim to investigate whether the brachial plexus block induces unilateral modulation of post-operative nervous system activity, assessed by inter-limb differences in NoL values during predefined nociceptive stimuli under general anesthesia. The secondary aim to evaluate the correlation between postoperative metrics, postoperative pain intensity, and analgesic consumption. From a clinical perspective, bilateral autonomic monitoring may offer a novel adjunctive method for intraoperative confirmation of block activity, particularly in sedated or anesthetized patients where traditional sensory testing is not feasible. Furthermore, inter-limb autonomic gradients could represent a future research pathway for objective assessment of regional anesthesia effectiveness beyond subjective pain scores.",[26],"Brachial Plexus Blockade",[28,29],"brachial plexus block upper extremity","nociception level","RECRUITING","2026-05-26",{"date":33,"type":34},"2026-06-02","ACTUAL",{"date":36,"type":34},"2023-03-28",{"date":38,"type":21},"2026-09-30",{"name":40,"class":41},"Carmel Medical Center","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100618999","dose-finding-study-mev90-for-local-anesthetic-in-interscalene-block-for-supraclavicular-nerves-block-100618999","NCT07338916","Dose-Finding Study: MEV90 for Local Anesthetic in Interscalene Block for Supraclavicular Nerves Block","Minimum Effective Volume (MEV90) of Local Anesthetic Required for Ultrasound-Guided Interscalene Block for Supraclavicular Nerve Block: A Dose-Finding Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* ASA physical status I to III\n* Body Mass Index (BMI) between 18 and 35 kg\u002Fm²\n* Weight ≥ 50 kg\n* Scheduled for shoulder arthroscopy requiring an interscalene brachial plexus block for analgesia\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Coagulopathy (platelet count ≤100,000; INR ≥1.4)\n* Significant pulmonary disease (restrictive or obstructive)\n* Renal insufficiency (creatinine ≥1.2 mg\u002FdL)\n* Hepatic insufficiency (transaminases ≥100 U\u002FL)\n* Allergy to local anesthetics\n* Pregnancy\n* Pre-existing neuropathy\n* Previous surgery in ipsilateral cervical or supraclavicular region\n* Contralateral hemidiaphragmatic paralysis or vocal cord paralysis",{"count":51,"type":21},55,"INTERVENTIONAL",[54],"NA","This study aims to determine the minimum effective volume (MEV90) of local anesthetic required to achieve sensory block of the supraclavicular nerves when performing a single-shot ultrasound-guided interscalene brachial plexus block (ISB). These nerves provide sensation to the skin over the clavicle and shoulder and are often involved in surgeries such as shoulder arthroscopy and clavicle repair.",[26,57,58],"Shoulder Surgery","Superficial Cervical Plexus Block",[60,26,61,57,62,63],"Interscalene Block","Supraclavicular nerves block","Miminum Effective Volume 90","MEV90","2026-04-06",{"date":66,"type":34},"2026-04-08",{"date":68,"type":21},"2026-04",{"date":70,"type":21},"2026-12",{"name":72,"class":41},"Hospital del Trabajador de Santiago"]