[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brachial-plexus-blocks\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brachial-plexus-blocks":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,77,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100632755","comparison-between-ultrasound-guided-costoclavicular-and-lateral-sagittal-infraclavicular-brachial-plexus-blocks-in-adult-distal-upper-limb-surgeries-100632755",false,"NCT07517809","Comparison Between Ultrasound-Guided Costoclavicular and Lateral-Sagittal Infraclavicular Brachial Plexus Blocks in Adult Distal Upper Limb Surgeries","Comparison Between Ultrasound-Guided Costoclavicular and Lateral-Sagittal Infraclavicular Brachial Plexus Blocks in Adult Distal Upper Limb Surgeries : A Randomized Controlled Trial","Inclusion Criteria:\n\n* ASA physical status I-III\n* Distal upper limb surgery requiring brachial plexus block.\n* Patient approval after written and informed consent to participate.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Allergy to drugs used.\n* Infection at puncture site.\n* Coagulopathy or anticoagulant therapy.\n* Pre-existing neuropathy or neurological deficit in the affected limb.\n* Severe pulmonary disease.\n* BMI \\> 40 kg\u002Fm².","ALL","21 Years","65 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of the study is to compare the onset time of the costoclavicular approach of brachial plexus block with that of the lateral-sagittal infraclavicular approach in adults distal upper limb surgeries.",[27,28],"Regional Anesthesia Block","Brachial Plexus Blocks","RECRUITING","2026-06-22",{"date":32,"type":33},"2026-06-24","ACTUAL",{"date":35,"type":33},"2026-02-16",{"date":37,"type":21},"2026-09",{"name":39,"class":40},"Ain Shams University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100621771","phase-4-minimal-effective-volume-90-for-double-injection-costoclavicular-block-100621771","NCT07374952","Minimal Effective Volume 90% for Double-injection Costoclavicular Block","Minimum Effective Volume of Lidocaine for Double-Injection Ultrasound-Guided Costoclavicular Block","Inclusion Criteria:\n\n* Age between 18 and 70 years\n* American Society of Anesthesiologists classification 1-3\n* Body mass index between 20 and 30\n\nExclusion Criteria:\n\n* Adults who are unable to give their own consent\n* Pre-existing neuropathy (assessed by history and physical examination)\n* Coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets≤ 100, International Normalized Ratio≥ 1.4 or partial prothrombin time ≥ 50)\n* Renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine≥ 100)\n* Hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases≥ 100)\n* Allergy to LA\n* Pregnancy\n* Prior surgery in the infraclavicular region\n* Chronic pain syndromes requiring opioid intake at home","18 Years","70 Years",{"count":52,"type":21},60,[54],"PHASE4","In 2020, a trial demonstrated that a 2-injection technique constitutes the optimal method for the costoclavicular block.\n\nThis study aims to determine the minimum amount of medication required to achieve a successful double-injection costoclavicular nerve.\n\nBlock dose assignment will be done using an up-and-down sequential method, called the Biased Coin Design (BCD).\n\nThe double-injection technique for US-guided costoclavicular block consists in depositing two thirds of the LA volume in the deep compartment (to anesthetize the posterior and medial cords), and one third of the injectate in the superficial compartment (to anesthetize the lateral cord).\n\nThe ED90 will be calculated using isotonic regression with a 95% confidence interval derived by bootstrapping.",[28,57,58,59,60],"Lidocaine","Nerve Block","Dose Finding Study","Costoclavicular Block",[62,63,64,65,66],"costoclavicular block","double injection technique","dose finding","nerve block","lidocaine","NOT_YET_RECRUITING","2026-02-18",{"date":70,"type":33},"2026-02-20",{"date":72,"type":21},"2026-02-01",{"date":74,"type":21},"2026-12-31",{"name":76,"class":40},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":18,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":41},"100615997","phase-4-perineural-dexamethasone-dexmedetomidine-or-their-combination-to-reduces-rebound-pain-after-supraclavicular-brachial-plexus-block-100615997","NCT07299877","Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block","Perineural Dexamethasone, Dexmedetomidine or Their Combination: an Effort to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block: A Triple-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* from 20-65 years old\n* and ASA physical status I or II and III,\n* and of either gender,\n* who provided informed, written, and valid consent,\n* were scheduled for elective orthopedic upper limb surgeries for traumatic fractures under Supraclavicular Brachial Plexus Block.\n\nExclusion Criteria:\n\n* Patients with coagulopathies,\n* neurological disorders,\n* hypersensitivity to any of the study drugs, or\n* a history of previous surgeries on the affected limb\n* and those who refused to sign informed consent","20 Years",{"count":86,"type":21},75,[54],"Dexmedetomidine, an α2 adrenoceptor agonist, and dexamethasone, a potent anti-inflammatory steroid, are commonly used, effective, and safe adjuvants to peripheral nerve block (PNB). Both have been found to delay and reduce the incidence of rebound pain (RP), prolong the duration of sensory and motor block, and enhance analgesia without causing significant respiratory depression. Few studies have explored the effectiveness of dexmedetomidine or dexamethasone as sole adjuvants to PNB for preventing or reducing RP. However, no study has directly compared the effectiveness of these two drugs in reducing RP when used as adjuvants to local anesthetic (LA) in PNB. Due to differences in their mechanism of action, their effects on RP may differ significantly. The investigators hypothesized that the combination of dexamethasone and dexmedetomidine reduces the incidence of RP when used as adjuvants to LA in PNB.",[28],[91,92],"Dexamethasone","dexmedetomidine","2026-01-08",{"date":95,"type":33},"2026-01-09",{"date":97,"type":21},"2025-12-28",{"date":99,"type":21},"2026-10-15",{"name":101,"class":40},"Al-Azhar University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":4},"100600084","early-detection-of-supraclavicular-brachial-plexus-block-failure-using-infrared-thermography-and-perfusion-index-100600084","NCT07092891","Early Detection of Supraclavicular Brachial Plexus Block Failure Using Infrared Thermography and Perfusion Index","Early Detection of Supraclavicular Brachial Plexus Block Failure Using Infrared Thermography and Perfusion Index: Randomized Double-Blind Controlled Study","Inclusion Criteria:\n\n* Adults aged 18-70 years\n* ASA Physical Status I-III\n\nExclusion Criteria:\n\n* General\n\n  * Coagulopathy\n  * Allergy to local anesthetics\n* Special\n\n  * Neurological deficits in the affected limb\n  * Peripheral vascular disease or Raynaud's phenomenon\n  * Infections or skin lesions at the site of injection\n  * Use of a tourniquet",{"count":110,"type":21},80,[24],"Successful peripheral nerve blockade is fundamental to modern regional anesthesia, particularly for upper limb surgeries. Ensuring the efficacy of a nerve block early in the perioperative period is critical, as delayed recognition of block failure may lead to intraoperative pain, the need for additional sedation or general anesthesia, and overall poorer patient outcomes. Conventional methods for assessing block success, such as sensory testing with pinprick or cold stimuli and motor assessment using strength scales, require patient cooperation and often take 15-30 minutes to yield definitive results. These delays are especially limiting in fast-paced surgical environments or when early decisions regarding anesthesia management are necessary.\n\nEmerging non-invasive monitoring technologies offer promising alternatives for the early, objective assessment of block efficacy. Infrared Thermography (IRT) measures skin surface temperature, which increases due to sympathetic nerve blockade-induced vasodilation.",[114,28],"Regional Anaesthsia",[28,116],"Regional Anaesthesia","2025-07-22",{"date":119,"type":33},"2025-07-30",{"date":121,"type":21},"2025-08-15",{"date":123,"type":21},"2026-09-01",{"name":125,"class":40},"Assiut University"]