[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-computer-interfaces\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-computer-interfaces":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100635494","prospective-randomized-parallel-controlled-study-of-brain-computer-interface-integrated-robotic-mirror-therapy-for-post-stroke-upper-limb-motor-function-disorder-100635494",false,"NCT07553416","Prospective, Randomized, Parallel-Controlled Study of Brain Computer Interface Integrated Robotic Mirror Therapy for Post-Stroke Upper Limb Motor Function Disorder","A Prospective, Randomized, Parallel-Controlled Clinical Study Protocol of Non-Invasive Brain Computer Interface Robot Based on Mirror Rehabilitation Theory in the Treatment of Upper Limb Motor Function Disorder After Stroke","BCI-RMT","Inclusion Criteria:\n\n1. Aged 30 to 80 years\n2. Patients with unilateral upper limb motor dysfunction caused by primary ischemic\u002Fhemorrhagic stroke within 1 to 6 months prior to enrollment\n3. Cerebral magnetic resonance diffusion-weighted imaging (DWI) at the time of onset indicating that the stroke lesion is limited to the unilateral basal ganglia region\n4. Modified Rankin Scale (mRS) score of 0 to 2 before stroke onset\n5. Fugl-Meyer Motor Function Assessment of Upper Extremities (FMA-UE) score of 10 to 42\n6. Montreal Cognitive Assessment (MoCA) score \\> 18\n7. Fugl-Meyer Balance Assessment score \\> 6\n8. Normal binocular visual acuity or corrected visual acuity\n9. Normal hearing and intact verbal comprehension ability\n10. Provided written informed consent\n\nExclusion Criteria:\n\n1. Patients with other severe cardiovascular and cerebrovascular diseases and unstable vital signs\n2. Patients with motor dysfunction caused by other etiologies, such as amyotrophic lateral sclerosis, myasthenia gravis, muscular dystrophy, hypokalemic periodic paralysis, spondylitis, arthritis, osteomyelitis, etc.\n3. Patients with severe diseases of the lungs, liver, kidneys and other vital organs\n4. Patients with limb movement impairment caused by diseases such as fractures and arthritis\n5. Modified Ashworth Scale (MAS) score \\> 3\n6. Patients unable to understand and cooperate with limb rehabilitation training due to factors such as severe aphasia\n7. Presence of severe visual field defects or visual impairments (e.g., hemianopsia, hemispatial neglect, etc.\n8. History of previous stroke\n9. A history of severe motor injury and\u002For surgical intervention of the affected upper limb, such as muscle tear, tendon rupture, rhabdomyolysis\n10. Life expectancy of less than 1 year due to the underlying disease\n11. Undergoing major surgery within the past 30 days or planning to undergo major surgery within the next 90 days\n12. Pregnant or lactating women\n13. History of drug or alcohol abuse, head trauma or central nervous system infection; current use of cognition-impairing medications such as psychoactive or sedative drugs\n14. With definite psychiatric and psychological disorders, such as depression, anxiety disorder, obsessive-compulsive disorder, schizophrenia, autism, chronic sleep disorder, consciousness disorder, etc.\n15. Having implanted electronic devices in the body that interfere with magnetic resonance imaging (MRI), such as cochlear implants, cardiac pacemakers\u002Fdefibrillators, drug delivery pumps\n16. Poor compliance of the subject, their family members and caregivers, or inability to complete at least 12 months of follow-up as required by the study\n17. Having been enrolled in other clinical studies that conflict with this study\n18. Judged by the Indication Evaluation Committee as ineligible for or not falling within the scope of this study.","ALL","30 Years","80 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to utilize non-invasive brain-computer interface technology in conjunction with mirror therapy to design a new paradigm for rehabilitation robots to induce compensatory movements on the healthy side in stroke patients, evaluate the potential rehabilitation value of this paradigm for patients with severely impaired motor areas on the affected side, explore the neural rehabilitation compensation mechanism, and provide more personalized rehabilitation treatment strategies for patients with post-stroke motor dysfunction.",[28,29,30,31],"Ischemic Stroke","Intracranial Haemorrhage","Brain-Computer Interfaces","Rehabilitation Exercise",[28,29,30,31,33],"Mirror rehabilitation robot","NOT_YET_RECRUITING","2026-04-22",{"date":37,"type":38},"2026-04-28","ACTUAL",{"date":40,"type":22},"2026-05-01",{"date":42,"type":22},"2027-12-31",{"name":44,"class":45},"Beijing Tiantan Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100601097","near-infrared-imaging-of-motor-imagery-effects-in-spinal-cord-injury-100601097","NCT07106060","Near-Infrared Imaging of Motor Imagery Effects in Spinal Cord Injury","A Near-Infrared Functional Imaging Study on Motor Imagery Training in Patients With Spinal Cord Injury","Inclusion Criteria:\n\n1. The vital signs are stable and the spine is stable, making the subject suitable for exercise testing.\n2. Patients with spinal cord injury (SCI) who meet the international diagnostic criteria for SCI neurology revised by the American SCI Society in 2019 and have been diagnosed by CT or MRI.\n3. The injury level of SCI is C5-T12, and the ASIA grade is A-C.\n4. The course of the disease is ≤12 months (but the spinal shock period must have passed).\n5. Age: 18-75 years old, regardless of gender.\n6. Good cognitive function, able to understand and actively participate in the training program, and willing to sign the informed consent form for this clinical study.\n\nExclusion Criteria:\n\n1. Those with tumors, tuberculosis, hematologic diseases, or dysfunction of important organs such as the heart and liver;\n2. Those with unstable fractures;\n3. Those with severe abnormal limb muscle tone and joint contracture deformities;\n4. Those with severe pain that cannot tolerate activities;\n5. Those with severe emotional problems who cannot cooperate to complete the study.","18 Years","75 Years",{"count":57,"type":22},36,[25],"The primary objective of this clinical trial is to investigate the efficacy of motor imagery-based brain-computer interface (MI-BCI) technology in improving motor function among patients with spinal cord injury (SCI), as well as its impact on cortical motor area function across varying states. To achieve this, the study will implement MI-BCI intervention in SCI patients, evaluate post-treatment motor function improvements, and assess changes in cortical motor area oxygen metabolism (via functional near-infrared spectroscopy, fNIRS) and neural activity (via electroencephalography, EEG). The ultimate goal is to establish a novel rehabilitation strategy for SCI.\n\nSpecifically, the trial aims to: (1) determine whether MI-BCI effectively enhances motor function in SCI patients; and (2) clarify the differential effects of MI-BCI on cortical motor area function under distinct states (e.g., resting vs. task-performing) in this population.\n\nParticipants will be randomly assigned to one of two groups: the experimental group will undergo MI-BCI training, while the control group will receive active cycling training (as a conventional rehabilitation control). Both interventions will be structured as 20-minute sessions, administered 5 days per week, over a total of 4 weeks.Pre- and post-treatment assessments will include: lower limb motor function (measured by the Lower Limb Motor Score), activities of daily living (evaluated via the Modified Barthel Index), walking capacity (quantified using the Spinal Cord Injury Walking Index), and cortical motor activity (captured through fNIRS and EEG measurements).",[61,62,30],"SCI - Spinal Cord Injury","Motor Imagery",[61,64,30,65],"motor imagery","Functional near-infrared spectroscopy","RECRUITING","2025-07-30",{"date":69,"type":38},"2025-08-06",{"date":71,"type":38},"2025-01-01",{"date":73,"type":22},"2026-02-01",{"name":75,"class":45},"Shengjing Hospital",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":46},"100549353","stereoeeg-motor-neuronal-potentials-decoding-100549353","NCT06432907","StereoEEG Motor Neuronal Potentials Decoding","Decoding of Neuronal Potentials Associated With Motor Performance and Motor Imagery Obtained Using Intracranial stereoEEG Electrodes","Inclusion Criteria:\n\n* male and female patients who have had stereoEEG electrodes implanted for medical reasons;\n* voluntary informed consent to participate in the study;\n* age from 18 to 70 years.\n\nExclusion Criteria:\n\n* patient refusal to participate in the study;\n* cognitive impairment that prevents following the study instructions;\n* severe visual impairment that does not allow viewing visual instructions on a computer screen;\n* upper limb paresis or other motor disorders;\n* pain in the hand of any etiology;\n* any acute diseases, exacerbation of chronic diseases, acute life-threatening conditions;\n* occurrence of an epileptic attack during the experiment.","70 Years",{"count":85,"type":22},30,[25],"The goals of this study are (1) to evaluate the rate of stereoEEG brain-computer interface (BCI) classification accuracy and (2) to collect the dataset of neuronal signals recorded from stereoEEG electrodes during motor performance, motor imagery or brain-computer interface control. The study enrolls hospitalised patients suffering from resistant epilepsy with already implanted intracranial stereoEEG electrodes for medical reasons (i.e. for preoperative localization of the epileptogenic foci). The number and location of electrodes are determined solely for the clinical purposes of stereoEEG monitoring and are not related to the protocol of the current study.\n\nAfter obtaining informed consent to participate in the study, each patient will participate in one experimental session lasting no more than 60 minutes, recording brain signals associated with hand movement, motor imagery, and BCI control. All tasks and instructions presented during the study session are not pro-epileptogenic and cannot provoke an epileptic attack. The experiments will take place in the patient's room, without interruption of observation by the department's medical staff.\n\nThe data recorded in this study will be used to improve or develop new algorithms for decoding motor signals from deep brain structures for their potential use in invasive BCIs.",[89,30],"Drug Resistant Epilepsy",[91,62,92,93],"Brain-Computer Interface","Motor Performance","Intracranial Electroencephalography","2025-07-21",{"date":96,"type":38},"2025-07-24",{"date":98,"type":38},"2024-06-06",{"date":100,"type":22},"2026-12-25",{"name":102,"class":103},"Research Center of Neurology, Russia","OTHER_GOV"]