[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-edema\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-edema":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100487083","setting-families-on-a-positive-path-to-recovery-after-pediatric-tbi-road-to-recovery-100487083",false,"NCT05622461","Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery","Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery, A Randomized Control Trial","Inclusion Criteria:\n\nCaregivers will be eligible if they are over 18 years of age, and if their child meets all of the following criteria:\n\n* Ages 3 months to 18 years at time of discharge from hospital\n* Sustained a complicated mild to severe TBI as defined by a Glasgow Coma Scale (GCS) of 13-15 with imagining abnormalities or GCS 3-12 with or without imaging abnormalities\n* Admitted overnight to the hospital\n* 0-3 months post-discharge\n\nExclusion Criteria:\n\nThe caregiver will be excluded from participation if any of the following occur:\n\n* Child did not survive the injury\n* Child sustained a non-blunt head trauma (e.g. gunshot wound)\n* Child does not reside with parent\u002Fcaregiver for study duration\n* English is not primary language spoken in the home","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial. To achieve the second goal, we will employ a between-groups randomized treatment design with repeated measures at baseline, one-month post-randomization, and at a six-month follow-up. The two conditions will be: a) usual medical care plus access to internet resources regarding pediatric brain injury (Internet Resources Comparison group, IRC), and b) usual medical care plus the R2R-TBI intervention (Road-to-Recovery group, R2R-TBI).",[26,27,28,29,30,31],"Traumatic Brain Injury","Head Injury","Head Injuries, Closed","Brain Hemorrhage, Traumatic","Brain Edema","Intracranial Edema","RECRUITING","2025-06-20",{"date":35,"type":36},"2025-06-25","ACTUAL",{"date":38,"type":36},"2023-02-13",{"date":40,"type":20},"2026-08-31",{"name":42,"class":43},"Children's Hospital Medical Center, Cincinnati","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":55,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100550808","early-identification-of-malignant-brain-edema-in-large-artery-occlusive-stroke-after-endovascular-therapy-embrace-study-100550808","NCT06451887","Early Identification of Malignant Brain Edema in laRge Artery oCclusive Stroke After Endovascular Therapy (EMBRACE Study)","EMBRACE","Inclusion Criteria:\n\n* (1)Age \\> 18 years old; (2)Onset of stroke to hospital admission \\\u003C 24 hours; (3)Admission with a head CT scan ruling out hemorrhage; (4)Patients undergoing CT perfusion scan before treatment; (5)Confirmation of internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion or tandem occlusion by Digital Subtraction Angiography (DSA) and subsequent EVT; (6)complete 3-months follow-up.\n\nExclusion Criteria:\n\n* (1)Poor quality of preoperative CT perfusion imaging; (2)Posterior circulation occlusion or isolated anterior cerebral artery occlusion; (3)Presence of other severe diseases such as malignant tumors, severe organ failure, or other life-threatening conditions with an expected survival period of less than 90 days; (4)Incomplete imaging and clinical data.","80 Years",{"count":54,"type":20},1950,"3 Months","OBSERVATIONAL","To design and validate a predictive model for malignant brain edema after endovascular thrombectomy.",[59,30,60,61],"Endovascular Therapy","Prediction Model","Ischemic Stroke",[63,64,65,66],"Endovascular therapy","Brain edema","Prediction model","Ischemic stroke","2024-06-06",{"date":69,"type":36},"2024-06-11",{"date":71,"type":36},"2024-04-01",{"date":73,"type":20},"2027-06",{"name":75,"class":43},"Zhejiang Provincial People's Hospital",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":44},"100371317","haemodynamical-optimization-during-brain-surgery-100371317","NCT04114799","Haemodynamical Optimization During Brain Surgery","A Comparison of Perioperative Fluid Management Using Invasive Haemodynamical Measurement of Fluid Responsiveness (Aisys GE) and Non-invasive Measurement of Haemodynamics (ClearSight System, Edwards) During Brain Surgery","Inclusion Criteria:\n\n* Glasgow Coma scale 15\n* ASA Physical Status Classification System I-III\n* planed surgery for brain tumor to 5 hours\n* postoperative awakening\n* sinus rhythm\n\nExclusion Criteria:\n\n* NYHA III, IV\n* BMI over 40 in females and over 35 in men\n* awake operation\n* postoperative artificial ventilation",{"count":84,"type":20},50,[23],"The decision to give fluids perioperatively could be based on methods used to identify preload responsiveness, either invasive or noninvasive estimates of stroke volume variation during mechanical ventilation. This study compares fluid management using invasive measurement SPV\u002FPPV (Aisys GE) and noninvasive haemodynamic measurement (ClarSight, Edwards).",[30],[89,90,91],"fluid responsiveness","haemodynamical monitoring","ClearSight","2024-05-09",{"date":94,"type":36},"2024-05-10",{"date":96,"type":36},"2019-04-01",{"date":98,"type":20},"2026-11-30",{"name":100,"class":43},"University Hospital Hradec Kralove"]