[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-function":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,49,90,131,165,200,227,250,280],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100586047","whole-brain-dynamics-in-the-natural-menstrual-cycle-vs-an-ovarian-stimulated-cycle-impact-of-hormonal-fluctuations-on-healthy-women-undergoing-ovarian-stimulation-100586047",false,"NCT06910293","Whole-Brain Dynamics in the Natural Menstrual Cycle vs. an Ovarian Stimulated Cycle: Impact of Hormonal Fluctuations on Healthy Women Undergoing Ovarian Stimulation","Inclusion Criteria:\n\n* Age group: 25 - 35 years old\n* BMI: 20 - 30\n* Anti-Mullerian Hormone (AMH): 1.3 - 5.9 ng\u002Fml\n* Regular Menstrual Cycle: 26-35 days\n* In case of previous use of hormonal contraception: wash-out period of 3 month\n* Meet standard safety and eligibility criteria for MRI scanning, including the absence of contraindications such as metallic implants, claustrophobia, or other medical conditions that preclude MRI\n\nExclusion Criteria:\n\n* History of ovarian surgery\n* Pathology of the ovaries\n* Mental health disorders\n* Use of medication influencing brain function\n* Ongoing use of hormonal contraception (this would include OCP, but also patches and Mirena containing IUD)",true,"FEMALE","25 Years","35 Years",{"count":20,"type":21},15,"ESTIMATED","8 Weeks","OBSERVATIONAL","The investigators aim is to investigate the brain's dynamic complexity across three phases of an ovarian stimulation cycle (basal, pre-OPU, mid-luteal), to observe the impact of externally administered hormones, and compare it with the corresponding phases of a natural menstrual cycle (early follicular, pre-ovulatory, mid-luteal) in the same woman. Brain activity patterns will be examined using resting-state fMRI in a sample of young, healthy, naturally cycling women.",[26,27,28,29],"Neural Activity","Brain Function","Neurodynamics","Brain Connectivity",[31,32,33,34,35],"Menstrual Cycle","Ovarian Stimulated Cycle","Endocrine Profile","neural activity","neurodynamics","RECRUITING","2026-06-22",{"date":39,"type":40},"2026-06-23","ACTUAL",{"date":42,"type":40},"2025-04-07",{"date":44,"type":21},"2026-12-31",{"name":46,"class":47},"ART Fertility Clinics LLC","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":15,"sex":56,"minAge":4,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":89},"100375228","early-institutionalization-intervention-impact-project-100375228","NCT04165746","Early Institutionalization Intervention Impact Project","EI-3","Inclusion Criteria:\n\n* newly entering the institution system in and near São Paulo, Brazil, and the institution director or foster parent is the guardian at the time of baseline,\n* at the time of baseline assessment the child is less than 24 months old,\n* the child's birth weight must be at or above 2500 grams; none should be small or large for dates.\n\nExclusion Criteria:\n\n* the child does not have a neurological or other genetic condition that severely impairs typical development (e.g. Cerebral Palsy, Fetal Alcohol Syndrome, Down Syndrome)\n* the child is below 2500 grams.","ALL","24 Months",{"count":59,"type":21},220,"INTERVENTIONAL",[62],"NA","The purpose of this study is to determine the effects of early intervention (placement into foster care, and a caregiving training) on physical, cognitive, social and brain development and psychiatric symptomatology in children place in out-of-home care.",[65,66,67,27,68],"Socioemotional Development","Cognitive Ability","Behavioral and Neural Patterns of Attention","Psychopathology",[70,71,72,73,74,75,76,77,78,79],"Brazil","children","foster care","institutionalization","attachment","brain function","language","growth","Intelligence Quotient (IQ)","early intervention","2026-03-16",{"date":82,"type":40},"2026-03-18",{"date":84,"type":40},"2023-03-16",{"date":86,"type":21},"2029-03-31",{"name":88,"class":47},"Boston Children's Hospital",1,{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":56,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":60,"phases":102,"briefSummary":103,"conditions":104,"keywords":113,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":4},"100628619","effects-of-habitual-water-intake-on-thirst-in-healthy-young-adults-explained-by-osmoadaptive-metabolism-brain-and-kidney-function-adapt-thirst-100628619","NCT07464002","Effects of Habitual Water Intake on Thirst in Healthy Young Adults Explained by Osmoadaptive Metabolism, Brain and Kidney Function (Adapt-Thirst)","Studie Zum Habituellen Durst Und Adapt Durst Studie: Habitual Thirst Study and Adapt Thirst Study","Adapt-Thirst","All randomized participants must have complete data from 4 weeks of screening. All inclusion criteria below must be met:\n\n* 4 weeks of 3-day mean total water intake of 35 ml\u002Fkg body weight\n* 4 weeks of \\\u003C1L\u002Fd drinking water\n* 4 weeks of \\\u003C1 hr\u002Fd moderate or vigorous physical activity given daily life conditions in Salzburg, Austria\n* No history of chronic disease\n* Normal blood pressure,\n* Normal blood chemistry and complete blood count (CBC) test results\n* Normal overnight urine concentration, and normal acute urine dilution after 500mL drinking water\n* Normal weight and height between 160-170 cm for women and 175-185 cm for men)\n* After overnight food and water restriction urine osmolality above 800 mmol\u002Fkg, salivary osmolality above 100 mmol\u002Fkg, and a thirst score below 70 mm on a 100 mm visual analog scale.\n\nExclusion Criteria:\n\n* Individuals will be excluded from participation if the gender-specific target numbers have already been reached\n* Perceived stress score of \\> 20 at any time during Weeks 1-4\n\n  * Schedule that does not allow continuous study participation\n  * Intention to spend more than a day outside the Salzburg area during the study period (to reduce exposure to ground water with different background D2O as potential source of error)\n* Headache within the last six months\n* Pregnant, planning a pregnancy, or irregular or unknown menstrual cycle\n\n  * Active use of tobacco or e-cigarettes\n  * Daily consumption of alcohol\n  * Regular use of medication\n  * Agoraphobia or claustrophobia that would prevent brain fMRI testing\n  * Metal-containing intrauterine device (IUD) that would prevent fMRI testing\n  * Doubtful or unwilling to complete all study procedures (including drinking alcohol; drinking plain tap water, blood tests, 24-hour urine collection, fMRI scans, and stable isotope tests)\n  * Unwilling to be randomly assigned to intervention or control\n  * Incomplete baseline data in Weeks 1-4 (including blood tests, 24-hour urine collection, and MRI scans).","19 Years","29 Years",{"count":101,"type":21},120,[62],"Social relevance:\n\nFor 30 years, people have been confused about how much plain water to drink. Over 30 years, health professionals have criticized media advice to drink 8 glasses of water per day, citing lack of evidence (Valtin et al, 2002; Yamada et al, 2022). Health authorities have not set drinking water-specific recommendations, assuming 1) that any or all types of drinks hydrate equivalently, i.e. that people do not need to drink plain water to replace lost body water, and 2) the average healthy person can rely on thirst as guide for water intake.\n\nThe lack of drinking water-specific recommendations significantly impacts daily lives because it translates into limited or no support for drinking water in public health services, laws, and retail options.\n\nScientific relevance:\n\nThirst is considered the primary driver of water intake and main defense against body water deficit in healthy young adults (IOM, 2005). Health authorities set total water intake recommendations for the average healthy man and woman (e.g. 2.5 L\u002Fd for men and 2.0 L\u002Fd for women in Europe) but, additionally, advise people to use thirst as a guide for water intake, recognizing that individual water requirements vary widely (EFSA, 2010; IOM, 2005).\n\nAlthough thirst can be satiated by water intake, it can also be ignored per custom (Greenleaf, 1992) or suppressed by an upward-shifted thirst threshold. The thirst threshold, the set-point where osmoreceptor cells shrink and release their neural or hormonal signal, is a function of the solute concentration or osmolality inside and outside the osmoreceptor cells (Nose et al, 1988a,b). Cells with higher intracellular solute content require a higher external osmolality to shrink.\n\nSpecific Aims The ultimate goal of this study is to address gaps in the literature about drinking water and check assumptions that limit the development of drinking water-specific recommendations. The study will examine if osmoadaptation to chronic hypertonicity, due to daily intake of hypertonic fluid sources, can explain suppressed thirst in healthy individuals under conditions of daily life. To facilitate causal inference about drinking water effects for long-term health, this study was designed to link experimental data about osmoadaptation at the cellular level with clinical data relevant for conditions of daily life in Salzburg Austria with population-based data about water intake and chronic disease risk in Salzburg Austria.\n\nThis study will test effects of drinking enough plain water to dilute urine everyday for 4 weeks (about 500 mL 4 times per day in summer). The study will include healthy, normal weight, young, men and women, who all usually meet European adequate intake recommendations for total water intake (TWI), but usually consume less than 1L\u002Fd PWI, and have biomarkers of chronic hypertonic stress (concentrated urine and saliva) for 4 consecutive weeks before starting the randomized study.",[105,106,107,108,109,110,111,27,112],"Chronic Underhydration","Thirst; Due to Deprivation of Water","Aestivation Metabolism","Warburg Effect","Osmoadaptation","Dysglycemia","Protein Breakdown","Healthy",[114,115,116,117,118,119,120],"Randomized clinical trial","Drinking water","Metabolomics","Zinc isotope","Amino acid tracing (13C,15N-glycine)","Deuterium elimination","Oura ring","NOT_YET_RECRUITING","2026-03-05",{"date":124,"type":40},"2026-03-11",{"date":126,"type":21},"2026-05-01",{"date":128,"type":21},"2027-12-31",{"name":130,"class":47},"Jodi Stookey",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":15,"sex":56,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":60,"phases":142,"briefSummary":143,"conditions":144,"keywords":148,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":89},"100623151","food-intake-related-brain-and-metabolic-responses-in-obesity-100623151","NCT07392905","Food Intake-Related Brain and Metabolic Responses in Obesity","Association Between Food Intake-Related Brain Functional Patterns and Metabolic Profiles in Patients With Obesity: A Randomized Crossover Trial","Inclusion Criteria:\n\nObese participants:\n\n1. BMI ≥ 28 kg\u002Fm²;\n2. Age 18-40 years;\n3. Any gender;\n4. Right-handed.\n\nHealthy control participants:\n\n1. BMI 18.5-23.9 kg\u002Fm²;\n2. Age 18-40 years;\n3. Any gender;\n4. Right-handed.\n\nExclusion Criteria:\n\n1. Diabetes mellitus;\n2. Contraindications or allergies to any ingredient in the standardized meal or macronutrient challenges used in this study;\n3. Central nervous system disorders (e.g., traumatic brain injury, acute cerebral infarction, epilepsy) or psychiatric disorders (e.g., depression, schizophrenia); use of medications acting on the central nervous system within the past 3 months or long-term use;\n4. Severe impairment of liver, kidney, heart, or gastrointestinal function, including alanine aminotransferase (ALT) and\u002For aspartate aminotransferase (AST) levels \\>2 times the upper limit of normal; estimated glomerular filtration rate (eGFR) \\\u003C45 mL\u002Fmin\u002F1.73 m² calculated by the CKD-EPI equation; history of unstable angina or myocardial infarction within the past 3 months, or heart failure classified as New York Heart Association (NYHA) class II or higher; history of gastrointestinal stoma, bowel resection, intestinal obstruction, or peptic ulcer disease;\n5. Contraindications to MRI, such as implanted metallic devices or claustrophobia;\n6. Pregnancy or lactation;\n7. Participation in another clinical trial currently or within the past 3 months; use of nutritional supplements within the past 3 months or long-term use;\n8. History of prior metabolic\u002Fbariatric surgery;\n9. Use of antibiotics or probiotics within the past 1 month;\n10. Use of medications affecting metabolism or causing weight loss within the past 1 month; body weight fluctuation exceeding 3 kg during the month prior to screening;\n11. Unusual dietary habits; daily alcohol intake \\>40 grams, smoking \\>10 cigarettes per day, or coffee consumption ≥2 cups per day.","18 Years","40 Years",{"count":141,"type":21},60,[62],"This study is a prospective, single-center, randomized, controlled, crossover intervention trial. A total of 60 participants, including 30 patients with obesity and 30 healthy controls, will be enrolled. Each participant will receive an isocaloric liquid meal challenge (glucose, fat, or protein) on three separate experimental days, with a washout period of at least 7 days between visits to eliminate carryover effects from the previous intervention. The primary objective is to investigate the association between brain functional patterns and plasma metabolic profiles following the ingestion of different macronutrients in patients with obesity, aiming to uncover potential neuro-metabolic imbalance features.",[145,27,116,146,147],"Obesity","Feeding Behavior","Macronutrients",[149,150,151,152,153,154,155],"obesity","macronutrient","fMRI","Cross-over trial","Plasma metabolome","Satiety","Nutrient challenge","2026-01-31",{"date":158,"type":40},"2026-02-06",{"date":160,"type":40},"2025-12-21",{"date":162,"type":21},"2027-09-01",{"name":164,"class":47},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":15,"sex":56,"minAge":173,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":60,"phases":177,"briefSummary":178,"conditions":179,"keywords":184,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":4},"100616602","motor-focused-exercise-and-brain-development-in-preschool-children-100616602","NCT07307742","Motor-Focused Exercise and Brain Development in Preschool Children","Effects of Motor-Focused Exercise Training on Brain Function and Gross Motor Skills in Preschool Children","MoBraD","Inclusion Criteria:\n\n* Children aged 4 to 6 years enrolled in participating kindergartens in Changsha, China\n* Physically healthy and able to safely participate in structured physical education activities\n* Written informed consent provided by a parent or legal guardian\n\nExclusion Criteria:\n\n* Diagnosed neurological, developmental, or musculoskeletal disorders that may interfere with motor performance or EEG measurement\n* Currently enrolled in specialized sports or motor-training programs outside of the kindergarten curriculum\n* Unable to comply with EEG assessment procedures due to behavioral or sensory intolerance","4 Years","6 Years",{"count":176,"type":21},110,[62],"This study will test whether a structured motor-focused exercise program can improve both brain function and gross motor skills in preschool children. About 110 children aged 4 to 6 years will be recruited from kindergartens in Changsha, China. Classes will be randomly assigned to receive either (1) motor-focused physical education three times per week for 16 weeks, or (2) ordinary physical education of the same frequency and duration.\n\nThe motor-focused program includes playful, game-based activities designed to strengthen locomotor skills (such as running and hopping) and object-control skills (such as throwing and catching). The main outcome will be changes in children's gross motor skills, measured with a standardized motor test (TGMD-3). Brain activity will also be assessed using portable electroencephalography (EEG) during rest and simple tasks related to attention and memory. Parents and teachers will complete short questionnaires about children's behavior and executive function.\n\nThe results of this study may provide new insights into how physical education influences both movement skills and brain development in early childhood.",[180,181,182,27,183],"Child Development","Motor Skills","Neurodevelopment","Executive Function (Cognition)",[185,186,187,188,189,190],"Preschool children","Physical education","Gross motor skills","Motor development","Neurocognitive development","Early childhood education","2025-12-25",{"date":193,"type":40},"2025-12-29",{"date":195,"type":21},"2026-03-01",{"date":197,"type":21},"2026-07-01",{"name":199,"class":47},"Hunan Normal University",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":56,"minAge":138,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":60,"phases":209,"briefSummary":210,"conditions":211,"keywords":213,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":48},"100591941","retrograde-versus-antegrade-perfusion-in-low-moderate-hypothermia-for-aortic-arch-surgery-100591941","NCT06986967","Retrograde Versus Antegrade Perfusion in Low-Moderate Hypothermia for Aortic Arch Surgery","ACP vs RCP","Inclusion Criteria:\n\n1. \\> 18 years of age\n2. Participant's that are scheduled for elective proximal aortic reconstructive surgery (ascending aorta + aortic valve or root) with concomitant proximal hemi-arch replacement via median sternotomy\n\nExclusion Criteria:\n\n1. \\\u003C 18 years of age\n2. history of symptomatic cerebrovascular disease, e.g., prior stroke with residual deficit\n3. current alcoholism (\\> 2 drinks\u002Fday)\n4. current psychiatric illness requiring pharmacotherapy\n5. current drug abuse (any illicit drug use in the past 3 months)\n6. hepatic insufficiency (liver function tests \\> 1.5 times the upper limit of normal)\n7. severe pulmonary insufficiency (requiring home oxygen therapy)\n8. renal failure (serum creatinine \\> 2.0 mg\u002FdL)\n9. claustrophobic fear\n10. unable to read and thus unable to complete the cognitive testing\n11. pregnant women\n12. patients who score \\\u003C19 om the Montreal Cognitive Assessment (MoCA) or ≥27 on the baseline Center for Epidemiological Studies Depression (CES-D) scale\n13. patients who have pre-existing unsafe implants for 3 Tesla magnetic resonance imaging (MRI)\n14. Patients who have received chemotherapy in the last 12 months or radiation to the brain",{"count":208,"type":21},30,[62],"The purpose of this study is to compare brain function after surgical circulatory arrest using either antegrade perfusion or retrograde perfusion.",[27,212],"Hemiarch Cardiac Procedure",[214,215,216,217],"Antegrade Perfusion","Retrograde Perfusion","Brain Perfusion","Circulatory Arrest","2025-08-13",{"date":220,"type":40},"2025-08-15",{"date":222,"type":40},"2025-04-18",{"date":224,"type":21},"2027-03",{"name":226,"class":47},"Duke University",{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":11,"sex":56,"minAge":138,"maxAge":234,"enrollmentInfo":235,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":248,"locationsCount":89},"100586945","brain-function-and-psychological-changes-related-to-cell-therapy-for-autoimmune-hemolytic-anemia-100586945","NCT06921980","Brain Function and Psychological Changes Related to Cell Therapy for Autoimmune Hemolytic Anemia","Brain Function and Psychological Assessment in Patients With Autoimmune Hemolytic Anemia Undergoing Cell Therapy","Inclusion Criteria:\n\n* Diagnosis of AIHA\n* Subjects will receive cell therapy such as CAR T-cell therapy\n* Male or female, aged 18-65 years\n* Willing and able to comply with the requirements for this study and written informed consent\n\nExclusion Criteria:\n\n* History of psychiatric illness\n* History of severe brain disease\n* Subjects that the investigator believes have other reasons that make them unsuitable for inclusion in this study","65 Years",{"count":236,"type":21},20,"Cell therapy is an innovative treatment with significant efficacy in hematologic and certain autoimmune diseases. Although it offers potential benefits for autoimmune hemolytic anemia (AIHA), it may result in cognitive and other potential impairments, which can adversely affect patients' cognition and behavior.\n\nBrain function and psychological assessment are essential for the early detection of potential impairments, allowing timely interventions to prevent complications and ensure patient safety. This study aims to comprehensively evaluate the physical and psychological impacts of cell therapy on AIHA patients to develop safer and more effective treatment strategies that enhance their quality of life.",[239,240,27,241],"CAR T-cell Therapy","Autoimmune Hemolytic Anemia","Psychological Well-Being","2025-07-31",{"date":244,"type":40},"2025-08-05",{"date":246,"type":40},"2025-02-25",{"date":44,"type":21},{"name":249,"class":47},"Institute of Hematology & Blood Diseases Hospital, China",{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":15,"sex":56,"minAge":258,"maxAge":139,"enrollmentInfo":259,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":261,"conditions":262,"keywords":264,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":48},"100579591","7t-anatomo-functional-characterization-of-structures-in-the-action-observation-network-100579591","NCT06826287","7T Anatomo-functional Characterization of Structures in the Action Observation Network","More Than Cerebral Cortex: 7T Anatomo-functional Characterization of Cortical, Subcortical, and Cerebellar Structures Involved in THE Network of Action Observation","7T-ATHENA","For CP patients\n\nInclusion Criteria:\n\n* Patients with pre-, peri- or post-natal brain injury, documented by a previous MRI examination of the brain;\n* Intellectual development within the norm or within the mild deficit area, to guarantee understanding and cooperation in the 7T fMRI study;\n* Understanding of the Italian language;\n\nExclusion Criteria:\n\n* Contraindications to performing the 7T fMRI exam;\n* Neuropsychiatric comorbidity that precludes collaboration in the 7T fMRI study;\n* Lack of capacity to understand and to will;\n* Pregnancy;\n\nFor Healthy Controls\n\nInclusion Criteria:\n\n* Absence of known neurological and psychiatric pathologies;\n* Understanding of the Italian language;\n\nExclusion Criteria:\n\n* Contraindications to performing the 7T fMRI exam;\n* Neuropsychiatric comorbidity that precludes collaboration in the 7T fMRI study;\n* Lack of capacity to understand and to will;\n* Pregnancy;","11 Years",{"count":260,"type":21},40,"The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the AON circuit, using an ultra-high field (7T), high spatial resolution Magnetic Resonance Imaging protocol.\n\nThe main questions it aims to answer are:\n\n* Can we demonstrate the involvement of subcortical areas and cerebellum in the AON circuit in each single-subject?\n* Can we obtain similar results in a small group of patients with Cerebral Palsy (CP), in order to demonstrate the feasibility of this approach for the study of the mechanisms of AON reorganization, after early brain damage?\n* Are different patterns of functional activation correlated to different clinical characteristics of CP patients?\n\nParticipants will perform a 7 Tesla MRI scan, with a functional and anatomical dedicated protocol and will have a comprehensive clinical assessment before the MRI exam.",[27,263],"Cerebral Palsy",[265,266,267,268,269,270],"magnetic resonance imaging","ultra high field","action observation network","cerebral palsy","functional re-organization","neural plasticity","2025-02-12",{"date":273,"type":40},"2025-02-13",{"date":275,"type":40},"2024-12-02",{"date":277,"type":21},"2025-08-09",{"name":279,"class":47},"IRCCS Fondazione Stella Maris",{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":286,"eligibilityCriteria":287,"healthyVolunteers":15,"sex":56,"minAge":174,"maxAge":4,"enrollmentInfo":288,"targetDuration":4,"studyType":60,"phases":290,"briefSummary":291,"conditions":292,"keywords":294,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":89},"100568146","neurocatch-reference-interval-database-100568146","NCT06677424","NeuroCatch Reference Interval Database","Empirical Distributions of ERP Components Elicited by the NeuroCatch® Platform 2: Development of a Reference Interval Database","RR","INCLUSION CRITERIA\n\n1. Any sex, at least 6 years of age or older\n2. Able to understand the informed consent\u002Fassent form (in English), study procedures and willing to participate in study; participants under 19 must also have a parent\u002Fguardian who is able to understand and provide informed consent on their behalf.\n3. Able to remain seated and focused for 7 minutes\n4. In good health with no history of clinically relevant neurological illness or injury\n\nEXCLUSION CRITERIA\n\n1. Requires the use of hearing aids or a cochlear implant, diagnosed with tinnitus that is currently active, or has temporary damage to hearing (e.g., punctured ear drum). Or unable to detect a 740Hz tone played at 85dB in both ears.\n2. Implanted pacemaker or other electrical stimulator(s)\n3. Metal or plastic implants in the skull, excluding dental\u002Ffacial implants.\n4. Not native-level in English\n5. Previous exposure to the NeuroCatch® Platform 2 audio sequences in the last 3 months\n6. History of clinically relevant neurological disorders or injury (e.g., epilepsy, Parkinson's disease, traumatic brain injury, etc.)\n7. History of chronic pain or chronic headache disorders (e.g. migraine, tension headaches, fibromyalgia, etc.)\n8. Currently diagnosed with any sleeping disorders (e.g. sleep apnea, hypersomnia, insomnia, parasomnia, etc.)\n9. Diagnosed with any memory disorders.\n10. History of clinically relevant major psychiatric disorders (e.g., schizophrenia, bipolar disorder, etc.)\n11. History of alcohol or substance misuse that, in the opinion of the Investigator, may impact brain function\n12. Use of medications that affect brain function (e.g., antiepileptic drugs, antipsychotics, stimulants, etc.)\n13. Serious medical conditions affecting brain functions (e.g., stroke, brain tumor, neurodegenerative diseases, etc.)\n14. Undergoing chemotherapy or any form of intensive long-term therapy that, in the opinion of the Investigator, may impact brain function.\n15. Unhealthy scalp (e.g., apparent open wounds and\u002For bruised or weakened skin)\n16. Allergy to EEG gel",{"count":289,"type":21},810,[62],"The purpose of this study is to understand how the brain responds to sounds and words, and how this response varies between individuals. The purpose if this study is to develop data set comparing the results from one individual with those from other members (a reference interval database of NeuroCatch® Platform 2) and to quantify the expected distribution across sex and age. NeuroCatch® Platform 2, is a medical device approved by Health Canada. The plan is to enroll 810 participants, the study includes screening for eligibility and one brain scan. The study is conducted at the Centre for Neurology Studies in Surrey, BC or at its satellite sites ( if required).",[293,27],"Healthy Controls",[295],"Brain Scan, NeuroCatch®","2024-11-05",{"date":298,"type":40},"2024-11-06",{"date":300,"type":40},"2024-08-05",{"date":302,"type":21},"2026-08",{"name":304,"class":305},"HealthTech Connex Inc.","INDUSTRY"]