[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-imaging\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-imaging":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,71,103,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100614038","assessment-of-early-post-operative-nuclear-imaging-in-neurosurgery-a-safety-and-feasibility-study-in-patients-operated-for-glioblastoma-100614038",false,"NCT07274397","Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma","EARLYBRAINPET","Inclusion Criteria:\n\n* First resection for a suspected glioblastoma in the past 72h\n* Signed informed consent\n\nnon-inclusion Criteria:\n\n* Deprived of liberty or under legal protection (e.g, guardianship, trusteeship)\n* Patients under 18 years old\n* Absence of social security cover\n* Pregnancy\n* Emergency procedure\n* Contraindication to brain MRI, including claustrophobia\n* Contraindication to radiotracers or gadolinium injection\n* Preoperative cognitive impairment impeding patient information\n\nExclusion criteria :\n\n* Any postoperative behavioral disorders or medical condition or symptom impeding the completion of brain imaging\n* Postoperative medical dependency impeding the patient transfer to the nuclear medicine department (including, but not limited to, invasive ventilation, need for external ventricular drainage…)\n* Postoperative histological diagnosis different from glioblastoma","ALL","18 Years",{"count":19,"type":20},15,"ESTIMATED","INTERVENTIONAL",[23],"NA","This clinical trial aims to evaluate the feasibility and safety of early post-operative brain PET-MRI imaging in adult patients who have undergone surgery for suspected glioblastoma. The study also seeks to validate specific nuclear imaging parameters for better detection of residual tumor tissue compared to standard gadolinium-enhanced MRI. The main objectives are to determine whether early PET-MRI within 48 hours post-surgery is feasible, to assess potential side effects related to imaging procedures, and to explore if PET parameters such as SUVmax, metabolic volume, and tumor-to-striatum ratio can improve the detection of tumor residue. A total of 15 patients will be included at a single site in France. Participants will undergo PET-MRI using 18F-DOPA and gadolinium, and will be monitored for radiation exposure and possible adverse events up to 24 hours after imaging.",[26,27,28],"Glioblastoma","Brain Tumors","Brain Imaging",[26,30,31,32,33,34,35],"brain tumors","PET-MRI","18F-DOPA","Radiotracer","Diagnostic Imaging","Nuclear Medicine","RECRUITING","2026-06-05",{"date":39,"type":40},"2026-06-08","ACTUAL",{"date":42,"type":40},"2026-04-17",{"date":44,"type":20},"2027-04-17",{"name":46,"class":47},"Beta Emitting Accurate Monitored Systems","INDUSTRY",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":48},"100627084","a-pilot-study-of-a-portable-head-only-mri-scanner-100627084","NCT07444034","A Pilot Study of a Portable Head-Only MRI Scanner","Inclusion Criteria:\n\n* 18 years of age or older\n* Able to consent for themselves\n* Free of contraindications for MRI\n\nExclusion Criteria:\n\n* Currently pregnant\n* Extremely claustrophobic",true,{"count":57,"type":20},20,[23],"This is a pilot study to demonstrate human brain imaging with a new portable 0.7 Tesla (T) MRI brain scanner recently developed at the CMRR.",[28],"2026-02-24",{"date":63,"type":40},"2026-03-02",{"date":65,"type":40},"2025-05-08",{"date":67,"type":20},"2026-12-31",{"name":69,"class":70},"University of Minnesota","OTHER",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":55,"sex":16,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":48},"100603298","the-impacts-of-chronic-non-specific-low-back-pain-on-cognitive-functions-of-older-adults-a-longitudinal-study-100603298","NCT07134699","The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: A Longitudinal Study","Inclusion Criteria:\n\n* Older adults with and without chronic non-specific low back pain (CNSLBP) aged between 60 and 85 years\n* Having normal cognitive function (Hong Kong Montreal Cognitive Assessment ≥ 26)13\n* Right-handed\n* Cantonese speaking\n* Having at least 6 years of formal education and know how to read and write Chinese\n* Agreeing to sign an informed consent form\n* Being able to communicate via email or text message because several study measures will be collected electronically.\n\nExclusion Criteria:\n\n* Inability to ambulate without assistance from another person (canes or walkers will be allowed)\n* Having specific causes of LBP (e.g., spinal stenosis, lumbar disc herniation, spondylolisthesis, recent vertebral fracture, spinal infection)\n* Having other concurrent musculoskeletal conditions at other body parts (e.g., fibromyalgia, or neck or knee pain)\n* Self-reported history of lumbar or lower extremity surgery\n* Self-reported history of neurological or psychiatric disorders (e.g., stroke, brain surgery, head trauma; schizophrenia, multiple personality disorder, dissociative identity disorder, stroke) or self-reported cancer history\n* Self-reported specific inflammatory disorder: rheumatoid arthritis, rheumatica, scleroderma, lupus, or polymyositis\n* Unexplained, unintended weight loss of 20 lbs or more in the past year\n* Cauda equina syndrome\n* Uncorrected visual deficit\n* Drug or alcohol addiction\n* Taking alcohol, opioids or benzodiazepines medicines 24 hours before the experiment\n* Claustrophobia\n* Contraindications for undergoing the magnetic resonance imaging (MRI) examination based on the MRI safety screening form of University Research Facility in Behavioral and Systems Neuroscience at The Hong Kong Polytechnic University","60 Years","85 Years",{"count":80,"type":20},60,"OBSERVATIONAL","Chronic non-specific low back pain (CNSLBP) is a common condition among older adults and has been associated with an increased risk of executive function impairment. Research shows that older adults experiencing chronic pain are more likely to show worse cognitive performance compared to healthy individuals. While there is a bidirectional relationship between pain and executive functions, cognitive performance especially for some executive functions (e.g. inhibition, switching, working memory) is crucial for managing pain in older adults. Furthermore, executive dysfunctions are associated with decline in functional status among the population, particularly in performing instrumental activities in daily living. Therefore, maintaining executive function emerges as a pivotal consideration for older adults with CNSLBP.\n\nStudies provide preliminary evidence that connects brain changes with chronic pain and cognitive functions. For instance, multisite chronic pain may increase the risk of cognitive decline through structural changes like hippocampal atrophy. Besides, functional brain changes in chronic pain may reduce deactivation several key default mode network regions, predisposing individuals to cognitive impairments. Despite the aforementioned brain changes, no direct evidence supports the hypothesis that structural and functional brain changes caused by CNSLBP in older adults may be associated with cognitive decline. It remains unclear that whether structural changes (e.g. reduced hippocampal, cerebellar gray matter, white matter volume in the right frontal region) and\u002For functional changes (e.g. deactivation of default mode network regions, heightened activation in the anterior cingulate cortex) cause by CNSLBP are associated with cognitive decline. With neuroimaging techniques, brain mechanisms connecting CNSLBP and executive function deficits can be explained.\n\nTo deepen understanding of the brain mechanisms underlying executive function decline in older adults with CNSLBP, this study will directly compare pain intensity, executive functions, brain structure, and functional changes of the brain between older adults with CNSLBP and age-matched healthy controls. A longitudinal approach is established to quantify the relationship between CNSLBP-related brain changes and executive functions in older adults, providing insights into the development of new treatment strategies to improve or prevent executive function decline in older adults with CNSLBP.",[84,85,86,87,28],"Chronic Non-Specific Low Back Pain","Cognitive Decline","Longitudinal Study","Older Adults",[89,90,91,92,93],"Chronic Non-Specific low back pain","Cognitive decline","longitudinal study","older adults","brain imaging","2025-08-14",{"date":96,"type":40},"2025-08-21",{"date":98,"type":40},"2025-05-06",{"date":100,"type":20},"2026-08-31",{"name":102,"class":70},"The Hong Kong Polytechnic University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":55,"sex":16,"minAge":77,"maxAge":78,"enrollmentInfo":109,"targetDuration":111,"studyType":81,"phases":4,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},"100570221","the-impacts-of-chronic-non-specific-low-back-pain-on-cognitive-functions-of-older-adults-100570221","NCT06704425","The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults","The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: a Cross-sectional Study",{"count":110,"type":20},80,"6 Months","Chronic non-specific low back pain (CNSLBP) is a prevalent condition among older adult and has been associated with an increased risk of executive function impairment. Studies have shown that older adults with chronic pain are more likely to show poor cognitive performance than healthy controls. Cognitive performance is particularly important when managing pain in older adults, especially for some executive functions (e.g., inhibition, switching, working memory) because pain and executive functions have their bidirectional relationship. Further, executive dysfunctions are associated with a decline in functional status among older adults, particularly the impairment of instrumental activities of daily living. Given the above, the preservation of executive functions emerges as a pivotal consideration among old adults with CNSLBP. Studies have provided preliminary evidence of the correlation between brain changes associated with chronic pain and cognitive functions. For example, multisite chronic pain may contribute to an increased risk of cognitive decline via structural change in hippocampal atrophy. For another example, functional brain changes in chronic pain reduced the deactivation of several key default mode network regions, thereby predisposing individuals to cognitive impairments. Despite the aforementioned brain changes, no research has provided direct evidence to support the hypothesis that structural and functional brain changes caused by CNSLBP in older adults may be associated with cognitive decline. Specifically, whether CNSLBP may lead to structural changes (e.g., smaller hippocampal, cerebellar gray matter, white matter volume in the right frontal region) and\u002For functional changes (e.g., deactivation of default mode network regions, heightened activation in the anterior cingulate cortex) associated with cognitive decline remains unclear. With the help of neuroimaging, the knowledge about the underlying brain mechanisms between CNSLBP (chronic non-specific low back pain) and executive functions can be explained.\n\nTo gain a better understanding of the brain mechanisms underlying executive function decline in older adults with CNSLBP, this study will directly compare pain intensity, executive functions, brain structure, and functional changes of the brain between older adults with CNSLBP and age-matched healthy controls. The results of this study have the potential to quantify the association between CNSLBP-related brain changes and executive functions in older adults, and provide insights into the development of new treatment strategies to improve or prevent executive function decline in older adults with CNSLBP.",[84,85,114,87,28],"Cross-Sectional Study",[89,116,117,92,93],"cognitive decline","Cross-Sectional study","2024-11-23",{"date":120,"type":40},"2024-11-26",{"date":122,"type":40},"2024-04-20",{"date":124,"type":20},"2025-11-01",{"name":102,"class":70},3,{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":55,"sex":16,"minAge":134,"maxAge":135,"enrollmentInfo":136,"targetDuration":4,"studyType":21,"phases":138,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":155,"leadSponsor":157,"locationsCount":48},"100509349","orchestra-in-class-a-novel-booster-for-executive-functions-and-brain-development-in-young-primary-school-children-100509349","NCT05912270","Orchestra in Class, a Novel Booster for Executive Functions and Brain Development in Young Primary School Children","ORBIT","Inclusion Criteria:\n\n* School grade 3P\u002F4P (3rd and 4th year of elementary school (6-8-year-old children)\n* Right-handedness\n* Sufficient Mastery of the French Language\n* Able to give oral informed consent (child)\n* Able to give written informed consent (parent)\n\nExclusion Criteria:\n\n* Non-consent (children and or parents)\n* Repeated or skipped a class with respect to standard curriculum\n* Not corrected\u002Fsevere hearing deficits\n* Not corrected\u002Fsevere vision deficits\n* Severe neurodevelopmental disorders (eg. severe dyslexia, severe ADHD)\n* Older than 7 at the beginning of the school year if 3P\n* Older than 8 at the beginning of the school year if 4P\n* Protocolled music instrumental practice in the preceding year\n* Protocolled visual arts courses in the preceding year\n* MRI incompatibility (physical or psychological)\n* Psychometric battery incompatibility (psychological)","6 Years","8 Years",{"count":137,"type":20},150,[23],"How to optimally stimulate the developing brain is still unclear. Executive functions (EF) exhibited substantially stronger far transfer effects in children who learned to play a musical instrument than in children who acquired other arts.\n\nWhat is crucially lacking is a large-scale, long-term genuine randomized controlled trial (RCT) in cognitive neuroscience, comparing musical instrumental training (MIP) to another art form and a control group. Collected data of this proposal will allow, using machine learning, to build a data-driven multivariate model of children's interconnected brain and EF development over the first 2 years of their academic curriculum (6-8 years), with or without music or other art training.",[141,142,143,144,145,146,147,28,148,149,150],"Development, Child","Executive Functions","Interventions","Music","Arts","Brain Plasticity","Behavior","Magnetic Resonance Imaging","Functional Magnetic Resonance Imaging","Structural Brain Connectivity","2023-12-12",{"date":153,"type":40},"2023-12-18",{"date":153,"type":20},{"date":156,"type":20},"2027-04-30",{"name":158,"class":70},"School of Health Sciences Geneva"]