[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-mri\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-mri":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100605855","the-spiral-mri-study-100605855",false,"NCT07167953","The Spiral MRI Study","MRI Technology for Greater Efficiency and Improved Value","Healthy Controls Inclusion Criteria:\n\n* Adults at least 18 years\n* Able to provide written informed consent on their own behalf\n\nBrain MR Inclusion Criteria:\n\n* Adults at least 18 years\n* Able to provide written informed consent on their own behalf\n* Scheduled for standard of care brain MRI\n\nExclusion Criteria (ALL):\n\n* Unable or unwilling to provide informed consent\n* Contraindication(s) to or inability to undergo MRI\n* Currently pregnant\n* Participants requiring intravenous (IV) conscious sedation for imaging are not eligible; participants requiring mild, oral anxiolytics for the clinical MRI will be allowed as long as the following criteria are met:\n* participant has their own prescription for the medication\n* informed consent process is conducted prior to the self-administration of the medication\n* they come to the research visit with a driver",true,"ALL","18 Years",{"count":20,"type":21},131,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to find out if new Magnetic Resonance Imaging (MRI) computer software will:\n\n* help make scans and exams faster\n* reduce artifacts\n* make MRI easier to understand\n* allow technicians to focus more on the participant and less on the scanner\n\nParticipants will complete one brain MRI imaging session, lasting about 60 minutes.",[27],"Brain MRI","NOT_YET_RECRUITING","2026-06-30",{"date":31,"type":32},"2026-07-01","ACTUAL",{"date":34,"type":21},"2028-08",{"date":36,"type":21},"2031-05",{"name":38,"class":39},"University of Wisconsin, Madison","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":40},"100628625","advanced-brain-imaging-tka-fmri-tka-100628625","NCT07464080","Advanced Brain Imaging-TKA (fMRI-TKA)","Brain Network-based Precision Medicine to Predict Dissatisfaction Following Total Knee Arthroplasty","fMRI-TKA","Inclusion Criteria:\n\n1. Male and female patients aged 18 years or older\n2. Primary TKA\n3. Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis\n\nExclusion Criteria:\n\n1. Inability or refusal to sign informed consent form\n2. Non-English or French speaking, and no licensed translator, family member or substitute decision maker available\n3. History of major neurological disorders (e.g traumatic brain injury, epilepsy, multiple sclerosis\n4. Cognitive impairment or dementia\n5. Revision and\u002For Bilateral TKA\n6. Chronic Opioid use",{"count":50,"type":21},50,[24],"Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges.\n\nThis study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.",[54,55,56,57,27],"Knee Osteoarthritis (Knee OA)","Knee Pain Chronic","Brain Network Connectivity","Patient Satisfaction","RECRUITING","2026-03-09",{"date":61,"type":32},"2026-03-11",{"date":63,"type":21},"2026-04-01",{"date":65,"type":21},"2028-12-31",{"name":67,"class":39},"Ottawa Hospital Research Institute"]