[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-reperfusion-or-regain-of-brain-function-during-normothermic-regional-perfusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-reperfusion-or-regain-of-brain-function-during-normothermic-regional-perfusion":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100625538","multimodal-neuromonitoring-during-normothermic-regional-perfusion-for-organ-donors-determined-dead-by-circulatory-criteria-following-withdrawal-of-life-sustaining-measures-100625538",false,"NCT07423936","Multimodal Neuromonitoring During Normothermic Regional Perfusion for Organ Donors Determined Dead by circuLatory Criteria Following Withdrawal of Life Sustaining Measures","Multimodal NeurOmonitoring During NormOthermic Regional PerFusion for Organ Donors Determined Dead by CircuLatory Criteria fOllowing Withdrawal of Life Sustaining Measures (NONOFLOW): A Proof-of-Concept Study","NONOFLOW","Inclusion Criteria:\n\n1. Age \\> 18;\n2. Planned DCD within the next 96 hours.\n\nExclusion Criteria:\n\n1. Coagulopathy (International normalized ratio \\> 1.5, prothrombin time \\> 45 seconds, platelets \\\u003C 50);\n2. Therapeutic anticoagulant medication administration.","ALL","19 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","The aim of this study is to demonstrate that cerebral blood flow and brain function do not resume after death declaration in organ donors who undergo normothermic regional perfusion to restore organ function following death determination by circulatory criteria, when appropriate safeguards are applied.\n\nTo assess the absence of cerebral perfusion and function, investigators will use continuous and comprehensive multimodal neuromonitoring throughout the withdrawal of life-sustaining therapies, the dying process and the NRP procedure.",[25,26],"Organ Preservation","Brain Reperfusion or Regain of Brain Function During Normothermic Regional Perfusion",[28,29,30],"Normothermic regional perfusion","donation after cardiac death","organ donation","RECRUITING","2026-02-13",{"date":34,"type":35},"2026-02-20","ACTUAL",{"date":37,"type":35},"2025-02-24",{"date":39,"type":21},"2028-12",{"name":41,"class":42},"University of British Columbia","OTHER"]