[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-stimulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-stimulation":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,60],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":36,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100574927","the-effect-of-non-invasive-brain-stimulation-rtms-on-hand-muscles-in-chronic-stroke-patients-100574927",false,"NCT06765642","The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.","Evaluation of 3 Patterned rTMS Stimulation Dosage on Corticospinal Excitability and Motor Learning in Stroke Patients","REALISE","Inclusion criteria:\n\n1. Age \\>=21 years old of any race or gender\n2. First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 3 months from stroke onset\n3. Unilateral arm weakness measured by FM-UM scale \\\u003C= 62 out of 66\n4. Inducible rest motor threshold and testing motor threshold recorded from the affected first dorsal interosseous (FDI) muscle from the study subject\n\nExclusion criteria\n\n1. Bilateral strokes (infarcts and\u002For hematoma)\n2. Other co-existent neuromuscular disorders affecting upper extremity motor impairment.\n3. History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study.\n4. Uncontrolled hypertension despite medical treatment(s) at the time of randomization, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and randomized later).\n5. Presence of any MRI\u002FrTMS risk factors including but not limited to:\n\n   1. an electrically, magnetically, or mechanically activated metallic or nonmetallic implant including cardiac pacemaker, intracerebral vascular clips or any other electrically sensitive support system.\n   2. a non-fixed metallic part in any part of the body, including a previous metallic injury to the eye.\n   3. history of seizure disorder before stroke or seizure after stroke.\n   4. preexisting scalp lesion or bone defect or hemicraniectomy.\n6. Concurrent enrollment in another interventional stroke recovery study.\n7. Concerns that the subject cannot comply with study procedures and visits.\n8. Pregnant individuals","ALL","21 Years",{"count":20,"type":21},26,"ESTIMATED","INTERVENTIONAL",[24],"NA","The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better.",[27,28,29,30,31,32,33,34,35],"Stroke","Stroke Patients","Arm Weakness as a Consequence of Stroke","Brain Stimulation","Transcranial Magnetic Stimulation Repetitive","Transcranial Magnetic Stimulation","Motor Learning","Chronic Stroke Patients","Chronic Stroke Survivors",[37,38,39,40,41,42,43,44,45,46],"stroke","arm weakness","arm weakness as a consequence of stroke","stroke patients","transcranial magnetic stimulation","transcranial magnetic stimulation repetitive","motor learning","chronic stroke","chronic stroke patients","chronic stroke survivors","RECRUITING","2026-05-19",{"date":50,"type":51},"2026-05-22","ACTUAL",{"date":53,"type":51},"2025-06-09",{"date":55,"type":21},"2027-04-30",{"name":57,"class":58},"Duke University","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":4,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":22,"phases":72,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":4},"100617176","cortical-excitability-and-role-of-non-invasive-brain-stimulation-in-adhd-and-autism-100617176","NCT07315217","Cortical Excitability and Role of Non Invasive Brain Stimulation in ADHD and AUTISM","Cortical Excitability and Role of Non Invasive Brain Stimulation in ADHD and AUTISM : Double Blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Age 6-19 years.\n* ASD trial: DSM-5 diagnosis of ASD confirmed by CARS-2.\n* ADHD trial: DSM-5 diagnosis of ADHD confirmed by structured interview\u002FCONORS\n* IQ ≥ 70.\n* Stable medication for ≥4 weeks (if any).\n\nExclusion Criteria:\n\n* Epilepsy or seizure history.\n* Metallic implants or devices incompatible with TMS.\n* Severe psychiatric comorbidity (e.g., psychosis).\n* Inability to tolerate TMS procedures.",true,"6 Years","19 Years",{"count":71,"type":21},80,[24],"This double-blind, randomized, sham-controlled clinical trial will evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on children and adolescents with attention-deficit\u002Fhyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and matched healthy controls. Participants aged 6-19 years will be assigned to active or sham rTMS protocols targeting the dorsolateral prefrontal cortex over 3 weeks, with assessment of changes in disorder-specific symptoms and cortical excitability. The study aims to determine the safety, feasibility, and preliminary efficacy of rTMS as a non-invasive neuromodulation approach in pediatric neurodevelopmental disorders.",[75,30,76,77],"Cortical Excitability","ADHD","Autism",[79,80,76,77],"Cortical excitability","non invasive brain stimulation","NOT_YET_RECRUITING","2025-12-18",{"date":84,"type":51},"2026-01-02",{"date":86,"type":21},"2026-01",{"date":88,"type":21},"2027-02",{"name":90,"class":58},"Assiut University"]