[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-structure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-structure":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100460586","brain-health-in-youth-with-normal-weight-overweight-and-obesity-at-risk-for-type-2-diabetes-t2d-100460586",false,"NCT05277558","Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)","Brain Health Across the Metabolic Continuum in Youth at Risk for Type 2 Diabetes (T2D)","Metabrain","Inclusion Criteria:\n\n* 12-17 yrs. old at visit 1, 12-19 yrs. old at visit 2, Tanner II or above (determined through an exam by a pediatric endocrinologist or certified nurse practitioner trained in pediatric endocrinology), otherwise healthy except for obesity, \\\u003C450 lbs. (due to MRI scanner limits), able and willing to lie flat within the MRI scanner and do cognitive testing, fluent in English.\n\nExclusion Criteria:\n\n* Syndromic obesity, history of bariatric surgery, insulin treatment (metformin allowed if \\\u003C 6 months) for T2D, contraindications for MRI (metal, claustrophobia), braces, pregnant (pregnancy test will be done on post-menarchal girls) or breastfeeding, inability to participate in cognitive testing due to sensory or language issues, intellectual disability, special education, pharmacologic treatment for Attention Deficit Hyperactivity Disorder (ADHD), prematurity (\\\u003C36 weeks gestation), complications at birth, neurologic co-morbidities (e.g., seizures, stroke, head injury with \\>10 min loss of consciousness), significant psychiatric disorders (e.g., schizophrenia, bipolar disorder, current major depression), taking psychoactive medications (e.g., antipsychotics) that would interfere with testing or reporting illegal drug use. Self-reported smoking and alcohol use and length of time with obesity will be assessed by history (although these measures may not be fully reliable).",true,"ALL","12 Years","17 Years",{"count":22,"type":23},117,"ESTIMATED","OBSERVATIONAL","Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, inflammation, β-cell dysfunction and dysglycemia) that pose a risk for the brain. Investigators will determine which of these factors are most associated with differences in brain structure and function among groups, over time, and how these effects differ from normal neurodevelopment.",[27,28,29,30,31,32,33,34,35,36,37],"Type2 Diabetes","Type 2 Diabetes Mellitus in Obese","Dysglycemia","Microvascular Complications","Brain Structure","Obesity, Childhood","Diabetes in Adolescence","Inflammation","Insulin Resistance","Overweight, Childhood","Cognitive Decline",[39],"Brain, Health, Youth, Type 2 Diabetes Mellitus, overweight, obesity","RECRUITING","2025-12-16",{"date":43,"type":44},"2025-12-18","ACTUAL",{"date":46,"type":44},"2022-05-24",{"date":48,"type":23},"2027-10-31",{"name":50,"class":51},"Washington University School of Medicine","OTHER",2,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":72,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":90},"100560170","neurophysiological-changes-after-perturbation-based-training-in-older-adults-100560170","NCT06573658","Neurophysiological Changes After Perturbation-based Training in Older Adults","Short-term Neurophysiological Changes After a Perturbation-based Training in Community-dwelling Older Adults: A Pilot Study","Inclusion Criteria:\n\n* Aged ≥ 60 years old\n* Community-dwelling\n* Right-handed\n* Able to communicate effectively in Cantonese or Mandarin\n* Able to walk independently on level ground for ≥ 30 minutes\n* Abbreviated Mental Test (Hong Kong version) score ≥ 6\n\nExclusion Criteria:\n\n* Metal implants (e.g. pacemaker, artificial cochlea)\n* Uncorrected vision or hearing impairment\n* Osteoporosis\n* Hip or knee replacement within the last year\n* Musculoskeletal, cardiovascular, mental, or neurological disorders (such as Parkinson's disease) which can affect MRI examination, balance control, or exercise participation.","60 Years",{"count":62,"type":23},88,"INTERVENTIONAL",[65],"NA","This is an assessor-blinded neurophysiological study. Participants will be randomly assigned to a perturbation-based training (PBT) or a walking (control) group. Changes in postural stability and neurophysiology in the brain following PBT compared to walking exercise without perturbation will be investigated.",[68,69,70,71,31],"Falling","Community Dwelling Older Adults","Postural Stability","Brain Connectivity",[73,74,75,76,77,78,79,80],"Perturbation","Magnetic Resonance Image","MRI","step training","responsive postural control","balance","external disturbance","fall","2025-09-19",{"date":83,"type":44},"2025-09-24",{"date":85,"type":44},"2024-04-18",{"date":87,"type":23},"2026-10-14",{"name":89,"class":51},"The Hong Kong Polytechnic University",1,{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":17,"sex":18,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":63,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":90},"100558816","investigating-the-effects-of-transcranial-direct-current-stimulation-to-different-brain-regions-on-ankle-tracking-motor-learning-motor-adaptation-and-brain-connectivity-in-healthy-middle-aged-and-older-adults-and-patients-with-subcortical-stroke-100558816","NCT06556043","Investigating the Effects of Transcranial Direct Current Stimulation to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke","Investigating the Effects of Transcranial Direct Current Stimulation (tDCS) to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke","tDCS","Inclusion Criteria: Part 1: healthy middle-aged and older adults\n\n1. age between 40 and 80 years old\n2. intact cognitive function (MMSE ≧ 27)\n3. normal ankle dorsiflexor and plantarflexor strength (manual muscle strength testing= 5) and passive range of motion (ankle dorsiflexion ≧10 degrees; ankle plantarflexion ≧ 45 degrees)\n4. corrected far vision ≥ 0.8 (Landolt C test) and uncorrected near vision ≥ 0.04 (Comprehensive Color Blindness Checklist)\n\nExclusion Criteria: Part 1: healthy middle-aged and older adults\n\n1. having any contraindications for MRI or tDCS;\n2. serious or uncontrolled systematic diseases;\n3. symptoms or history of neurological diseases, including transient ischemic attack, stroke, epilepsy, history of abnormal electroencephalogram (EEG), meningitis, encephalitis, brain tumors, brain surgery, and sensory disorders, etc.;\n4. severe musculoskeletal problems that would affect lower limb functions;\n5. visual spatial perception disorders and hearing loss;\n6. color blindness;\n7. depression and psychiatric disorders;\n8. use of any medication that could affect the central nervous system function;\n9. drug, substance, or alcohol addiction;\n10. those participating in research involving invasive or non-invasive brain stimulation;\n11. those deemed unsuitable for MRI or tDCS after evaluation by the attending physician;\n12. those affiliated with any research-conducting institution.\n\nInclusion Criteria: Part 2: patients with chronic subcortical stroke\n\n1. aged between 40 and 80 years old;\n2. intact cognitive function (MMSE ≥ 27);\n3. first-ever onset of subcortical stroke occurring at least 3 months prior to enrollment, with brain lesions involving unilateral subcortical regions only;\n4. hemiplegic or hemiparetic;\n5. no spatial neglect;\n6. able to actively perform at least 5 degrees of ankle dorsiflexion and 10 degrees of ankle plantarflexion with the affected ankle;\n7. no excessive spasticity;\n8. no severe contracture (passive range of motion ≥ 10 degrees for ankle dorsiflexion and ≥ 20 degrees for ankle plantarflexion) in the affected leg;\n9. mild-to moderate disability;\n10. can walk independently or under supervision without assistance;\n11. corrected far vision ≥ 0.8 (Landolt C test) and uncorrected near vision ≥ 0.04 (Comprehensive Color Blindness Checklist.)\n\nExclusion Criteria: Part 2: patients with chronic subcortical stroke The exclusion criteria will be the same as those listed for healthy participants described in Part 1 except for items (3) and (4). Item (3) will be changed to \"(3a) symptoms or history of other neurological diseases, including epilepsy, history of abnormal EEG, meningitis, encephalitis, brain tumors, brain surgery, and sensory disorders, etc.\" and item (4) will be changed to \"(4a) severe musculoskeletal problems of the non-hemiparetic limbs that would affect mobility functions\".","40 Years","80 Years",{"count":102,"type":23},120,[65],"Ankle control is essential to safe over-ground navigation for humans. Middle- aged and older adults and patients with stroke whose ankle control is poor often lose their balance or fall. Transcranial direct current stimulation (tDCS) is an emerging non-invasive brain stimulation technology that has great potential to be applied to neurorehabilitation; however, the optimization of its applications still needs further studies. The aims of this project are to compare the effects of anodal tDCS (AtDCS) applied to the primary motor cortex (M1) contralateral to the moving leg (cM1), posterior parietal cortex (PPC) contralateral to the moving leg (cPPC), and cerebellar cortex (CBM) ipsilateral to the moving leg (iCBM) on motor learning, motor adaptation, and brain connectivity in healthy middle-aged and older adults and hemiparetic patients with chronic subcortical stroke.",[106,107,108,109,31,71,110],"Transcranial Direct Current Stimulation","Ankle","Motor Learning","Adaptation","Stroke","2024-08-15",{"date":113,"type":44},"2024-08-19",{"date":115,"type":44},"2024-07-09",{"date":117,"type":23},"2026-07-31",{"name":119,"class":51},"National Taiwan University Hospital"]