[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-trauma":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,88,125,152],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100643795","bridge-us-bridging-readiness-in-deployed-neurotrauma-gaps-for-excellence-100643795",false,"NCT07636213","BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence","BRIDGE-US","Inclusion Criteria:\n\n1. Age: Subjects aged 16 years and older\n2. Injury Type\u002FEvidence: Patients with a confirmed PBI as demonstrated by head imaging or physical exam (evidence of dural penetration by a projectile)\n3. Timeframe: Patients must be enrolled within 8 hours of injury\n\nExclusion Criteria:\n\nNo subjects will be excluded based on gender or ethnicity for this study. Subjects under the age of 16 will be excluded. These subjects differ significantly in terms of neurodevelopment, physiology, and trauma response, which introduces heterogeneity that could confound study results. Additionally, pediatric PBI has distinct etiologies, treatment pathways, and prognostic indicators compared to adult PBI (note that age 16 and up are treated medically as adults).\n\nFULL EXCLUSION CRITERIA:\n\n1. Dead on Arrival (DOA): Patients who receive CPR with no return of pulse\n2. Non-penetrating injury: Patients with head injuries that do not include dural penetration\n3. Polytrauma: Patients with penetrating or blunt injuries to other parts of the body\n4. Known or suspected pregnancy\n5. Known or suspected prisoner","ALL","16 Years",{"count":19,"type":20},270,"ESTIMATED","7 Days","OBSERVATIONAL","The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago). Biospecimens will undergo biomarker analysis - biomarker data specific to PBI is extremely limited, and could provide critical insight to outcome identification and clinical decision making.\n\nThis data will be used to build the first comprehensive PBI Data Commons, biorepository, and imaging repository which will create the infrastructure necessary to close critical knowledge gaps, advance biomarker discovery specific to PBI, and provide the foundation for future research aimed at improving prognostication and treatment for patients with this devastating injury.",[25,26,27,28],"Brain Injuries, Acute","Brain Trauma","Penetrating Head Injury","Traumatic Brain Injury","NOT_YET_RECRUITING","2026-06-08",{"date":32,"type":33},"2026-06-09","ACTUAL",{"date":35,"type":20},"2026-07-01",{"date":37,"type":20},"2035-12-31",{"name":39,"class":40},"University of Chicago","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":69,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":87},"100547838","remotely-supervised-tdcs-for-complex-attention-in-mtbi-cognetric-100547838","NCT06413173","Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)","Remotely Supervised tDCS Combined With Cognitive Training to Improve Complex Attention in Active Duty Service Members and Veterans With Mild TBI (Cognetric)","COGNETRIC","Inclusion Criteria:\n\n1. Active-Duty Service Members.\n2. Ages 18 to 60.\n3. All genders.\n4. All racial and ethnic groups.\n5. History of mild TBI (as defined by the DOD\u002FVA criteria used in conjunction with the OSU TBI-ID) sustained at least 3 months and no more than 10 years prior to enrollment.\n6. Self-reported attention and\u002For concentration difficulties.\n7. At least one cognitive symptom reported on the Neurobehavioral Symptom Inventory (NSI) cognitive subscale.\n\nExclusion Criteria:\n\n1. Presence of a medical, psychiatric, physical or non-physical disease, disorder, condition, injury, disability or pre-existent history such that study participation, in the opinion of the PI: (a) may pose a significant risk to the participant; (b) raises the possibility that the participant is unlikely to successfully complete all of the requirements of the study according to the study protocol; or (c) might adversely impact the integrity of the data or the validity of the study results. Specific conditions include (but are not limited to) a history of: brain tumor, epilepsy, cerebral vascular accident (CVA), Schizophrenia, Bipolar Disorder, and Mania.\n2. History of prior treatment with ECT or neuromodulation in the last 12 months.\n3. Current, diagnosed substance dependence.\n4. Newly prescribed medication within the previous 3 weeks.\n5. Diagnosis of intellectual disability or pervasive developmental disorder (i.e., premorbid IQ less than or equal to 70).\n6. Any medical condition or treatment other than mild TBI (e.g., stroke, tumor, HIV, moderate-severe TBI), with significant neurological disorder or insults that, based on the Principal Investigator's judgment, would impact risk.\n7. Psychosis or mania within 30 days of enrollment, as determined by the PI, based on a psychiatric history and examination and\u002For a review of available medical records\n8. Contraindications for tDCS (e.g., metallic cranial plates\u002Fscrews or implanted device, eczema or skin lesions on scalp)\n9. A positive pregnancy report.","18 Years","60 Years",{"count":53,"type":20},160,"INTERVENTIONAL",[56],"NA","The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called \"Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training\" (RS-tDCS+) which has shown promise for improving complex attention in both healthy and clinical populations. RS-tDCS+ is a home-based, low-risk, non-invasive technique that is designed to boost cognitive training by enhancing learning and the brain's ability to reorganize connections. This study will evaluate RS-tDCS+ for improving complex attention in Active Duty Service Members (ADSM) and Veterans with a history of mTBI. Different tests of complex attention and symptom questionnaires will be used to determine the effects of real versus sham (placebo) RS-tDCS+. Second, the investigators will investigate electrical and connectivity changes in the brain associated with RS-tDCS+ using electroencephalogram (EEG) and magnetic resonance imaging (MRI). Third, the investigators will investigate the lasting effects of any observed changes by evaluating participants at 1 and 6 weeks post-treatment. Lastly, the investigators will explore the impact of individual differences (e.g., PTSD, depression, sleep quality, time since injury, baseline impairment, age, sex, ADSM versus Veteran) on treatment outcome.",[59,26,60,61,62,63,64,65,66,67,68],"Brain Concussion","Attention Concentration Difficulty","Brain Injuries","Brain Injuries, Traumatic","Neurocognitive Dysfunction","Attention Impaired","Memory Impairment","Mild Traumatic Brain Injury","Mild Cognitive Impairment","Post Concussive Symptoms",[70,71,72,73,74,75],"Military Health","Brain Stimulation","Cognitive Training","Cognitive Rehabilitation","Telehealth","Neuromodulation","RECRUITING","2025-11-07",{"date":79,"type":33},"2025-11-12",{"date":81,"type":33},"2024-07-25",{"date":83,"type":20},"2028-09-30",{"name":85,"class":86},"United States Naval Medical Center, San Diego","FED",2,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":54,"phases":98,"briefSummary":99,"conditions":100,"keywords":105,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":41},"100469827","biofeedback-for-hemianopia-vision-rehabilitation-100469827","NCT05397873","Biofeedback for Hemianopia Vision Rehabilitation","Biofeedback Training to Improve Fixation Stability, Visual Function Outcomes, and Quality of Life in Hemianopia Cases","Inclusion Criteria:\n\n* hemianopia cases previously diagnosed accordingly by microperimetry and other tests as needed\n* 18-90 years old\n* ability to follow the visual and auditory stimuli and training instructions\n\nExclusion Criteria:\n\n* previous or current treatment for low vision rehabilitation\n* ocular diseases\n* other serious clinical conditions not related to the hemianopia physiopathology\n* both eyes with media opacity that impairs microperimetry testing\n* lack of ability to perform the tests and training","90 Years",{"count":97,"type":20},32,[56],"Patients with brain injury secondary to stroke, surgery, or trauma frequently suffer from homonymous hemianopia, defined as vision loss in one hemifield secondary to retro- chiasmal lesion. Classic and effective saccadic compensatory training therapies are current aim to reorganize the control of visual information processing and eye movements or, in other words, to induce or improve oculomotor adaptation to visual field loss. Patients learn to intentionally shift their eyes and, thus, their visual field border, into the area corresponding to their blind visual field. This shift brings the visual information from the blind hemifield into the seeing hemifield for further processing. Patients learn, therefore, to efficiently use their eyes \"to keep the 'blind side' in sight\". Biofeedback training (BT) is the latest and newest technique for oculomotor control training in cases with low vision when using available modules in the new microperimetry instruments. Studies in the literature highlighted positive benefits from using BT in a variety of central vision loss, nystagmus cases, and others.The purpose of this study is to assess systematically the impact of BT in a series of cases with hemianopia and formulate guidelines for further use of this intervention in vision rehabilitation of hemianopia cases in general.",[101,102,103,104,26],"Hemianopsia, Homonymous","Brain Injury","Stroke","Brain Tumor",[106,107,108,109,110,111,112,113,114,115],"hemianopsia","stroke","brain tumor","brain trauma","visual fields","visual loss","low vision","fixation stability","biofeedback training","MAIA microperimeter","2025-05-05",{"date":118,"type":33},"2025-05-09",{"date":120,"type":33},"2021-12-01",{"date":122,"type":20},"2026-07",{"name":124,"class":40},"University Health Network, Toronto",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":54,"phases":134,"briefSummary":135,"conditions":136,"keywords":138,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":41},"100574994","characterization-of-the-sleep-wake-cycle-in-traumatic-brain-injury-patients-with-a-disorder-of-consciousness-100574994","NCT06766513","Characterization of the Sleep-Wake Cycle in Traumatic Brain Injury Patients with a Disorder of Consciousness","SLEEPDOC","Inclusion Criteria:\n\n* Admission to the Post-Resuscitation Rehabilitation Unit or the Neurological Intensive Care Unit\n* Consciousness disorders: Vegetative State or Minimally Conscious State (according to the CRS-R)\n* Traumatic brain injury\n* Patient aged 18 years or older\n* Presence of relatives able to express non-opposition to the study\n* Subjects affiliated with a social security scheme (or beneficiaries)\n\nExclusion Criteria:\n\n* Admission for status epilepticus\n* Individuals admitted to a healthcare or social care facility for purposes other than research\n* Adults under legal protection measures (guardianship, conservatorship)\n* Individuals not affiliated with a social security scheme or not benefiting from a similar scheme",{"count":133,"type":20},40,[56],"Each year in France, 160,000 peoples suffer from a mild or severe traumatic brain injury (TBI). Sleep plays a crucial role in the process of brain plasticity, which is essential for neurological and cognitive recovery. However, the sleep-wake cycle is rarely, if ever, evaluated in patients with TBI and consciousness disorders within Post-Resuscitation Rehabilitation Units (SRPR). Caregivers develop, on a daily basis, an intuitive understanding of the patient's overall condition. This expertise deserves to be validated using objective sleep assessment tools (actigraphy). If proven accurate, it could lead to the implementation of a sleep-wake cycle evaluation protocol within SRPRs.",[137,26],"Trauma, Nervous System",[139,140,141,142],"Traumatic brain injury","Disorders of consciousness","Vegetative State","Minimally Conscious State","2025-01-08",{"date":145,"type":33},"2025-01-09",{"date":147,"type":20},"2025-02-01",{"date":149,"type":20},"2028-08-01",{"name":151,"class":40},"Hospices Civils de Lyon",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":54,"phases":160,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":4},"100526238","visar-augmented-reality-navigation-of-ventriculostomy-100526238","NCT06132139","VisAR Augmented Reality Navigation of Ventriculostomy","Inclusion Criteria:\n\n* Adult patients, 18 years and older, determined to need an external ventricular drain (EVD) or ventriculostomy catheter by the attending neurosurgeon secondary to a variety of pathologies, including obstructive hydrocephalus, trauma and subarachnoid hemorrhage.\n\nExclusion Criteria:\n\n* Patients less than 18 years of age.\n* Pregnant women.\n* Prisoners.",{"count":159,"type":20},50,[56],"This study is intended to evaluate the feasibility of using VisAR augmented reality surgical navigation during placement of an external ventricular drain (EVD). The investigators are interested in confirming the design of the VisAR headset is compatible with this bedside procedure.",[163,164,26],"Obstructive Hydrocephalus","Subarachnoid Hemorrhage","2024-08-06",{"date":167,"type":33},"2024-08-07",{"date":169,"type":20},"2024-10",{"date":171,"type":20},"2025-05",{"name":173,"class":40},"Dartmouth-Hitchcock Medical Center"]