[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brca2-gene-mutation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brca2-gene-mutation":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100385147","tubectomy-with-delayed-oophorectomy-in-high-risk-women-to-assess-the-safety-of-prevention-100385147",false,"NCT04294927","TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention","TUBectomy With Delayed Oophorectomy as Alternative for Risk-reducing Salpingo-oophorectomy in High Risk Women to Assess the Safety of Prevention: TUBA-WISP II Study.","TUBA-WISP-II","Inclusion Criteria:\n\n* Women with a class 5 (definitely pathogenic) BRCA1, BRCA2, RAD51C, RAD51D or BRIP1 germline mutation in one of the participating centers.\n* Age at inclusion;\n\n  * BRCA1: 25-40 years\n  * BRCA2: 25-45 years\n  * RAD51C, RAD51D, BRIP1: 25-50 years\n* Childbearing completed\n* Presence of at least one fallopian tube\n* Participants may have a personal history of non-ovarian malignancy\n* Informed consent must be obtained and documented according to national and local regulatory requirements and the local rules followed in the institution.\n\nExclusion Criteria:\n\n* Postmenopausal status (natural menopause or due to treatment)\n* Wish for second stage RRO within two years after RRS\n* Legally incapable\n* Prior bilateral salpingectomy\n* A personal history of ovarian, fallopian tube or peritoneal cancer\n* Current diagnosis or treatment for malignant disease","FEMALE","25 Years","50 Years",{"count":21,"type":22},3000,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.",[28,29,30,31,32,33],"BRCA1 Gene Mutation","BRCA2 Gene Mutation","RAD51C Gene Mutation","RAD51D Gene Mutation","BRIP1 Gene Mutation","Ovarian Cancer","RECRUITING","2026-03-31",{"date":37,"type":38},"2026-04-06","ACTUAL",{"date":40,"type":38},"2020-03-01",{"date":42,"type":22},"2040-02-17",{"name":44,"class":45},"University Medical Center Nijmegen","OTHER",66,"brca2 Gene Mutation"]