[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"breast-abscess\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:breast-abscess":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100606703","phase-2-a-phase-2-study-of-methylene-blue-photodynamic-therapy-for-treatment-of-breast-abscesses-100606703",false,"NCT07179003","A Phase 2 Study of Methylene Blue Photodynamic Therapy for Treatment of Breast Abscesses","Inclusion Criteria:\n\n* Adults 18 years or older\n* Clinical signs of breast abscess, including pain, redness, and\u002For heat of the breast\n* Approval by the primary care team to pursue PDT and discuss enrollment with the patient\n\nExclusion Criteria:\n\n* Pregnancy\n* Lactation\n* Allergy to contrast media, narcotics, sedatives, atropine or eggs\n* Necrotic tissue that requires surgical debridement\n* Severely compromised cardiopulmonary function or hemodynamic instability\n* Thrombocytopenia (\\\u003C50,000\u002Fmm3)\n* Uncorrectable coagulopathy\n* Poor kidney function (serum creatinine \\>3mg\u002Fdl)\n* Glucose-6-phosphate dehydrogenase (G6PD) deficiency\n* Patients with hidradenitis suppurativa\n* Patients with granulomatous mastitis\n* Unable or unwilling to understand or to provide informed consent\n* Unable or unwilling to undergo study procedures\n* Patient unable to cooperate with, or to be positioned for the procedure\n* Unable to comply with necessary follow up","ALL","18 Years",{"count":18,"type":19},50,"ESTIMATED","INTERVENTIONAL",[22],"PHASE2","The objective of this Phase 2 study is to evaluate the efficacy of methylene blue photodynamic therapy (MB-PDT) performed at the time of percutaneous breast abscess drainage for disinfection of breast abscesses. The study includes two arms: (1) standard of care breast abscess drainage and (2) MB-PDT plus standard of care breast abscess drainage. The primary endpoint is time to resolution of clinical symptoms. Secondary endpoints include imaging evidence of abscess resolution, abscess recurrence, need for repeated intervention, and cure rate across treatment groups. Responses will be compared between the two study arms for the per protocol population to determine the efficacy of MB-PDT relative to standard of care. The investigators hypothesize that the addition of MB-PDT to standard of care will significantly reduce the time to symptom resolution, compared to standard of care alone.",[25],"Breast Abscess",[27,28,29,30],"Breast abscess","Drainage","Photodynamic therapy","Methylene blue","NOT_YET_RECRUITING","2025-09-17",{"date":34,"type":35},"2025-09-23","ACTUAL",{"date":37,"type":19},"2026-04",{"date":39,"type":19},"2031-03",{"name":41,"class":42},"University of Rochester","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":20,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":43},"100561754","comparison-of-efficacy-in-treating-breast-abscess-with-systemic-antibiotics-against-local-instillation-of-antibiotics-along-with-ultrasound-guided-aspiration-100561754","NCT06594276","Comparison of Efficacy in Treating Breast Abscess, With Systemic Antibiotics Against Local Instillation of Antibiotics Along With Ultrasound Guided Aspiration.","Effectiveness of Local Instillation of Antibiotics Compared to Systemic Antibiotics, as Adjunct to Ultrasound Guided Aspiration in the Management of Breast Abscess; a Randomized Controlled Trial","Inclusion Criteria:\n\n\\- Female gender Age range 14-60 years Lactating or non-lactating Clinical signs : erythema, tenderness, fever, fluctuation\n\nExclusion Criteria:\n\nPatients refusal Male gender Acute mastitis Malignant lesion (inflammatory carcinoma) Antibioma Draining abscess\u002FSinus Skin ulcers \u002F gangrene Diagnosed case of Tuberclosis H.I.V\n\n\\-","FEMALE","14 Years","60 Years",{"count":55,"type":19},104,[57],"NA","Breast abscess, marked by localized collection of pus, frequently follows mastitis. Its prevalence soars up to 16% in the developing world. It usually presents in lactating mothers but also develops in prepubertal females as well. Conventionally it has been treated by surgical incision and drainage with antibiotic coverage, whether oral, intramuscular or intravenous. This approach requires hospital stay and general anesthesia but also have complications like scarring and disfigurement. With the financial and emotional impacts of this technique , surgeons have opted needle aspiration of breast abscess as a standardized treatment. It has been very successful in the management of breast abscess as it spares the patients from long hospital stays and the cosmetic complications. It may require to repeat the procedure till the complete resolution of symptoms which can be effectively assessed by the clinical symptoms of the patient like redness of the skin, pain, tenderness and ultrasonographical evidence of pus accumulation. Systemic antibiotics are still frequently administered for prophylactic and therapeutic purposes. It has been shown in previous studies that systemic antibiotics may not be as effective as deemed earlier due to local pathogenesis. The use of local antibiotics is not a novel concept but a firmly established fact , whether its the earliest sterilization of the operative field or treating open wounds and fractures . Studies have shown great effect of local use of antibiotics in different scenarios and this may help in limit the use of antibiotics and providing the systemic bypass with maximum local impact. In patients of breast abscess, along with ultrasound guided aspiration the inclusion of locally injecting the antibiotics may reduce the frequency of procedure till the absolute resolution of symptoms and also markedly decrease the failure rate of this technique , which usually resorts to the conventional incision and drainage.",[25],[61],"treatment of breast abscess","RECRUITING","2024-09-10",{"date":65,"type":35},"2024-09-19",{"date":67,"type":19},"2024-10",{"date":69,"type":19},"2025-04",{"name":71,"class":42},"Gujranwala medical college District Headquarters Hospital, Gujranwala"]