[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"breast-cancer-prevention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:breast-cancer-prevention":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,62,88,117,139,165,188],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":5},"100608351","meliora-virtual-coach-intervention-for-breast-cancer-prevention-100608351",false,"NCT07200427","MELIORA Virtual Coach Intervention for Breast Cancer Prevention","Multimodal Engagement and Sustainable Lifestyle Interventions Optimizing Breast Cancer Risk Reduction Supported by Artificial Intelligence","MELIORA","Inclusion Criteria:\n\nMELIORA-HEALTHY study participants must meet all of the following criteria in order to be deemed eligible for study participation:\n\n* Reside in Greece, Lithuania, or Spain.\n* Be female and at least 18 years of age.\n* Have access to and be able to use a smartphone (iOS or Android) compatible with the MELIORA app.\n* Be willing and able to use the MELIORA app for the entire study duration.\n* Willing to provide informed consent to participate in the study.\n* Have at least one of the following behavioural or metabolic risk factors for BC, assessed in a random order (each site may determine the order that is most convenient for them) until eligibility is confirmed. If a risk factor is identified, the subsequent assessments can be skipped:\n* Increased alcohol consumption: More than 1 drink per day.\n* Increased body mass index (BMI): BMI ≥ 25 kg\u002Fm² or waist circumference ≥80 cm for normal weight individuals.\n* Physical inactivity: Not meeting World Health Organization (WHO) guidelines of at least 150 minutes of moderate-intensity or 75 minutes of high-intensity aerobic exercise per week during the last month.\n* Suboptimal diet: Low diet quality based on the rapid Prime Diet Quality Score Screener (rPDQS).\n\nMELIORA-PATIENTS study participants must meet all of the following criteria in order to be deemed eligible for study participation:\n\n* Reside in Spain or Lithuania.\n* Be female and at least 18 years old.\n* Have access to and be able to use a smartphone (iOS or Android) compatible with the MELIORA app.\n* Be willing and able to use the MELIORA app for the entire study duration.\n* Willing to provide informed consent to participate in the study.\n* Have been diagnosed with breast cancer (BC) within the last 6 months and\u002For currently undergoing treatment (chemotherapy, radiotherapy, immunotherapy, hormone therapy) and\u002For in active follow-up.\n* Have at least one of the following behavioural or metabolic risk factors for BC, assessed in a random order (each site may determine the order that is most convenient for them) until eligibility is confirmed. If a risk factor is identified, the subsequent assessments can be skipped:\n* Increased alcohol consumption: More than 1 drink per day.\n* Increased body mass index (BMI): BMI ≥ 25 kg\u002Fm² or waist circumference ≥80 cm for normal weight individuals.\n* Physical inactivity: Not meeting World Health Organization (WHO) guidelines of at least 150 minutes of moderate-intensity or 75 minutes of high-intensity aerobic exercise per week during the last month.\n* Suboptimal diet: Low diet quality based on the rapid Prime Diet Quality Score Screener (rPDQS).\n\nMELIORA-SURVIVORS study participants must meet all of the following criteria in order to be deemed eligible for study participation:\n\n* Reside in Spain, Lithuania, or Sweden.\n* Be female and at least 18 years old.\n* Have access to and be able to use a smartphone (iOS or Android) compatible with the MELIORA app.\n* Be willing and able to use the MELIORA app for the entire study duration.\n* Willing to provide informed consent to participate in the study.\n* Have completed primary treatment for breast cancer (surgery, chemotherapy, radiotherapy, immunotherapy, targeted therapy, etc.) and currently be in remission.\n* Be considered \"cancer-free\" according to their treating physician and may enter the study immediately following this diagnosis.\n* Ongoing adjuvant hormone therapy is permitted.\n* Have at least one of the following behavioural or metabolic risk factors for BC, assessed in a random order (each site may determine the order that is most convenient for them) until eligibility is confirmed. If a risk factor is identified, the subsequent assessments can be skipped:\n* Increased alcohol consumption: More than 1 drink per day.\n* Increased body mass index (BMI): BMI ≥ 25 kg\u002Fm² or waist circumference ≥80 cm for normal weight individuals.\n* Physical inactivity: Not meeting World Health Organization (WHO) guidelines of at least 150 minutes of moderate-intensity or 75 minutes of high-intensity aerobic exercise per week during the past month.\n* Suboptimal diet: Low diet quality based on the rapid Prime Diet Quality Score Screener (rPDQS).\n\nExclusion Criteria:\n\nMELIORA-HEALTHY study participants will be excluded from study participation if they meet any of the following criteria:\n\n* Inability to provide fully informed consent.\n* Inability to understand or communicate in the local language i.e. Greek in Greece, Lithuanian in Lithuania, Spanish in Spain.\n* Current or past diagnosis of cancer or other uncontrolled chronic diseases (e.g., cardiovascular disease, diabetes) that affect lifestyle, dietary habits, or communication skills.\n* Mental illness or disorders that affect lifestyle, dietary habits, or communication skills.\n* Use of medication that affects lifestyle, dietary habits, or communication skills.\n* Recreational drug use.\n* Pregnancy, lactation, or intention to become pregnant shortly before, during, or after the intervention.\n* Participation in another clinical trial or program aimed at promoting behavioural changes or weight loss at the time of recruitment. If subjects already use health-related apps that affect their weight and lifestyle, including dietary habits and physical activity, the research team will ask them to pause their use until the end of the 12-month study period. However, the use of these applications by the participants cannot be controlled.\n\nMELIORA PATIENTS and MELIORA SURVIVORS study participants will be excluded from study participation if they meet any of the following criteria:\n\n* Inability to provide fully informed consent.\n* Inability to understand or communicate in the local language (i.e., Lithuanian in Lithuania, Spanish in Spain, Swedish in Sweden), unless appropriate translation support is available to ensure full understanding of study procedures and informed consent.\n* Current or past diagnosis of cancer (other than breast cancer, except skin cancer treated with surgery only) or other uncontrolled chronic diseases (e.g., cardiovascular diseases, diabetes) that affect lifestyle, dietary habits, or communication skills.\n* Mental illness or disorders that affect lifestyle, dietary habits, and communication skills.\n* Use of medication that affects lifestyle, dietary habits, or communication skills.\n* Recreational drug use.\n* Pregnancy, lactation, or intention to become pregnant shortly before, during, or after the intervention.\n* Participation in another clinical trial or program to promote behavioural changes or weight loss during recruitment. Suppose participants are already using health-related apps affecting their weight and lifestyle, including dietary habits and physical activity. In that case, they will be asked to suspend their use until the end of the 12-month study period. However, the research team cannot control the use of these applications by the participants.\n* Severe adherence issues with previous treatments that may interfere with compliance with study tasks (subject to the investigator's assessment).",true,"FEMALE","18 Years",{"count":21,"type":22},2080,"ESTIMATED","INTERVENTIONAL",[25],"NA","Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide, with early-onset cases increasing due to genetic and lifestyle factors. Traditional prevention strategies have shown limited effectiveness, creating the need for innovative approaches. The MELIORA project develops an AI-driven digital tool, the Virtual Coach (VC), to promote sustainable behaviour change in physical activity, diet, and alcohol use. Three randomized-controlled studies will be conducted: MELIORA-HEALTHY (women at risk, n=1080 in Greece, Lithuania, Spain), MELIORA-PATIENTS (women undergoing treatment, n=400 in Lithuania, Spain), and MELIORA-SURVIVORS (post-treatment survivors, n=600 in Lithuania, Spain, Sweden). Participants across diverse regions and backgrounds will be randomized to standard lifestyle advice or the same advice plus the MELIORA VC app. Each study lasts 12 months, with outcomes assessed at baseline, 6, and 12 months. The primary outcome is physical activity, with secondary outcomes including sedentary behaviour, diet, alcohol use, and quality of life. If effective, the MELIORA VC could offer a scalable, cost-effective model for BC prevention and survivorship care, providing valuable evidence to guide public health strategies.",[28],"Breast Cancer Prevention",[30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49],"Behavior change","Disease prevention","Health behaviour","Primary prevention","Public and environmental health","Breast cancer","Cancer prevention","Sustainable intervention","Nutrition","Diet","Physical activity","Exercise","Lifestyle","Public health","Cancer risk factors","Health communication","Digital health","Health technologies","Artificial intelligence","randomized controlled trial","RECRUITING","2026-06-12",{"date":53,"type":54},"2026-06-15","ACTUAL",{"date":56,"type":54},"2026-03-01",{"date":58,"type":22},"2027-09",{"name":60,"class":61},"Harokopio University","OTHER",{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":17,"sex":70,"minAge":19,"maxAge":4,"enrollmentInfo":71,"targetDuration":4,"studyType":73,"phases":4,"briefSummary":74,"conditions":75,"keywords":4,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100575562","rutgers-university-study-of-the-genetics-of-breast-cancer-100575562","NCT06773897","Rutgers University Study of the Genetics of Breast Cancer.","The Rutgers University Genetics Coordinating Center Breast Cancer Study","RUGCC-BC","Inclusion Criteria:\n\n* age 18 years or older\n* currently living in the United States\n* able to understand and follow written instructions in English\n* have access to the internet and a computer, laptop, tablet or smart phone\n* willing to provide written informed consent for participation\n* willing to provide DNA via a saliva sample using a collection kit mailed to the study participant's home\n* willing to complete a survey with questions about health related to the study of breast cancer.\n\nExclusion Criteria:\n\n* Not able to meet or fulfill any of the inclusion criteria","ALL",{"count":72,"type":22},25000,"OBSERVATIONAL","The goal of this observational study is to learn more about how genes impact the risk of breast cancer. Anyone 18 or older living in the US is eligible, and a diagnosis of cancer is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.",[76,28,77],"Breast Cancer Risk","Breast Cancer","2026-05-21",{"date":80,"type":54},"2026-05-22",{"date":82,"type":54},"2024-04-15",{"date":84,"type":22},"2028-04-30",{"name":86,"class":61},"Rutgers, The State University of New Jersey",1,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":17,"sex":18,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":103,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":87},"100611246","active-mammography-and-counseling-100611246","NCT07238088","Active Mammography and Counseling","Monitoreo Activo de Mamografía y Orientación","MAMO","Inclusion Criteria:\n\n* Women (biological sex at birth) aged 40- 74\n* Residing in one of 39 municipalities across Puerto Rico whose having a low breast cancer screening rate below the median (38.6%): Aibonito, Arecibo, Barceloneta, Caguas, Camuy, Comerío, Corozal, Florida, Las Piedras, Loíza, Naguabo, Vieques, Villalba, Añasco, Carolina, Cayey, Dorado, Guayanilla, Guaynabo, Isabela, Juana Diaz, Juncos, Luquillo, Manatí, Peñuelas, Quebradillas, Cabo Rojo, Canóvanas, Ceiba, Ciales, Coamo, Culebra, Fajardo, Morovis, Ponce, Sabana Grande, San Juan, Santa Isabel, and Trujillo Alto.\n* Overdue for breast cancer screening by one or more years, in accordance with annual guidelines\n* Adequate cognitive orientation as verified by a brief version of the Mini-Mental State Examination\n* Access to a telephone for follow-up and communication\n* Ability to read and comprehend Spanish to engage with educational materials.\n\nExclusion Criteria:\n\n* Women outside the specified age range (40-74)\n* Up to date in breast cancer screening according to the annual recommendations.\n* No cognitive orientation\n* Participants without access to a telephone\n* Unable to read and comprehend Spanish\n* Women undergoing active cancer treatment\n* History of radical mastectomy","40 Years","74 Years",{"count":99,"type":22},1020,[25],"The Puerto Rico Community Engagement Alliance (PR-CEAL) is an NIH-funded initiative which aims to improve health literacy and healthcare access across Puerto Rico. In 2024, the program developed a new study which goal is to improve breast cancer screening rates in Puerto Rico titled Monitoreo Activo de Mamografía y Orientación (MAMO). This multi-level study will recruit non-adherent women based on residence, age (40 to 74 years old), and having had two or more years since their last breast cancer screening. The intervention will focus on 39 municipalities with screening rates below the median, through three different levels: educational, navigation, and integration.\n\nAt the educational level, the intervention will employ a community-based recruitment strategy led by Community Health Workers (CHWs), who will identify eligible women at community venues and conduct follow-up via telephone to provide educational support. Drawing on findings from a previous pilot study and addressing barriers specific to non- adherent women, the navigation-level intervention will incorporate the role of a Community Navigator to deliver tailored support and facilitate breast cancer screening uptake through collaboration with local networks and partnerships. The integration-level intervention will build upon the educational and navigation components by enhancing knowledge, attitudes, skills, and organizational processes within Federally Qualified Health Clinics (FQHCs). This component is designed to foster a supportive healthcare environment that encourages routine mammography screening. The integration-level intervention will be implemented in four FQHCs across PR.",[28],[104,105,106,107],"breast cancer","Puerto Rico","cancer screening overdue","FQHC","2026-04-17",{"date":110,"type":54},"2026-04-22",{"date":112,"type":54},"2026-01-14",{"date":114,"type":22},"2028-02-28",{"name":116,"class":61},"University of Puerto Rico Comprehensive Cancer Center",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":23,"phases":127,"briefSummary":128,"conditions":129,"keywords":130,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":138,"locationsCount":5},"100607554","meliora-data-collection-campaigns-100607554","NCT07190066","MELIORA Data Collection Campaigns","Data Collection Campaigns for Early Development Versions of the MELIORA Digital Tools","DCC","Inclusion Criteria:\n\n* Individuals residing in Greece, Lithuania, Spain or Sweden.\n* Female adults (i.e. ≥18 years of age).\n* Ability to understand and complete the outcome measures in one of the participating countries' local languages.\n* Ability to provide fully informed consent.\n* Having access to and being able to use a smartphone that supports the project app (i.e., iOS or Android smartphone)\n* Meeting the criteria for allocation to one of the three following groups:\n\n  * Healthy women with a calculated Βody Μass Ιndex (BMI) ≥ 25 or not meeting the World Health Organization's recommendations of ≥150 minutes of moderate-to-vigorous physical activity per week.\n  * Women currently undergoing active treatment for breast cancer or awaiting to begin active treatment for breast cancer.\n\n    * Women survivors of BC having completed active treatment at least six months prior to study enrolment\n\nExclusion Criteria:\n\n* Inability to provide fully informed consent.\n* Inability to understand and communicate in one of the recruitment countries' local languages.",{"count":126,"type":22},300,[25],"To support the development of the MELIORA digital app for the MELIORA main intervention, an initial pilot study (Data Collection Campaign, DCC) is being conducted with the three target participant groups: healthy women at increased risk of developing breast cancer (BC), BC patients, and BC survivors across the four intervention countries (Spain, Greece, Lithuania, Sweden). The planned sample size for each group is 156 healthy women at risk (defined as not meeting recommendations for a healthy lifestyle), 58 BC patients, and 86 BC survivors. Each participant is asked to test and evaluate a preliminary version of the MELIORA app over a 14-day period. The DCC takes place in the early stages of the project, as part of the intervention development phase, to inform the technical refinement and preliminary evaluation of the MELIORA digital app.",[28],[131,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49],"Behaviors change","2025-09-25",{"date":134,"type":54},"2025-09-30",{"date":136,"type":54},"2025-04-22",{"date":134,"type":22},{"name":60,"class":61},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":17,"sex":18,"minAge":96,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":150,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":164},"100579700","physical-activity-targeting-metabolic-syndrome-for-prevention-of-breast-cancer-in-sai-women-100579700","NCT06827704","Physical Activity Targeting Metabolic Syndrome for Prevention of Breast Cancer in SAI Women","Physical Activity Targeting Metabolic Syndrome for Prevention of Breast Cancer in South Asian Indian Immigrant Women","MetS-BC","Inclusion Criteria:\n\n* Self-identified first-generation SAI woman aged 40-65 years without breast cancer diagnosis (permanent residency in US or are in the process of obtaining permanent residency)\n* Insufficiently active (self-reported \\\u003C150 minutes\u002Fweek of moderate-intensity or \\\u003C75 minutes\u002Fweek of vigorous-intensity PA in the past month)\n* Conversant in Hindi\n* Owns a smartphone for Fitbit application\n* Has a computer or mobile device with Internet access\n* Willing to participate in recorded Virtual intervention sessions\n* Medical clearance if has Type 1 diabetes, or Type 2 diabetes with an A1C ≥ 9.0%, or have an A1C of ≥ 6.5% without a prior diabetes diagnosis\n* Has no disabilities preventing regular PA determined by Physical Activity Readiness Questionnaire (PAR-Q \\& You)\n\nExclusion Criteria:\n\n* Major signs\u002Fsymptoms of pulmonary or CVD, unstable cardiac or pulmonary disease in the past month, or other conditions interfering with walking (per PAR-Q \\& You)\n* Systolic BP ≥160 and\u002For diastolic BP ≥100","65 Years",{"count":149,"type":22},96,[25],"This study aims to to improve physical activity and metabolic outcomes for breast cancer prevention in South Asian Indian immigrant women.",[153,28,154],"Metabolic Syndrome","Physical Activity","2025-07-23",{"date":157,"type":54},"2025-07-24",{"date":159,"type":54},"2025-05-01",{"date":161,"type":22},"2026-12-31",{"name":163,"class":61},"Rush University Medical Center",2,{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":173,"targetDuration":175,"studyType":73,"phases":4,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":178,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":4},"100594228","adherence-to-the-mediterranean-diet-among-women-attending-mammographic-screening-100594228","NCT07016711","Adherence to the Mediterranean Diet Among Women Attending Mammographic Screening","Adherence to the Mediterranean Diet Among Women Attending Mammographic Screening in the \"Prevention Caravan\" by Komen Italy: a Cross-sectional Study","PREVCAR","Inclusion Criteria:\n\n* Women who participate in the \"Prevention Caravan\" program;\n* Women who undergo breast cancer screening, including mammography or breast ultrasound;\n* Women who complete the MEDAS questionnaire.\n\nExclusion Criteria:\n\n* Women who do not participate in the \"Prevention Caravan\" program;\n* Women who participate in the \"Prevention Caravan\" program but undergo screenings or consultations for conditions other than breast cancer, such as gynecological cancers, thyroid ultrasounds, or dermatological evaluations;\n* Women who do not complete the MEDAS questionnaire.",{"count":174,"type":22},35000,"5 Years","The PREVCAR study is a cross-sectional investigation aimed at evaluating dietary habits among women undergoing breast cancer screening. Specifically, the study focuses on adherence to the Mediterranean diet, a dietary pattern recognized for its potential protective role against chronic diseases, including breast cancer. The PREVCAR study will include approximately 35,000 women aged 18 and older who participate in the \"Prevention Caravan\" and complete both the breast cancer screening and the MEDAS (Mediterranean Diet Adherence Screener) questionnaire. This 14-item questionnaire measures dietary behavior, with scores reflecting levels of adherence to the Mediterranean diet.\n\nThe primary objective of the study is to determine the average MEDAS score among participants. Secondary objectives include analyzing how adherence varies across different known breast cancer risk factors-such as age, menopausal status, hormonal therapy use, and reproductive history-and assessing the prevalence of malignant breast lesions identified through the screening.",[28],"NOT_YET_RECRUITING","2025-06-05",{"date":181,"type":54},"2025-06-12",{"date":183,"type":22},"2025-06",{"date":185,"type":22},"2030-05",{"name":187,"class":61},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":17,"sex":18,"minAge":196,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":23,"phases":200,"briefSummary":201,"conditions":202,"keywords":203,"overallStatus":178,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":4},"100571608","a-randomized-controlled-trial-to-increase-breast-cancer-screening-uptake-100571608","NCT06722469","A Randomized Controlled Trial to Increase Breast Cancer Screening Uptake","A Randomized Controlled Trial Evaluating a Mobile Messenger-initiated, Theory-based, Culturally Tailored, and Fully Automated Chatbot to Increase Breast Cancer Screening Uptake","BCS","Inclusion Criteria:\n\n1. asymptomatic Chinese Women\n2. 44-69 years old\n3. eligible to enroll in a government-subsidized risk-stratified BC screening program\n4. ability to read Chinese\n\nExclusion Criteria:\n\n1. moderate- or high-risk women as defined by the local risk-stratified BC screening program\n2. inability to provide informed consent\n3. incomplete conversation with the chatbot.","44 Years","69 Years",{"count":199,"type":22},470,[25],"Breast cancer (BC) is the fifth leading cause of cancer deaths in women worldwide. In Hong Kong (HK), BC is the most common cancer, ranking third in cancer deaths among females. International guidelines advocate regular mammographic screening for women aged 40-50 to 69-74, reducing BC mortality by 20%.\n\nThe success and effectiveness of an organized cancer screening program are largely dependent on high adherence or uptake rates. However, nonadherence to BC screening is common and the suboptimal uptake rate remains a challenge, particularly in Asian countries.\n\nConventional interventions are effective in increasing mammographic screening uptake but are time-consuming, labor-dependent, and expensive. Mobile messenger chatbots are a potential cost-saving tool for enhancing BC screening uptake because they involve only a one-off development cost and a small maintenance cost . Currently, most studies evaluating the effectiveness of mobile health interventions in improving mammography screening uptake have been conducted in Western populations . Health-seeking behaviors for cancer screening in the Chinese population differ from those of Caucasians because of differences in culture, health beliefs, and education, especially regarding breast-related diseases. Chinese women often feel embarrassed when talking with healthcare workers in person about breast health. Communicating with a fully automated chatbot can minimize embarrassment. Additionally, linguistically and culturally tailored interventions are effective in increasing cancer screening rates in the Chinese population.\n\nHowever, studies evaluating combined theory-based mHealth interventions to enhance BC screening uptake are scarce. Two theory-based WhatsApp chatbots were developed to promote CRC screening, and the longitudinal repeat fecal immunochemical test (FIT) adherence rate of a population-based CRC screening program in HK. These two chatbots used in investigator's previous studies had designs similar to that of the proposed chatbot, except for the health education materials. The chatbot design can be adopted directly with minor modifications to the workflow, replacement of content from CRC screening-related to BC screening-related, and culturally modified education materials. Consequently, the investigators can develop a new chatbot for this study at a lower cost and in a shorter time.",[28,76],[104,204,205,206],"automated chatbot","breast cancer screening","health belief model","2024-12-03",{"date":209,"type":54},"2024-12-09",{"date":211,"type":22},"2025-07-01",{"date":213,"type":22},"2027-12-31",{"name":215,"class":61},"Chinese University of Hong Kong"]