[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"breast-cancer-related-lymphedema\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:breast-cancer-related-lymphedema":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,41,71,97,126,153,186,214,241,267,292],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100644784","effects-of-core-focused-exercise-training-and-kinesiology-taping-in-women-with-breast-cancer-related-lymphedema-100644784",false,"NCT07673939","Effects of Core-Focused Exercise Training and Kinesiology Taping in Women With Breast Cancer-Related Lymphedema","Effects of Core-Focused Exercise Training and Kinesiology Taping Combined With Complex Decongestive Physiotherapy on Posture, Pain, Function, and Quality of Life in Women With Breast Cancer-Related Lymphedema","Inclusion Criteria:\n\n* Age between 40 and 65 years\n* Diagnosis of stage 1-2 lymphedema according to the International Society of Lymphology classification system\n* History of radical surgery due to primary breast cancer, with at least 6 months elapsed since surgery\n* Completion of cancer treatments such as chemotherapy and \u002F or radiotherapy\n* Presence of pain with a score of ≥3 on the Numeric Rating Scale (NRS) in at least one of the lumbar, thoracic, or cervical regions\n* No cooperation problems in completing the study questionnaires\n\nExclusion Criteria:\n\n* Body mass index (BMI) \\>30 kg\u002Fm²\n* Presence of active infection\n* Presence of active malignancy or metastasis\n* Presence of neurological disease\n* History of bilateral breast cancer\n* Presence of extremity deformity, scoliosis, cauda equina syndrome, or history of whiplash injury\n* Presence of motor or sensory neurological deficits (to be clinically assessed by manual muscle testing and superficial sensory examination)\n* History of spinal surgery\n* Presence of any spinal pathology","FEMALE","40 Years","65 Years",{"count":20,"type":21},46,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of the present study is to investigate the effects of trunk- focused exercise training and kinesiology taping, in addition to standard lymphedema treatment (complex decongestive therapy-CDT) on posture, pain, functionality and quality of life in women with breast cancer related lymphedema. This study is designed as a randomized placebo-controlled trial.\n\nLymphedema negatively affects the musculoskeletal system, leading to shoulder girdle muscle imbalances, cervical and thoracolumbar pain, scapular dysfunction and spinal postural alterations. Although CDT is considered the gold standard for edema management, its effects have primarily been evaluated in terms of edema reduction and symptom control, and there is limited evidence regarding its impact on posture, musculoskeletal symptoms, and quality of life, as well as the potential effects of prolonged compression bandaging applied during the intensive phase on these systems.\n\nTrunk-focused exercise training is expected to improve spinal stability, mobility and postural control, while kinesiology taping may help alleviate musculoskeletal symptoms by providing proprioceptive input and mechanical support. By combining these interventions, this study aims to provide a comprehensive rehabilitation approach targeting both physical and functional impairments. If additional improvements in posture, pain, function, and quality of life are observed compared to a control group receiving CDT combined with lower extremity exercise and placebo taping, these findings will support the added value of a multimodal rehabilitation approach beyond standard care.\n\nThe findings of this randomized placebo-controlled trial are expected to contribute to the literature by providing evidence for a comprehensive and holistic treatment approach in breast cancer-related lymphedema and to support the integration of trunk-focused exercise training and kinesiology taping into routine clinical practice. To the best of our knowledge, there is currently no randomized placebo-controlled study investigating the effects of trunk-focused exercise training and kinesiology taping in addition to CDT on posture, pain, functionality, and quality of life.",[27],"Breast Cancer Related Lymphedema","NOT_YET_RECRUITING","2026-06-23",{"date":31,"type":32},"2026-06-29","ACTUAL",{"date":34,"type":21},"2026-08-15",{"date":36,"type":21},"2027-08-15",{"name":38,"class":39},"Hacettepe University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100569662","investigation-of-the-effects-of-complex-decongestive-physiotherapy-on-sleep-quality-and-quality-of-life-in-women-with-breast-cancer-related-lymphedema-100569662","NCT06697158","Investigation of the Effects of Complex Decongestive Physiotherapy on Sleep Quality and Quality of Life in Women With Breast Cancer Related Lymphedema","Inclusion Criteria:\n\n* Participants must be aged between 18 or 85 years,\n* with a diagnosis of unilateral lymphedema in the upper extremity following breast cancer surgery\n* stage 2 lymphedema confirmed by a doctor\n* voluntary consent to participate in the study.\n\nExclusion Criteria:\n\n* refusal to participate in the study\n* development of lymphedema due to primary causes, presence of bilateral upper extremity lymphedema\n* active soft tissue infection in the lymphedematous arm\n* mental or cognitive disorders\n* inability to communicate or cooperate\n* acute deep vein thrombosis, arterial insufficiency in the upper extremity, systemic diseases that could cause edema other than lymphedema (e.g., renal failure, liver failure, heart failure)\n* use of sleep medications or antidepressants","18 Years","85 Years",{"count":50,"type":21},31,[24],"Breast cancer is the most common type of cancer among women globally and has the highest mortality rate. Surgical interventions are typically required in the treatment of breast cancer, but these procedures can lead to complications such as infection, seroma, hematoma, cellulitis, and particularly lymphedema due to disruptions in the physiology of axillary lymphatic vessels.\n\nBreast Cancer-Related Lymphedema (BCRL) commonly develops within the first two years following surgical intervention and its incidence varies depending on the surgical method used. The incidence of lymphedema after Sentinel Lymph Node Biopsy (SLNB) is around 5%, whereas it increases to 30-50% after Axillary Lymph Node Dissection (ALND).\n\nBCRL significantly impacts the quality of life (QoL) through physical symptoms such as swelling, pain, tightness, and limited range of motion, as well as psychosocial issues including depression, social isolation, and sleep disturbances. Sleep disorders, in particular, are associated with depression and contribute to a further decline in QoL.\n\nIn the treatment of BCRL, both conservative (non-surgical) and surgical methods are traditionally employed. Complex Decongestive Physiotherapy (CDP) is considered the gold standard for the conservative management of lymphedema. CDP comprises a two-phase treatment process. The first phase, known as the \"Decongestion Phase,\" generally lasts 2-4 weeks and includes manual lymphatic drainage (MLD), skin care, compression therapy with multi-layered short-stretch bandages, and muscle-pumping exercises. The second phase, the \"Maintenance Phase,\" is more prolonged and aims to sustain the results achieved in Phase 1. It includes compression with low-stretch elastic garments, skin care, exercises, and patient-administered MLD as needed.\n\nThe primary objectives of CDP are to improve lymphatic circulation, reduce swelling, pain, and tightness, increase the range of motion, and ultimately improve the QoL. Studies have shown that CDP significantly enhances sleep quality and QoL in women with BCRL.\n\nHowever, most existing studies examine all stages of BCRL without comparing the effects of CDP across different stages. The impact of CDP on sleep and QoL may vary depending on the stage of BCRL, highlighting the need for specific research on its effects in particular populations. Furthermore, many studies lack follow-up data, leaving the Maintenance Phase of CDP largely unexplored.\n\nThis study aims to investigate the effects of CDP, including both the Decongestion and Maintenance phases, on sleep quality and QoL specifically in women with Stage II BCRL.",[27],[55,56,57,58,59],"Breast Cancer-Related Lymphedema","Physiotherapy and Rehabilitation","Sleep Quality","Local Tissue Fluid","Quality of Life","RECRUITING","2026-03-27",{"date":63,"type":32},"2026-04-01",{"date":65,"type":32},"2024-01-01",{"date":67,"type":21},"2027-03-01",{"name":69,"class":39},"Abant Izzet Baysal University",2,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":18,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":40},"100604786","comparison-of-ipc-therapy-as-an-alternative-or-an-adjunct-to-mld-within-cdt-for-bcrl-100604786","NCT07154043","Comparison of IPC Therapy as an Alternative or an Adjunct to MLD Within CDT for BCRL","Comparison of Intermittent Pneumatic Compression Therapy as an Alternative or an Adjunct to Manual Lymphatic Drainage Within Complete Decongestive Therapy for Breast Cancer-Related Lymphedema","Inclusion Criteria:\n\n* Female gender\n* Patients aged 18-65 years\n* Having a history of unilateral mastectomy and lymph node dissection at least one year ago due to breast cancer diagnosis.\n* Having unilateral breast cancer-related upper extremity lymphedema (\\>20% volume difference between the two upper extremities or \\>2 cm difference in circumference at any measured point) according to the diagnostic criteria of the International Society of Lymphology (Committee 2023) for at least six months.\n* Not having received lymphedema treatment or exercise therapy for the last six months\n* Completing breast cancer primary treatment at least 6 months ago (except hormone therapy\u002Faromatase inhibitors)\n\nExclusion Criteria:\n\n* Bilateral breast cancer\n* Bilateral axillary lymph node dissection\n* Metastatic breast cancer\n* Receiving ongoing radiotherapy or chemotherapy\n* Primary or bilateral lymphedema\n* Having active cancer\n* Presence of stage 3 lymphedema\n* Uncontrolled serious systemic disease (cardiopulmonary diseases, arterial or venous diseases, renal dysfunction, uncontrolled hypertension or hypotension, cardiac arrhythmia, scleroderma, Sudek's atrophy).\n* Current or recent (within the last 3 months) infection (cellulitis, lymphangitis) or deep venous thrombosis\n* Presence of open wounds\n* Using medications that may affect body fluid and electrolyte balance (diuretics, etc.).\n* Individuals with serious mental and sensory problems\n* Being pregnant\n* Body mass index \\>40 kg\u002Fm2",{"count":79,"type":21},45,[24],"Breast cancer is the most common cancer among women worldwide and lymphedema is one of its most significant complications. Breast cancer-related lymphedema (BCRL) may develop shortly after treatment or even years later, causing physical and psychological burden, functional impairment, and reduced quality of life. Complete decongestive therapy (CDT), which includes manual lymph drainage (MLD), compression, skin care, and exercise, is the standard approach. Intermittent pneumatic compression (IPC) has been proposed as an additional option, and current consensus reports emphasize the need for studies evaluating IPC in combination with MLD.\n\nPrevious studies comparing IPC and MLD, either alone or in combination, have shown inconsistent results. Some reported no significant difference between treatment groups, while others suggested additional benefits of IPC, particularly in reducing limb heaviness and tension. However, there is still insufficient evidence to clarify the exact role of IPC within CDT.\n\nThe aim of this study is to investigate the acute effects of using IPC instead of MLD, or in combination with MLD, on arm circumference, arm volume, shoulder range of motion, and quality of life in patients with BCRL.",[55,83],"BCRL",[55,85,86,87],"Manual Lymph Drainage","Intermittent Pneumatic Compression","Complete Decongestive Therapy","2026-03-03",{"date":90,"type":32},"2026-03-04",{"date":92,"type":32},"2025-09-15",{"date":94,"type":21},"2026-12-01",{"name":96,"class":39},"Pamukkale University",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":40},"100624866","pedicled-lateral-chest-wall-lymph-adipofascial-flap-to-prevent-arm-lymphedema-after-breast-cancer-surgery-100624866","NCT07415200","Pedicled Lateral Chest Wall Lymph-Adipofascial Flap to Prevent Arm Lymphedema After Breast Cancer Surgery","Efficacy and Safety of Pedicled Lateral Chest Wall Lymph-Adipofascial Flap Axillary Reconstruction for the Prevention of Breast Cancer-Related Arm Lymphedema: A Prospective, Single-Arm, Phase II Clinical Study","LAF-ALND","Inclusion Criteria:\n\n1. Female patients aged 18 to 75 years;\n2. Histologically confirmed invasive breast cancer;\n3. Pathologically confirmed axillary lymph node metastasis requiring axillary lymph node dissection;\n4. Body mass index (BMI) ≥ 25 kg\u002Fm²;\n5. Planned to receive postoperative regional lymph node radiation therapy;\n6. Ability to understand the study procedures and provide written informed consent;\n7. Willingness and ability to comply with study follow-up and assessments.\n\nExclusion Criteria:\n\n1. Previous surgery involving the ipsilateral axilla;\n2. Previous radiation therapy to the ipsilateral axilla;\n3. Evidence of distant metastatic breast cancer;\n4. Bilateral breast cancer, or a history of contralateral breast cancer surgery;\n5. Severe hepatic or renal dysfunction, or severe cardiac insufficiency;\n6. Inability to read or understand Chinese sufficiently to complete study questionnaires and assessments;\n7. Pregnancy;\n8. Any condition or circumstance that, in the investigator's judgment, may interfere with study compliance or follow-up.","75 Years",{"count":107,"type":21},100,[24],"Breast cancer surgery that includes removal of lymph nodes from the armpit (axillary lymph node dissection) can disrupt normal lymphatic drainage and may lead to arm swelling, known as lymphedema. This condition can cause discomfort, limit arm function, and reduce quality of life. Patients with a higher body mass index and those who receive regional lymph node radiation are at particularly high risk.\n\nThis study aims to evaluate whether a preventive surgical technique, called axillary reconstruction using a pedicled lateral chest wall lymph-adipofascial flap, can reduce the risk of developing arm lymphedema after breast cancer surgery. During standard breast cancer surgery with axillary lymph node dissection, a small flap of tissue containing fat, fascia, and lymphatic tissue from the lateral chest wall is rotated into the axillary area to fill the surgical space and support lymphatic drainage.\n\nThis is a prospective, single-arm Phase II clinical study. Participants will be followed for up to 24 months after surgery to assess the occurrence of arm lymphedema, changes in arm volume and bioimpedance measurements, quality of life, and surgery-related complications. The results of this study may help determine whether this simple and widely applicable technique can safely reduce the risk of lymphedema in high-risk breast cancer patients.",[55,111,112],"Breast Cancer","Postoperative Complications",[55,111,114,115,116],"Axillary Lymph Node Dissection","Axillary Reconstruction","Preventive Surgery","2026-02-15",{"date":119,"type":32},"2026-02-17",{"date":121,"type":21},"2026-02-20",{"date":123,"type":21},"2030-03-01",{"name":125,"class":39},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":137,"conditions":138,"keywords":139,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":40},"100621053","combined-exercise-effects-in-breast-cancer-related-lymphedema-100621053","NCT07365618","Combined Exercise Effects in Breast Cancer-related Lymphedema","The Impact of Combined Exercise on Lymphedema, Body Composition, Muscle Strength, and Quality of Life in Breast Cancer Survivors","LymFit","Inclusion Criteria:\n\n* Aged 18 years or older;\n* Undergone breast cancer surgery with removal of at least one lymph node;\n* Clinical diagnosis of stable unilateral breast cancer-related lymphedema;\n* Willing and able to engage in exercise;\n* Have not participated in a structured exercise program in the previous 6 months;\n* Medical clearance to participate in the study.\n\nExclusion Criteria:\n\n* Unstable lymphedema (therapist-delivered treatment and more than one arm infection requiring antibiotics in the past 3 months);\n* Undergoing radiotherapy or chemotherapy by infusion for breast cancer;\n* Bilateral lymphedema;\n* Primary lymphedema;\n* Uncontrolled heart disease (e.g., uncontrolled coronary heart disease, heart failure, uncontrolled hypertension);\n* Type II diabetes;\n* Psychological disorders (e.g., Alzheimer's, dementia, Parkinson's);\n* Significant physical disabilities;\n* Pregnancy and\u002For breastfeeding;\n* Kidney disease.",{"count":135,"type":21},58,[24],"Breast cancer-related lymphedema (BCRL) is a common and debilitating condition that affects quality of life, mobility, and well-being. While exercise was once thought to worsen symptoms, current evidence suggests it may improve lymphatic function and symptom management. The LymFit project will test a 12-week combined exercise program (aerobic + resistance) in breast cancer survivors with BCRL compared to usual care.\n\nThis investigation aims to unravel the effects of a combined exercise program on BCRL management. A 12-week randomized controlled trial will be conducted with two arms: a combined exercise intervention (strength + aerobic training) and a control group. The LymFit project primarily aims to assess the effects of 12 weeks of combined exercise on L-Dex in BCRL patients. Secondary objectives include evaluating exercise's effects on i) ECW:ICW ratio (dilution techniques); ii) Body composition (dual-energy X-ray absorptiometry), handgrip strength (dynamometry), cardiorespiratory fitness, quality of life, arm disability, anxiety, depression (questionnaires), and inflammatory profile (blood analysis). The project also examines acute exercise (pre- to post-session) responses on iii) Lymphedema (L-Dex) and iv) Fluid shifts (ultrasound muscle thickness + PV measurement). By integrating clinical outcomes with mechanistic evaluations, this randomized controlled trial seeks to generate evidence-based recommendations for exercise in BCRL management and improve understanding of lymphatic fluid dynamics in this population.",[55],[111,140,141,142,143],"Exercise","Fluid Shifts","Edema","Bioelectrical Impedance Analysis","2026-01-19",{"date":146,"type":32},"2026-01-26",{"date":148,"type":21},"2026-04",{"date":150,"type":21},"2027-12",{"name":152,"class":39},"Faculdade de Motricidade Humana",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":163,"briefSummary":164,"conditions":165,"keywords":169,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":185},"100599129","effectiveness-of-kinesio-taping-in-patients-with-chronic-breast-andor-truncal-oedema-after-treatment-for-breast-cancer-100599129","NCT07080476","Effectiveness of Kinesio Taping in Patients With Chronic Breast and\u002For Truncal Oedema After Treatment for Breast Cancer.","Effectiveness of Kinesio Taping in Patients With Chronic Breast and\u002For Truncal Oedema After Breast Cancer Treatment: A Randomized Controlled Trial","KiTaLymph","Inclusion Criteria:\n\n* Female patients previously treated for breast cancer.\n* Suffering from persistent (\\>6 months) breast and\u002For truncal oedema, established at least six months after completion of radiotherapy.\n* Objective measurements:\n\n  * BrEQ score ≥9.\n  * PWC (LymphScanner) showing at least one of the following:\n\n    * Truncal oedema: ratio ≥ 1.32.\n    * Breast oedema: ratio ≥ 1.28.\n    * Local PWC of 52.90%.\n* Clinical evaluation:\n\n  * At least one positive sign of breast and\u002For truncal oedema such as:\n\n    * Visual swelling compared with the contralateral side.\n    * Visible imprint of the bra on the skin.\n    * Peau d'orange appearance on the breast.\n\nExclusion Criteria:\n\n* Presence of skin infections or wounds of the breast\u002Ftruncal region at the time of inclusion making it impossible to apply kinesio tape.\n* Age under 18 years.\n* Not able to read and understand Dutch language.\n* Having received mastectomy.\n* Metastatic breast cancer.",{"count":162,"type":21},128,[24],"The goal of the KiTaLymph trial is to investigate whether the application of kinesio tape is effective in women with persistent (\\>6 months) breast and\u002For truncal oedema after treatment for breast cancer.\n\nThe main objectives are to assess whether kinesio taping:\n\n* reduces pain and symptoms,\n* decreases swelling,\n* improves quality of life (QoL).\n\nThis study will compare a control group receiving standard care, decongestive lymphatic therapy (DLT), to an intervention group receiving DLT in combination with kinesio taping, in order to determine whether the addition of kinesio tape yields superior clinical outcomes.\n\nParticipants will be randomly allocated to one of the two study arms. Both groups will participate in a 4-week intervention phase, consisting of two treatment sessions per week. This will be followed by a 6-month follow-up period to assess the durability of treatment effects and cost-related outcomes.\n\nA total of approximately 128 participants will be recruited. Outcome assessments will be conducted at baseline, immediately post-intervention (1 month), and at 3 and 6 months following the end of the intervention. These assessments will include standardised patient-reported outcome measures evaluating symptoms, quality of life, and pain, namely, the Breast Edema Questionnaire (BrEQ), the EORTC-QLQ-BR23, the EQ-5D-5L, and a visual analogue scale (VAS), as well as objective physical measurements of oedema using the LymphScanner (expressed as percentage water content, PWC).\n\nIn addition to the primary research objective, several sub-studies will be conducted. These will include: (1) a longitudinal analysis of the effects of standard treatment; (2) an evaluation of the responsiveness and clinical utility of the BrEQ; and (3) a cross-sectional analysis of the compression pressure exerted by various compression bras. All sub-studies are methodologically feasible within the projected sample size of the primary objective and aim to provide supplementary insights into the clinical management of breast and truncal oedema.",[166,167,27,168],"Breast Edema","Breast Cancer Related Lymphoedema","Truncal Lymphedema",[170,171,172,173,174,175],"RCT","Decongestive Lymphatic Therapy (DLT)","Health-related quality of life (HRQoL)","Breast cancer","Kinesio taping","Breast oedema","2025-08-26",{"date":178,"type":32},"2025-09-03",{"date":180,"type":32},"2025-08-25",{"date":182,"type":21},"2028-12",{"name":184,"class":39},"Universiteit Antwerpen",4,{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":22,"phases":197,"briefSummary":198,"conditions":199,"keywords":200,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":212,"locationsCount":4},"100599558","reliability-of-myoton-in-evaluating-skin-biomechanics-in-breast-cancer-related-lymphedema-100599558","NCT07086053","Reliability of Myoton in Evaluating Skin Biomechanics in Breast Cancer-Related Lymphedema","Inter-rater And Intra-rater Reliability Of Biomechanical Skin Stiffness Characteristics Measurement Via MyotonPRO Device In Patients With Breast Cancer-Related Lymphedema (BCRL) And Their Relationship With Ultrasonographic Tissue Changes","MYOLYMPH","Inclusion Criteria:\n\n* Female participants aged 18-80 years\n* Unilateral upper extremity lymphedema secondary to breast cancer surgery\n* Diagnosed with lymphedema at International Society of Lymphology (ISL) Stage 0, I, II, or III\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Bilateral upper extremity lymphedema\n* Cognitive or mental disorders that interfere with cooperation\n* Neurological diseases\n* Active infection\n* Scleroderma or other skin disorders affecting elasticity\n* Significant cardiac conditions that may interfere with assessment","80 Years",{"count":196,"type":21},20,[24],"This study aims to evaluate the intra- and inter-rater reliability of the MyotonPRO, a handheld device that measures the viscoelastic properties of the skin, in patients with breast cancer-related lymphedema. Twenty women with unilateral upper extremity lymphedema will be included. Each participant will undergo repeated skin assessments using the MyotonPRO by two independent raters. Additionally, ultrasonographic tissue characteristics and limb volume measurements will be performed. The findings are expected to contribute to the validation of the MyotonPRO for use in clinical lymphedema evaluation.",[55],[201,111,202,203,204,205],"Lymphedema","Myoton","Skin Stiffness","Ultrasound","Reliability","2025-07-24",{"date":208,"type":32},"2025-07-28",{"date":210,"type":21},"2025-08-01",{"date":210,"type":21},{"name":213,"class":39},"Kahramanmaras Sutcu Imam University",{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":22,"phases":224,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":4},"100594964","supermicrosurgical-lymphaticovenous-anastomosis-for-prevention-of-upper-limb-lymphedema-100594964","NCT07026292","Supermicrosurgical Lymphaticovenous Anastomosis for Prevention of Upper Limb Lymphedema","A Phase Ⅲ, Multicenter, Prospective, Open-Label, Controlled Study of Supermicrosurgical Lymphaticovenous Anastomosis for Prevention of Upper Limb Lymphedema in Breast Cancer Patients Following Axillary Lymph Node Dissection and Adjuvant Radiotherapy","SLVA-PULL","Inclusion Criteria:\n\n1. Age \\>=18 years;\n2. Female;\n3. Pathologically confirmed invasive breast cancer;\n4. Unilateral breast cancer;\n5. Clinical stage T1-4 and N1-3 (post-neoadjuvant therapy staging for patients receiving neoadjuvant treatment);\n6. No clinical or radiographic evidence of distant metastasis;\n7. Scheduled to undergo axillary lymph node dissection with planned adjuvant radiotherapy;\n8. Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n1. Currently participating in other clinical trials that, in the investigator's judgment, may affect upper limb lymphatic drainage.\n2. No definitive indication for axillary lymph node dissection or adjuvant radiotherapy after neoadjuvant therapy.\n3. Pregnant or lactating women.\n4. Patients undergoing concurrent autologous tissue flap breast reconstruction or chest wall repair.\n5. Upper limb deformities, prior upper limb trauma, or surgical history that, in the investigator's assessment, may compromise lymphatic drainage.\n6. Pre-existing upper limb lymphedema at baseline.",{"count":223,"type":21},120,[24],"Breast cancer-related lymphedema (BCRL) is one of the most common chronic complications following breast cancer treatment. This study enrolls breast cancer patients who are required to undergo axillary lymph node dissection and postoperative adjuvant radiotherapy. Based on patients' preferences, they will be assigned to receive either immediate distal lymphaticovenous anastomosis (ID-LVA) following axillary lymph node dissection (experimental group) or not (control group). The study aims to evaluate the safety and efficacy of ID-LVA in preventing breast cancer-related upper limb lymphedema.",[55,201,227],"Breast Cancer Invasive",[229,201,111,230,231],"Supermicrosurgical Lymphaticovenous Anastomosis","Prevention","Immediate Distal Lymphaticovenous Anastomosis","2025-06-15",{"date":234,"type":32},"2025-06-18",{"date":236,"type":21},"2025-07-01",{"date":238,"type":21},"2029-05-31",{"name":240,"class":39},"Tianjin Medical University Cancer Institute and Hospital",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":22,"phases":251,"briefSummary":252,"conditions":253,"keywords":254,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":4},"100555049","development-of-the-wearable-arm-volume-measurement-device-and-mobile-application-100555049","NCT06507033","Development of the Wearable Arm Volume Measurement Device and Mobile Application","Development of the Wearable Arm Volume Measurement Device and Mobile Application (mobiLymphf) in the Prevention and Early Detection of Breast Cancer-related Lymphedema and Evaluation of Their Efficiency","mobiLymphf","Inclusion Criteria:\n\n* To agree to take part in the research,\n* Breast surgery including lymph node dissection within the last 6 months,\n* To be 18 years of age or older,\n* To be able to communicate in Turkish,\n* Using a smartphone with Android operating system,\n* No cognitive\u002Fcognitive impairment (electronic records of patients will be taken as basis)\n\nExclusion Criteria:\n\n* Patients who do not meet the inclusion criteria will be excluded from the study",{"count":250,"type":21},14,[24],"With the increase in the incidence of cancer in our country and the world, the number of breast cancer survivors is increasing rapidly due to the development of early diagnosis and treatment methods. One of the main problems in breast cancer survivors is lymphedema. Breast cancer-related lymphedema is a condition that can be treated when detected early, but has a very low success rate when detected in advanced stages. Therefore, the prevention and early detection of breast cancer-associated lymphedema is very important. In this project, it is aimed to prevent breast cancer-related lymphedema with the mobile application to be developed and to detect the volume increase in the arm before clinical findings with an arm volume measurement device that will work with this mobile application. The project consists of two main steps; (a)development of the arm volume measuring device and mobile application (b)evaluation of the effectiveness of the products. Five components will be involved in the development of the mobile application. These components are; (I)exercise, (II)education, (III)coping mechanisms, (IV)arm volume measurement\u002Frecords, and (V)reminder for exercise, measurement, and follow-ups. Exercise videos will include stretching exercises for the shoulder and arm area as recommended in the guides. The training content will be created in line with the guides and opinions will be taken from an expert panel. In support of coping mechanisms, existing problem areas in people will be determined with a qualitative study. People who have gone through a similar process in the past will be asked about the coping strategies they have developed for these problem areas. Themes obtained from patients who have gone through a similar process in the past (lymph node dissection due to breast cancer) and suggestions of the guidelines will be presented in the mobile application. In arm volume measurement, a wearable technology product to be designed in the form of an arm cuff and strain sensors to be placed on the arm will detect the increase in arm circumference. After Summary With the increase in the incidence of cancer in our country and the world, the number of breast cancer survivors is increasing rapidly due to the development of early diagnosis and treatment methods. One of the main problems in breast cancer survivors is lymphedema. Breast cancer-related lymphedema is a condition that can be treated when detected early, but has a very low success rate when detected in advanced stages. Therefore, the prevention and early detection of breast cancer-associated lymphedema is very important. In this project, it is aimed to prevent breast cancer-related lymphedema with the mobile application to be developed and to detect the volume increase in the arm before clinical findings with an arm volume measurement device that will work with this mobile application. The project consists of two main steps; (a)development of the arm volume measuring device and mobile application (b)evaluation of the effectiveness of the products. Five components will be involved in the development of the mobile application. These components are; (I)exercise, (II)education, (III)coping mechanisms, (IV)arm volume measurement\u002Frecords, and (V)reminder for exercise, measurement, and follow-ups. Exercise videos will include stretching exercises for the shoulder and arm area as recommended in the guides. The training content will be created in line with the guides and opinions will be taken from an expert panel. In support of coping mechanisms, existing problem areas in people will be determined with a qualitative study. People who have gone through a similar process in the past will be asked about the coping strategies they have developed for these problem areas. Themes obtained from patients who have gone through a similar process in the past (lymph node dissection due to breast cancer) and suggestions of the guidelines will be presented in the mobile application. In arm volume measurement, a wearable technology product to be designed in the form of an arm cuff and strain sensors to be placed on the arm will detect the increase in arm circumference. After measuring the arm circumference with the sensors located every five centimeters, the arm volume will be calculated with the cylindrical volume calculation method. When there is an increase of 5% or more in the arm of the individual (preclinical lymphedema), a notification will be sent to the person and his\u002Fher physician via the mobile application. The person will also be able to follow the past measurement results via the mobile application. Evaluation of the efficacy of the product will be based on a pilot randomized controlled trial, a reproducibility study, and patient feedback. This product to be developed will provide a new arm volume measurement method that will reduce patients' hospital admissions and will contribute to the prevention and early detection of lymphedema.",[27],[111,201,255,256,257],"Wearable Technology","Mobile Application","Nursing","2024-07-16",{"date":260,"type":32},"2024-07-18",{"date":262,"type":21},"2024-09",{"date":264,"type":21},"2027-03",{"name":266,"class":39},"Ayşe ARIKAN DÖNMEZ",{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":275,"targetDuration":4,"studyType":22,"phases":277,"briefSummary":278,"conditions":279,"keywords":281,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":70},"100415500","photobiomodulation-therapy-for-the-management-of-breast-cancer-related-lymphedema-100415500","NCT04690439","Photobiomodulation Therapy for the Management of Breast Cancer-related Lymphedema","Evaluating the Effectiveness of Photobiomodulation Therapy in the Management of Breast Cancer-Related Lymphedema: a Randomized Controlled Trial","LymphLight","Inclusion Criteria:\n\n* Diagnosed with breast cancer\n* Underwent ipsilateral lumpectomy or mastectomy + sentinel lymph node biopsy +\u002F- lymph node dissection\n* Underwent radiotherapy with or without chemotherapy\n* Diagnosed with BCRL (i.e. International Society of Lymphology (ISL) lymphedema stage I or higher)\n* Age ≥ 18 years\n* Able to comply to the study protocol\n* Able to sign written informed consent\n\nExclusion Criteria:\n\n* Metastatic disease\n* Pregnancy\n* History of surgery or trauma to the arm\n* History of arm infection in the past 3 months\n* Use of medications that affect body fluid (e.g., diuretics) in the last 3 months\n* Severe psychological disorder or dementia\n* Any condition that is unstable or could affect the safety of the patient and their compliance in the study as judged by the investigator",{"count":276,"type":21},104,[24],"Up to one out of five patients with breast cancer will develop lymphedema in the upper extremity after cancer treatment. Patients with breast cancer-related lymphedema (BCRL) suffer from pain, heaviness, tightness, and a decreased range of motion. Photobiomodulation therapy (PBMT) is a non-invasive therapy based on the application of visible and\u002For near-infrared light produced by a laser diode or a light-emitting diode. The scientifically proven biologic effects of PBM are improved wound healing, and a reduction in pain, inflammation, and oedema. Therefore, the aim of this study is to evaluate the effectiveness of PBMT on the management of BCRL.",[111,27,280],"Lymphedema of Upper Arm",[201,173,282],"Photobiomodulation","2023-02-27",{"date":285,"type":32},"2023-02-28",{"date":287,"type":32},"2021-02-22",{"date":289,"type":21},"2028-02",{"name":291,"class":39},"Jessa Hospital",{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":194,"enrollmentInfo":299,"targetDuration":4,"studyType":22,"phases":301,"briefSummary":302,"conditions":303,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":309,"leadSponsor":311,"locationsCount":40},"100413614","nomogram-to-predict-breast-cancer-related-lymphedema-100413614","NCT04665882","Nomogram to Predict Breast Cancer Related Lymphedema","Intraoperative Nomogram to Predict Breast Cancer- Related Lymphedema Based in Artificial Intelligence Image Recognition: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18 years or older with T1-3 invasive breast cancer;\n* Clinically node-positive breast cancer, defined as positive on preoperative axillary palpation, ultrasound examination, and computed tomography scan with contrast;\n* Patients who underwent mastectomy with a positive sentinel lymph node (SLN);\n* Patients who underwent breast-conserving surgery containing more than two positive SLNs.\n\nExclusion Criteria:\n\n* Neoadjuvant chemotherapy;\n* Previous history of breast cancer.",{"count":300,"type":21},600,[24],"It has been hypothesized that damaged arm lymphatic drainage is associated with the arm lymphedema after axillary lymph node dissection (ALND). However, the majority of breast cancer patients with complete ALND has not suffered from arm lymphedema, which appears to be due to the residual arm lymph nodes that has not been removed in the axillary dissection. With the compensation of the residual arm lymph flow above the level of axillary vein, the arm lymphatic drainage could keep balance and remain normal function.\n\nThis arm lymphedema prediction model that included the protective factor, the proportion of arm lymph flow above the level of axillary vein, allows intraoperative intervention to be performed for the high-risk group. The arm lymphatics of these distinguished patients would be preserved to eliminate the occurrence of arm lymphedema in this study.",[111,114,27,304],"Axillary Reverse Mapping","2020-12-11",{"date":307,"type":32},"2020-12-16",{"date":305,"type":32},{"date":310,"type":21},"2027-12-31",{"name":312,"class":39},"Wuhan University"]