[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"breast-cancer-survivor\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:breast-cancer-survivor":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,46,75,110,138,170,200,225,257,286,313,339,361,392],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100616989","testing-the-feasibility-of-a-virtual-application-to-support-breast-and-colorectal-cancer-survivors-100616989",false,"NCT07312786","Testing the Feasibility of a Virtual Application to Support Breast and Colorectal Cancer Survivors","Testing the Feasibility of a Virtual Application to Support Breast and Colorectal Cancer Survivors After Completing Primary Treatment","Inclusion Criteria:\n\n* Adults older than 18 years, capable of providing informed consent\n* Diagnosed with stage I-III breast or colorectal cancer, and have completed primary treatment for their cancer (surgery and\u002For adjuvant systemic or radiation therapy) 6 months - 5 years ago","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this study is to determine the feasibility of implementing a mobile health application for breast and colorectal cancer survivors following primary treatment. Developed in collaboration with Seamless MD, the intervention acts as an information hub, providing users with timely and evidence-based information related to follow-up care as well as health system\u002Fcommunity-based resources and programs to meet their needs during this period of care. The goal of the intervention is to encourage open communication regarding survivorship expectations and provide survivors with appropriate information and support to meet their needs.\n\nThis study will:\n\n1. Test the feasibility of implementing the virtual intervention at two cancer centres in Atlantic Canada (Nova Scotia and New Brunswick)\n2. Gather feedback regarding the intervention from cancer survivors and healthcare providers.\n\nParticipants will have access to the intervention for a period of six months. Questionnaires will be distributed to participants through the intervention at baseline, 90 days, and 180 days to assess user experience. Semi-structured interviews will be conducted with select survivor participants and healthcare providers (oncology and primary care) to determine the feasibility and acceptability of this intervention.",[26,27],"Breast Cancer Survivor","Colorectal Cancer Survivors",[29,30,31,32],"Cancer Survivorship","SeamlessMD","Supported self-management","Survivorship app","RECRUITING","2026-05-13",{"date":36,"type":37},"2026-05-14","ACTUAL",{"date":39,"type":37},"2026-04-20",{"date":41,"type":20},"2027-12",{"name":43,"class":44},"Nova Scotia Health Authority","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":54,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100639303","the-computerized-retraining-and-functional-treatment---group-intervention-100639303","NCT07591857","The Computerized Retraining and Functional Treatment - Group Intervention","The Computerized Retraining and Functional Treatment: Effectiveness-implementation Hybrid Trial of Group Teleintervention Among Breast Cancer Survivors With Cognitive Impairment","CRAFT-G","Inclusion Criteria:\n\n1. women, 18 years old and older\n2. A subjective concern about declines in cognitive functioning related to a diagnosis of breast cancer and\u002For cancer related treatment\n3. Objective cognitive decline with no dementia (19\\\u003CMOCA)\n4. 6 months or more after completion of an active treatment for cancer\n5. Daily access to the internet and sufficient basic skills to operate a computer\n\nExclusion Criteria:\n\n* Unstable psychiatric or other health condition according to participants' self-report and medical file.","FEMALE",{"count":56,"type":20},48,[23],"The goal of this clinical trial is to examine the efficacy of a novel, remotely-applied group intervention, Cognitive Retraining and Functional Treatment Group (CRAFT-G), designed to improve cognitive function, mental health and functional outcome in breast cancer survivors (BCS) with Cancer-Related Cognitive Impairment (CRCI) while simultaneously collecting data on the barriers and facilitators of implementation in clinical settings. The main question it aims to answer is:\n\nWe hypothesize that participants receiving CRAFT-G will show gains in mental health, cognitive and daily function, and that the CRAFT-G benefits will endure for three months following treatment completion.\n\nParticipants assigned to the waitlist control will crossover to the CRAFT-G intervention group after 6 weeks.\n\nParticipants will ask to complete CRAFT-G intervention, which include:\n\n* Six remote group sessions (1.5hr each)\n* Between the sessions, participants will be guided to complete CRCI-specific computerized cognitive training (CCT) 3 times per week delivered using dedicated app.\n* Psychoeducation materials Assessment will take place in 3 time points: before intervention (frontal meeting for baseline assessment), post intervetion and 3 months post intervention.\n\nThe study will be conducted to explore implementation barriers and facilitators. This will be done by endline qualitative interviews with the participants' research group.",[60,26],"Cancer Related Cognitive Impairment",[62,63,64],"Tele-rehabilitation","Cognitive training","Group therapy","2026-05-11",{"date":67,"type":37},"2026-05-18",{"date":69,"type":37},"2025-11-16",{"date":71,"type":20},"2028-06",{"name":73,"class":44},"Hadassah Medical Organization",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":74},"100588219","the-role-of-prolonged-nightly-fasting-to-improve-sleep-and-cognition-in-breast-cancer-survivors-100588219","NCT06938555","The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors","The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors (RESTORE)","RESTORE","Inclusion Criteria:\n\n1. ≥18 years old\n2. diagnosed with breast cancer (all stages included)\n3. ≥3 months post neoadjuvant or adjuvant chemotherapy (maintenance or palliative systemic therapy is included)\n4. score ≤30 or lower on the Patient Reported Outcome Measurement Information System Cognitive Function Short Form 8a (sr-CRCI)\n5. able to speak\u002Funderstand English\n6. have access to a computer and Wi-Fi\n7. live within the United States\n8. Identifies as female\n9. willing and able to fully participate in the study\n\nExclusion Criteria:\n\n1. type 1 diabetes\n2. actively enrolled in formal diet\u002Fweight loss program\n3. previous bariatric surgery\n4. eating disorder history\n5. night shift work\n6. pregnant, breast feeding, or trying to get pregnant\n7. dementia, psychological, psychiatric, or neurological diagnoses\n8. active brain or central nervous system disease\n9. prior or current use of memory enhancing medications\n10. history or current brain radiation\n11. frequently fasting for 12+ hours every night\n\n13\\) history of hypoglycemia 14) depression screening on PHQ9 with a score of 20 or greater across all 9 questions OR anything other than 0 on question 9",{"count":19,"type":20},[23],"The investigators are interested in finding out how Prolonged Nightly Fasting (PNF) and\u002For health education may impact health and cancer recovery for breast cancer patients and survivors.",[26,87,88,89],"Cancer Related Cognitive Difficulties","Sleep","Quality of Life",[91,92,93,94,95,96,97,98,99,100],"breast cancer","breast cancer survivor","brain fog","prolonged nightly fasting","nationwide","remote","non-invasive","health education","sleep","quality of life","2026-04-27",{"date":103,"type":37},"2026-05-01",{"date":105,"type":37},"2025-03-18",{"date":107,"type":20},"2026-12-31",{"name":109,"class":44},"Arizona State University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":21,"phases":120,"briefSummary":121,"conditions":122,"keywords":123,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":74},"100567710","self-determination-theory-informed-occupational-therapy-program-to-increase-physical-activity-among-survivors-of-breast-cancer-100567710","NCT06671730","Self-Determination Theory-informed Occupational Therapy Program to Increase Physical Activity Among Survivors of Breast Cancer","Digitally Mediated Occupational Therapy Program to Increase Physical Activity in Urban and Rural Breast Cancer Survivors Who Have Undergone Breast-conserving Surgery or Mastectomy","SDOTS","Inclusion Criteria:\n\n1. ≥18 years old.\n2. Ability to speak\u002Fread English.\n3. Ability to provide informed consent.\n4. Having ever received a histologically confirmed diagnosis of invasive breast carcinoma.\n5. Having undergone breast conserving surgery or mastectomy for BC in the last 12 months.\n6. Owning a smartphone and\u002For computer with internet access.\n7. Willing to participate in once-weekly telehealth-delivered OT sessions for eight weeks.\n\nExclusion Criteria:\n\n1. Currently undergoing chemotherapy or radiation as primary cancer treatment.\n2. Planning or preparing for surgery as primary treatment or as a reconstruction procedure in the next 3 months.\n3. Presence of distant metastasis.\n4. Reporting a Physical Activity Readiness Questionnaire (2017 PAR-Q+) score that indicates PA may potentially be unsafe, unless the participant produces a signed doctor's note. We will define 2017 PAR-Q+ scores as indicating that PA may potentially be unsafe as responding \"Yes\" to any of the follow-up questions except \\[1\\] if the individual indicates that they have high blood pressure but subsequent responses indicate that both they do not have problems keeping it under control and that their resting blood pressure is less than 160\u002F90 mmHg, and \\[2\\] if the individual indicates that they have a metabolic condition but subsequent responses indicate that they do not have problems controlling their blood sugar levels, do not any experience signs or symptoms of hypoglycemia, and do not have any signs of symptoms of listed diabetes complications).\n5. Already engaging in ≥ 75 min\u002Fweek of vigorous-intensity PA, ≥ 150 min\u002Fweek of moderate-intensity PA, or an equivalent combination of both over the last 3 months.\n6. Being a prisoner, pregnant, or planning to become pregnant.\n7. Currently participating in another PA- or OT-based study, or seeking physical therapy or occupational therapy treatment.",{"count":119,"type":20},38,[23],"We will evaluate a novel 8-week telehealth-delivered occupational therapy (OT) program among breast cancer survivors that seeks to promote engagement in aerobic physical activity (PA) and muscle strengthening exercise (MSE). The telehealth-based delivery of this OT program circumvents some barriers to OT access and participation (e.g., time burden; distance to OT clinic) among breast cancer survivors- particularly important for Oklahoma given that 33% of residents live in rural areas. Additionally, the focus of this program is to promote the preferred aerobic PA and MSE choices of each individual survivor to increase the likelihood of long-term PA engagement. In turn, participants will be more likely to experience the longer-term benefits associated with PA such as improved physical functioning, reduced anxiety, depressive, and pain symptoms, better sleep, and better cardiorespiratory fitness.",[26],[124,125,126,127,128,129,130],"Aerobic Physical Activity","Muscle Strengthening Exercise","Patient Reported Outcomes","Feasibility","Acceptability","Wearable Devices","Telehealth",{"date":103,"type":37},{"date":133,"type":37},"2024-11-27",{"date":135,"type":20},"2026-05-31",{"name":137,"class":44},"University of Oklahoma",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":54,"minAge":145,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":21,"phases":149,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":74},"100582626","collaborative-research-multiscale-modeling-and-intervention-for-improving-long-term-medication-100582626","NCT06865755","Collaborative Research: Multiscale Modeling and Intervention for Improving Long-Term Medication","Deploying and Evaluating a Technology Based System to Help People Adhere to Long Term Medications","Inclusion Criteria:\n\n* are English-speaking and reading;\n* are between ages 21 and 70 years;\n* are diagnosed with stage 0-3 breast cancer in the past 5 years;\n* have completed all surgery, radiation, and chemotherapy, except endocrine therapy;\n* are prescribed endocrine therapy;\n* do not have a physical impairment that would prevent them from using the MM system;\n* are able to provide informed consent;\n* are willing and able to use the MM system for 6 months;\n* have an Iphone or Android phone.","21 Years","70 Years",{"count":148,"type":20},15,[23],"The goal of this study is to learn about the impact of an integrated medication monitoring system in breast cancer survivors aged 21-70 who are prescribed endocrine therapy. The main question it aims to address is: Does the integrated medication monitoring system improve medication adherence among breast cancer survivors when used over a six-month period?\n\nFifteen English-speaking breast cancer survivors who meet the inclusion criteria will use a combination of smartphone-based ecological momentary assessments, a medication event monitoring system (Wisepill), and a wearable sensor (Fitbit). After 2 months, participants will be provided personalized content to facilitate medication adherence through an app (Digital Trails) and through WisePill. Participants will complete online surveys at baseline, 3 months, and 6 months to assess their experiences and adherence.",[26,152],"Breast Cancer Early Stage Breast Cancer (Stage 1-3)",[154,155,156,157,158,159,160],"Single-Arm Study Design","Medication Event Monitoring System (MEMS)","Medication Adherence","Breast Cancer Survivors","Personalized Interventions","endocrine therapy","mobile health","NOT_YET_RECRUITING","2026-04-22",{"date":101,"type":37},{"date":165,"type":20},"2026-07",{"date":167,"type":20},"2026-12",{"name":169,"class":44},"San Diego State University",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":54,"minAge":17,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":21,"phases":178,"briefSummary":180,"conditions":181,"keywords":182,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":199},"100572077","phase-2-enhanced-pain-coping-in-cancer-epic-a-study-of-managing-treatment-related-joint-pain-in-breast-cancer-survivors-100572077","NCT06728579","Enhanced Pain Coping in Cancer (EPIC): A Study of Managing Treatment-Related Joint Pain in Breast Cancer Survivors","Inclusion Criteria:\n\n* Age ≥18 years\n* English-proficient women with a history of stage I, II, or III breast cancer\n* Free of oncologic disease by clinical examination and history;\n* Receiving third-generation AI therapy (anastrozole, letrozole, or exemestane) for at least 28 days prior to consent with plan to continue for at least another 12 months;\n* Worst joint pain rated at least 4 or greater on a 0-10 numeric rating scale in the preceding week prior to consent;\n* Reporting at least 15 days with pain in the preceding 30 days prior to consent;\n* Experiencing joint pain for at least one month;\n* Pain attributed to AI therapy;\n* Willing to adhere to all study-related procedures, including randomization to one of two treatment arms: Mindfulness-Oriented Recovery Enhancement (MORE) or Supportive Group Psychotherapy (SG);\n* Able to attend video-call sessions in a quiet\u002Fprivate location.\n\nExclusion Criteria:\n\n* Metastatic breast cancer (stage IV);\n* Completed chemotherapy, surgery, or radiation therapy less than 4 weeks prior to enrollment;\n* Pain attributed to inflammatory arthritis (i.e. rheumatoid arthritis, gout, pseudogout);\n* Surgery or joint injection involving the affected joints within the last month or planned within the next six months;\n* Active suicidality or psychosis as determined by the Mini-International Neuropsychiatric Interview.",{"count":177,"type":20},200,[179],"PHASE2","The researchers are doing this study to compare two different types of group therapy and find out whether they are effective approaches for helping breast cancer survivors manage joint pain caused by aromatase inhibitors (AI). This type of joint pain is called AI-associated arthralgia, or AIA, and it is common in people taking AIs. AIA and its associated symptoms can make some people decide to stop taking their medication. The study will look at the effects of two different types of group therapy on participants' cancer-related symptoms (such as pain, fatigue, and anxiety), their ability to continue taking AIs on a regular schedule, and their quality of life. We will measure participants' quality of life by having them fill out questionnaires.\n\nBoth groups will have 2-hour group therapy sessions once a week, over the course of 8 weeks. During the sessions, you will be in a group of 6-10 participants, who may be a mixture of patients from both MSK and University of California San Diego (UCSD).",[26],[183,184,185,186,187,188,189],"Enhanced Pain Coping in Cancer","Mindfulness Oriented Recovery Enhancement","Aromatase inhibitors","Arthralgia","Ache","Cancer Pain","Cancer Survivors","2026-04-16",{"date":192,"type":37},"2026-04-17",{"date":194,"type":37},"2024-12-06",{"date":196,"type":20},"2028-12",{"name":198,"class":44},"Memorial Sloan Kettering Cancer Center",9,{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":54,"minAge":17,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":21,"phases":209,"briefSummary":210,"conditions":211,"keywords":212,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":221,"leadSponsor":223,"locationsCount":74},"100633123","baduanjin-exercise-on-upper-limb-dysfunction-among-breast-cancer-survivors-100633123","NCT07522593","Baduanjin Exercise on Upper Limb Dysfunction Among Breast Cancer Survivors","Feasibility and Preliminary Evaluation of an Evidence-based Baduanjin Exercise Program for Upper Limb Dysfunction in Breast Cancer Survivors: A Pilot Randomised Controlled Trial","Inclusion Criteria:\n\n1. Female, aged ≥ 18 years, diagnosed with non-metastatic unilateral Stage I-IIIa non-metastatic breast cancer, regardless of cancer type;\n2. Surgeries completed at least two months before enrolment, and completion of radiotherapy and\u002For chemotherapy, with or without aromatase inhibitor therapy, upon enrolment;\n3. Experiencing breast cancer treatment-related ULD, which is measured by the Disabilities of the Arm, Shoulder, and Hand (DASH) scale with a score of 20 or above;\n4. Karnofsky Performance Status Scale (KPS), used to measure a patient's ability to perform daily activities and self-care independently, with a score of 90 or above;\n5. Ability to read, write, and communicate in Chinese;\n6. Have a personal cellphone;\n7. Agree to participate in this study and provide written informed consent.\n\nExclusion Criteria:\n\n1. Any patient with a history of upper limb surgery, injury (fracture or shoulder dislocation), or other conditions not related to breast cancer treatments;\n2. With other complications or adverse medical conditions that cannot perform BdjE, such as severe lymphedema, axillary web syndrome, or adhesive capsulitis;\n3. Undergoing any physiotherapy for ULD or leading regular physical exercises in the previous three months;\n4. Had skin grafting and autologous myocutaneous flap breast reconstruction;\n5. Current clinical diagnosis of depression or anxiety, or receipt of active psychological treatment for significant mood or anxiety disorders;\n6. Currently involved in other clinical studies.",{"count":208,"type":20},76,[23],"The goal of this clinical trial is to learn if Baduanjin exercise could be adopted by breast cancer survivors and improve their upper limb dysfunction. The main questions it aims to answer are:\n\n* Does Baduanjin exercise improve upper limb dysfunction among breast cancer survivors?\n* What problems or adverse events do participants have if they adopt Baduanjin exercise to improve upper limb dysfunction?\n\nParticipants will:\n\n* Adopt Baduanjin exercise following an evidence-based intervention protocol\n* Report their exercise frequency, length, and unexpected symptoms\n* Receive three times assessment and follow-up every week",[26],[213,214,215,216],"breast cancer survivors","Baduanjin exercise","pilot study","randomised control trail","2026-04-07",{"date":219,"type":37},"2026-04-13",{"date":39,"type":20},{"date":222,"type":20},"2027-04",{"name":224,"class":44},"University of Southern Queensland",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":231,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":54,"minAge":17,"maxAge":4,"enrollmentInfo":233,"targetDuration":4,"studyType":21,"phases":235,"briefSummary":236,"conditions":237,"keywords":239,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":74},"100594169","moving-on-after-breast-cancer-trial-for-depressed-breast-cancer-survivors-in-pakistan-100594169","NCT07015944","Moving on After Breast Cancer Trial for Depressed Breast Cancer Survivors in Pakistan","Clinical and Cost-effectiveness of an Integrated Psychosocial Care Plan for Comorbid Depression in Breast Cancer Survivors In Pakistan: A Sequential Multiple Assignment Randomised Trial","Moving On ABC","Inclusion Criteria:\n\n* Women\n* Aged 18 years and above\n* Diagnosed with breast cancer (any stage)\n* Completed initial treatment (i.e., surgery and\u002For radiotherapy or chemotherapy) for breast cancer (even if they are currently on hormonal therapy post-initial treatment)\n* Total score of 10 or above on the Patient Health Questionnaire (PHQ-9)\n* Diagnosis of current Major Depressive Episode (MDE) confirmed using the Structured Clinical Interview for DSM-5 (SCID).\n\nExclusion Criteria:\n\n* Lacking capacity to provide informed consent, such as those identified by clinicians as having intellectual disabilities, dementia, or severe medical and\u002For psychiatric illnesses requiring hospitalisation\n* Unable to engage in assessments or interventions, including those with stage 4 breast cancer experiencing significant symptoms (e.g., metastatic lesions in the lungs, liver, or bones requiring daily treatment for symptomatic relief, such as the daily use of two or more painkillers), which restrict their capacity to participate\n* Currently receiving psychological therapy or taking antidepressant medications (e.g., SSRIs, SNRIs, or other prescribed antidepressants)",{"count":234,"type":20},26376,[23],"Breast cancer is the most common cancer among women worldwide, and many survivors experience comorbid mental health conditions such as depression and anxiety, which can significantly worsen health outcomes and increase mortality. This large-scale trial in Pakistan aims to evaluate the clinical and cost-effectiveness of a three-stage adaptive intervention to manage depression among breast cancer survivors. Using a Sequential, Multiple Assignment, Randomised Trial (SMART) design, the study will recruit 26,372 participants aged 18 and above who have completed initial breast cancer treatment (surgery and\u002For chemotherapy or radiotherapy). Participants will be identified through primary care units, outpatient departments, oncology clinics in public hospitals, and charitable organisations across Pakistan. Depression will be screened using the Patient Health Questionnaire PHQ-9, with diagnosis confirmed by the Structured Clinical Interview Schedule of DSM (SCID). Those randomised to the intervention arm will receive adaptive interventions: starting with low-intensity guided self-help, followed by a high-intensity cognitive behavioural therapy-based programme called \"Moving On After Breast Cancer Plus\" (Moving on ABC Plus), and for non-responders, an additional pharmacological component will be introduced. Participants in both adaptive intervention and enhance usual care groups will be assessed at multiple time points-baseline, 6, 18, 30, and 48 weeks post-randomisation-using validated tools to measure depression (primary outcome), and anxiety, self-esteem, intrusive thoughts, health-related quality of life, satisfaction with services, and health resource use (secondary outcomes). The study will also include qualitative interviews and focus groups discussions with patients, caregivers, healthcare providers, and policymakers to identify barriers and facilitators to implementation and ensure the intervention is both contextually appropriate and scalable.",[238,26],"Major Depressive Disorder (MDD)",[240,241,242,243,244,245,246,247],"Breast Cancer","LMICs","Depression","Multimorbidity","SMART","Adaptive interventions","Cognitive Behaviour Therapy","Low intensity intervention","2026-03-16",{"date":250,"type":37},"2026-03-18",{"date":252,"type":37},"2025-06-13",{"date":254,"type":20},"2028-12-30",{"name":256,"class":44},"Pakistan Institute of Living and Learning",{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":54,"minAge":17,"maxAge":4,"enrollmentInfo":265,"targetDuration":4,"studyType":21,"phases":267,"briefSummary":268,"conditions":269,"keywords":271,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":74},"100601594","tdcs-intervention-in-breast-cancer-survivors-with-and-without-obesity-reporting-cognitive-impairment-100601594","NCT07112521","tDCS Intervention in Breast Cancer Survivors With and Without Obesity Reporting Cognitive Impairment","Evaluating the Efficacy of Home-Based tDCS for Cancer-Related Cognitive Impairment and Its Moderation by Obesity: A Double-Blind Randomized Controlled Trial.","LUMINA-brain","Inclusion Criteria:\n\n* Female\n* Over 18 years old\n* Diagnosed with primary adult-onset breast cancer within the last 5 years\n* Completed all active cancer treatments at least 3 months prior to study participation\n* Capable of fulfilling study requirements, including having internet access.\n* Fluent in either Finnish or English\n* Have normal or corrected vision and hearing\n* Right-handed (based on the Edinburgh Handedness Inventory score; Oldfield, 1971)\n\nExclusion Criteria:\n\n* Have received primary cancer treatment (chemotherapy, radiotherapy, immunotherapy, or surgery) within the last 3 months\n* Have a history of childhood-onset cancer\n* Present with acute eczema on the scalp\n* Diagnosed with dementia, Alzheimer's disease, multiple sclerosis, or - Parkinson's disease\n* Have experienced unconsciousness for more than five minutes due to a head\u002Fbrain injury within the last 10 years\n* Have a history of stroke or transient ischemic attack\n* Suffer from claustrophobia\n* Are pregnant or breastfeeding\n* Have any of the following medical implants or devices: cardiac implantable electronic devices, metallic intraocular foreign bodies, neurostimulation systems, cochlear\u002Fear implants, drug infusion pumps, catheters with metal components, metallic fragments (e.g., bullets), cerebral aneurysm clips, magnetic dental implants, tissue expanders, artificial limbs, non-removable piercings, or face tattoos.\n* Weight exceeding 250 kg (the MRI table weight limit) or they are unable to fit within the 70 cm diameter bore of the MRI machine",{"count":266,"type":20},40,[23],"The goal of this intervention is to investigate whether transcranial Direct Current Stimulation (tDCS) can alleviate Cancer-Related Cognitive Impairment (CRCI) in breast cancer survivors, as measured by changes in brain structures and cognitive performance. To assess the efficacy of tDCS, the investigators will compare outcomes between participants receiving active stimulation and those receiving sham stimulation (a placebo condition where participants believe they are receiving stimulation, but are not).\n\nParticipants will:\n\n* Undergo a baseline MRI session\n* Receive either active or sham tDCS for six weeks\n* Undergo a follow-up MRI session\n* Complete cognitive tests and respond to psychosocial questionnaires before, during, and after the tDCS intervention",[26,270],"Obesity, Overweight",[272,273,213,274,275,276],"tdcs","CRCI","obesity","transcranial direct current stimulation","cancer related cognitive impairment","2025-08-29",{"date":279,"type":37},"2025-09-02",{"date":281,"type":20},"2025-09-01",{"date":283,"type":20},"2027-01",{"name":285,"class":44},"University of Helsinki",{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":294,"sex":54,"minAge":17,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":21,"phases":297,"briefSummary":298,"conditions":299,"keywords":301,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":308,"leadSponsor":310,"locationsCount":74},"100602360","a-targeted-electronic-health-approach-to-reduce-fear-of-recurrence-in-breast-cancer-survivors-fortitude-100602360","NCT07122492","A Targeted Electronic Health Approach to Reduce Fear of Recurrence in Breast Cancer Survivors (FoRtitude)","Randomized Controlled Trial of FoRtitude: Targeted eHealth Intervention to Reduce Fear of Recurrence Among Breast Cancer Survivors in Community Oncology Settings","FoRtitude","Inclusion Criteria:\n\n* Participant must be ≥ 18 years of age.\n* Participant must have had histologically confirmed Stage 0-III breast cancer at time of diagnosis.\n* Participant must have completed primary treatment 1-10 years prior to Step 0 registration.\n\nNOTE: Current hormonal therapy is allowed. NOTE: Primary treatment can include chemotherapy and\u002For surgery and\u002For radiation therapy.\n\n\\- Participant must be receiving their care (cancer treatment or survivorship care) from an oncology provider affiliated with the NCORP site and are expected to continue care at the site for the next 18 months.\n\nNOTE: This eligibility criteria is intended to ensure access to healthcare utilization data. Oncology provider can include an Advance Practice Provider, Advance Nurse Practitioner, oncologist, primary care provider, or nurse or physician responsible for survivorship care.\n\n* Participant must have no evidence of active cancer of any type at the time of Step 0 registration (per the assessment of the physician), excluding local basal cell or squamous cell carcinoma.\n* Participant must be fluent in written and spoken English.\n* Participant must have an ECOG Performance Status of 0-2.\n* Participant must have the ability to understand and the willingness to sign a written informed consent document. Participants with impaired decision-making capacity (IDMC) are not eligible.\n* Participant must complete the FCRI 9-item severity scale and report a score of 13 or higher.\n* Participant must have access to the internet (via smartphone, tablet, or computer).\n\nNOTE: The restriction to those with internet access is based on the primary intention of the study which involves internet-based delivery intervention content delivered via the internet.\n\n* Participant must have completed the Baseline Assessment within 60 days of Step 0 registration.\n* Randomization to Step 1 must occur within 60 days of Step 0 registration.\n\nExclusion Criteria:\n\n* Participant must not have any psychiatric or cognitive conditions that may affect the participant's ability to accurately provide self-report data, per clinical discretion.",true,{"count":296,"type":20},800,[23],"The goal of this study is to determine if the intervention or if general information about being a breast cancer survivor can help Breast Cancer Survivors reduce their fear of recurrence. The main question it aims to answer are:\n\nCan the FoRtitude intervention lower the fear of recurrence for Breast Cancer Survivors?\n\nParticipants will:\n\nAnswer questions about their fear of recurrence. Be randomized to 1 of the 3 following options: (1) a weblink to access an eHealth intervention which includes a website and an optional interactive text-messaging feature, (2) a weblink to a non-interactive website that will include links to external websites with general information that may be helpful for Breast Cancer Survivors, or (3) you will need to talk with your oncology team about your concerns about recurrence or seek psychosocial care in the community.\n\nBe asked to fill out questionnaires 5 times for up to 18 months.",[26,300],"Fear of Cancer Recurrence",[302,303],"Breast cancer survivor","Fear of recurrence","2025-08-07",{"date":306,"type":37},"2025-08-14",{"date":281,"type":20},{"date":309,"type":20},"2029-09-01",{"name":311,"class":312},"Eastern Cooperative Oncology Group","NETWORK",{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":54,"minAge":17,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":21,"phases":323,"briefSummary":324,"conditions":325,"keywords":326,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":338},"100598147","the-use-of-combined-motor-imagery-and-action-observation-to-evaluate-the-influence-on-functional-parameters-such-as-strength-range-of-motion-pain-or-fear-of-movement-among-others-in-females-breast-cancer-survivors-100598147","NCT07067710","The Use of Combined Motor Imagery and Action Observation to Evaluate the Influence on Functional Parameters Such as Strength, Range of Motion, Pain or Fear of Movement Among Others, in Females Breast Cancer Survivors.","Effectiveness of Combined Motor Imagery and Action Observation in Improving Pain, Range of Motion, and Upper Limb Lymphedema in Breast Cancer Survivors. Efectividad de Las Terapias de imaginería Motora y observación de la acción en la Mejora Del Dolor, la Movilidad y el Linfedema de la Extremidad Superior en Supervivientes de cáncer de Mama.","IM-OA23","Inclusion Criteria:\n\n* Female, over 18 years, have suffered breast cancer, have ended active treatments (chemotherapy, radiotherapy, surgery), have pain or functional limitation or lymphedema at upper limb afected.\n\nExclusion Criteria:\n\n* males, people with active treatments ongoning, other types of cancer, recurrence or metastasis of cancer",{"count":322,"type":20},108,[23],"The aim of this study is to evaluate the effectivity of the combined motor imagery and action observation therapies to improve functional parameters such as strenght, range of motion, pain or fear of movements among others in relation to upper limb in breast cancer survivors. The main question it aims to answer is: Will a combined therapy of motor imagery and action observation improve the strenght, rang of motion, pain, limb diameter and fear of movement of the upper limb in breast cancer survivor females? The participants will be part of the IM-OA23 proyect that consist on seeing some diferent videos about upper limb mobility and then they'll have to imagine the movements and to performed themselves. Researches will compare two groups (control group and intervention group) to evaluate the diferences between them.",[26],[327,328],"Motor imagery","Action observation","2025-07-15",{"date":331,"type":37},"2025-07-16",{"date":333,"type":37},"2025-02-25",{"date":335,"type":20},"2026-02",{"name":337,"class":44},"Fundacion Miguel Servet",3,{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":11,"sex":54,"minAge":17,"maxAge":146,"enrollmentInfo":346,"targetDuration":4,"studyType":21,"phases":348,"briefSummary":349,"conditions":350,"keywords":4,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":74},"100592509","acupuncture-for-anxiety-and-depression-100592509","NCT06994351","Acupuncture for Anxiety and Depression","The Effects of Acupuncture on Anxiety and Depression of Patients With Breast Cancer","Inclusion criteria\n\n1. Female, aged 18 to 70 years old;\n2. Meeting the diagnostic criteria for breast cancer and at TMN I-III;\n3. Having completed specialized active treatment for at least one month;\n4. With an ECOG score of 0-2;\n5. Mild to moderate anxiety and\u002For depression;\n6. Voluntarily joining this study and signing the informed consent form. Exclusion criteria\n\n(1) Starting to take or change the regimen of anti-anxiety and\u002For -depression disorder medication within one month before enrolment; (2) Received psychological intervention or physical therapy one month before enrolment or planning to use in the next 5 months; (3) With diagnosis of anxiety and\u002For depression disorder prior to the diagnosis of breast cancer; (4) Patients with suicidal tendencies, bipolar disorder and psychotic symptoms; (5) Patients with severe anxiety and\u002For depression； (6) Patients received acupuncture treatment within one month before enrolment; (7) Participating in other clinical studies on the treatment of anxiety and depression; (8) Combined with severe underlying diseases; (9) Patients with severe skin ulcers; (10) Pregnant or lactating patients; (11) Poor compliance.",{"count":347,"type":20},20,[23],"The study aims to primarily investigate the effects and safety of acupuncture on anxiety and depression among patients with breast cancer.",[351,26],"Anxiety and Depression","2025-05-25",{"date":354,"type":37},"2025-05-29",{"date":356,"type":20},"2025-05-18",{"date":358,"type":20},"2025-12-31",{"name":360,"class":44},"Guang'anmen Hospital of China Academy of Chinese Medical Sciences",{"id":362,"slug":363,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":365,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":11,"sex":54,"minAge":367,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":21,"phases":371,"briefSummary":372,"conditions":373,"keywords":376,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":74},"100589273","effects-of-two-strength-exercise-programs-on-upper-limb-functionality-in-breast-cancer-100589273","NCT06952270","Effects of Two Strength Exercise Programs on Upper Limb Functionality in Breast Cancer","Inclusion Criteria:\n\n* Pathological diagnosis of breast cancer.\n* Patients who have undergone a mastectomy, including unilateral, total breast, or breast-conserving surgery.\n* Postoperative chemotherapy or radiotherapy as required.\n* No other malignant tumors in the last 5 years.\n* Absence of contraindications related to physiotherapy or physical exercise.\n* Willingness to participate in the study and sign the informed consent form.\n\nExclusion Criteria:\n\n* Metastasis to other organs and tissues (liver, kidney, lung, brain, etc.) that prevent participation in the exercise program.\n* Underlying heart disease, cerebrovascular disease, or mental illness that impairs proper execution of the exercise program.\n* Pre-existing shoulder pathology before surgery.\n* Inability to understand the plyometric exercise program.","25 Years","75 Years",{"count":370,"type":20},24,[23],"The goal of this experimental study is to evaluate the effect of a therapeutic exercise program based on upper limb plyometric exercises in breast cancer patients and breast cancer survivors to determine changes in upper limb functionality.\n\nThe main question it aims to answer is: Does upper limb plyometric strength exercise improve upper limb dysfunctions in breast cancer patients and survivors? The researchers will compare the effects of plyometric exercise with the effects of strength training exercise to determine whether plyometric exercise improves shoulder dysfunctions in breast cancer patients and survivors.\n\nParticipants from the Pontevedra group will undergo the intervention using plyometric exercise (Experimental Group), while those from the Vigo group will perform strength training exercise (Control Group). They will complete two sessions per week for six weeks. Outcome variables related to upper limb functionality will be assessed at baseline and after the intervention.",[26,240,374,375],"Breast Cancer Patients","Breast Cancer - Female",[91,377,378,379,380,381,382],"plyometric exercise","upper limb","strength training","exercise","Recovery of Function","clinical trial","2025-04-26",{"date":385,"type":37},"2025-04-30",{"date":387,"type":20},"2025-05-02",{"date":389,"type":20},"2025-07",{"name":391,"class":44},"University of Vigo",{"id":393,"slug":394,"hasResults":11,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":4,"eligibilityCriteria":398,"healthyVolunteers":11,"sex":54,"minAge":399,"maxAge":4,"enrollmentInfo":400,"targetDuration":4,"studyType":21,"phases":402,"briefSummary":403,"conditions":404,"keywords":405,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":74},"100581111","a-mindfulness-based-self-compassion-program-100581111","NCT06846060","A Mindfulness-Based Self-Compassion Program","The Effect of a Mindfulness-Based Self-Compassion Program Applied to Women Diagnosed With Breast Cancer on Spiritual Well-Being and Self-Compassion Levels: A Randomized-Controlled Study","Inclusion Criteria:\n\n* Women diagnosed with breast cancer,\n* Women who are aware that they have been diagnosed with breast cancer,\n* Women who volunteer to participate in the study,\n* Women over the age of 18 with sufficient communication skills\n\nExclusion Criteria:\n\n* Being diagnosed with any mental illness","18 Days",{"count":401,"type":20},64,[23],"The purpose of this study is a pre-test-post-test, randomized controlled experimental study with a control group, planned to examine the effect of the mindfulness-based self-compassion program applied on women with breast cancer on spiritual well-being and self-compassion levels.",[26],[91,406,407,408],"minfulness","spiritual well-being","self-compassion","2025-02-20",{"date":333,"type":37},{"date":412,"type":20},"2025-03-03",{"date":414,"type":20},"2025-04-07",{"name":416,"class":44},"Nevsehir Haci Bektas Veli University"]