[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"breast-milk\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:breast-milk":67},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644410","phase-1-breast-milk-enema-administration-to-stimulate-passage-of-meconium-100644410",false,"NCT07661992","Breast-milk Enema Administration to Stimulate Passage of Meconium","Breast-Milk Enema Administration to Stimulate Meconium Passage in Preterm Infants","BEAM","Inclusion Criteria:\n\n* Preterm infants born at \\>23 and \\\u003C28 weeks' gestational age born at Atrium Health Wake Forest Baptist Hospital or transferred in the first 24 hours of life.\n* postnatal age \\>48 hours, absence of spontaneous passage of meconium by \\>48 hours of life\n* availability of mother's own milk\n* written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\n* Infants with Necrotizing Enterocolitis (NEC) ≥ stage II\n* spontaneous intestinal perforation (SIP)\n* gastrointestinal or anorectal malformations\n* infants that have developed severe hemodynamic instability or sepsis with need for vasoactive drugs\n* significant hematologic abnormalities such as neutropenia or thrombocytopenia.\n* Infants will also be excluded in the absence of written informed consent from a parent or legal guardian.","ALL","23 Weeks","28 Weeks",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","Lack of passage of meconium in preterm infants delays feeding advancement and may represent a risk factor for necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP). Usual management of meconium impaction has included glycerin suppositories and normal saline enemas. Various methods are used in routine neonatal care to promote meconium evacuation; however, there is no consensus on the agents used and the frequency of applications",[28],"Breast-milk",[30,31,32],"Meconium","rectal enemas","low birth weight infants","NOT_YET_RECRUITING","2026-06-25",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":22},"2026-07",{"date":41,"type":22},"2027-01",{"name":43,"class":44},"Wake Forest University Health Sciences","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":61,"conditions":62,"keywords":70,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":45},"100616529","the-effect-of-piomi-and-chronobiological-nutrition-on-readiness-for-feeding-full-transition-to-oral-feeding-and-body-weight-100616529","NCT07306793","The Effect of PIOMI and Chronobiological Nutrition on Readiness for Feeding, Full Transition to Oral Feeding and Body Weight","The Effect of Oral Motor Intervention and Chronobiological Approach to Feeding Models Applied to Preterm Infants on Infants' Readiness to Feed, Transition to Total Oral Feeding, and Body Weight","PIOMI","Inclusion Criteria:\n\n* Preterm infants with a postnatal age of 29-33 weeks,\n* Whose vital signs and clinical condition have been stable for at least 24 hours,\n* Whose APGAR score at 1 and 5 minutes (Activity-Pulse-Grimace-Appearance-Respiration) is 4 or higher.\n\nExclusion Criteria:\n\n* Infants with major congenital anomalies (such as congenital heart disease, cleft palate, cleft lip) or birth trauma,\n* Infants with RDS,\n* Infants diagnosed with asphyxia,\n* Infants with intraventricular hemorrhage,\n* Infants with Neonatal Withdrawal Syndrome,\n* Infants with Fetal Alcohol Syndrome,\n* Infants included in the study group who develop any complications or whose stable condition deteriorates during the follow-up period,\n* Infants with feeding intolerance or who are interrupted from feeding for more than 48 hours,\n* Infants who develop sepsis,\n* Infants who develop necrotizing enterocolitis,\n* Infants receiving mechanical ventilation support,\n* Infants who receive narcotic analgesia or sedation,",true,"29 Weeks","33 Weeks",{"count":58,"type":22},54,[60],"NA","This is a randomized controlled experimental study evaluating the effects of oral motor intervention and chronobiological approach to feeding model applied to preterm infants on feeding readiness, transition to total oral feeding and body weight.",[63,64,65,66,67,68,69],"Neonatal İntensive Care","Nutrition With A Chronobiological Approach","Readiness For Feding","Body Weight","Breast Milk","Nutrition","Premature Birth",[63,64,65,66,71,72,73],"Transitioning To Total Oral Feeding","Premature Infant Oral Motor Intervention (PIOMI)","Prematüre","RECRUITING","2026-01-01",{"date":77,"type":37},"2026-01-06",{"date":79,"type":37},"2025-03-01",{"date":81,"type":22},"2026-09-30",{"name":83,"class":44},"Aydin Adnan Menderes University",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":54,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":45},"100566133","impact-of-breast-milk-mirnas-on-the-infant-gut-microbiota-100566133","NCT06651216","Impact of Breast Milk miRNAs on the Infant Gut Microbiota","MiMilk","Inclusion Criteria:\n\n* Pregnant women in the 3rd trimester of pregnancy (3T) with a normal course of pregnancy up to 39 weeks consulting for the monitoring visit at the Robert-Debré hospital.\n* Patients who did not receive antibiotic treatment or probiotics in 3T.\n* Patient with a negative PV for Strepto B\n* Patients who do not have complications such as pre-eclampsia or gestational diabetes.\n* Breastfeeding (+\u002F- milk pump) or exclusive artificial breastfeeding.\n* No opposition from the mother\n* Ability to master the French language required.\n* Freezer at home.\n* Affiliation to a social security scheme.\n\nExclusion Criteria:\n\n* Cesarean delivery\n* Perinatal pathologies (Anoxia, IUGR, etc.)\n* Neonatal pathologies (FGR, malformations, etc.)\n* Initial choice of mixed breastfeeding\n* Patient under AME (State Medical Aid)Critères d'exclusions :\n* Antibiotics for the mother or child before day 60\n* Antifungal for the mother or child before day 60\n* Complete cessation of breastfeeding before day 60","FEMALE","18 Years","50 Years",{"count":95,"type":22},200,"OBSERVATIONAL","The first 1000 days of life are a critical period for future health. A healthy gut microbiota (GM) is essential for preventing both short-term and long-term health issues. Breast milk (BM) plays a key role in establishing the GM, as, unlike formula milk, it contains miRNAs that may interact with and modulate the microbiota.\n\nPrimary Objective: To study the effect of BM on the composition of fecal miRNAs in exclusively breastfed infants compared to those fed with formula milk at different times (D10, D30, D60, M6, M12).\n\nSecondary Objectives:\n\nAnalyze the effect of BM miRNAs on infant fecal microbiota, taking environmental confounding factors into account.\n\nStudy the influence of BM microbiota on miRNA profiles in the milk. Examine the effect of BM microbiota on the infants' gut microbiota. Explore the links between BM miRNAs, infant gut microbiota, and intestinal inflammation.",[67,99],"Stools","2024-10-18",{"date":102,"type":37},"2024-10-21",{"date":104,"type":22},"2024-11-01",{"date":106,"type":22},"2027-05-31",{"name":108,"class":44},"Assistance Publique - Hôpitaux de Paris"]