[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"breast-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:breast-surgery":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,42,68,92,124,152,180,205,226,246,275,301,331,355],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100641905","efficacy-of-written-versus-video-patient-education-materials-for-postmastectomy-breast-reconstruction-100641905",false,"NCT07602374","Efficacy of Written Versus Video Patient Education Materials for Postmastectomy Breast Reconstruction","Evaluating the Efficacy of Written Versus Video Patient Education Materials for Postmastectomy Breast Reconstruction Patients: Knowledge, Confidence, and Anxiety","Inclusion Criteria:\n\n* Adults aged 18 or older\n* Presenting as a new patient to the UCSF plastic surgery breast reconstruction clinic\n* Considering mastectomy, including:\n* \\- Therapeutic mastectomy in the setting of a breast cancer diagnosis\n* \\- Prophylactic mastectomy in the setting of a confirmed high-risk genetic variant\n* \\- Staged procedures, including delayed mastectomy with initial reduction\n* Participants who are undecided between lumpectomy and mastectomy\n\nExclusion Criteria:\n\n* Established patients returning for follow-up, in order to minimize confounding variables of individual surgeon education style on outcome measures\n* Participants who are primarily considering lumpectomy or oncoplastic reduction at the time of their visit\n* Non-English speakers, as educational materials are currently available in English only","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a prospective, randomized controlled trial evaluating the comparative efficacy of written, video, and combined written and video patient education materials relative to no supplemental education for University of California, San Francisco (UCSF) patients presenting for post-mastectomy breast reconstruction consultation.",[26],"Breast Surgery",[28],"Health Education","RECRUITING","2026-06-10",{"date":32,"type":33},"2026-06-12","ACTUAL",{"date":35,"type":33},"2026-06-06",{"date":37,"type":20},"2029-03-31",{"name":39,"class":40},"University of California, San Francisco","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":51,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":41},"100643308","prospect-registry-post-market-clinical-follow-up-study-100643308","NCT07631468","PROspect Registry :Post Market Clinical Follow-up Study","A Retrospective, Multi-center, Post-market Registry Study of Surgical Procedures in Endoscopy, Breast, and Urology (PROspect)","Inclusion Criteria:\n\n* Subject was ≥ 18 years of age at the time of the surgery\n* Patients who have undergone breast surgical procedures using MOLLI, SPY-PHI, and\u002For SPY AGENT GREEN\n\nExclusion Criteria:\n\n* Subjects who are less than 1-month post-intervention\n* Concurrent participation in an interventional investigational clinical study at the time of initial surgery\n* Subjects whose surgery date was prior to January 2022.\n* Pregnant or lactating females at the time of initial surgery",{"count":50,"type":20},5000,"5 Years","OBSERVATIONAL","Retrospective, multi-center, chart review (only to include data that is part of the surgeons' standard practice)",[26],[56],"Breast surgery","NOT_YET_RECRUITING","2026-06-05",{"date":60,"type":33},"2026-06-08",{"date":62,"type":20},"2026-06-01",{"date":64,"type":20},"2031-12-01",{"name":66,"class":67},"Stryker Endoscopy","INDUSTRY",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":76,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":21,"phases":79,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":41},"100637699","endoscopic-video-assisted-nipple-sparing-mastectomy-100637699","NCT07579117","Endoscopic Video-Assisted Nipple-Sparing Mastectomy","EVA - Endoscopic Video-Assisted Nipple-Sparing Mastectomy (E-NSM): A Pilot Study","EVA","Inclusion Criteria:\n\n* Female patients aged ≥18 years\n* Candidates for nipple-sparing mastectomy (NSM) with immediate reconstruction\n* Histologically confirmed invasive carcinoma cT1N0, or carriers of pathogenic germline mutations undergoing prophylactic mastectomy\n* Breast size I-III and absence of significant glandular ptosis\n* Signed informed consent\n\nExclusion Criteria:\n\n* Inflammatory breast cancer\n* Locally advanced clinical stage (cT2-T4 or N+)\n* Ductal carcinoma in situ (DCIS) without invasive component\n* Previous radiotherapy to the affected breast\n* Locoregional recurrence\n* Clinical conditions contraindicating prosthetic reconstruction\n* Indication for skin-sparing (SSM) or skin-reducing mastectomy (SRM)\n* Ongoing or completed neoadjuvant chemotherapy before surgery\n* Refusal or inability to sign informed consent\n* Inability to complete scheduled follow-up","FEMALE",{"count":78,"type":20},10,[23],"Endoscopic video-assisted nipple-sparing mastectomy (E-NSM) is an advancement in minimally invasive breast surgery designed to reduce surgical trauma and improve cosmetic outcomes while maintaining strict oncologic safety. The procedure will be carried out by a dedicated surgical team in which at least one operator holds certified laparoscopic surgical training issued by a recognized scientific society, ensuring appropriate technical expertise and adherence to surgical safety standards.",[82,26,83],"Endoscopic Video-assisted Nipple-sparing Mastectomy","Breast Cancer","2026-05-28",{"date":62,"type":33},{"date":87,"type":33},"2026-05-23",{"date":89,"type":20},"2027-07",{"name":91,"class":40},"European Institute of Oncology",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":76,"minAge":17,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":21,"phases":102,"briefSummary":103,"conditions":104,"keywords":107,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":4},"100627487","breathing-interventions-for-postoperative-breast-surgery-patients-100627487","NCT07449273","Breathing Interventions for Postoperative Breast Surgery Patients","Effects of Pranayama and Pursed-lip Breathing Exercises on Pain, Anxiety and Vital Signs After Breast Surgery","BREATH-RCT","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Able to communicate effectively\n* Patients undergoing elective surgery for the first time, including radical mastectomy, modified radical mastectomy, or simple mastectomy\n\nExclusion Criteria:\n\n* Patients undergoing breast-conserving surgery\n* Patients who develop any postoperative complications, such as bleeding or anesthesia-related complications\n* Individuals with cognitive or mental impairments\n* Patients who wish to withdraw from the study at any stage\n* Patients with hearing or speech impairments\n* Patients with a psychiatric diagnosis or those using psychiatric medications\n* Patients unable to comply with breathing exercises",{"count":101,"type":20},126,[23],"This randomized controlled trial aims to evaluate the effects of pranayama and pursed-lip breathing exercises on postoperative pain, anxiety, and vital signs in patients undergoing breast surgery. Postoperative pain and anxiety are common problems that can negatively affect recovery, physiological stability, and overall well-being. Non-pharmacological interventions such as breathing exercises may help reduce these adverse outcomes and support recovery.\n\nParticipants will be randomly assigned to one of three groups: a pranayama breathing exercise group, a pursed-lip breathing exercise group, or a control group receiving routine postoperative care. Breathing exercises will be performed three times daily for five minutes. Outcomes including pain, anxiety, and vital signs will be measured at baseline (pretest), postoperative day 1, and postoperative day 2. The findings of this study are expected to provide evidence on the effectiveness of breathing exercises as supportive nursing interventions in the postoperative care of breast surgery patients.",[83,26,105,106],"Postoperative Pain","Anxiety",[108,109,110,111,112,113,114],"Pranayama","Pursed-lip breathing","Breathing exercises","Non-pharmacological intervention","Postoperative care","Randomized controlled trial","Nursing intervention","2026-05-07",{"date":117,"type":33},"2026-05-11",{"date":119,"type":20},"2026-05",{"date":121,"type":20},"2027-04-27",{"name":123,"class":40},"Ondokuz Mayıs University",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":76,"minAge":17,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":21,"phases":133,"briefSummary":134,"conditions":135,"keywords":138,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":4},"100619131","b4p-trial---bloom43-for-preconditioning-100619131","NCT07340632","B4P Trial - BLOOM43 for Preconditioning","BLOOM43 for Preconditioning (B4P): A Pilot Study to Evaluate the Use of the Plexaa Preconditioning Device (BLOOM43) for Reconstructive Breast Surgery - A Prospective Cohort Multicentre Study","Inclusion Criteria:\n\n* All females over the age of 18 years (no maximum age limit)\n* Patients undergoing skin-sparing mastectomy or nipple-sparing mastectomy and immediate breast reconstruction (autologous and\u002For implant)\n\nExclusion Criteria:\n\n* Delayed (two-stage) breast reconstruction patients\n* Patients undergoing simple mastectomy or wide local excision of a breast tumour\n* Inflammatory breast cancer patients\n* Patients with ulcerated breast tumours\n* Patents with T4 breast cancer\n* Presence of open breast skin wounds, or infected or inflamed breast skin\n* Presence of a cardiac pacemaker, defibrillator or any other implantable electronic device",{"count":132,"type":20},60,[23],"The goal of this clinical trial is to evaluate the use of the Plexaa preconditioning device (BLOOM43) in patients undergoing reconstructive breast surgery for breast cancer. This study aims to understand a participant's experience of the device, including its usability and acceptability.\n\nParticipants will use the device to precondition their breast the evening before undergoing surgery (mastectomy with immediate autologous and\u002For implant-based reconstruction).",[136,137,26],"Skin Necrosis","Breast Reconstruction",[139,140,56,141,142],"Mastectomy skin flap necrosis","Breast reconstruction","Preconditioning","Skin necrosis","2026-03-17",{"date":145,"type":33},"2026-03-19",{"date":147,"type":20},"2026-04-16",{"date":149,"type":20},"2026-12-31",{"name":151,"class":67},"Plexaa Ltd",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":21,"phases":161,"briefSummary":162,"conditions":163,"keywords":166,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":179},"100628208","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-on-perioperative-negative-emotions-in-breast-cancer-surgery-patients-100628208","NCT07458646","Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Breast Cancer Surgery Patients","Effect of Intraoperative Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery: A Multicenter, Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Aged ≥18 years. Scheduled for elective breast cancer surgery. ASA physical status I-III. Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Preoperative MMSE score \\\u003C 24; severe communication barriers. History of diagnosed dementia, Parkinson's disease, schizophrenia, bipolar disorder, major depressive disorder, or long-term use of psychotropic drugs.\n\nSkin lesions, infection, or deformity of bilateral ears; history of ear surgery or nerve injury; allergy to electrode materials.\n\nSevere arrhythmia; implanted electronic devices (e.g., pacemaker, ICD). Participation in another interventional trial within 3 months. Other conditions deemed unsuitable by investigators.",{"count":160,"type":20},232,[23],"A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of a single session of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on perioperative negative emotions (anxiety and depression), pain, nausea, sleep, and recovery in patients undergoing elective breast cancer surgery.",[164,165,106,26],"Depression","Postoperative",[167,168,164,106,169],"Transcutaneous Vagus Nerve Stimulation","Breast Cancer Surgery","Randomized Controlled Trial","2026-03-04",{"date":172,"type":33},"2026-03-09",{"date":174,"type":20},"2026-02-28",{"date":176,"type":20},"2027-02-28",{"name":178,"class":40},"Chinese PLA General Hospital",2,{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":76,"minAge":17,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":21,"phases":190,"briefSummary":191,"conditions":192,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":4},"100624386","co2lift-and-t-junction-breakdown-rates-evaluation-after-breast-reduction-surgery-pilot-trial-100624386","NCT07408960","CO2Lift and T-Junction Breakdown Rates Evaluation After Breast Reduction Surgery Pilot Trial","Evaluating the Effect of CO2Lift Pro® Carboxy Gel on T-Junction Breakdown Rates After Breast Reduction Surgery: A Feasibility Study","CO2-BREAST","Inclusion Criteria:\n\n* Female patients aged 18 to 85 years\n* Undergoing bilateral reduction mammoplasty using an inverted-T (Wise pattern) technique\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Able and willing to provide informed consent\n* Willing and able to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\n* Prior radiation therapy to either breast\n* Prior breast reduction surgery to either breast\n* Known allergy or sensitivity to CO2Lift®, Vaseline®, or any of the ingredients\n* Pregnant or breastfeeding\n* History of immunosuppressive therapy\n* History of keloid formation\n* Active local or systemic infection at the time of surgery\n* Current smoker or history of substance abuse (including alcohol or illicit drugs)\n* Use of asymmetrical breast reduction techniques\n* Anticipated inability to complete follow-up or loss to follow-up","85 Years",{"count":78,"type":20},[23],"The goal of this pilot study is to determine the feasibility of a larger randomized controlled trial evaluating CO₂Lift® Pro Carboxy Gel to reduce wound breakdown after bilateral breast reduction in adult female patients undergoing elective bilateral breast reduction surgery. The main question it aims to answer is: Is it feasible to recruit, retain, and treat patients while maintaining blinding and monitoring safety?\n\nExploratory questions include: (1) Does CO₂Lift® reduce the incidence of wound breakdown compared with placebo? (2) Is CO₂Lift® safe and well-tolerated in the postoperative period?\n\nResearchers will compare CO₂Lift® applied to one breast to placebo (Vaseline®) applied to the contralateral breast to see if CO₂Lift® can improve wound healing and tissue oxygenation.\n\nParticipants will:\n\n* Undergo bilateral breast reduction surgery.\n* Receive CO₂Lift® on one breast and placebo on the other, starting immediately after surgery and daily in clinic from postoperative days 1 to 6.\n* Attend weekly postoperative follow-up visits for 12 weeks for wound assessment and monitoring of adverse events.\n* Have standardized photographs and near-infrared spectroscopy measurements taken to evaluate tissue oxygenation and healing.",[193,194,195,26],"Wound Breakdown","Breast Reduction","Surgical Wound","2026-02-10",{"date":198,"type":33},"2026-02-13",{"date":200,"type":20},"2026-04-01",{"date":202,"type":20},"2027-12-31",{"name":204,"class":40},"University of Calgary",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":76,"minAge":17,"maxAge":211,"enrollmentInfo":212,"targetDuration":4,"studyType":21,"phases":214,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":41},"100617632","a-retrospective-analysis-of-robot-assisted-versus-endoscopic-breast-conserving-surgery-for-breast-cancer-100617632","NCT07321145","A Retrospective Analysis of Robot-Assisted Versus Endoscopic Breast-Conserving Surgery for Breast Cancer","Inclusion Criteria:\n\n* Female patients aged 18 to 80 years\n* Pathologically confirmed breast cancer prior to surgery\n* Sufficient glandular volume with a tumor-to-breast volume ratio ≤20%\n* A unifocal lesion confined to the glandular tissue\n* Clear desire for breast conservation and willingness to undergo R-BCS or E-BCS\n* No evidence of distant metastasis, no involvement of the skin or chest wall\n* Eligibility for standard postoperative radiotherapy\n\nExclusion Criteria:\n\n* The presence of diffuse suspicious lesions or microcalcifications for which wide local resection was unlikely to achieve adequate negative margins or satisfactory aesthetic outcomes\n* Bilateral breast cancer or inflammatory breast cancer\n* After neoadjuvant therapy, requirement for additional concurrent surgical procedures\n* Inability to tolerate general anesthesia or undergo surgery\n* Contraindications to radiotherapy or a history of prior chest wall irradiation, pregnancy- or lactation-associated breast cancer\n* Refuse to undergo R-BCS or E-BCS","80 Years",{"count":213,"type":20},200,[23],"Robotic surgical systems provide notable advantages including enhanced dexterity, a magnified three-dimensional high-definition view, and high-resolution imaging, thereby improving operative stability and precision. These features make robotic systems particularly suitable for procedures performed within confined operative spaces. As the breast is a solid organ without a natural cavity, robotic systems demonstrate strong adaptability for breast surgery. Robot-assisted breast-conserving surgery (RABCS) is one of the currently utilized robotic techniques in clinical breast cancer surgery. However, as robotic breast surgery remains in its early stage of development, evidence regarding the clinical outcomes of RABCS remains limited in the literature. Therefore, this study compares the surgical outcomes of endoscopic breast-conserving surgery and robot-assisted breast-conserving surgery in breast cancer patients, aiming to assess and elucidate the clinical value of RABCS.",[83,26],"2025-12-26",{"date":219,"type":33},"2026-01-06",{"date":221,"type":33},"2025-06-27",{"date":223,"type":20},"2026-05-31",{"name":225,"class":40},"Sixth Affiliated Hospital, Sun Yat-sen University",{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":232,"targetDuration":234,"studyType":52,"phases":4,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":41},"100614709","the-impact-of-breast-surgery-on-patients-quality-of-life-100614709","NCT07283120","The Impact of Breast Surgery on Patients' Quality of Life","Inclusion Criteria:\n\n* adults who underwent any type of breast surgery at the University Hospital of Basel\n\nExclusion Criteria:\n\n* Patients under the age of 18 years, without general consent or written informed consent, with insufficient language comprehension or other factors limiting their ability to co-operate in the study",{"count":233,"type":20},1000,"10 Years","The investigators aim to document the surgery-specific and overall Quality of life parameters of patients undergoing all types of breast surgery at the University Hospital of Basel",[26],"2025-12-02",{"date":239,"type":33},"2025-12-15",{"date":241,"type":33},"2025-05-16",{"date":243,"type":20},"2035-06-30",{"name":245,"class":40},"University Hospital, Basel, Switzerland",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":254,"targetDuration":4,"studyType":21,"phases":256,"briefSummary":257,"conditions":258,"keywords":260,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":4},"100582923","omission-of-axillary-lymph-node-dissection-in-case-of-tumor-spread-to-lymph-nodes-in-the-armpit-in-breast-cancer-100582923","NCT06869629","Omission of Axillary Lymph Node Dissection in Case of Tumor Spread to Lymph Nodes in the Armpit in Breast Cancer","SENOMAC-ULTRA: A Prospective Randomised Trial on the Omission of Axillary Lymph Node Dissection in Ultrasound-detectable Axillary Metastases in Primary Breast Cancer Treated by Upfront Surgery","SENOMAC-ULTRA","Inclusion Criteria:\n\n* Patients with primary invasive breast cancer clinical stage II-III\n* Palpable or non-palpable axillary metastases visible by ultrasound (other imaging accepted if confirmatory ultrasound is performed) and confirmed by fine needle aspiration or core biopsy\n* Written informed consent\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Distant metastases\n* Ipsilateral metastases in internal mammary, infra- or supraclavicular lymph nodes without confirmed axillary nodal involvement\n* Preoperative suspicion of extensive nodal involvement, i.e. locally advanced disease\n* Nodes fixed to each other or to neighbouring structures on palpation or imaging\n* History of contralateral invasive breast cancer within 5 years\n* Bilateral invasive breast cancer if (i) one side meets any exclusion criteria or (ii) both sides meet all inclusion criteria\n* Pregnancy\n* Neoadjuvant systemic treatment (short course of neoadjuvant endocrine therapy \\\u003Cthree months is allowed)\n* Medical contraindications for or expressed preoperative wish to abstain from radiotherapy or the recommended adjuvant systemic treatment which complies with standard of care, taking age and comorbidity into consideration\n* Inability to absorb or understand the meaning of the study information; for example, through disability, inadequate language skills or dementia",{"count":255,"type":20},1380,[23],"SENOMAC-ULTRA enrols patients who are planned for upfront surgery for a breast cancer that has spread to lymph nodes in the armpit, and that have been detected already prior to surgery by imaging, e.g. ultrasonography. In this situation, a full axillary lymph node dissection, removing more than 10 lymph nodes from the arm pit, is unnecessarily extensive in about half of the patients. More extensive surgery leads to a risk for arm lymphedema and functional problems with the arm and shoulder region, which should be avoided if not beneficial for diagnosis or prognosis. This trial seeks to ascertain that less extensive surgery, performed by only removing the first lymph node\u002Fs in the armpit (the sentinel lymph node\u002Fs) and the known metastatic lymph nodes (targeted axillary dissection, TAD), offers non-inferior survival outcomes to a full axillary lymph node dissection.",[259,83,26],"Breast Carcinoma",[261,262,263,264,265],"axillary metastases","axillary lymph node dissection","targeted axillary dissection","sentinel lymph node biopsy","axillary ultrasonography","2025-11-27",{"date":268,"type":33},"2025-12-05",{"date":270,"type":20},"2026-01-01",{"date":272,"type":20},"2040-12-31",{"name":274,"class":40},"Karolinska Institutet",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":76,"minAge":282,"maxAge":283,"enrollmentInfo":284,"targetDuration":4,"studyType":21,"phases":285,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":41},"100588917","ultrasound-guided-pectoral-nerve-blocks-thoracic-erector-spinae-plane-block-and-serratus-anterior-plane-block-for-breast-surgery-100588917","NCT06947642","Ultrasound-guided Pectoral Nerve Blocks, Thoracic Erector Spinae Plane Block and Serratus Anterior Plane Block for Breast Surgery","Comparison Between Ultrasound-guided Pectoral Nerve Blocks, Thoracic Erector Spinae Plane Block and Serratus Anterior Plane Block for Breast Surgery: A Prospective Randomized Study","Inclusion Criteria:\n\n• Age from 21 to 65 years old female, American Society of Anesthesiologists (ASA) physical status I or II, who will undergo breast surgeries under general anesthesia.\n\nExclusion Criteria:\n\n* Patient refusal to participate in research.\n* Body Mass Index (BMI) ≥35 kg\u002Fm2.\n* Sensitivity to the intervention drugs.\n* Coagulation abnormalities.\n* Psychiatric disorder and communication difficulties.\n* Chronic neurological disease.\n* Any skin infection at the needle puncture site.\n* Chest wall deformity","21 Years","65 Years",{"count":132,"type":20},[23],"The study will compare ultrasound-guided Pectoral nerve block, Erector Spinae Plane block, and Serratus anterior plane block for pain management following elective breast surgeries",[288,289,290,291,26],"Ultrasound","Pectoral Nerve Blocks","Thoracic Erector Spinae Plane Block","Serratus Anterior Plane Block","2025-05-19",{"date":294,"type":33},"2025-05-20",{"date":296,"type":33},"2025-04-30",{"date":298,"type":20},"2026-09-30",{"name":300,"class":40},"Tanta University",{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":21,"phases":311,"briefSummary":312,"conditions":313,"keywords":315,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":41},"100589100","safety--performance-of-canopus-pintuition-surgical-marker-navigation-100589100","NCT06950021","Safety & Performance of CANOpus PINtuition Surgical Marker Navigation","Safety & Performance of CANOpus PINtuition Surgical Marker Navigation (CANOPIN)","CANOPIN","Inclusion Criteria:\n\n1. Subject is willing and able to provide informed consent for the investigation\n2. Subject is at least 18 years of age\n3. Subject is diagnosed with a single, pathologically confirmed unifocal breast tumour (DCIS or invasive)\n4. Tumour is ultrasound visible\n5. Subject is indicated for primary breast conserving surgery and\u002For targeted axillary dissection\n6. Subject is indicated for preoperative localization using a single marker in the primary breast lesion and\u002For a single marker in an axillary lymph node\n\nExclusion Criteria:\n\n1. Subject is lactating or pregnant\n2. Subject is expected to have surgery scheduled more than 6 weeks after implantation of the Canopus Marker.\n3. Subject has an ICD or other active implant such as a pacemaker less than 5 cm away from the intended target location(s)\n4. Subject has a proven infection or clinically significant hematoma at or close to the intended target location(s)\n5. Subject is expected to require an MRI scan in the period between implantation and surgery\n6. Known hypersensitivity to Titanium or Nickel",{"count":310,"type":20},35,[23],"The goal of this clinical trial is to evaluate the safety and performance of the Canopus Marker in adult breast cancer patients who are scheduled for breast-conserving surgery. The main questions it aims to answer are:\n\n1. Can the Canopus Marker be safely and effectively used to mark tissue for surgical removal?\n2. What is the satisfaction level of radiologists, surgeons, and patients with the use of the Canopus Marker?\n\nParticipants will:\n\n* Have the Canopus Marker implanted into the tumor or nearby tissue using ultrasound guidance.\n* Undergo surgery where the Canopus Marker will help guide the surgeon to the tumor, and the marker will be removed along with the tumor. This surgery is performed using an FDA cleared and CE-marked detection device (Sirius Pintuition Detector).\n* Attend a follow-up visit two weeks after surgery to assess any adverse events and overall satisfaction.",[26,314],"Lymph Node Excision",[316,317,318,319,320,321],"Breast conserving surgery","magnetic seed localization","pintuition","breast sparing surgery","surgical localization","surgical navigation","2025-04-22",{"date":324,"type":33},"2025-04-29",{"date":326,"type":20},"2025-07-01",{"date":328,"type":20},"2026-02-01",{"name":330,"class":67},"Sirius Medical Systems B.V.",{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":337,"eligibilityCriteria":338,"healthyVolunteers":11,"sex":76,"minAge":17,"maxAge":211,"enrollmentInfo":339,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":340,"conditions":341,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":41},"100561583","affecting-factors-for-chronic-pain-after-mastectomy-100561583","NCT06592053","Affecting Factors for Chronic Pain After Mastectomy","Affecting Factors for the Incidence of Chronic Pain After Mastectomy","CPMP","Inclusion Criteria:\n\n* Between the ages of 18-80\n* BMI 18-35 kg\u002Fm2\n* ASA (American Society of Anesthesiologists) Scoring I-II-III\n* Elective mastectomy surgery\n* Elective mastectomy and axillary dissection surgery\n* Patients who will undergo general anesthesia\n* Patients who agree to participate in the study and sign a form\n\nExclusion Criteria:\n\n* Patients under 18 and over 80 years of age\n* Patients who do not want to participate in the study\n* Patients with chronic pain or chronic opioid use\n* Patients with alcohol, substance or drug addiction\n* Patients with a history of previous mastectomy\n* Patients with limited cooperation such as dementia, psychiatric disorders\n* Pregnant and breastfeeding patients will be excluded from the study\n* Patients who cannot communicate in their native language will be excluded from the study",{"count":213,"type":20},"Chronic post-mastectomy pain (CPMP) is a significant issue affecting many women after mastectomy. Factors like age, treatment type, and pre-surgery pain can increase the risk of developing this condition. By evaluating these factors, CPMP can be prevented more successfully and treatment strategies can be developed. This study aims to investigate the factors contributing to CPMP and contribute to the existing literature on this important topic.",[342,343,344,26,168],"Mastectomy","Pain, Chronic","Pain, Acute","2025-01-31",{"date":347,"type":33},"2025-02-04",{"date":349,"type":33},"2024-09-25",{"date":351,"type":20},"2026-10-30",{"name":353,"class":354},"Ankara Etlik City Hospital","OTHER_GOV",{"id":356,"slug":357,"hasResults":11,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":361,"eligibilityCriteria":362,"healthyVolunteers":11,"sex":76,"minAge":17,"maxAge":4,"enrollmentInfo":363,"targetDuration":365,"studyType":52,"phases":4,"briefSummary":366,"conditions":367,"keywords":371,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":379,"locationsCount":41},"100572073","partial-breast-reconstruction-with-chest-wall-perforator-flap-100572073","NCT06728527","PARTial BREast RECONstruction With Chest Wall Perforator Flap","PartBreCon-Pro Study: PARTial BREast RECONstruction With Chest Wall Perforator Flap, a PROspective Study of Clinical and Patient Reported Outcomes","PartBreCon","Inclusion Criteria:\n\n* Patients undergoing partial breast reconstruction using CWPF for primary breast cancer\n* Delayed correction of breast deformity following previous BCS\n* Each surgeon is to have performed a minimum of 10 CWPFs\n* Each centre anticipates completing a minimum of 10\u002Fyear\n\nExclusion Criteria:\n\n* Patients undergoing volume displacement BCS\n* Patients undergoing mastectomy +\u002F- immediate breast reconstruction",{"count":364,"type":20},1001,"6 Months","The goal of this observational study is to ascertain the outcomes following partial breast reconstruction using chest wall perforator flaps after breast conservation surgery.",[368,259,369,26,370],"Breast Cancer Early Stage Breast Cancer (Stage 1-3)","Breast Neoplasms","Breast Reconstruction Surgery",[372],"breast oncoplastic, recon, chest wall perforator flap, PROMS","2024-12-07",{"date":375,"type":33},"2024-12-11",{"date":377,"type":33},"2023-06-01",{"date":223,"type":20},{"name":380,"class":40},"Cambridge University Hospitals NHS Foundation Trust"]