[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"breath-tests\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:breath-tests":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,85,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":34,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":4},"100612988","augmented-response-of-volatile-biomarkers-in-the-assessment-of-oesophagogastric-cancer-aroma2-100612988",false,"NCT07260734","AUGMENTED RESPONSE OF VOLATILE BIOMARKERS IN THE ASSESSMENT OF OESOPHAGOGASTRIC CANCER (AROMA2)","AROMA2","Inclusion Criteria:\n\n* Aged ≥ 18 years old.\n* Participants referred from primary care according to the urgent suspected cancer referral guidelines for potential underlying oesophagogastric cancer a for the reference test (described below).\n* Willing and able to provide informed written consent to take part in study.\n\nExclusion Criteria:\n\n* Previous oesophageal or gastric resection\n* History of cancer within three years (other than non-melanoma skin cancers)\n* Co-morbidities preventing breath collection\n* Pregnant participants\n* Allergies to any of the constituents of the nutrient drink including glucose, glycerol, iron sulphate, Maltodextrin (Corn, Potato), Xanthan Gum, Potassium Chloride, tyrosine, phenylalanine, and glutamic acid\n* Unable or unwilling to provide informed written consent.",true,"ALL","18 Years",{"count":20,"type":21},6000,"ESTIMATED","3 Months","OBSERVATIONAL","Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific. The study team has developed a non-invasive test for cancers of the stomach and oesophagus based on the detection of volatile organic compounds in exhaled breath. These compounds are known to be produced by both cancers as well as cancer associated bacteria within the gut.\n\nThe proposed innovation is to improve the accuracy of this test by investigating whether simple metabolic substrates can increase the production of these volatile organic compounds by both the tumour and its associated bacteria.",[26,27,28,29,30,31,32,33],"OESOPHAGO-GASTRIC CARCINOMA","Oesophageal Adenocarcinoma","Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma","Oesophageal Cancer Nos","Oesophageal Cancer","Oesophageal Junction Cancer","Breath Tests","Volatile Organic Compound",[35,36,37,38,39,40,41,42],"Oesophageal adenocarcinoma","Gastric adenocarcinoma","Breath testing","Microbiome","Augmentation","Volatile Organic Compounds","Volatilomics","Breathomics","NOT_YET_RECRUITING","2025-11-21",{"date":46,"type":47},"2025-12-03","ACTUAL",{"date":49,"type":21},"2025-12-01",{"date":51,"type":21},"2028-11-01",{"name":53,"class":54},"Imperial College London","OTHER",{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100604135","combined-lactulose-h2-breath-test-with-abdominal-imaging-100604135","NCT07145580","Combined Lactulose H2-breath Test With Abdominal Imaging","Clinical Application of a Combined Lactulose H2-breath Test With Abdominal Imaging to Assess the Digestive Function: a Retrospective Cohort Study","Inclusion Criteria:\n\n* Patients referred for breath testing to assess the causes of digestive symptoms or maldigestion 2020-2024\n* Patients signed general consent to allow use of clinical data obtained during clinical assessment and breath testing to be used in research project.\n\nExclusion Criteria:\n\n\\-",{"count":63,"type":21},500,"Hydrogen (H₂) breath tests serve several purposes. (i) detect malabsorption of carbohydrates such as lactose and fructose, (ii) measurement of oro-caecal transit time (iii) associate hydrogen production with the onset of abdominal symptoms like bloating, flatulence, pain, and diarrhea (which indicates carbohydrate intolerance), and (iv) diagnose small intestinal bacterial overgrowth (SIBO).\n\nIt is important to distinguish between carbohydrate intolerance and SIBO because their treatments differ significantly. Carbohydrate intolerance is typically managed through dietary restrictions, while SIBO requires antibiotic therapy. However, recent guidelines have questioned the accuracy of hydrogen breath tests in diagnosing SIBO due to variability in OCTT measurements. This limitation can be addressed by combining H₂ breath tests with imaging techniques such as scintigraphy, which independently confirm OCTT. When this combined approach is used, SIBO is diagnosed if the rise in breath H₂ occurs before the contrast agent appears in the large bowel. Despite its benefits, this combined method faces organizational and financial challenges that limit its routine clinical use.\n\nThis retrospective cohort study aims to assess the clinical performance of a cheap and simple test that combines a 20g lactulose H₂ breath test with simple radiographic abdominal imaging to assess OCTT, SIBO, and carbohydrate tolerance. The novel innovation in this method is to confirm oro-caecal transit by taking an X-ray of the abdomen when H₂ production increases during the examination. If the contrast agent is not visible in the cecum when H₂ rises, this indicates the presence of SIBO. Conversely, if the contrast agent is present in the cecum at that time, it confirms normal OCTT, and any abdominal symptoms occurring after this point support a diagnosis of carbohydrate intolerance.\n\nIf the method is proven to be valid, then this simple test will greatly facilitate the accurate diagnosis of SIBO and carbohydrate intolerance, allowing for more appropriate treatment decisions.",[66,67,32],"Food Intolerance Syndromes","Small Intestinal Bacterial Overgrowth Syndrome (SIBO)",[69,70,71,66,72,73],"Irritable bowel syndrome (IBS)","Functional bloating","Functional Diarrhea","Small intestinal bacterial overgrowth syndrome (SIBO)","Hydrogen Breath Test","RECRUITING","2025-08-20",{"date":77,"type":47},"2025-08-28",{"date":79,"type":47},"2025-08-01",{"date":81,"type":21},"2026-12-31",{"name":83,"class":54},"Klinik Arlesheim",1,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100590501","exploring-clinical-characteristics-of-liver-disease-patients-based-on-digestive-metabolic-exhaled-air-100590501","NCT06968234","Exploring Clinical Characteristics of Liver Disease Patients Based on Digestive Metabolic Exhaled Air","Inclusion Criteria:\n\n① Patients diagnosed with chronic liver disease or cirrhosis through liver biopsy pathology or clinical laboratory and imaging examinations;\n\n② Undergo molecular breath testing within one week of admission.\n\nExclusion Criteria:\n\n* Patients who have received antibiotic treatment within one month; ② Patients with severe pulmonary diseases, such as chronic obstructive pulmonary disease (COPD), asthma, or lung malignancies that have not been clinically cured; ③ Patients who are unable to successfully complete the molecular breath test.",{"count":92,"type":21},1000,"Cirrhosis is a common digestive system disease and represents the final stage of the progression of various chronic liver diseases. During cirrhosis, the intestinal microenvironment is affected due to liver damage and increased portal venous pressure. Displacement of gut microbiota is closely related to the occurrence and development of cirrhosis. Disruption of the gut microbiota is associated with changes in the levels of nitric oxide (NO), hydrogen (H₂), methane (CH₄), and hydrogen sulfide (H₂S). Breath testing is an emerging method for assessing gut microbiota. This project aims to investigate the characteristics and prognosis of patients with chronic liver disease by detecting exhaled breath markers such as nitric oxide (NO), hydrogen (H₂), methane (CH₄), and hydrogen sulfide (H₂S), in conjunction with results from serological tests, gut microbiota analysis, and radiomics. The goal is to identify new diagnostic biomarkers and therapeutic targets, to recognize high-risk patients at an early stage, and to improve patient survival rates and quality of life.",[95,96,32],"Cirrhosis","Microbiota","2025-05-05",{"date":99,"type":47},"2025-05-13",{"date":101,"type":47},"2025-03-01",{"date":103,"type":21},"2028-12",{"name":105,"class":54},"Shanghai Zhongshan Hospital",3,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":16,"sex":17,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":118,"briefSummary":120,"conditions":121,"keywords":126,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":84},"100562717","the-effects-of-cervical-and-thoracic-manipulation-therapy-applied-to-weightlifting-athletes-100562717","NCT06606795","The Effects of Cervical and Thoracic Manipulation Therapy Applied to Weightlifting Athletes","Inclusion Criteria:\n\n* Being a weightlifter,\n* Having asymptomatic dysfunction in the cervical and thoracic spine,\n* Not having received any manipulative treatment in the last six months,\n* Individuals who do not have a condition that prevents chiropractic manipulation treatment will be included in the study.\n\nExclusion Criteria:\n\n* Having had an injury related to the musculoskeletal system in the upper and lower extremities in the last month,\n* Having any neurological and psychiatric disorders,\n* Having cervical disc herniations,\n* Having a disorder related to the cardiac and respiratory systems,\n* Having an infectious, rheumatological, metabolic and endocrinological disorder,\n* Having dislocation, osteoporosis, ankylosing spondylitis, discopathy, rheumatoid arthritis,\n* Taking anticoagulant treatment,\n* Individuals who have recently undergone an operation involving the cervical and thoracic regions will not be included in the study.","13 Years","35 Years",{"count":116,"type":21},40,"INTERVENTIONAL",[119],"NA","The effects of manipulation therapy on the autonomic nervous system have been examined in the literature and while no sympathetic or parasympathetic changes were found after upper thoracic manipulation, a decrease in sympathetic data was observed after lower thoracic manipulation and an increase in parasympathetic data was observed. On the other hand, a different study found that thoracic manipulation did not cause any changes such as an increase or decrease in the autonomic nervous system. Therefore, although there are uncertainties in the autonomic role of manipulation therapy, its effect on respiration is intriguing when positive studies are considered.\n\nIn a study aiming to evaluate the effect of thoracic manipulation on respiratory function, segmental manipulation treatment was applied to healthy individuals by detecting the vertebrae in the thoracic region where normal joint movements were lost, and it was determined that the respiratory functions of the manipulation group improved significantly compared to the group that did not receive treatment. In another study conducted on healthy individuals, the subjects were divided into manipulation group, exercise and manipulation group and control groups. At the end of the study, it was determined that there was a significant increase in the respiratory functions of the participants in the manipulation group, while an additional increase was observed in the group combined with exercise, but this was not significant. No change was observed in the control group.\n\nWhen the literature is examined, it is noteworthy that the effects of manipulation treatments on respiration remain unclear, and especially the inadequacy of studies on Olympic-style weightlifters and the ongoing search for increasing athletic performance in this area.\n\nThis study aims to examine the effects of cervical and thoracic manipulation treatments on respiratory muscle strength, respiratory functions and cervical and thoracic region joint range of motion in weightlifters.\n\nThe main question it aims to answer is:\n\n\\- Is cervical and thoracic manipulation therapy applied to Olympic style weightlifters effective on respiration?",[122,123,32,124,125],"Weightlifting","Breathing","Athlete","Spinal Manipulation",[122,127,123,125,124],"Chiropractic","2024-09-19",{"date":130,"type":47},"2024-09-23",{"date":132,"type":21},"2024-10-04",{"date":134,"type":21},"2025-04-01",{"name":136,"class":54},"Selcuk University"]