[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"breathing-techniques\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:breathing-techniques":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,69,111,144,165],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100619277","early-intervention-for-postpartum-ptsd-comparing-written-exposure-and-capnometry-guided-breathing-therapy-100619277",false,"NCT07342530","Early Intervention for Postpartum PTSD: Comparing Written Exposure and Capnometry-Guided Breathing Therapy","Early Intervention for Postpartum PTSD: Comparing Written Exposure and Capnometry Guided Breathing Therapy","Inclusion Criteria:\n\n* Age ≥18\n* Delivered a live infant within 5 days\n* Severe maternal morbidity or infant admitted to NICU\n* PCL-5 ≥28\n* English-speaking\n* Able to consent and participate\n\nExclusion Criteria:\n\n* Active psychosis or mania\n* Current suicidal crisis\n* Current suicidal intent or plan\n* Cognitive impairment preventing participation","FEMALE","18 Years",{"count":19,"type":20},70,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to examine two early interventions, Written Exposure Therapy and Capnometry Guided Breathing, to reduce post-traumatic stress disorder (PTSD) symptoms in women after childbirth as compared to usual care.",[26,27,28,29],"Written Exposure Therapy","Breathing Techniques","PTSD (Childbirth-Related)","Postpartum Care","RECRUITING","2026-04-21",{"date":33,"type":34},"2026-04-24","ACTUAL",{"date":36,"type":34},"2026-03-09",{"date":38,"type":20},"2027-12",{"name":40,"class":41},"Stanford University","OTHER",2,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100631819","breathing-and-decision-making-prolex-context-100631819","NCT07505641","Breathing and Decision-Making (ProlEx-Context)","ProlEx-Context","Inclusion Criteria:\n\n* 18- to 40-year-old men and women\n* Consent to participate\n* Fluent in German\n* Right-handed\n* Physically and mentally healthy without regular medication\n* Body-mass index of 18-25 kg\u002Fm2\n* Alcohol consumption of less than 15 glasses a week (equivalent to one glass of wine\u002Fbeer, a glass of higher-percentage alcohol counts as two glasses of beer)\n* No illegal drug consumption in the week previous to the experiment\n* No smoking\n* No competitive athletes\n* Normal day-night rhythm (no shift work)\n* Normal vision without required vision correction (i.e., glasses, contact lenses; ability to clearly read texts at a distance of up to 50 cm without vision aids)\n\nExclusion Criteria:\n\n* Former or current illnesses of:\n* Brain or mind (including anxiety disorders, depression, eating disorders, personality disorders, alcohol, drugs or drug dependence, neurological disorders other than occasional headache, psychiatric or neurological abnormalities)\n* Heart or blood circulation\n* Lung Diseases\n* Other serious past or present medical conditions (for example, metabolic syndrome, diabetes)\n* Current medication and medication over a period of two weeks prior to the examination\n* Other serious health problems or present strong mental or physical stress\n* Current infection or excessive stress\n* Missing consent to receive information about incidental findings from the MRI\n* Tendency to claustrophobia, dizziness, or panic attacks\n* Wearing a non-removable pacemaker, defibrillator, hearing aid, drug pump, neurostimulator or implant with solenoid valve (e.g., artificial bowel outlet)\n* Metal parts or implants inside the body, for example, due to surgery or injury with a metallic foreign object (e.g., hip replacements, artificial joints, heart valves, vessel occlusions or dilatations, surgical clips, bone screws or plates, coil, shunts, catheters, electrodes, coils, radiation sources, shrapnel, projectiles, stents)\n* Having non-removable metal parts or metal-containing devices on or in the body\n* Having ferromagnetic metal parts or implants inside the body (e.g., hip replacements, artificial joints, heart valves, vessel occlusions or dilatations, surgical clips, bone screws or plates, coils, shunts, catheters, electrodes, coils, radiation sources, shrapnel, projectiles, stents)\n* Wearing magnetically fixed implants (e.g. amalgam fillings, glass eye)\n* Professionally or privately being involved in the processing of ferromagnetic metals\n* Large tattoos (whole limbs)\n* Pregnancy\n* Wearing an intra-uterine device\n* Having tinnitus\n* Extensive lung function (e.g. apnoe diver, singer, professional musician with lung-involving instruments)\n* Previous participation in the ProlEx-MRI study (the precursor to the current study)",true,"ALL","40 Years",{"count":54,"type":20},50,[23],"The ProlEx-Context study aims to investigate how a slow-paced breathing technique with prolonged exhalation affects decision-making in the context of acute social stress.",[27,58,59],"Stress Management","Decision-Making","NOT_YET_RECRUITING","2026-03-26",{"date":63,"type":34},"2026-04-01",{"date":63,"type":20},{"date":66,"type":20},"2027-04-01",{"name":68,"class":41},"German Institute of Human Nutrition",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":50,"sex":51,"minAge":76,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":21,"phases":79,"briefSummary":80,"conditions":81,"keywords":95,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":4},"100628685","feasibility-of-breathwork-intervention-with-older-adults-after-knee-surgery-100628685","NCT07464860","Feasibility of Breathwork Intervention With Older Adults After Knee Surgery","A Box Breathing Intervention and the Surgical Stress Response in Older Adults Undergoing Total Knee Arthroplasty: A Randomized Controlled Feasibility Trial","Adults aged 65 years or older of any sex, gender and ethnic background who meet the following criteria will be eligible to enroll in the present study:\n\nInclusion Criteria:\n\n* scheduled for elective TKA within the next week to two months (can be second knee, but cannot be a revision of the original knee)\n* self-reported good health, including denial of debilitating illness that may affect participation in or be potentially exacerbated by deep, controlled breathing (i.e., chronic obstructive pulmonary disorder \\[COPD\\], symptomatic or advanced heart failure, complete heart block, glaucoma, epilepsy)\n* denial of conditions that alter cortisol release or that require corticosteroid therapy (i.e., Cushing's syndrome, Addison's disease, pituitary tumors, adrenal gland tumors, asthma)\n* denial of severe psychiatric or cognitive conditions that warrant the need for a durable power of attorney (DPOA)\n* able to understand written and verbal English.\n\nExclusion Criteria:\n\n* currently taking oral, injectable, intranasal, topical, or inhaled corticosteroid medications (i.e., prednisone, hydrocortisone, dexamethasone, methylprednisolone, methylprednisolone acetate, triamcinolone, betamethasone, mometasone, fluticasone, budesonide, clobetasol)\n* do not have the technology requirements to complete data collection (i.e., participant does not have a smartphone, tablet, laptop, or desktop computer; lack of reliable internet)\n\nThe following exclusion criteria may affect participants' ability to remain in the study following enrollment:\n\n• Development of complications during surgery that require prolonged hospitalization into Postoperative Day (POD) 2 (e.g., postoperative intubation and ventilation requirements, intractable pain, intractable nausea\u002Fvomiting, signs of infection or sepsis)","65 Years",{"count":78,"type":20},32,[23],"Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients. Older adults (≥65 years) are particularly vulnerable to postoperative complications and their associated morbidities due to the biological aging process. Older adults comprise nearly half of surgical patients worldwide, and this number is expected to increase in the next 10-20 years as the aging population continues to grow. TKA is the most common procedure undergone by older adults, and the rate of TKA procedures is also expected to rise. Despite perioperative guidelines and protocols to prevent postoperative complications, the prevalence of postoperative complications following TKA is approximately 12%. Given these statistics, millions of older adults undergoing TKA may be at risk for postoperative complications and their associated morbidities in the coming decades. Therefore, additional interventions are needed to combat postoperative complications in this population.\n\nThe body's natural response to surgery, also known as the surgical stress response (SSR), contributes to postoperative complications through complex mechanisms involving the autonomic nervous system (ANS). Increased sympathetic nervous system (SNS) activity, or the body's fight-or-flight response, causes dysregulation in feedback systems that regulate the stress response, potentially leading to poorer outcomes. Interventions, such as breathwork, that induce the parasympathetic nervous system (PNS), or the body's rest-and-digest response, have been shown to balance the ANS, regulate stress biology, and improve outcomes. This study will examine the feasibility of adding a breathwork intervention (Box Breathing), compared to an attention control, to standard perioperative care for older adults undergoing TKA. This study will also examine the proof of concept that Box Breathing, compared to an attention control, may help regulate the SSR by assessing an objective measure of stress-related biology, diurnal cortisol rhythm, and gathering self-report information on pain, anxiety, depression, and quality of recovery following TKA.",[82,83,84,85,27,86,87,88,89,90,91,92,93,94],"Surgical Stress Response","Stress Physiological","Stress Physiology","Stress Psychological","Breathing Exercises","Hypothalamic Pituitary Adrenal","Relaxation","Relaxation Therapy","Cortisol","Postoperative Pain","Postoperative Anxiety","Postoperative Depression","Quality of Recovery (QoR-15)",[82,96,97,98,86,27,99,91,92,93,100,101],"Total Knee Arthroplasty","Hypothalamic-Pituitary-Adrenal Axis","Breathwork","Postoperative Complications","Quality of Recovery","Diurnal Cortisol Rhythm","2026-03-06",{"date":104,"type":34},"2026-03-11",{"date":106,"type":20},"2026-04-06",{"date":108,"type":20},"2026-09-30",{"name":110,"class":41},"University of Arizona",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":51,"minAge":17,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":21,"phases":120,"briefSummary":121,"conditions":122,"keywords":127,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":4},"100621908","effects-of-controlled-breathing-on-cardiorespiratory-variables-in-multiple-myeloma-100621908","NCT07376733","Effects of Controlled Breathing on Cardiorespiratory Variables in Multiple Myeloma","Efficacy of a Controlled Breathing and Therapeutic Exercise Program on Cardiorespiratory Variables in Patients With Multiple Myeloma","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Confirmed diagnosis of multiple myeloma, currently undergoing active treatment with daratumumab, and under clinical follow-up by the Hematology Department of HU12O.\n* Explicit medical indication for supervised physical activity issued by the responsible hematologist and documented in the medical record.\n* No scheduled hematopoietic stem cell transplantation within the 60 days following the planned start date of the intervention (verified through medical record review).\n* Functional status of ECOG 0-2 (Eastern Cooperative Oncology Group), assessed by a healthcare professional from the Hematology Department, ensuring the ability to perform at least basic and light instrumental activities of daily living, including independent ambulation.\n* Access to a smartphone with stable internet connection, required for monitoring and recording adherence to the intervention.\n* Ability to provide written informed consent, demonstrating understanding of the study's nature, purpose, and procedures.\n\nExclusion Criteria:\n\n* Medical risk contraindicating exercise or breathing techniques:\n\n  * Clinically significant cardiovascular disease, including:decompensated heart failure, acute myocardial infarction within the past 3 months, clinically uncontrolled arrhythmias, unstable angina, acute-phase deep vein thrombosis or pulmonary embolism, pacemakers or cardiac devices whose monitoring parameters contraindicate supervised exercise according to cardiology.\n  * Severe decompensated respiratory disease, such as acute exacerbation of COPD, severe respiratory insufficiency, or persistently low resting oxygen saturation \\\u003C 90% (not correctable).\n* High musculoskeletal or bone risk:\n\n  * Extensive lytic bone lesions, high risk of pathological fracture, or unstable vertebral fracture, documented by imaging or based on the assessment of the Hematology\u002FTraumatology specialist.\n  * Uncontrolled pain that prevents safe participation in an exercise program.\n* Hematologic or systemic conditions contraindicating exercise:\n\n  * Severe anemia: hemoglobin \\\u003C 9 g\u002FdL in women or \\\u003C 8 g\u002FdL in men (latest laboratory test ≤ 14 days).\n  * Active systemic infection contraindicating exercise, fever ≥ 38 °C, or neutropenia \\\u003C 0.5 × 10⁹\u002FL.\n  * Severe cytopenias that, in the opinion of the hematologist, preclude moderate exercise.\n* Functional or procedural limitations:\n\n  * Inability to remain in the supine position for ≥ 5 minutes, required for part of the breathing intervention.\n  * Confirmed pregnancy or reasonable suspicion of pregnancy.\n  * Severe cognitive impairment, major psychiatric disorders, or neurological diseases that limit understanding of the procedures or safe participation.\n  * Significant difficulty understanding the language (spoken or written) that prevents following essential instructions or completing validated questionnaires.",{"count":119,"type":20},26,[23],"A randomized, parallel, double-blind, controlled, clinical trial. Two groups of participants will be included, both receiving a therapeutic exercise intervention and an educational session on the importance of proper breathing over a 6-week period. One of the groups will additionally perform a home-based controlled breathing exercise protocol. Pre- and post-intervention assessments (6 weeks) will be conducted, along with a follow-up evaluation 4 weeks after completion of the intervention. The goal is to determine the effectiveness of adding a controlled breathing exercise program to a therapeutic exercise intervention on cardiorespiratory variables in individuals with multiple myeloma.",[123,27,86,124,125,126],"Multiple Myeloma (MM)","Exercise Activity","Diaphragmatic Breathing","Heart Rate Variability (HRV)",[128,129,130,131,132,133,134],"multiple myeloma","Breathing","Diaphragmatic breathing","Slow breathing","exercise activity","Breathing exercises","heart rate variability","2026-01-21",{"date":137,"type":34},"2026-01-29",{"date":139,"type":20},"2026-01",{"date":141,"type":20},"2026-09",{"name":143,"class":41},"Universidad Complutense de Madrid",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":51,"minAge":17,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":21,"phases":152,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":162,"leadSponsor":164,"locationsCount":4},"100617001","effects-of-controlled-breathing-added-to-therapeutic-exercise-in-multiple-myeloma-100617001","NCT07312942","Effects of Controlled Breathing Added to Therapeutic Exercise in Multiple Myeloma","Effects of Adding a Controlled Breathing Protocol to a Therapeutic Exercise Program in Adults With Multiple Myeloma","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Confirmed diagnosis of multiple myeloma, currently undergoing active treatment with daratumumab, and under clinical follow-up by the Hematology Department of HU12O.\n* Explicit medical indication for supervised physical activity issued by the responsible hematologist and documented in the medical record.\n* No scheduled hematopoietic stem cell transplantation within the 60 days following the planned start date of the intervention (verified through medical record review).\n* Functional status of ECOG 0-2 (Eastern Cooperative Oncology Group), assessed by a healthcare professional from the Hematology Department, ensuring the ability to perform at least basic and light instrumental activities of daily living, including independent ambulation.\n* Access to a smartphone with stable internet connection, required for monitoring and recording adherence to the intervention.\n* Ability to provide written informed consent, demonstrating understanding of the study's nature, purpose, and procedures.\n\nExclusion Criteria:\n\n* Medical risk contraindicating exercise or breathing techniques:\n\n  +Clinically significant cardiovascular disease, including: decompensated heart failure, acute myocardial infarction within the past 3 months, clinically uncontrolled arrhythmias, unstable angina, acute-phase deep vein thrombosis or pulmonary embolism, pacemakers or cardiac devices whose monitoring parameters contraindicate supervised exercise according to cardiology.\n  * Severe decompensated respiratory disease, such as acute exacerbation of COPD, severe respiratory insufficiency, or persistently low resting oxygen saturation \\\u003C 90% (not correctable).\n* High musculoskeletal or bone risk:\n\n  * Extensive lytic bone lesions, high risk of pathological fracture, or unstable vertebral fracture, documented by imaging or based on the assessment of the Hematology\u002FTraumatology specialist.\n  * Uncontrolled pain that prevents safe participation in an exercise program.\n* Hematologic or systemic conditions contraindicating exercise:\n\n  * Severe anemia: hemoglobin \\\u003C 9 g\u002FdL in women or \\\u003C 8 g\u002FdL in men (latest laboratory test ≤ 14 days).\n  * Active systemic infection contraindicating exercise, fever ≥ 38 °C, or neutropenia \\\u003C 0.5 × 10⁹\u002FL.\n  * Severe cytopenias that, in the opinion of the hematologist, preclude moderate exercise.\n* Functional or procedural limitations:\n\n  * Inability to remain in the supine position for ≥ 5 minutes, required for part of the breathing intervention.\n  * Confirmed pregnancy or reasonable suspicion of pregnancy.\n  * Severe cognitive impairment, major psychiatric disorders, or neurological diseases that limit understanding of the procedures or safe participation.\n  * Significant difficulty understanding the language (spoken or written) that prevents following essential instructions or completing validated questionnaires.",{"count":78,"type":20},[23],"A randomized, parallel, double-blind, controlled, multicenter clinical trial with two intervention arms. Two groups of participants will be included, both receiving a therapeutic exercise intervention and an educational session on the importance of proper breathing over a 6-week period. One of the groups will additionally perform a home-based controlled breathing exercise protocol. Pre- and post-intervention assessments (6 weeks) will be conducted, along with a follow-up evaluation 4 weeks after completion of the intervention.\n\nThe goal is to determine the effectiveness of adding a controlled breathing exercise program to a therapeutic exercise intervention on somatic symptoms in individuals with multiple myeloma",[155,27,86,124,125],"Multiple Myeloma",[157,129,130,131,132,133],"Multiple myeloma","2026-01-15",{"date":160,"type":34},"2026-01-20",{"date":139,"type":20},{"date":163,"type":20},"2026-07",{"name":143,"class":41},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":51,"minAge":172,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":21,"phases":176,"briefSummary":177,"conditions":178,"keywords":183,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":197},"100594912","effects-of-buteyko-breathing-exercise-in-children-with-uncontrolled-asthma-100594912","NCT07025616","Effects of Buteyko Breathing Exercise in Children With Uncontrolled Asthma","Effectiveness of Buteyko Breathing Exercise in Children With Uncontrolled Asthma: A Single Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Children aged 7-17 years\n2. Uncontrolled or partially controlled asthma (GINA Symptom Control Tool score \\> 1)\n3. Receive bronchodilator therapy, either oral or inhaler from a pediatrician.\n4. Children and parents\u002Fcare givers agree to participate in the study until the end, and parents\u002Fcare givers sign the informed consent form.\n5. Can understand instructions.\n\nExclusion Criteria:\n\n1. Inpatients\n2. Have received Buteyko breathing exercises or other breathing exercises.\n3. Have congenital heart disease, pneumonia, or other significant and uncontrolled health disorders.\n4. Have severe physical disabilities or mental retardation that could potentially prevent the implementation of Buteyko breathing exercises.\n5. Have contraindications for spirometry examination","7 Years","17 Years",{"count":175,"type":20},74,[23],"This randomized controlled trial study aimed to measure the effectiveness of the combination of 4-weeks Buteyko breathing exercises and pharmacological therapy compared with pharmacological therapy alone in children with uncontrolled asthma.",[27,179,180,181,182],"Asthma Control Level","Asthma in Children","Asthma Patients","Breathing Exercise",[184,185,186,187],"Asthma","Buteyko","breathing retraining","pediatrics","2025-06-13",{"date":190,"type":34},"2025-06-17",{"date":192,"type":20},"2025-06",{"date":194,"type":20},"2025-12",{"name":196,"class":41},"Ivan Sofian Wibowo",1]