[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bronchial-hyperresponsiveness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bronchial-hyperresponsiveness":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100595334","methacholine-challenge-test-in-school-children-withwithout-asthma-riska-100595334",false,"NCT07031102","Methacholine Challenge Test in School Children With\u002FWithout Asthma RISKA","RISKA: Respiratory Irritability With School Kids With\u002FWithout Asthma - Assessment of Methacholine Responsiveness in Pediatric Asthma: A Comparative Study With Healthy Controls","RISKA","Inclusion Criteria: Healthy Controls\n\n* • Aged 7-15 years, both sexes\n\n  * No diagnosis of asthma in childhood\n  * No inhaled asthma medication during the previous 2 years\n  * No wheezing or shortness of breath during the previous 2 years\n  * Written informed consent from the participant and guardian\n\nInclusion Criteria: Children with Asthma\n\n* Aged 7-15 years, both sexes\n* Physician-diagnosed asthma (ICD-10 codes J45.0\u002FJ45.1\u002FJ45.9)\n* Inhaled corticosteroid treatment for at least 6 months\n* Either:\n\n  * Well-controlled asthma (c-ACT\u002FACT score ≥20) and no clinical need to intensify medication, or\n  * Poorly controlled asthma with physician-confirmed need for intensified asthma medication\n\nExclusion Criteria:\n\n* • Premature birth before 32 gestational weeks\n\n  * Other chronic cardiopulmonary or neurological conditions affecting airways (excluding asthma)\n  * Severe underlying illness such as malignancy\n  * Beta-blocker medication\n  * Active immunological disease",true,"ALL","7 Years","15 Years",{"count":22,"type":23},260,"ESTIMATED","OBSERVATIONAL","The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.",[27,28,29],"Asthma Bronchiale","Lung Function Tests","Bronchial Hyperresponsiveness",[31,32,33,34,35],"Asthma","Lung function test","children","Methacholine challange test","Bronchial provocation test","RECRUITING","2025-06-12",{"date":39,"type":40},"2025-06-22","ACTUAL",{"date":42,"type":40},"2024-11-06",{"date":44,"type":23},"2027-12",{"name":46,"class":47},"Helsinki University Central Hospital","OTHER"]