[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brown-adipose-tissue\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brown-adipose-tissue":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100596664","intermittent-cold-exposure-and-brown-adipose-tissue-hyperplasia-100596664",false,"NCT07048405","Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia","Investigating the Cellular Heterogeneity of Human Brown Adipose Tissue and Its (Patho)Physiological Regulation","ICEBATH","Inclusion Criteria:\n\n* Aged 18-40 years\n* Body mass index 18.5-25 kg\u002Fm2\n* Weight change of less than 5% in the past 6 months\n* No acute or chronic medical conditions\n* On no regular medications (other than contraceptives in female participants)\n* No claustrophobia\n* Alcohol intake ≤14 units\u002F week\n* Screening blood tests within acceptable limits (of no clinical significance)\n* Not currently pregnant, lactating or breastfeeding (female participants only)\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Not meeting inclusion criteria\n* Contra-indication to PET\u002FCT scan\n* Allergy to local anaesthetic",true,"ALL","18 Years","40 Years",{"count":22,"type":23},12,"ESTIMATED","INTERVENTIONAL",[26],"NA","This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health. While intermittent cold exposure has been shown to increase BAT activity and mass, as measured by fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography\u002Fcomputed tomography (PET\u002FCT) scans, the molecular adaptations within BAT and other thermogenic tissues including skeletal muscle and white adipose tissue (WAT) remain poorly understood.\n\nHealthy adults aged 18 to 40 years (6 males and 6 females) will participate in a 10-day cold acclimation protocol (2 hours per day using water-perfused cooling blankets). The primary objective is to determine how cold exposure alters cellular heterogeneity and gene expression in BAT, WAT, and skeletal muscle.\n\nParticipants will undergo baseline assessments, including measurements of energy expenditure, core and skin temperature, muscle activity, and blood sampling, each performed in both warm and cold conditions. These assessments will be followed by dynamic total-body PET\u002FCT imaging during cold exposure and tissue biopsies from BAT, subcutaneous WAT, and skeletal muscle. These procedures will be repeated after the cold acclimation protocol to evaluate physiological and molecular changes. Additional outcomes include changes in energy expenditure, cold tolerance, and immune cell responses induced by cold exposure.",[29,30,31],"Brown Adipose Tissue","Cold Exposure","18F-FDG PET\u002FCT",[29,30,31],"RECRUITING","2026-06-29",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":37},"2025-05-01",{"date":41,"type":23},"2027-07",{"name":43,"class":44},"University of Edinburgh","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100638613","brown-adipose-tissue-as-a-mechanistic-determinant-of-semaglutide-treatment-response-in-obesity-bat-sema-study-100638613","NCT07621640","Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study)","Brown Adipose Tissue as a Mechanistic Determinant of GLP-1 Receptor Agonist Treatment Response in Adults With Obesity: A Multicenter Prospective Cohort Study Using ¹⁸FDG-PET\u002FCT and Cold Stimulation Protocol","BAT-Sema","Inclusion Criteria:\n\n1. Age 20-70 years at the time of enrollment\n2. Initiating semaglutide (Wegovy) treatment for obesity (newly starting treatment)\n3. BMI ≥ 27 kg\u002Fm² with at least one weight-related comorbidity:\n\n   * Hypertension (SBP ≥130 or DBP ≥80 mmHg, or on antihypertensive medication)\n   * Dyslipidemia (LDL-C ≥130, TG ≥150, or low HDL-C, or on lipid-lowering medication)\n   * Non-alcoholic fatty liver disease (NAFLD\u002FMASLD, confirmed by imaging or ALT\u002FAST ≥1.5× ULN)\n   * Obstructive sleep apnea (AHI ≥5\u002Fhr or clinically diagnosed)\n   * Established cardiovascular disease (CAD, stroke, PAD)\n   * Obesity-related osteoarthritis of knee or hip with functional impairment OR BMI ≥ 30 kg\u002Fm² (regardless of comorbidity)\n4. Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n1. Diagnosis of type 1 or type 2 diabetes mellitus\n2. History of neck surgery or radiation therapy to the neck\n3. Use of anti-obesity medications within 1 month prior to enrollment, or current use of beta-adrenergic blocking agents\n4. Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2)\n5. Active malignancy, severe renal disease (eGFR \\\u003C30 mL\u002Fmin\u002F1.73m²), severe hepatic disease, or other severe endocrine disorders\n6. Pregnancy or breastfeeding\n7. Severe psychiatric illness or cognitive impairment precluding informed consent\n8. Contraindication to MRI (pacemaker, cochlear implant, non-MRI-compatible implants)\n9. Severe claustrophobia","20 Years","70 Years",{"count":57,"type":23},80,[26],"This study investigates whether the activity of brown adipose tissue (BAT) - a special type of fat that burns energy as heat - can predict how well individuals with obesity respond to semaglutide (Wegovy), a once-weekly injectable weight loss medication. Participants who are starting semaglutide treatment will undergo ¹⁸FDG-PET\u002FCT imaging before and after 24 weeks of treatment. Prior to each PET\u002FCT scan, participants will wear a water-circulating cooling vest to activate BAT. By measuring BAT activity at baseline and comparing it with the degree of weight loss and metabolic improvement at 24 weeks, the investigators aim to identify BAT as a predictive biomarker for personalized obesity treatment.",[61,62,29],"Obesity","Metabolic Syndrome",[64,65,66,61,67,68,69,70,71],"Brown adipose tissue","Semaglutide","GLP-1 receptor agonist","FDG-PET\u002FCT","BAT","Biomarker","Weight loss","PDFF","NOT_YET_RECRUITING","2026-05-27",{"date":75,"type":37},"2026-06-02",{"date":77,"type":23},"2026-06",{"date":79,"type":23},"2031-02",{"name":81,"class":44},"Hallym University",2,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":94,"conditions":95,"keywords":101,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":82},"100577805","investigation-of-the-mechanisms-of-the-tendency-to-hypothermia-in-newborns-and-premature-neonates-100577805","NCT06803069","Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Neonates","Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Infants During Surgical Interventions and in the Intensive Care Unit (Non-Interventional, Single-Center, Prospective Clinical Research)","Inclusion Criteria:\n\n* For Substudy 1: Patients admitted to the Neonatal Intensive Care Unit at the University of Pécs, Department of Obstetrics and Gynaecology (premature infants or those in neonatal intensive care).\n* For Substudy 2: Patients under 2 years of age undergoing elective surgery lasting more than 30 minutes at the University of Pécs, Department of Paediatrics.\n* For both substudies: Written consent for participation in the study has been provided by the patient's parent, guardian, or legal representative.\n\nExclusion Criteria:\n\n* For both substudies: If the patient cannot be mobilized (e.g., during the post-operative phase of abdominal or thoracic surgery; presence of chest tubes for pneumothorax or other reasons; hemodynamic instability; need for continuous electrocardiogram (ECG) monitoring; or use of an external pacemaker).\n* The patient's parent, guardian, or legal representative does not consent to the study or withdraws their consent at any point.\n* For Substudy 2: if the patient is older than 2 years.","2 Years",{"count":92,"type":23},100,"OBSERVATIONAL","Newborns have thermoregulatory mechanisms that differ from those of adults. Instead of producing heat through shivering, newborns primarily rely on non-shivering thermogenesis by the brown adipose tissue. The development of this thermogenic tissue starts around the 26th gestational week and continues until shortly before birth, after which no further growth occurs. As a result, premature infants, who have less developed brown fat, are more prone to reduced heat production and are at higher risk for hypothermia. There are few human studies examining the thermoregulatory differences and mechanisms between full-term and premature neonates, and the findings remain inconclusive.\n\nIn this study, the investigators aim to conduct a prospective, observational research. Researchers will compare body temperature, brown adipose tissue activity, and specific plasma markers between full-term and premature neonates in insensive care units and during elective surgeries.",[96,29,97,98,99,100],"Neonatal Hypothermia","Preterm and Term Infants","Neonate","Thermogenesis","Blood Markers",[102,103,104,105,106,107,108],"brown adipose tissue","neonate","neonatal hypothermia","preterm","nonshivering thermogenesis","infant","newborn","2025-02-18",{"date":111,"type":37},"2025-02-19",{"date":113,"type":37},"2024-07-01",{"date":115,"type":23},"2029-07-01",{"name":117,"class":44},"University of Pecs"]