[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bruxism\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bruxism":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,44,76,108,133,169,194,224,243,271,300,328,353,380,406,430,458,478,499,523,543],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100642065","bruxism-therapy-of-facial-pain-100642065",false,"NCT07611643","Bruxism Therapy of Facial Pain","Effect of Therapy for Myofascial Facial Pain on Bruxism\u002FNocturnal Clenching. Prospective, Non-profit Interventional Study Using a Device.","BRUXI","Inclusion Criteria:\n\n* Adult subjects aged ≥ 18 years\n* Subjects willing to provide written informed consent\n* Patients with temporomandibular disorders who have an indication for treatment with a gnathological occlusal splint\n\nExclusion Criteria:\n\n* Patients who change their pharmacological regimen during the monitoring period, as drug therapy may affect facial pain and\u002For muscle activity.",true,"ALL","18 Years",{"count":21,"type":22},42,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective, non-profit study aims to better understand how occlusal splints (gnathological splints) affect daytime and nighttime bruxism (teeth grinding) and clenching in adults with chronic myofascial pain of the jaw muscles, a common form of temporomandibular disorder (TMD). Bruxism and clenching are repetitive or sustained jaw muscle activities that can contribute to jaw pain and dysfunction, and their accurate diagnosis requires instrumental assessment of muscle activity. In this study, muscle activity will be objectively measured using a portable device (dia-BRUXO®) worn for 24 hours, which records the electrical activity of the chewing muscles during both wakefulness and sleep. Adult patients with TMD who are prescribed a night-time occlusal splint will undergo three 24-hour recordings: before using the splint, two weeks after starting treatment, and two months later. During each recording, participants will also report their facial pain levels and awareness of clenching or grinding during the day. Their results will be compared with those of a matched control group without TMD. The main goal is to compare jaw muscle activity between patients and healthy individuals, while secondary goals include analyzing how long the muscles are active and how these patterns relate to symptoms. By combining objective measurements and patient-reported experiences, this study seeks to clarify how occlusal splints influence muscle activity and symptoms, helping clinicians improve diagnosis and treatment of bruxism and TMD.",[28,29,30],"Bruxism","Bruxism, Sleep-Related","Sleep Quality","RECRUITING","2026-06-15",{"date":34,"type":35},"2026-06-17","ACTUAL",{"date":37,"type":35},"2026-01-12",{"date":39,"type":22},"2027-01-10",{"name":41,"class":42},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100643150","early-phase-1-botulinum-toxin-a-for-bruxism-using-digital-occlusal-analysis-100643150","NCT07640035","Botulinum Toxin-A for Bruxism Using Digital Occlusal Analysis","Objective Assessment of Bruxism and Treatment Response Using Digital Occlusal Analysis: A Clinical Study of Botulinum Toxin-A","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Diagnosis of bruxism based on self-report and clinical assessment\n* Systemically healthy individuals\n* Angle Class I occlusion\n* Ability and willingness to provide written informed consent and comply with study procedures\n\nExclusion Criteria:\n\n* Presence of temporomandibular joint pathology\n* Neuromuscular disorders\n* Pregnancy or lactation\n* Known allergy or hypersensitivity to Botulinum Toxin-A\n* Use of medications that may affect muscle function\n* Missing posterior teeth\n* Ongoing orthodontic treatment\n* Angle Class II or Class III malocclusion\n* Previous Botulinum Toxin injection into the masseter muscles","64 Years",{"count":53,"type":22},36,[55],"EARLY_PHASE1","Bruxism is a repetitive jaw-muscle activity that may lead to tooth wear, muscle pain, headaches, and functional limitations. Current diagnostic approaches mainly rely on self-reported symptoms and clinical examination findings, which may not accurately reflect ongoing muscle activity. Digital occlusal analysis systems offer an objective method for evaluating bite force and occlusal function.\n\nThe aim of this randomized, placebo-controlled clinical trial is to investigate whether a digital occlusal analysis system can objectively assess bruxism and monitor treatment response following Botulinum Toxin-A (BTX-A) injections. Thirty-six adults diagnosed with bruxism will be randomly assigned to receive either BTX-A injections or placebo injections into the masseter muscles.\n\nClinical examinations, patient-reported outcomes, and digital occlusal measurements will be collected at baseline and at 2 weeks, 3 months, and 6 months after treatment. Primary outcomes include bite force characteristics, force distribution, occlusion time, disocclusion time, and center of force. Secondary outcomes include pain intensity, maximum mouth opening, muscle tenderness, functional limitation scores, and self-reported bruxism-related symptoms.\n\nThis study aims to provide objective evidence regarding the usefulness of digital occlusal analysis in the diagnosis and follow-up of bruxism and to evaluate the effectiveness of Botulinum Toxin-A treatment using both objective and subjective outcome measures.",[28],[28,59,60,61,62,63,64,65],"Digital Occlusal Analysis","Bite Force","Masseter Muscle","Occlusal Force Distribution","Botulinum Toxin Type A","Masticatory Muscle Activity","Placebo-Controlled Trial","NOT_YET_RECRUITING","2026-06-05",{"date":69,"type":35},"2026-06-10",{"date":71,"type":22},"2026-07-20",{"date":73,"type":22},"2027-07-20",{"name":75,"class":42},"Bilecik Seyh Edebali Universitesi",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":18,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100639187","impact-of-distress-level-sleep-quality-and-occlusal-trauma-on-periodontal-status-among-bruxers-100639187","NCT07615153","Impact of Distress Level, Sleep Quality and Occlusal Trauma on Periodontal Status Among Bruxers","Impact of Distress Level, Sleep Quality and Occlusal Trauma on Periodontal Status Among Bruxers - a Cross Sectional Study","Inclusion Criteria:\n\nTest Group:\n\n* Adults aged 30-45 years\n* Patients diagnosed with periodontitis according to the 2017 World Workshop classification of periodontal and peri-implant diseases and conditions.\n* Patients who are probable bruxers according to BRUXSCREEN-Q\n* Minimum of 20 natural teeth\n\nControl Group:\n\n* Adults aged 30-45 years\n* Patients diagnosed with periodontitis according to the 2017 World Workshop classification of periodontal and peri-implant diseases and conditions.\n* Patients who are not probable bruxers according to BRUXSCREEN-Q\n* Minimum of 20 natural teeth\n\nExclusion Criteria:\n\n* Systemic conditions affecting periodontium (e.g., diabetes, auto immune disorders)\n* History of drugs having the potential impact on periodontal status like phenytoin, cyclosporin, calcium-channel blockers or antidepressant drugs\n* Patients with pulpal pathology\n* Pregnant or lactating females","30 Years","45 Years",{"count":86,"type":22},128,"OBSERVATIONAL","Increased distress levels and impaired sleep quality are known to exacerbate bruxism by enhancing masticatory muscle activity, leading to excessive and prolonged occlusal forces. These abnormal forces may result in occlusal trauma, which can compromise the adaptive capacity of the periodontal tissues by increasing tooth mobility, widening the periodontal ligament space, and accelerating alveolar bone loss, particularly in the presence of existing periodontal inflammation. Although occlusal trauma alone may not initiate periodontal disease, it can act as an important modifying factor in disease progression. Despite the recognized individual associations of distress, sleep quality, bruxism, and periodontal health, limited evidence exists regarding their combined impact on periodontal status among bruxers. Therefore, evaluating the influence of distress level, sleep quality, and occlusal trauma on periodontal status is essential to better understand disease progression and to facilitate comprehensive, multidisciplinary management strategies for individuals with bruxism.",[90,28,30,91,92],"Periodontitis","Distress Level","Occlusal Trauma",[94,95,96,97,98],"periodontits","bruxism","sleep quality","distress level","occlusal trauma","2026-06-01",{"date":101,"type":35},"2026-06-03",{"date":103,"type":22},"2026-06-22",{"date":105,"type":22},"2027-12-27",{"name":107,"class":42},"Postgraduate Institute of Dental Sciences Rohtak",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":18,"minAge":83,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":43},"100638717","psychological-resilience-perceived-stress-and-periodontal-status-among-bruxers-100638717","NCT07615140","Psychological Resilience, Perceived Stress and Periodontal Status Among Bruxers","Psychological Resilience as a Modifier of the Relationship Between Perceived Stress and Periodontal Status Among Bruxers: a Cross-sectional Study","Inclusion Criteria:\n\n* Patients with age group 30-50 years diagnosed with generalized periodontitis.\n* Probable bruxers (as per BruxScreen questionnaire)\n* Presence of minimum 20 teeth excluding third molars\n* Able to read\u002Funderstand Hindi or English (for questionnaires)\n\nExclusion Criteria:\n\n* Systemic diseases that may affect periodontal disease progression or outcome of treatment (diabetes, autoimmune diseases)\n* History of Periodontal treatment within last 6 months\n* History of Antibiotic use within the previous 3 months\n* History of Steroid, immunosuppressive and psychiatric drug use\n* Pregnant and lactating women\n* Smoking or substance abuse","50 Years",{"count":117,"type":22},75,"The present study aims to evaluate psychological resilience as a modifier of the relationship between perceived stress and periodontal status among bruxers. Given that both stress and inflammation share common neuroendocrine and immunological pathways, resilience may play a crucial role in buffering stress-induced periodontal breakdown. Understanding this relationship could shift periodontal management toward a biopsychosocial model, integrating psychological assessment and resilience enhancement with conventional non-surgical therapy. Such insights could help design personalized periodontal care strategies addressing both biological and psychological determinants of disease progression.",[90,28,120],"Perceived Stress",[122,95,123,124],"periodontitis","stress","resilience","2026-05-30",{"date":127,"type":35},"2026-06-02",{"date":129,"type":22},"2026-06-21",{"date":131,"type":22},"2026-12",{"name":107,"class":42},{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":23,"phases":144,"briefSummary":145,"conditions":146,"keywords":151,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":166,"locationsCount":4},"100638786","efficacy-and-safety-of-ha35-gel-nighttime-occlusive-application-for-tmd-pain-100638786","NCT07584642","Efficacy and Safety of HA35 Gel Nighttime Occlusive Application for TMD Pain","A Prospective, Single-Arm, Open-Label Pilot Clinical Study to Evaluate Efficacy and Safety of Nighttime Occlusive 10% 35 kDa Hyaluronan (HA35) Gel for Temporomandibular Joint Disorder (TMD) Pain and Muscle Over-Tension","HA35-TMJ","Inclusion Criteria:\n\n* Age 18-60 years, male or female\n* Clinically diagnosed with TMD with TMJ pain and\u002For muscle over-tension\n* Baseline TMJ pain NRS score ≥3\n* History of bruxism or jaw clenching\n* Ability to complete NRS assessments independently\n* Signed written informed consent\n\nExclusion Criteria:\n\n* TMJ treatment (medication, physical therapy, injection) within 2 weeks\n* Topical analgesic\u002Fanti-inflammatory use within 24 hours\n* Skin damage, allergy, or infection in the TMJ application area\n* Severe systemic disease (cardiovascular, diabetes, autoimmune)\n* Known hypersensitivity to hyaluronan or gel components\n* Pregnant or lactating women","60 Years",{"count":143,"type":22},30,[25],"This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of nighttime occlusive application of 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with temporomandibular joint disorder (TMD). Eligible participants will apply HA35 gel to the TMJ area nightly under occlusive conditions for 8-12 hours. The primary objectives are to assess rapid pain relief and muscle over-tension reduction at 60 seconds and 12 hours after application. Safety and local tolerability will be evaluated throughout the study period. This is a minimal-risk, non-pharmacological, non-invasive intervention.",[147,148,149,150,28],"Temporomandibular Joint Disorders","TMD","Temporomandibular Joint Pain","Jaw Muscle Over-Tension",[152,153,154,155,148,149,156,157,158,159],"Hyaluronan","35 kDa Hyaluronan","Nighttime Occlusive","TMJ","Muscle Over-Tension","Analgesia","Non-invasive Treatment","Pilot Clinical Study","2026-05-07",{"date":162,"type":35},"2026-05-13",{"date":164,"type":22},"2026-05-20",{"date":71,"type":22},{"name":167,"class":168},"Nakhia Impex LLC","INDUSTRY",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":178,"conditions":179,"keywords":181,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":43},"100637661","bruxism-anxiety-and-periodontal-status-among-dental-students-100637661","NCT07579416","Bruxism, Anxiety, and Periodontal Status Among Dental Students","An Observational Cross-Sectional Study of the Relationship Between Bruxism, Anxiety, and Periodontal Status Among Fourth- and Fifth-Year Dental Students at Al-Hawash Private University","Inclusion Criteria:\n\n* Undergraduate dental students in the fourth or fifth year.\n* Age 18 years or older.\n* Willing to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Orthodontic treatment.\n* Systemic disease affecting periodontal status.\n* Medications that may affect bruxism or anxiety.\n* Major psychiatric disorders.\n* Pregnancy, if relevant to periodontal assessment.\n* Incomplete questionnaire or incomplete clinical data.",{"count":177,"type":22},100,"This observational cross-sectional study aims to evaluate the relationship between bruxism, anxiety, and periodontal status among fourth- and fifth-year dental students at Al-Hawash Private University. Bruxism is a parafunctional habit that may be influenced by psychological stress and anxiety, and it may be associated with periodontal changes. Dental students are an important population to study due to their academic workload and potential stress exposure. The study will assess probable bruxism, anxiety levels, and periodontal parameters to identify possible associations between these variables.",[28,180],"Anxiety",[28,180,182,183,184,185],"Periodontal Status","Dental Students","Cross-sectional Study","Observational Study",{"date":187,"type":35},"2026-05-12",{"date":189,"type":35},"2026-03-20",{"date":191,"type":22},"2026-09",{"name":193,"class":42},"Al-Hawash Private University",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":17,"sex":201,"minAge":19,"maxAge":115,"enrollmentInfo":202,"targetDuration":4,"studyType":23,"phases":204,"briefSummary":205,"conditions":206,"keywords":210,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":222,"locationsCount":43},"100599904","effect-of-occlusal-splint-on-head-and-neck-muscles-in-patients-with-bruxism-and-myofascial-pain-100599904","NCT07090551","Effect of Occlusal Splint on Head and Neck Muscles in Patients With Bruxism and Myofascial Pain","Effect of Occlusal Splint on Head and Neck Muscles in Patients With Bruxism and Myofascial Pain: An Ultrasonographic Study","Inclusion Criteria:\n\nPatients who have presented to the Faculty of Dentistry at Istanbul University with temporomandibular disorder (TMD) complaints, Patients diagnosed with myospasm and\u002For myofascial pain syndrome in the masseter and\u002For temporalis muscles prior to treatment, Patients with no physical or mental disabilities, Patients over the age of 18, Patients who have not previously received any treatment for TMD.\n\nExclusion Criteria:\n\nPatients with any type of TMD other than masticatory muscle disorders, Patients who have previously received any form of TMD treatment, Patients under the age of 18.","FEMALE",{"count":203,"type":22},40,[25],"The study group will be selected from patients who previously presented with various temporomandibular disorder (TMD) complaints to the \"Temporomandibular Disorders Clinic\" of the Department of Complete and Removable Dentures at the Faculty of Dentistry, Istanbul University. During routine examinations, TMD-DC (Diagnostic Criteria for Temporomandibular Disorders) forms are completed to aid in achieving an accurate diagnosis. Subsequently, patients suspected of having TMD of masticatory muscle origin but without a definitive diagnosis are routinely referred for ultrasonographic (USG) imaging. Patients meeting these criteria will be included in the study.\n\nParticipants will be divided into two groups. The first group will consist of patients who have already undergone USG imaging during their routine examination, have been definitively diagnosed with masticatory muscle disorders based on clinical and radiographic findings, and have initiated routine occlusal splint therapy in the clinic. The 12-week treatment process of these patients will not be altered in any way. At the final follow-up session after the 12-week routine treatment protocol, the TMD-DC form completed at baseline will be re-administered, and the two forms will be compared to evaluate changes in symptoms and pain levels. Another USG imaging will also be performed at this session.\n\nThe second group, serving as the control group, will include patients who have previously undergone USG imaging during routine examination and have received a definitive diagnosis of masticatory muscle disorders based on clinical and radiographic evaluations, but have not yet begun treatment. Patients whose turn for treatment begins during the study period will be excluded from this group. At the end of the 12-week period, the TMD-DC form will be re-administered, and a second USG imaging will be performed. This process will not interfere with the patients' position in the treatment queue, and treatment will commence as scheduled. In the second USG session, changes in the thickness and elasticity of the masseter, temporalis, trapezius, sternocleidomastoid, and splenius capitis muscles will be assessed by comparing the two imaging records.",[207,208,209,28],"Myofacial Pain Syndrome","Local Myalgia","Masticatory Muscle Pain",[211,95,212,213,214,215],"myofacial pain syndrome","ultrasonography","occlusal splint","masseter muscle","splenius capitis muscle","2026-05-02",{"date":218,"type":35},"2026-05-05",{"date":220,"type":35},"2025-05-05",{"date":218,"type":22},{"name":223,"class":42},"Istanbul University",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":84,"enrollmentInfo":231,"targetDuration":4,"studyType":23,"phases":232,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":4},"100636553","comparison-of-the-effects-of-different-massage-techniques-in-individuals-with-bruxism-100636553","NCT07567183","Comparison of the Effects of Different Massage Techniques in Individuals With Bruxism","Comparison of the Effects of Different Massage Techniques on Pain, Orofacial Muscle Characteristics, Disability, and Sleep Quality in Individuals With Bruxism","Inclusion Criteria:\n\n* Possible diagnosis of sleep bruxism,\n* Reporting jaw or chewing muscle pain within the last 3 months\n\nExclusion Criteria:\n\n* Having any orthopedic, neurological, or psychiatric diagnosis,\n* Having systemic and\u002For degenerative disorders,\n* Neurological or psychiatric disorders (excluding anxiety and depression),\n* Using medications that affect sleep or motor behavior,\n* Having arthrogenic or mixed temporomandibular disorders,\n* Using an intraoral prosthesis,\n* Having a history of direct trauma or previous surgery in the orofacial region,\n* Using muscle relaxants and non-steroidal anti-inflammatory drugs,\n* Using a removable prosthesis,\n* Receiving any treatment for bruxism within the last 4 weeks.",{"count":21,"type":22},[25],"The aim of this study is to compare the effects of occlusal splint therapy and different massage techniques on pain intensity and orofacial muscle tone and stiffness in individuals with possible sleep bruxism. A secondary aim is to evaluate the effects of these interventions on oral parafunctional behaviors, disability, and sleep quality.",[28],"2026-04-28",{"date":218,"type":35},{"date":238,"type":22},"2026-05-01",{"date":240,"type":22},"2026-09-01",{"name":242,"class":42},"Okan University",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":17,"sex":18,"minAge":250,"maxAge":251,"enrollmentInfo":252,"targetDuration":4,"studyType":23,"phases":254,"briefSummary":255,"conditions":256,"keywords":257,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":43},"100635116","effect-of-night-guard-use-on-masseter-muscle-thickness-in-children-with-bruxism-100635116","NCT07548502","Effect of Night Guard Use on Masseter Muscle Thickness in Children With Bruxism","Ultrasonographic Assessment of Masseter Muscles in Pediatric Bruxism: Effects of Night Guard Therapy at 3 and 6 Month Intervals","Inclusion Criteria:\n\n1. Children aged 10-12 years\n2. Diagnosis of bruxism based on parental report and clinical findings\n3. Willingness to participate\n4. Parental consent and child assent obtained\n\nExclusion Criteria:\n\n1. Missing posterior teeth causing unilateral chewing\n2. History of psychological disorders\n3. Neurological disorders or craniofacial abnormalities\n4. Use of medications affecting muscle activity\n5. Presence of skeletal malocclusions\n6. Ongoing orthodontic treatment","10 Years","12 Years",{"count":253,"type":22},20,[25],"This prospective study aims to evaluate the clinical findings of bruxism and masseter muscle thickness in children aged 10-12 years using ultrasonography, and to assess the effects of night guard use on these parameters over time.",[28,29],[258,259,260,261],"Pediatric bruxism","Masseter muscle thickness","Ultrasonography","Night Guard","2026-04-23",{"date":264,"type":35},"2026-04-29",{"date":266,"type":35},"2026-03-15",{"date":268,"type":22},"2026-10",{"name":270,"class":42},"Nigde Omer Halisdemir University",{"id":272,"slug":273,"hasResults":11,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":278,"enrollmentInfo":279,"targetDuration":4,"studyType":23,"phases":281,"briefSummary":282,"conditions":283,"keywords":284,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":43},"100631903","effects-of-different-graston-technique-application-speeds-on-trapezius-muscle-stiffness-pressure-pain-threshold-pain-and-muscle-oxygenation-in-patients-with-bruxism-100631903","NCT07506733","Effects of Different Graston Technique Application Speeds on Trapezius Muscle Stiffness, Pressure Pain Threshold, Pain, and Muscle Oxygenation in Patients With Bruxism","A Study on the Effects of Different Application Speeds of the Graston Technique on Trapezius Muscle Stiffness, Pressure Pain Threshold, Pain Intensity, and Muscle Oxygenation in Individuals With Bruxism","Inclusion Criteria:\n\n* Diagnosed with bruxism.\n* Aged 18-55 years.\n* Presence of trigger points in the trapezius muscle, according to the criteria defined by Travell and Simons.\n\nExclusion Criteria:\n\n* Acute tears, tendon ruptures, or severe muscle injuries.\n* Conditions that prevent the application of the Graston Technique (e.g., skin lesions, open wounds, infections).\n* Having received botox injections in the temporomandibular joint (TMJ) region within the last 6 months.\n* Psychological disorders that may affect participation or measurements.","55 Years",{"count":280,"type":22},34,[25],"This randomized crossover study aims to address an important gap in manual therapy by examining the acute physiological effects of different Graston Technique application speeds (60 BPM vs. 120 BPM) on the dominant upper trapezius muscle in patients with bruxism. Although the Graston Technique is widely used, the specific impact of application speed on parameters such as muscle stiffness, muscle oxygenation, pressure pain threshold, and pain intensity remains under-investigated. By utilizing a crossover design with a 1-week washout period, this study allows for a precise within-subject comparison of the two speeds. The findings will clarify the optimal application frequency, providing objective data to guide the development of more effective, evidence-based manual therapy protocols for bruxism management.",[28],[285,286,287,288,289,290],"Graston technique","muscle stiffness","trapezius","oxygenation","pain","trigger points","2026-03-28",{"date":293,"type":35},"2026-04-02",{"date":295,"type":35},"2025-03-25",{"date":297,"type":22},"2026-04-30",{"name":299,"class":42},"Gazi University",{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":17,"sex":18,"minAge":307,"maxAge":308,"enrollmentInfo":309,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":310,"conditions":311,"keywords":315,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":43},"100626281","association-between-child-and-parental-stress-and-bruxism-in-children-aged-8-11-years-100626281","NCT07433595","Association Between Child and Parental Stress and Bruxism in Children Aged 8-11 Years","A Prospective Observational Case-Control Study on the Association Between Child and Parental Stress and Bruxism in Children Aged 8-11 Years","Inclusion Criteria:\n\nChildren aged 8-11 years Mixed or permanent dentition Presentation to the Department of Pediatric Dentistry For bruxism group: clinically diagnosed bruxism For control group: absence of clinical signs of bruxism Written informed consent obtained from parent\u002Flegal guardian\n\nExclusion Criteria:\n\nAbsence of signed informed consent Presence of chronic or systemic diseases","8 Years","11 Years",{"count":177,"type":22},"This prospective observational case-control study aims to evaluate the association between perceived stress levels in children and their parents and the presence of clinically diagnosed bruxism in children aged 8-11 years. Children with bruxism and age-matched controls will be recruited from the Department of Pediatric Dentistry. Child perceived stress, parental perceived stress, parenting-related stress, and parental awareness of child stress\u002Fanxiety will be assessed using validated questionnaires. Associations between stress-related measures and bruxism status will be analyzed.",[28,312,313,314],"Stress","Parent Stress","Parent and Child Stress",[316,317,28,318],"Child stress","Parenting stress","Parental and child stress","2026-02-20",{"date":321,"type":35},"2026-02-25",{"date":323,"type":22},"2026-03-01",{"date":325,"type":22},"2026-04-15",{"name":327,"class":42},"Bezmialem Vakif University",{"id":329,"slug":330,"hasResults":11,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":4,"eligibilityCriteria":334,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":115,"enrollmentInfo":335,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":337,"conditions":338,"keywords":340,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":43},"100616633","the-effect-of-bruxism-on-balance-100616633","NCT07308145","The Effect of Bruxism on Balance","The Effect of Bruxism on Dynamic Balance in Desk Workers","Inclusion Criteria:\n\n* Age between 18 and 50 years,\n* Participants must be diagnosed with bruxism by a dentist,\n* Voluntary participation and signing the informed consent form,\n* The participant must have the cognitive capacity to communicate and understand instructions,\n* Desk work hours must be at least 4 hours.\n\nExclusion Criteria:\n\n* Unable to cooperate,\n* Having active inflammatory arthritis,\n* Having had hip or knee surgery within the last 3 months,\n* Having a diagnosed psychiatric illness,\n* Having dentofacial anomalies,\n* Being pregnant,\n* Having a physical or cognitive condition that would prevent completion of the given test protocols,\n* Inability to comply with or cooperate with test procedures during the measurement period.",{"count":336,"type":22},54,"This study will investigate the effect of bruxism on dynamic balance in desk-bound individuals. Participants will be divided into two groups based on whether they are diagnosed with bruxism or not. Dynamic balance and proprioception will be compared between individuals from each group.",[339,28],"Orthopedic Physical Therapy",[28,341,342,343],"Dynamic Balance","Desk Workers","Temporomandibular joint","2026-01-13",{"date":346,"type":35},"2026-01-15",{"date":348,"type":35},"2025-12-31",{"date":350,"type":22},"2026-03-30",{"name":352,"class":42},"Istinye University",{"id":354,"slug":355,"hasResults":11,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":84,"enrollmentInfo":360,"targetDuration":4,"studyType":23,"phases":361,"briefSummary":362,"conditions":363,"keywords":364,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":377,"locationsCount":379},"100618781","somatosensory-training-versus-exercise-therapy-in-awake-bruxism-100618781","NCT07336082","Somatosensory Training Versus Exercise Therapy in Awake Bruxism","Somatosensory Training Versus Exercise Therapy in Awake Bruxism: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 45 years\n* Clinical diagnosis of awake bruxism confirmed using standardized diagnostic criteria (STAB and DC\u002FTMD Axis I)\n* Presence of at least one measurable somatosensory alteration confirmed at baseline using digital and clinical assessments\n* Self-reported daytime jaw clenching or parafunctional activity\n* Baseline orofacial pain intensity of ≥5\u002F10 on a Visual Analog Scale (VAS)\n* Chronic pain graded as GCPS Grades I-III according to DC\u002FTMD Axis II (Turkish validated version)\n* Willingness to comply with the study protocol and attend scheduled treatment sessions\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* GCPS Grade IV (high disability level)\n* Presence of systemic inflammatory, neurological, or rheumatological disorders\n* Diagnosis of severe chronic pain conditions unrelated to bruxism\n* Use of occlusal splints or participation in jaw, neck, or facial therapy within the past 3 months\n* Psychiatric disorders or cognitive impairment that could interfere with study participation\n* Pregnancy, due to potential effects on joint laxity and postural parameters",{"count":253,"type":22},[25],"Awake bruxism (daytime teeth clenching or jaw tension) is a common condition that can cause jaw pain, facial pain, muscle fatigue, and reduced quality of life. Although current treatments often focus on the jaw muscles and posture, recent research suggests that changes in the brain's sensory processing may also play an important role in bruxism-related pain.\n\nThis randomized controlled trial aims to compare two physiotherapy-based treatment approaches with a wait-list control group in adults with awake bruxism. Participants will be randomly assigned to one of three groups: (1) somatosensory awareness-based training, (2) jaw and posture exercise therapy, or (3) a wait-list control group.\n\nThe somatosensory training program focuses on improving body awareness and sensory perception of the face and jaw, while the exercise program includes jaw mobility, postural alignment, and cervical exercises. Both active interventions will be delivered over a 4-week period. Participants will be assessed at baseline, immediately after treatment, and during follow-up to evaluate changes over time.\n\nThe main outcome of this study is orofacial pain intensity. Secondary outcomes include jaw function, sensory processing, muscle structure, oral parafunctional behaviors, and oral health-related quality of life. The results of this study may help improve physiotherapy-based treatment strategies for people with awake bruxism by addressing both physical and sensory aspects of the condition.",[28],[365,366,367,368,369,370,371],"orofacial pain","somatosensory awareness","exercise therapy","awake bruxism","sensorimotor training","neuroplasticity","physical therapy","2026-01-02",{"date":344,"type":35},{"date":375,"type":35},"2025-12-16",{"date":131,"type":22},{"name":378,"class":42},"Aydin Adnan Menderes University",2,{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":387,"targetDuration":4,"studyType":23,"phases":389,"briefSummary":390,"conditions":391,"keywords":392,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":43},"100611526","bruxism-and-diadinamic-current-100611526","NCT07241728","Bruxism and Diadinamic Current","The Effect of Diadynamic Current Combined With Rehabilitation in Patients With Bruxism: A Randomized Controlled Trial","Inclusion Criteria: The study will include patients of both genders who have been clinically diagnosed with bruxism over the age of 18 and who report pain around the jaw (3 or higher on the VAS), and who have provided informed consent.\n\nExclusion Criteria: Patients who have previously used physical therapy or complementary-alternative medicine methods for similar complaints, those with neurological or psychiatric disorders, those with systemic diseases, those with pacemakers or implantable defibrillators; those with a history of cancer, those with an acute infection in the relevant area, those with a history of trauma to the jaw area, those using muscle relaxants, analgesics, or non-steroidal anti-inflammatory drugs, those who have participated in another study within the last 6 months, and individuals who do not agree to participate in the study will be excluded.",{"count":388,"type":22},24,[25],"This study was designed to investigate the effectiveness of diadynamic current, one of the electrotherapy methods added to rehabilitation in the treatment of bruxism. Individuals over the age of 18 diagnosed with bruxism will be randomly assigned to one of the following groups using the sealed envelope method: rehabilitation program (control group) or rehabilitation program combined with diadynamic current (experimental group). The intervention will consist of an exercise program conducted jointly for the experimental and control groups. Participants will be given a structured exercise program to be performed in person 3 days a week for 6 weeks. In addition to the exercise program, the experimental group will receive diadynamic current treatment at each session. Pain intensity will be assessed using the Visual Analog Scale (VAS), pressure pain threshold with an algometer, muscle strength with a hand-held dynamometer, bite force with a pinch meter, maximal mouth opening with a caliper, and head posture with the craniovertebral angle. Oral habits will be evaluated using the Oral Behavior Checklist, and anxiety levels will be assessed with the State-Trait Anxiety Inventory (STAI).",[28],[28,343,393,394,395,396],"Pain","Exercise","Electric Stimulation Therapy","Diadynamic Current","2025-11-20",{"date":399,"type":35},"2025-11-21",{"date":401,"type":35},"2025-09-22",{"date":403,"type":22},"2026-12-31",{"name":405,"class":42},"Inonu University",{"id":407,"slug":408,"hasResults":11,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":4,"eligibilityCriteria":412,"healthyVolunteers":17,"sex":18,"minAge":413,"maxAge":4,"enrollmentInfo":414,"targetDuration":4,"studyType":23,"phases":416,"briefSummary":418,"conditions":419,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":43},"100601391","phase-4-effectiveness-of-chlorzoxazone-versus-orphenadrine-citrate-in-alleviating-bruxism-pain-100601391","NCT07109882","Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism Pain","Clinical Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism- Related Orofacial Pain: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients aged above 15 years-old complaining of orofacial and temporomandibular disorder\u002Fpain.\n* Patients with no history of chronic systemic illness.\n\nExclusion Criteria:\n\n* Patients with orofacial injuries.\n* Patients with head injuries.\n* Patients Taking analgesics for the last 14 days.","15 Years",{"count":415,"type":22},60,[417],"PHASE4","To evaluate the clinical effectiveness of chlorzoxazone in comparison to orphenadrine Citrate in relieving the orofacial pain in bruxers. Subjects and Methods: 60 patients above 15-years old complaining of orofacial and temporomandibular disorder\u002Fpain, with no history of chronic systemic illness, will be recruited. Patients will randomly be allocated into two groups (n=30): the first group will receive Relaxon (chlorzoxazone) twice daily for two weeks, while the second group will receive Norgesic (orphenadrine Citrate) twice daily for two weeks as well. Pain severity will be assessed by Visual Analogue Scale (VAS) at day 0, 7, and day 14. In addition, a temporomandibular joint (TMJ) evaluation form will be utilized to assess the TMJ parameters before and after initiation of the treatment protocol, i.e at 0 and 14 days. Non parametric statistical analysis will be conducted to explain the results using SPSS V29.",[420,28],"Orofacial Pain","2025-07-30",{"date":423,"type":35},"2025-08-07",{"date":425,"type":35},"2025-07-22",{"date":427,"type":22},"2025-08-30",{"name":429,"class":42},"University of Baghdad",{"id":431,"slug":432,"hasResults":11,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":4,"eligibilityCriteria":436,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":437,"targetDuration":4,"studyType":23,"phases":439,"briefSummary":440,"conditions":441,"keywords":444,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":456,"locationsCount":43},"100594695","behavioral-interventions-for-controlling-oral-behaviors-100594695","NCT07022795","Behavioral Interventions for Controlling Oral Behaviors","Effectiveness of an Ecological Momentary Assessment Intervention to Reduce Masticatory Muscle Activity in Individuals at Risk for Temporomandibular Disorders","Individuals reporting a score greater than or equal to 25 on the oral behavior checklist (OBC). The OBC is a self-report questionnaire used to assess the frequency of various daytime and sleep-related oral behaviors, such as teeth clenching, grinding, and jaw tension.\n\nIt helps identify habits that may contribute to temporomandibular disorders (TMD) and orofacial pain.",{"count":438,"type":22},32,[25],"Ecological momentary assessment (EMA) interventions via mobile devices can be implemented to monitor an individual's negative health behaviors in real-time, increase awareness, and assist patients in overting those behaviors. In recent years, EMA interventions have been used to improve patients' awareness of specific oral behaviors, such as tooth clenching or awake bruxism, which can produce excessive forces on the muscles of mastication and lead to or exacerbate symptoms of temporomandibular disorders (TMD). Yet, whether EMA interventions are effective in reducing oral behaviors and masticatory muscle activity in the short- and long-term, or whether they are more effective than patient education remains unclear.\n\nIn this randomized clinical trial, we aim to test the effects of a 1-week EMA intervention combined with structured information on masticatory muscle activity and determine whether a combined approach including an EMA intervention and structured information is more effective in reducing masticatory muscle activity than structured information alone.\n\nOur study will have a significant impact on orofacial pain clinical research as it will provide clinically relevant measures which could inform multimodal approaches for the management of painful TMD.",[442,28,443],"Temporomandibular Disorders (TMD)","Masseter",[368,445,446,447,448,449],"temporomandibular disorders","masseter","oral behaviors","surface electromyography","tooth clenching","2025-06-07",{"date":452,"type":35},"2025-06-15",{"date":454,"type":35},"2025-04-15",{"date":131,"type":22},{"name":457,"class":42},"University of Toronto",{"id":459,"slug":460,"hasResults":11,"nctId":461,"briefTitle":462,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":11,"sex":18,"minAge":464,"maxAge":465,"enrollmentInfo":466,"targetDuration":4,"studyType":23,"phases":467,"briefSummary":468,"conditions":469,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":476,"locationsCount":43},"100584831","a-comparative-study-of-emg-biofeedback-and-pharmacotherapy-for-the-treatment-of-masticatory-muscle-hyperactivity-in-bruxism-patients-100584831","NCT06894472","A Comparative Study of EMG Biofeedback and Pharmacotherapy for the Treatment of Masticatory Muscle Hyperactivity in Bruxism Patients","Inclusion Criteria:\n\n* Twenty adult subjects with definite mild to moderate bruxism examined by a dentist prior to the study.\n* Tenderness of masticatory muscles on palpation grade one and two according to the digital palpating scale\n* Mild to moderate myofascial pain around the temporomandibular joint causing discomfort in the morning.\n\nExclusion Criteria:\n\n* Took any Botox or PRP injection treatment for this condition for the last six months\n* Had any advanced periodontal disease.\n* Any intraoral fixed splints.\n* Pregnancy.\n* Under psychiatric care.\n* Parkinson\n* Have any visual or auditory impairment.\n* Any cervical posture abnormalities.","20 Years","25 Years",{"count":143,"type":22},[25],"This study examines the effect of electromyography biofeedback on masticatory muscles hyperactivity on patients with bruxism.",[28],"2025-03-19",{"date":295,"type":35},{"date":473,"type":22},"2025-03-26",{"date":475,"type":22},"2025-05-01",{"name":477,"class":42},"Beni-Suef University",{"id":479,"slug":480,"hasResults":11,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":484,"eligibilityCriteria":485,"healthyVolunteers":11,"sex":18,"minAge":464,"maxAge":141,"enrollmentInfo":486,"targetDuration":4,"studyType":23,"phases":487,"briefSummary":488,"conditions":489,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":491,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":4},"100566210","analysis-of-occlusal-force-distribution-in-digital-and-conventional-occlusal-splint-100566210","NCT06652217","Analysis of Occlusal Force Distribution in Digital and Conventional Occlusal Splint","Analysis of Occlusal Force Distribution in Digital and Conventional Occlusal Splint (Randomized Clinical Trial)","splint","Inclusion Criteria:• Age range from 20 to 60 years old.\n\n* Medically healthy patients.\n* Patients with signs (as teeth attrition, muscles hypertrophy, and increased muscles activity) and symptoms (as muscles pain, headache, patient reporting) of bruxism for the last 6 months with no condylar or disc attrition.\n* Fully dentate with presence of first molar in both arches\n* Patients with good oral hygiene.\n* Absence of any intra-oral pathological condition. Exclusion Criteria:• Patients with a history of psychosomatic disease.\n* Patients with addiction to alcohol, drugs, or analgesics.\n* Pregnant patients.\n* Patients with malignant disease.\n* Acute events such as trauma or inflammation.\n* Bisphosphonate therapy within the last 5 years.\n* Removable dental prostheses.\n* Known hypersensitivity to materials.\n* Extensive temporomandibular disorder that renders the stabilizing splints not to be the treatment of choice.",{"count":388,"type":22},[25],"Each eligible patient will be randomly into one of two groups:\n\nGroup A: The digital splint group, digital splint will be constructed to each patient.\n\nGroup B: The conventional splint group, conventional splint will be constructed to each patient.\n\n* For both groups, thorough clinical examination, scaling and root-planning will be done. Patient will receive a motivational oral hygiene program with detailed explanation regarding the study process and outcome expectations.\n* A precise history and clinical examination will be done by (F.M) under supervision of Dr S.G.\n\nThe digital splint construction method:\n\n* First, complete arch intraoral digital scans of the maxillary and mandibular arches will be performed using the intra oral scanner following the scanning protocol recommended by the manufacturer.\n* For inter maxillary relation recording using optical jaw tracking device, step-by-step procedure for tracking and recording the maxillomandibular relationship and mandibular motion by using an optical jaw tracking system will be illustrated to the patient.\n* The occlusal device will be designed using a CAD software program.\n* The occlusal device will be printed using a 3D printer\n* The occlusal device will be finished and polished manually.\n\nThe conventional splint construction method:\n\n* The first step is making an impression using a quick-setting addition polyvinyl siloxane impression material. A stone model will be obtained after pouring the impression using extra-hard dental stone.\n* In the second visit a face bow transfer and a centric relation record will be utilized to mount the casts on a semi adjustable articulator.\n* For centric relation recording, a jig will be made with an incisal plateau from modeling plastic impression compound and the jig will be inserted between the central incisors. To measure centric relation as precisely as possible (by avoiding translational movement in the temporomandibular joint),\n* The jig will be adjusted with a scalpel to create a distance of no more than 2 mm between the maxillary and mandibular arches. Then the relation will be recorded using a fast-setting polyvinyl siloxane occlusal registration material. The occlusal registrations will be trimmed to the buccal cusp tips to be transferred accurately to the articulator without interference.\n* After mounting of the centric relation the protrusive record will be taken and the horizontal condylar angle will be adjusted accordingly.\n* The device will be fabricated from clear prosthetic resin. Production followed a standardized protocol with a minimum inter maxillary thickness of 1.5 mm and a buccal extension to 1 mm below the survey line.\n* The device will be finished and occlusion will be adjusted on the articulator. outcomes assessment:\n\n  1. Occlusal force distribution will be measured using osslusosense.\n  2. Cost effectiveness will be assessed using the following equation(CE ratio = C\u002FE).",[28],"2024-10-21",{"date":492,"type":35},"2024-10-22",{"date":494,"type":22},"2024-10",{"date":496,"type":22},"2025-06",{"name":498,"class":42},"Cairo University",{"id":500,"slug":501,"hasResults":11,"nctId":502,"briefTitle":503,"officialTitle":504,"acronym":4,"eligibilityCriteria":505,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":506,"targetDuration":507,"studyType":87,"phases":4,"briefSummary":508,"conditions":509,"keywords":510,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":515,"startDateStruct":517,"completionDateStruct":519,"leadSponsor":521,"locationsCount":4},"100564013","34salivary-melatonin-and-cortisol-levels-in-individuals-with-bruxism34-100564013","NCT06623643",""Salivary Melatonin and Cortisol Levels in Individuals with Bruxism"","The Investigation of Melatonin and Cortisol Levels in the Saliva of Individuals with Bruxism","Inclusion Criteria:\n\n\\- Individuals without any known hormonal diseases, not using antidepressants or medications that could alter saliva content, without degenerative diseases affecting the salivary glands, without cysts or tumors affecting the temporomandibular region, and not undergoing insomnia treatment will be included in the study\n\nExclusion Criteria:\n\n* Individuals with systemic diseases that affect or may potentially affect saliva content, or those using medications that cause these effects, will not be included in the study",{"count":177,"type":22},"1 Day","The effects of the hormones melatonin and cortisol, which play a highly effective role in regulating the sleep-wake cycle, on teeth grinding will be scientifically evaluated. Based on the research results, more effective methods for treating patients suffering from bruxism may be identified.",[28],[511,512,513],"melatonin","saliva","cortizol","2024-10-02",{"date":516,"type":35},"2024-10-04",{"date":518,"type":22},"2024-10-30",{"date":520,"type":22},"2025-02-28",{"name":522,"class":42},"Yuzuncu Yil University",{"id":524,"slug":525,"hasResults":11,"nctId":526,"briefTitle":527,"officialTitle":527,"acronym":4,"eligibilityCriteria":528,"healthyVolunteers":17,"sex":18,"minAge":83,"maxAge":115,"enrollmentInfo":529,"targetDuration":4,"studyType":23,"phases":531,"briefSummary":532,"conditions":533,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":540,"leadSponsor":542,"locationsCount":43},"100549529","impact-of-subgingival-instrumentation-on-psychological-distress-and-mental-health-status-in-bruxers-with-periodontitis-100549529","NCT06435208","Impact of Subgingival Instrumentation on Psychological Distress and Mental Health Status in Bruxers With Periodontitis","Inclusion Criteria:\n\n* Systemically healthy patients\n* Patient having periodontitis with bruxism\n* Age between 30-50 years\n\nExclusion Criteria:\n\n* History of mental health disorder\n* History of systemic disease\n* History of drugs having the potential impact on periodontal status like phenytoin, cyclosporin, calcium-channel blockers or antidepressant drugs\n* Pregnant or lactating females",{"count":530,"type":22},45,[25],"Bruxism is a non-functional repetitive jaw-muscle activity characterized by grinding or clenching the teeth. Bruxism, characterized by the involuntary grinding or clenching of teeth, is a prevalent parafunctional habit affecting individuals of all ages. Stress, anxiety, and depression are the psychological factors most commonly associated with the presence of bruxism.",[534,28,90,535],"Periodontal Diseases","Distress, Emotional","2024-07-04",{"date":538,"type":35},"2024-07-08",{"date":536,"type":35},{"date":541,"type":22},"2025-02-01",{"name":107,"class":42},{"id":544,"slug":545,"hasResults":11,"nctId":546,"briefTitle":547,"officialTitle":547,"acronym":4,"eligibilityCriteria":548,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":141,"enrollmentInfo":549,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":551,"conditions":552,"keywords":553,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":565,"locationsCount":4},"100551250","mrna-expression-and-genetic-polymorphisms-affecting-drd3-rs6280-and-htr2a-rs6313-in-bruxism-100551250","NCT06457646","mRNA Expression and Genetic Polymorphisms Affecting DRD3 (rs6280) and HTR2A (rs6313) in Bruxism","Inclusion Criteria:\n\n* be above 18 years of age and have a confirmed diagnosis of bruxism\n\nExclusion Criteria:\n\n* Systemic diseases,\n* orofacial dysfunction,\n* acute symptoms such as neurodegenerative diseases (specifically Parkinsons disease),\n* Taking medication such as anxiolytics",{"count":550,"type":22},169,"The goal of this observational study is to learn about the genetic factors influencing bruxism, a condition characterized by teeth grinding, in a group of participants. The main questions it aims to answer are:\n\n* Is there a significant association between the rs6313 polymorphism of the HTR2A gene and bruxism?\n* Is there a significant association between the rs6280 polymorphism of the DRD3 gene and bruxism?\n\nParticipants will:\n\nProvide DNA samples for genotyping of the DRD3 (rs6280) and HTR2A (rs6313) polymorphisms.\n\nProvide RNA samples to assess changes in the expression of HTR2A and DRD3. Researchers will compare the genetic data and RNA expression levels between individuals with bruxism and those without (controls) to see if there are significant genetic differences and expression changes associated with bruxism.",[28],[554,28,555,556,557],"Gene Expression","Sleep bruxism","Polymorphism","Genetic","2024-06-08",{"date":560,"type":35},"2024-06-13",{"date":562,"type":22},"2024-06-02",{"date":564,"type":22},"2024-12-17",{"name":566,"class":42},"University of Monastir"]