[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bupivacaine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bupivacaine":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,51,79,102,130,157,184,210,237,264,296,318,339,364,395],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100053344","phase-4-comparison-of-low-dose-versus-standard-dose-hyperbaric-bupivacaine-in-spinal-anesthesia-100053344",false,"NCT07684989","Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia","Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia: Hemodynamic Stability and Recovery Profile in Elderly Patients Undergoing Lower Limb Orthopedic Surgery","Inclusion Criteria:\n\n* Male or female patients aged 65 years and above.\n* Patients scheduled for elective lower limb orthopedic surgery under spinal anesthesia.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Patients willing to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Refusal to participate in the study.\n* Contraindications to spinal anesthesia (e.g., infection at puncture site, coagulopathy, severe hypovolemia, raised intracranial pressure).\n* Known hypersensitivity or allergy to bupivacaine.\n* Severe valvular heart disease.\n* Significant cardiac arrhythmias.\n* Uncontrolled hypertension.\n* Severe hepatic or renal impairment.\n* Pre-existing neurological disorders affecting lower limb motor or sensory function.\n* Severe spinal deformity or previous lumbar spine surgery interfering with spinal anesthesia.\n* Cognitive impairment or inability to provide informed consent.\n* Emergency orthopedic procedures.","ALL","65 Years",{"count":19,"type":20},180,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this randomized controlled trial is to determine whether low-dose hyperbaric bupivacaine provides better hemodynamic stability and postoperative recovery compared with standard-dose hyperbaric bupivacaine in elderly patients undergoing lower limb orthopedic surgery under spinal anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does low-dose hyperbaric bupivacaine reduce the incidence of intraoperative hypotension and bradycardia compared with standard-dose hyperbaric bupivacaine?\n* Does low-dose hyperbaric bupivacaine improve postoperative recovery profile compared with standard-dose hyperbaric bupivacaine?\n\nResearchers will compare elderly patients receiving low-dose hyperbaric bupivacaine with those receiving standard-dose hyperbaric bupivacaine to determine whether a lower intrathecal dose improves cardiovascular stability and recovery without compromising the effectiveness of spinal anesthesia.\n\nParticipants will:\n\n* Provide written informed consent before enrollment.\n* Undergo elective lower limb orthopedic surgery under spinal anesthesia.\n* Be randomly assigned to receive either low-dose or standard-dose hyperbaric bupivacaine.\n* Have their blood pressure, heart rate, and other vital signs monitored throughout the surgical procedure.\n* Be assessed for intraoperative hypotension and bradycardia according to predefined study criteria.\n* Be evaluated for postoperative recovery parameters, including motor recovery and readiness for postoperative recovery and mobilization.\n\nThe information obtained from this study may help identify a safer and more effective spinal anesthetic technique for elderly patients undergoing orthopedic surgery.",[26,27,28,29,30],"Anesthesia, Spinal","Orthopedic Procedures","Postoperative Recovery in Elderly Patients","Hemodynamics","Bupivacaine",[32,33,34,35,36,37],"Low-Dose Hyperbaric Bupivacaine","Standard-Dose Hyperbaric Bupivacaine","Spinal Anesthesia","Geriatric Anesthesia","Lower Limb Orthopedic Surgery","Hemodynamic Stability","NOT_YET_RECRUITING","2026-07-10",{"date":41,"type":42},"2026-07-13","ACTUAL",{"date":44,"type":20},"2026-07-01",{"date":46,"type":20},"2027-06-30",{"name":48,"class":49},"Mayo Hospital Lahore","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":17,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":50},"100622646","impact-of-bupivacaine-dilution-with-dextrose-or-saline-on-infraclavicular-block-outcomes-100622646","NCT07386327","Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes","The Effect of Diluting Bupivacaine With 5% Dextrose and 0.9% NaCl on Block Success and Duration of Analgesia in Infraclavicular Block","Inclusion Criteria:\n\n* Patients who agree to participate in the study and provide written informed consent\n* Patients scheduled for elective upper extremity surgery for whom infraclavicular block is considered appropriate for anesthetic management\n* Age between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients with a normal neurological examination in the extremity scheduled for peripheral nerve block\n\nExclusion Criteria:\n\n* Patients who decline to participate in the study or refuse to provide informed consent\n* History of allergy or hypersensitivity to study medications\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* Body weight less than 40 kg\n* Age below 18 years or above 65 years\n* History of significant cardiac disease (e.g., arrhythmia, conduction disorders)\n* Presence of coagulopathy (international normalized ratio \\[INR\\] \\> 1.5 and\u002For platelet count \\\u003C 100,000\u002Fmm³)\n* Hepatic failure or significant liver dysfunction\n* Pregnant patients\n* Infection at the planned peripheral block site\n* Presence of neurological deficit in the extremity planned for peripheral nerve block\n* Patients with uncontrolled diabetes mellitus and\u002For established diabetic neuropathy\n* American Society of Anesthesiologists (ASA) physical status IV","18 Years",{"count":60,"type":20},90,[62],"NA","D5W) has long been used as an intravenous fluid for hydration and energy supplementation and has recently gained increasing clinical interest in perineural injection therapies and ultrasound-guided hydrodissection. D5W has been shown to improve pain and functional outcomes in entrapment neuropathies by mechanically releasing perineural adhesions and potentially modulating neurogenic inflammation. In contrast, 0.9% sodium chloride (normal saline) is routinely used as a dilution medium for local anesthetics in peripheral nerve blocks; however, emerging evidence suggests that alternative diluents such as D5W may influence block onset and efficacy.\n\nThe infraclavicular block is a commonly used ultrasound-guided technique for brachial plexus anesthesia, providing reliable anesthesia and postoperative analgesia for upper extremity surgery. This study aims to compare the effects of diluting bupivacaine with either D5W or 0.9% NaCl on block success and duration of analgesia in patients undergoing infraclavicular block. Secondary outcomes include block onset characteristics, sensory and motor block profiles, and perioperative analgesic requirements. The findings may help determine whether D5W represents a safe and effective alternative diluent to saline in routine regional anesthesia practice.",[65,66,30,67,68],"Infraclavicular Brachial Plexus Block","Dextrose","Block Success","Postoperative Analgesia","RECRUITING","2026-06-22",{"date":72,"type":42},"2026-06-23",{"date":74,"type":42},"2026-03-09",{"date":76,"type":20},"2026-07-15",{"name":78,"class":49},"Burçin Alaçam, MD",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":17,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":50},"100633134","intrathecal-dexmedetomidine-with-bupivacaine-in-patients-undergoing-knee-orthopedic-surgery-100633134","NCT07522736","Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery","The Analgesic Effect of Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery: A Randomized Double-Blinded Dose-Finding Trial","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Male patients scheduled for knee orthopedic surgery.\n\nExclusion Criteria:\n\n* Patients with psychiatric disorders.\n* History of drug addiction.\n* Contraindication for regional anesthesia.\n* History of hypersensitivity to the study drugs.\n* Previous administration of opioids and\u002For other central nervous system depressants during current hospital admission.",{"count":87,"type":20},120,[62],"This study aims to compare the duration of analgesia (as the primary outcome) and adverse effects (as the secondary outcome) after intrathecal administration of dexmedetomidine with hyperbaric bupivacaine to patients undergoing knee orthopedic surgery.",[91,30,92],"Intrathecal Dexmedetomidine","Knee Orthopedic Surgery","2026-04-04",{"date":95,"type":42},"2026-04-13",{"date":97,"type":42},"2025-03-01",{"date":99,"type":20},"2026-08-30",{"name":101,"class":49},"Cairo University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":111,"briefSummary":112,"conditions":113,"keywords":118,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100624480","phase-4-bupivacaine-liposome-versus-bupivacaine-for-ultrasound-guided-suprascapular-nerve-combined-with-axillary-nerve-block-in-analgesia-after-arthroscopic-shoulder-surgery-100624480","NCT07410182","Bupivacaine Liposome Versus Bupivacaine for Ultrasound-Guided Suprascapular Nerve Combined With Axillary Nerve Block in Analgesia After Arthroscopic Shoulder Surgery","Inclusion Criteria:\n\n1. Aged 18-60 years\n2. ASA physical status I-II\n3. Undergoing unilateral arthroscopic shoulder surgery\n4. The Operative time between 1and 4 hours\n\nExclusion Criteria:\n\n1. Anticipated operative time \\\u003C 1 h or \\> 4 h\n2. Severe cardiopulmonary insufficiency\n3. Hepatic or renal dysfunction\n4. Coagulopathy\n5. Diabetic peripheral neuropathy\n6. History of nerve injury on the operative side\n7. Skin infection at the block site\n8. Allergy to amide local anesthetics\n9. Refusal to participate or any other condition deemed unsuitable.","60 Years",{"count":110,"type":20},60,[23],"This trial is designed to compare the post-operative analgesic efficacy and safety of liposomal bupivacaine versus plain bupivacaine when both are used for ultrasound-guided combined suprascapular and axillary nerve block in patients undergoing elective arthroscopic shoulder surgery.",[114,115,30,116,117],"Arthroscopic Shoulder Surgery","Ultrasound Guided Nerve Block","Suprascapular Nerve Block","Axillary Nerve Block",[114,119,120,117],"ultrasound guided nerve block","suprascapular nerve block","2026-02-07",{"date":123,"type":42},"2026-02-13",{"date":125,"type":20},"2026-03-01",{"date":127,"type":20},"2026-12-30",{"name":129,"class":49},"Huazhong University of Science and Technology",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":21,"phases":139,"briefSummary":140,"conditions":141,"keywords":144,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":4},"100621913","effect-of-patient-position-on-bupivacaine-dose-requirement-and-hemodynamic-stability-in-spinal-anesthesia-100621913","NCT07376798","Effect of Patient Position on Bupivacaine Dose Requirement and Hemodynamic Stability in Spinal Anesthesia","Inclusion Criteria:\n\n* Age 18-70 years\n* American Society of Anesthesiologists (ASA) physical status classification I-II\n* Scheduled for elective urogenital surgery\n* Suitable candidate for spinal anesthesia\n* Able to read, understand, and provide written informed consent\n* Body Mass Index (BMI) less than 35 kg\u002Fm²\n* Willing to participate in the study\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (coagulopathy, infection at injection site, patient refusal)\n* History of neurological disease\n* Spinal deformity or previous spinal surgery\n* History of allergic reaction to local anesthetics (amide-type)\n* ASA physical status classification III or higher\n* Emergency surgery\n* Pregnancy\n* Psychiatric illness preventing effective communication\n* Refusal to participate in the study\n* Unable to understand or provide informed consent","70 Years",{"count":138,"type":20},100,[62],"This study compares different combinations of local anesthetic doses and patient positions during spinal anesthesia for urogenital surgery. Spinal anesthesia is a common and safe technique where medication is injected into the lower back to numb the body during surgery.\n\nThe study will test two different doses of bupivacaine (a numbing medication): a lower dose (8 mg) and a standard dose (12 mg). It will also test two different patient positions after the spinal injection: lying flat (neutral position) and lying with the head slightly lower than the feet (Trendelenburg position).\n\nParticipants will be randomly assigned to one of four groups:\n\n* Group 1: Lower dose + lying flat\n* Group 2: Lower dose + head-down position\n* Group 3: Standard dose + lying flat\n* Group 4: Standard dose + head-down position\n\nThe study will measure how well the anesthesia works, how high the numbness spreads in the body, and how it affects blood pressure and heart rate. The goal is to find the best combination of dose and position that provides good anesthesia while keeping blood pressure stable.\n\nThis research may help doctors choose the safest and most effective anesthesia approach for each patient based on their individual needs.",[34,142,143,30],"Hemodynamic Changes","Patient Positions",[34,30,145,146],"Patient Positioning","hemodynamic changes","2026-01-21",{"date":149,"type":42},"2026-01-29",{"date":151,"type":20},"2026-01-30",{"date":153,"type":20},"2026-06-30",{"name":155,"class":156},"University of Health Sciences Balikesir Hospital Eduation and Research","OTHER_GOV",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":164,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":182,"locationsCount":50},"100496957","ultrasound-guided-tapb-vs-surgical-tapb-with-bupivacaine-in-cesarean-section-100496957","NCT05750992","Ultrasound Guided TAPB vs Surgical TAPB With Bupivacaine in Cesarean Section","Ultrasound Guided Transversus Abdominis Plane Block (TAPB) vs Surgical TAPB With Bupivacaine for Acute Pain Control in Cesarean Section: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Full term pregnant women\n* Older than 21 years of age\n* Had elective cesarean section with Pfannenstiel incision.\n\nExclusion Criteria:\n\n* Patients with cesarean section using different surgical incision\n* History of addiction \\[including opioids and benzodiazepines\\]\n* Allergy to the anesthetic analgesia\n* Psychological disorders\n* Coagulopathies\n* Infection at the block injection site.","FEMALE","21 Years","35 Years",{"count":168,"type":20},50,[62],"The aim of this study is to compare Surgical Transversus abdominis plane block and Ultrasound guided transversus abdominis plane block (TAPB) as a postoperative analgesic regimen in female patients undergoing elective cesarean delivery.",[172,173,174,30,175],"Cesarean Section","Ultrasound Guided Transversus Abdominis Plane Block","Surgical Transversus Abdominis Plane Block","Acute Pain","2026-01-04",{"date":178,"type":42},"2026-01-06",{"date":180,"type":42},"2023-04-10",{"date":127,"type":20},{"name":183,"class":49},"Al-Azhar University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":21,"phases":194,"briefSummary":195,"conditions":196,"keywords":200,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":206,"leadSponsor":208,"locationsCount":4},"100617890","effect-of-dexamethasone-on-plasma-levels-of-bupivacaine-and-dexamethasone-after-a-single-injection-interscalene-nerve-block-100617890","NCT07324499","Effect of Dexamethasone on Plasma Levels of Bupivacaine and Dexamethasone After a Single-injection Interscalene Nerve Block.","Effect of Dexamethasone on Plasma Levels of Bupivacaine and Dexamethasone Following a Single-injection Interscalene Nerve Block: A Randomized Controlled Study","Inclusion Criteria:\n\n\\- ASA I-II patients, with a body mass index (BMI) between 20 and 34 kg\u002Fm2 scheduled for shoulder surgery requiring single-needle interscalene block\n\nExclusion Criteria:\n\n\\- Chronic opioid use, liver failure, kidney failure, allergy to protocol drugs","90 Years",{"count":193,"type":20},40,[62],"Recent studies have highlighted the comparative advantages of perineural dexamethasone, particularly regarding its safety profile and its ability to prolong analgesia in various peripheral nerve blocks. A recent systematic review demonstrated that perineural administration of dexamethasone significantly extends the duration of analgesia compared to intravenous administration.\n\nThe mechanism of action of perineural dexamethasone remains unclear. Moreover, there is a lack of research comparing the systemic absorption of local anesthetics administered perineurally with or without dexamethasone, and the systemic absorption and bioavailability of dexamethasone when used as a perineural adjuvant have not been studied.\n\nObjective: This study aims to compare plasma concentrations of bupivacaine following a single-shot interscalene block with dexamethasone administered either perineurally or intravenously.\n\nMethodology: A prospective, randomized, double-blind trial will be conducted involving 40 patients undergoing shoulder surgery requiring a single-shot interscalene block. Each patient will receive 20 mL of 0.25% bupivacaine combined with 8 mg of dexamethasone administered either perineurally or intravenously. Venous blood samples (5 mL) will be collected at 5, 10, 20, 40, 80, 120, and 240 minutes post-block, and one sample at discharge, to measure plasma concentrations of both enantiomers of bupivacaine (D(+)-bupivacaine and L(-)-bupivacaine) and dexamethasone.\n\nOutcomes: The study will compare plasma levels of bupivacaine between groups, characterize the pharmacokinetics of bupivacaine and dexamethasone, and assess block duration and opioid consumption.",[197,198,199,30],"Pain","Interscalene Blocks","Dexamethasone",[199,30,197,201],"Interscalene blocks","2025-12-30",{"date":204,"type":42},"2026-01-07",{"date":125,"type":20},{"date":207,"type":20},"2027-12-01",{"name":209,"class":49},"Pontificia Universidad Catolica de Chile",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":108,"enrollmentInfo":217,"targetDuration":4,"studyType":21,"phases":219,"briefSummary":220,"conditions":221,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":50},"100614228","intrathecal-dexmedetomidine-fentanyl-combination-versus-fentanyl-alone-as-adjuvant-to-bupivacaine-in-spinal-anesthesia-for-above-knee-amputation-in-sarcomas-of-lower-extremity-100614228","NCT07276867","Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity","Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity: A Randomized, Comparative Study","Inclusion Criteria:\n\n* Age from 18 to 60 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status of II-III.\n* Height between 150-185 cm.\n* Body mass index between 18-35 kg\u002Fm².\n* Scheduled for above-knee amputation due to lower limb sarcomas.\n\nExclusion Criteria:\n\n* Allergy to any of the investigated drugs.\n* History of heart block, arrhythmia, or ongoing therapy with beta- or calcium channel- blockers, or angiotensin-converting-enzyme inhibitors.\n* Contraindications to spinal anesthesia.\n* Pregnancy or lactation.\n* Presence of psychiatric illness or chronic pain conditions.",{"count":218,"type":20},58,[62],"The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.",[222,223,224,30,34,225,226,227],"Intrathecal","Dexmedetomidine","Fentanyl","Above Knee Amputation","Sarcomas","Lower Extremity","2025-11-30",{"date":230,"type":42},"2025-12-11",{"date":232,"type":42},"2025-10-20",{"date":234,"type":20},"2026-04-01",{"name":236,"class":49},"National Cancer Institute, Egypt",{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":244,"enrollmentInfo":245,"targetDuration":4,"studyType":21,"phases":246,"briefSummary":247,"conditions":248,"keywords":252,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":50},"100572751","phase-4-bupivacaine-liposomes-or-bupivacaine-for-cmb-on-postoperative-analgesia-in-laparoscopic-hepatobiliary-pancreatic-surgery-100572751","NCT06737341","Bupivacaine Liposomes or Bupivacaine for CMB on Postoperative Analgesia in Laparoscopic Hepatobiliary Pancreatic Surgery","Effect of Bupivacaine Liposomes or Bupivacaine for Ultrasound-guided CMB on Postoperative Analgesia in Laparoscopic Hepatobiliary Pancreatic Surgery: a Prospective, Single Blind, Completely Randomized, Active Controlled Clinical Trial","Inclusion Criteria:\n\n* 18-80 years old ASA Level I-III Laparoscopic Hepatobiliary Pancreatic Surgery\n\nExclusion Criteria:\n\n* Body Mass Index (BMI) ≥ 30 kg\u002Fm ² or ≤ 15 kg\u002Fm ² Known alcohol or drug abuse History of upper abdominal surgery Congenital coagulation dysfunction Localized or systemic infection Peripheral neuropathy Unable to understand the research plan","80 Years",{"count":110,"type":20},[23],"Numerous studies have confirmed that regional analgesia using peripheral nerve block has great potential for perioperative analgesia in abdominal surgery. Ultrasound guided costal margin block (CMB) is a new regional anesthesia technique that has been proven to compensate for the analgesic effects of regional analgesia techniques such as transverse abdominal muscle plane (TAP) and rectus abdominis sheath (RSB) on mid abdominal incisions, but it is difficult to meet the analgesic needs of anterior and outer abdominal wall incisions. According to relevant anatomy and research, the application of local anesthetics along the rib margin under the rectus abdominis muscle or under the external oblique muscle on the rib surface can block the lateral and anterior cutaneous branches of the thoracoabdominal nerve, known as CMB. Ultrasound guided CMB requires the injection of local anesthetics onto the surface of the rib along the plane below the rectus abdominis and oblique muscles, covering most of the upper abdominal incision pain. However, there are few reports on other types of upper abdominal surgeries such as liver, gallbladder, and pancreas surgeries.\n\nBupivacaine liposomes are an important innovation, which encapsulate bupivacaine in polycystic liposomes using DepoFoam technology to achieve slow drug release and effectively prolong pain relief time by up to 72 hours. This ultra long acting local anesthetic has significant advantages in reducing opioid use, improving analgesic satisfaction, reducing complications, and shortening hospital stays, and has been applied in the ERAS concept.\n\nThe investigators designed a prospective, single blind, randomized, active controlled clinical trial to investigate the effect of bupivacaine liposomes in combination with bupivacaine mixture or bupivacaine alone for ultrasound-guided bilateral CMB on postoperative analgesia in patients undergoing laparoscopic hepatobiliary pancreatic surgery. Our main hypothesis is that the use of bupivacaine liposomes and a mixture of bupivacaine for ultrasound-guided CMB in a multimodal analgesia regimen can more effectively reduce the dosage of intravenous patient-controlled analgesia (PCA) opiates within 72 hours after laparoscopic hepatobiliary pancreatic surgery compared to using bupivacaine alone. Secondary outcomes include the dosage of PCA opiates within 24-48 hours, pain score values, patient satisfaction, adverse reactions, and complications.",[30,249,250,251],"Ultrasound-Guided","Analgesia, Postoperative","Opioids",[253,254,255],"Bupivacaine Liposome","Costal Margin Block","Laparoscopic Hepatobiliary Pancreatic Surgery","2025-09-30",{"date":258,"type":42},"2025-10-03",{"date":260,"type":20},"2025-10-08",{"date":262,"type":20},"2026-02-01",{"name":129,"class":49},{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":272,"sex":16,"minAge":58,"maxAge":108,"enrollmentInfo":273,"targetDuration":4,"studyType":21,"phases":275,"briefSummary":276,"conditions":277,"keywords":282,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":50},"100601981","phase-4-d-fab-pour-trial-dexmedetomidine-vs-fentanyl-as-adjuvants-to-bupivacaine-on-postoperative-urinary-retention-100601981","NCT07117565","D-FAB-POUR Trial: Dexmedetomidine vs Fentanyl as Adjuvants to Bupivacaine on Postoperative Urinary Retention","Comparison of Intrathecal Dexmedetomidine Versus Intrathecal Fentanyl as Adjuvants to Bupivacaine on Post-Operative Urinary Retention in Lower Limb Surgery","D-FAB-POUR","Inclusion Criteria:\n\n* Adults aged 18 to 60 years\n* Scheduled for elective lower limb surgery under spinal anesthesia\n* Classified as American Society of Anesthesiologists (ASA) physical status II or III\n* Minimum height of 150 cm (to ensure uniform drug volume)\n* Able to understand the study procedures and provide written informed consent (in English or Nepali)\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (e.g., coagulopathy, infection at injection site, hemodynamic instability)\n* Known allergy or hypersensitivity to bupivacaine, fentanyl, or dexmedetomidine\n* Chronic pain conditions or long-term opioid use\n* Neurological, Cardiac, Renal, or uncontrolled diabetic conditions\n* Current treatment for prostatic pathology or use of alpha-2 blockers\n* Presence of a Foley's catheter preoperatively\n* Estimated surgical duration: \\>2.5 hours\n* Inability or unwillingness to provide informed consent",true,{"count":274,"type":20},190,[23],"This study aims to compare two medications, dexmedetomidine and fentanyl, when used alongside a commonly used spinal anesthetic called bupivacaine in patients undergoing lower limb surgery. The main focus of the study is to see which combination causes fewer problems with urination after surgery - a condition known as postoperative urinary retention (POUR). POUR can lead to discomfort, delayed recovery, and a need for catheterization. Dexmedetomidine is a newer drug that may help reduce this problem compared to fentanyl, which is more commonly used but may increase the risk of urinary retention. This trial will help determine which medication combination provides better pain relief while reducing urinary side effects. The study is being conducted as a randomized, double-blind trial at a hospital in Nepal and will include 190 adult patients.\n\n\\-",[34,278,223,224,26,30,279,280,281],"Postoperative Complications","POUR","Orthopedic Surgery","Urinary Retention Postoperative",[283,284,285,223,224,286],"Postoperative urinary retention","Spinal anesthesia","Intrathecal adjuvants","Perioperative complications","2025-08-09",{"date":289,"type":42},"2025-08-12",{"date":291,"type":20},"2025-09-15",{"date":293,"type":20},"2026-11-25",{"name":295,"class":49},"Tribhuvan University Teaching Hospital, Institute Of Medicine.",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":17,"enrollmentInfo":302,"targetDuration":4,"studyType":21,"phases":303,"briefSummary":304,"conditions":305,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":314,"leadSponsor":316,"locationsCount":50},"100592476","dexmedetomidine-as-an-adjuvant-to-bupivacaine-in-scalp-block-versus-bupivacaine-alone-for-postoperative-pain-management-in-patients-undergoing-craniotomy-100592476","NCT06993922","Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block Versus Bupivacaine Alone for Postoperative Pain Management in Patients Undergoing Craniotomy","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Undergoing supratentorial elective planned craniotomies.\n\nExclusion Criteria:\n\n* Patients refusal.\n* History of known allergy to the used local anesthetic or dexmedetomidine.\n* Bleeding disorders.\n* Evidence of local infection at the site of injection.\n* Emergency craniotomy.\n* Psychotic disorder.\n* Patients who will not be extubated in the operating room after surgery.",{"count":168,"type":20},[62],"This study aims to compare dexmedetomidine as an adjuvant to bupivacaine in scalp block versus bupivacaine alone for postoperative pain management in patients undergoing craniotomy.",[223,306,30,307,308,309],"Adjuvant","Scalp Block","Postoperative Pain","Craniotomy","2025-05-29",{"date":312,"type":42},"2025-05-30",{"date":310,"type":42},{"date":315,"type":20},"2025-11-01",{"name":317,"class":49},"Ain Shams University",{"id":319,"slug":320,"hasResults":11,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":11,"sex":16,"minAge":325,"maxAge":326,"enrollmentInfo":327,"targetDuration":4,"studyType":21,"phases":328,"briefSummary":329,"conditions":330,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":336,"leadSponsor":338,"locationsCount":4},"100577692","phase-4-age-based-and-weight-based-bupivacaine-dosing-for-pediatric-spinal-anesthesia-for-elective-infra-umbilical-surgeries-100577692","NCT06801600","Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia for Elective Infra-Umbilical Surgeries","A Comparative Study Between Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia in Children Undergoing Elective Infra-Umbilical Surgeries: A Randomized Double-Blinded Controlled Trial","Inclusion Criteria:\n\n* ASA I and II\n* Both genders\n* Elective infra-umbilical surgeries with anticipated duration ≤ 90 minutes.\n\nExclusion Criteria:\n\n* Guardian refusal.\n* Children with major congenital heart disease, including septal defects.\n* Patients with neuromuscular disorders or high intracranial pressure.\n* Children with spinal deformities or morbid obesity (BMI above the 99th percentile).\n* Children with a history or family history of coagulation disorders.\n* Children with local infection at the site of skin puncture for spinal anesthesia.\n* Children with known allergy to bupivacaine.\n* Surgeries requiring head down (Trendelenburg) or prone position.\n* Unexpected prolongation of surgery \\> 90 minutes.","1 Year","6 Years",{"count":110,"type":20},[23],"Pediatric anesthesia presents distinctive challenges, particularly concerning appropriate dosage administration of local anesthetics for spinal anesthesia (SA). Spinal anesthesia in infants has been linked to a lower incidence of hypotension, hypoxia, bradycardia, and postoperative apnea in comparison to general anesthesia (GA); ensuring a high level of cardiovascular and respiratory stability.\n\nAdditionally, SA has been linked to lower operating room time, post-anesthesia care unit, hospital length of stay, corticosteroid administration, narcotic requirements, postoperative emesis, and cardiopulmonary complications in comparison to GA.\n\nA reduction in systemic blood pressure frequently accompanies neuraxial blocks in adults, necessitating intervention. Nevertheless, spinal, caudal, or epidural blocks administered to children under six years old are not associated with any substantial alterations in blood pressure. In children aged 6 to 10, there is a linear decrease in blood pressure that will reach a plateau at approximately a 30% decrease in those beyond the age of 10. Conversely, younger children require no additional precautions.\n\nBupivacaine, has a narrow therapeutic index in children, and its dosing requires careful consideration to strike a balance between effective anesthesia and the risk of toxicity. The traditional method of dosing bupivacaine in pediatric spinal anesthesia is based on the child's body weight. This weight-based dosing considers the assumption that children's drug clearance correlates with their body mass. However, this approach might not account for the maturational changes in drug handling by pediatric patients or the variability in spinal column length and cerebrospinal fluid volumes, not always proportional to weight but may evolve with age.\n\nEmerging evidence suggests that age-based dosing may be more effective. It hypothesizes that developmental pharmacokinetics, including changes in body composition, organ function, and drug-receptor differences, can influence bupivacaine metabolism and action more significantly than body mass alone. By accounting for the age-related anatomical and physiological changes, age-based dosing could result in more precise and effective anesthesia with a decreased risk of adverse outcomes.\n\nTo the authors knowledge, there is no study comparing age-based and weight-based bupivacaine dosing for pediatric spinal anesthesia in children undergoing elective infra-umbilical surgery.",[34,331,30],"Local Anesthetic","2025-01-25",{"date":334,"type":42},"2025-01-30",{"date":334,"type":20},{"date":337,"type":20},"2025-06-05",{"name":101,"class":49},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":11,"sex":16,"minAge":346,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":21,"phases":350,"briefSummary":351,"conditions":352,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":4},"100569425","phase-4-suprazygomatic-maxillary-nerve-block-for-management-of-postoperative-pain-in-adenotonsillectomy-patients-100569425","NCT06694077","Suprazygomatic Maxillary Nerve Block for Management of Postoperative Pain in Adenotonsillectomy Patients","Comparative Study of Dexamethasone Plus Bupivacaine Versus Bupivacaine in Suprazygomatic Maxillary Nerve Block for Management of Postoperative Pain in Adenotonsillectomy Patients","Inclusion Criteria:\n\n* Parturient of American Society of Anesthesiologists (ASA) class I or II physical status\n* Children scheduled for tonsillectomy with adenoidectomy\n\nExclusion Criteria:\n\n* Patient's guardian refusal to participate in the study. Children with Behavioural changes; physical or developmental delay; neurological disorder or psychological disorder.\n* Children on sedative or anticonvulsant medication.\n* Bleeding diathesis\n* History of sleep apnea\n* Significant organ dysfunction, cardiac dysrhythmia, congenital heart disease\n* Known allergy to the study drugs.\n* Skin lesions or wounds at the puncture site of the proposed block","3 Years","10 Years",{"count":349,"type":20},80,[23],"This study explores the effectiveness of adding dexamethasone to a suprazygomatic maxillary nerve block for postoperative pain relief in children undergoing adenotonsillectomy. The procedure, often performed to address recurrent infections and airway obstruction, results in significant pain due to inflammation and nerve irtypicallyritation. Traditional pain management methods, such as systemic analgesics, may be inadequate or lead to side effects in children. By combining dexamethasone, a potent anti-inflammatory, with local anesthetics, this trial aims to determine if enhanced pain control and a reduction in opioid use can be achieved.\n\nThe randomized, double-blind clinical trial will involve 80 children aged 3 to 10 years, randomized into two groups: one receiving the nerve block with bupivacaine and dexamethasone, and the other receiving bupivacaine alone. Pain will be assessed postoperatively using the FLACC score, with secondary measures including time to first analgesia, total analgesic use, hemodynamic stability, and any complications.\n\nThis study aims to demonstrate that the addition of dexamethasone may provide superior pain management in pediatric adenotonsillectomy, offering a safer, opioid-sparing alternative for postoperative care.",[353,354,30],"Tonsillectomy Postoperative Adverse Events","Dexamethasone Administration","2024-11-16",{"date":357,"type":42},"2024-11-19",{"date":359,"type":20},"2024-12-01",{"date":361,"type":20},"2026-06-01",{"name":363,"class":49},"Assiut University",{"id":365,"slug":366,"hasResults":11,"nctId":367,"briefTitle":368,"officialTitle":368,"acronym":369,"eligibilityCriteria":370,"healthyVolunteers":11,"sex":16,"minAge":371,"maxAge":244,"enrollmentInfo":372,"targetDuration":4,"studyType":21,"phases":374,"briefSummary":376,"conditions":377,"keywords":380,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":394},"100502598","early-phase-1-testing-the-feasibility-of-using-ropivacaine-in-spinal-anesthesia-for-patients-with-lower-back-surgery-100502598","NCT05824338","Testing the Feasibility of Using Ropivacaine in Spinal Anesthesia for Patients With Lower Back Surgery","SASS","Inclusion Criteria:\n\n* Adult patients who are equal to or greater than 18 years old\n* Undergoing elective one or two-level lumbar surgery via posterior surgical approach in the prone position (between L2-S1)\n* Expected surgery duration of no greater than 2 hours\n* ASA Physical Status Class 1 to 3\n* Patient can have either spinal anesthesia or general anesthesia\n* Able to provide consent and understand information in English, and capable of answering questions in English\n\nExclusion Criteria:\n\n* Allergy to either ropivacaine, bupivacaine, or local anesthetics\n* Contraindications to spinal anesthesia (i.e. coagulopathy or on anticoagulants, severe aortic or mitral valve stenosis, sepsis or bacteremia, thrombocytopenia, high intracranial pressure, infection at the puncture site)\n* Surgery is expected to take more than 2 hours\n* Emergency surgery\n* Previously had back surgery at the level of the spine currently being operated on\n* Comorbidities that require the patient to undergo general anesthesia\n* Inability to stay still during the surgery\n* Inability to move legs preoperatively\n* Body Mass Index (BMI) \\>35\n* Multilevel severe spinal stenosis","19 Years",{"count":373,"type":20},45,[375],"EARLY_PHASE1","The goal of this pilot clinical trial is to test the feasibility of conducting a randomized controlled trial that will examine the use of ropivacaine in the spinal anesthesia for patients undergoing elective 1- or 2-level lower spine surgery. This study aims to:\n\n* Determine the rates of eligibility, recruitment, consent, and attrition\n* Determine the acceptability among patients, surgeons, anesthesiologists, and nurses of doing spine surgery under spinal anesthesia\n* Gather preliminary data on outcomes relevant to a future dose-finding study\n\nParticipants will be randomized to one of three treatment groups:\n\n* General anesthesia with endotracheal tube\n* Spinal anesthesia with bupivacaine\n* Spinal anesthesia with ropivacaine",[26,378,379,30],"Neurosurgery","Ropivacaine",[381,382,383,384],"Anesthesia","Spinal","Lumbar surgery","Lower back","2024-10-04",{"date":387,"type":42},"2024-10-08",{"date":389,"type":42},"2024-08-27",{"date":391,"type":20},"2025-12-31",{"name":393,"class":49},"Fraser Health",2,{"id":396,"slug":397,"hasResults":11,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":11,"sex":164,"minAge":58,"maxAge":402,"enrollmentInfo":403,"targetDuration":4,"studyType":21,"phases":404,"briefSummary":405,"conditions":406,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":50},"100559757","lignocaine-vs-bupivacaine-infiltration-for-postpartum-perineal-pain-after-vaginal-delivery-with-episiotomy-in-primigravidae-100559757","NCT06568289","Lignocaine vs Bupivacaine Infiltration for Postpartum Perineal Pain After Vaginal Delivery With Episiotomy in Primigravidae","Lignocaine vs Bupivacaine Infiltration for Postpartum Perineal Pain After Vaginal Delivery With Episiotomy in Primigravidae: A Prospective Randomized, Double-Blind, Clinical Trial","Inclusion Criteria:\n\n* Primigravidae with the full term undergoing vaginal delivery with episiotomy.\n* Pregnancies and singleton vertex cephalic fetuses.\n* In the active phase of the first stage of labor.\n\nExclusion Criteria:\n\n* Patients with history of drug allergies to study drugs as this will increase the risk of complications.\n* Patients undergoing vaginal delivery under epidural or spinal anesthesia as they will affect post-operative pain and interfere with assessment of efficacy of local infiltration of the study drugs.\n* Evidence of local infection at site of injection as this will interfere with the action of the study drug and will increase the risk of complications.\n* Inability to cooperate as this will affect our assessment.\n* Patient's refusal.\n* Any intraoperative complications that will affect our outcome criteria (bleeding, organ injury) as they will affect patient's vital data and affect our assessment.\n* Neurological comorbidities (chronic pain disorder, chronic systemic disease, neurological disorder, neuropathic pain) as they will need more analgesia.\n* Drug abuse as they will be tolerant to the used analgesics.","40 Years",{"count":110,"type":20},[62],"In this study, we will compare the effect and safety of lignocaine versus bupivacaine infiltration for postpartum perineal pain after vaginal delivery with episiotomy in primigravidae.",[407,30,408,409,410,411],"Lignocaine","Postpartum Perineal Pain","Vaginal Delivery","Episiotomy","Primigravidae","2024-08-22",{"date":414,"type":42},"2024-08-23",{"date":416,"type":42},"2024-03-01",{"date":418,"type":20},"2024-09-01",{"name":317,"class":49}]