[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"burn-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:burn-injuries":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100618267","turkish-adaptation-and-validation-of-the-burnt-hand-outcome-tool-bhot-100618267",false,"NCT07329400","Turkish Adaptation and Validation of the Burnt Hand Outcome Tool (BHOT)","Turkish Adaptation of the Burnt Hand Outcome Tool (BHOT): A Validity and Reliability Study in Adult Patients With Hand Burns","Inclusion Criteria:\n\n* Age 18 years or older\n* History of second-degree or higher burn injury in one or both hands\n* Ability to read and understand Turkish\n* Willingness to participate and provision of written informed consent\n\nExclusion Criteria:\n\n* History of trauma, surgery, or rheumatologic disease affecting hand function prior to the burn injury\n* Age under 18 years\n* Cognitive impairment or psychiatric disorder preventing completion of the questionnaires\n* Refusal to participate or withdrawal from the study at any time","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to evaluate the validity and reliability of the Turkish adaptation of the Burnt Hand Outcome Tool (BHOT) in adults with a history of hand burns. The participant population will include adults aged 18 years and older who have experienced unilateral or bilateral hand burns and can read and understand Turkish.The main questions this study aims to answer are:\n\nDoes the Turkish version of the BHOT demonstrate high internal consistency, test-retest reliability, and construct validity? How strongly are BHOT scores associated with objective hand function measures such as grip strength and sensory evaluation? Participants will not be assigned to comparison groups, as this is a methodological validation study.\n\nParticipants will: Complete a sociodemographic information form. Complete the Turkish version of the BHOT and the QuickDASH questionnaire. Undergo objective assessments including hand grip strength using a dynamometer and sensory evaluation using Semmes-Weinstein monofilaments. Participate in repeated assessments at baseline, 1 month, 3 months and 6 months for reliability analyses.",[24,25,26],"Hand Burn","Hand Injuries","Burn Injuries",[28,29,30,31,26],"Hand Burns","Burnt Hand Outcome Tool (BHOT)","Validation Study","Reproducibility of Results","RECRUITING","2026-01-11",{"date":35,"type":36},"2026-01-13","ACTUAL",{"date":38,"type":36},"2025-11-17",{"date":40,"type":20},"2026-11",{"name":42,"class":43},"Necmettin Erbakan University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":44},"100609011","dynamics-of-dysbiosis-in-the-skin-and-gut-microbiome-of-burn-patients-100609011","NCT07209007","Dynamics of Dysbiosis in the Skin and Gut Microbiome of Burn Patients","An Exploratory Study on the Dynamics of Microbiome Dysbiosis (Microbial Imbalance) in the Skin and Gut Microbiome of Burn Patients","BURN-MICRO","Inclusion Criteria\n\n* Adults aged 19 to 65 years\n* Patients with partial- or full-thickness burns whose wounds have completely healed following debridement, grafting, or conservative treatment\n* Ability to understand study objectives and provide written informed consent\n\nExclusion Criteria\n\n* Use of systemic or topical antibiotics, probiotics, steroids, or immunosuppressants within 2 weeks prior to sample collection\n* Pregnancy or breastfeeding\n* Chronic skin diseases (e.g., psoriasis, eczema) or systemic illnesses affecting the skin microbiome\n* Active infections at the sampling site\n* Any medical condition judged by the investigator to make participation inappropriate","19 Years","65 Years",{"count":56,"type":20},600,"This prospective observational cohort study aims to investigate the longitudinal changes in the skin and gut microbiome of burn patients after injury and compare them with healthy controls. Burn injuries are known to induce systemic physiological and immune responses that may lead to widespread microbial dysbiosis (microbial imbalance) beyond the injured site. However, the dynamics of microbial community changes in both burned and non-burned skin, as well as the gut, remain poorly understood.\n\nIn this study, a total of 660 participants will be enrolled, including 600 burn patients and 60 healthy controls. For burn patients, skin swabs from burned scars and matched non-burned skin, stool samples, and physiological skin measurements will be collected at multiple time points (baseline, 3 months, 6 months, 12 months, and 24 months). Healthy controls will provide skin and stool samples at baseline only.\n\nMicrobial profiling will be performed using 16S ribosomal RNA (rRNA) gene sequencing, and functional prediction will be analyzed using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2 (PICRUSt2). Physiological skin-barrier measurements, including transepidermal water loss (TEWL), hydration, pH, erythema, and elasticity, will be assessed using standardized instruments. Blood biomarkers, including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), will also be measured.\n\nThe findings of this study will improve our understanding of burn-related microbial dysbiosis, provide insights into microbiome-driven skin-barrier recovery, and inform potential therapeutic strategies for long-term burn care.",[26,59,60,61],"Skin Disease","Microbiome","Microbiome Dysbiosis",[63,64,65,66,67],"Burn Injury","Skin Microbiome","Gut Microbiome","Dysbiosis","16S rRNA Sequencing","2025-09-29",{"date":70,"type":36},"2025-10-06",{"date":72,"type":36},"2025-09-15",{"date":74,"type":20},"2030-12-31",{"name":76,"class":43},"Cho Yoon soo"]