[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"burn-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:burn-injury":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,39,76,101,129,151,177,216,249,264,282,303,329,360,385,408],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100645134","deepview-hhf-training-and-validation-study-100645134",false,"NCT07677657","Deepview HHF Training and Validation Study","Deepview HHF Training and Validation Label Expansion Study","UK HHF","Inclusion Criteria:\n\n1. Willing and able to give informed consent, have a witnessed verbal consent, family discussion if intubated and retrospective consent for those that are intubated\n2. Life expectancy \\> 1 month\n3. Thermal burn mechanism (flame, scald, or contact)\n4. The Study Burn(s) occurred less than 72 hours prior to the time of first imaging\n5. Minimum burn wound size for adult or paediatric participants is 0.25% TBSA per region\n6. Have burn(s) on the head, hands and\u002For feet that meet the criteria for a Study Burn. If multiple regions meet the Study Burn criteria, per the discretion of the Investigator, all Study Burn regions should be included.\n\nExclusion Criteria:\n\n1. Sepsis at the time of enrolment\n2. Infection of the burn wound at the time of enrolment\n3. Immunosuppression \u002F radiation \u002F chemotherapy \\\u003C 3 months prior to enrolment\n4. Concurrent use of investigational products with a known effect on the burn sites; and\u002For imaging\n5. Concurrent use of products such as chemical debriding agents, skin substitutes and others that the principal investigator deems will have an impact on the image quality and healing potential of a Study Burn\n6. Any condition that, in the opinion of the Investigator, may prevent compliance with the study requirements or compromise Participant safety\n7. Participants without a burn on the hands, feet, head or neck, or burns located on these regions only on the palmar or plantar surfaces\n8. Chemical or any other non-thermal burns\n\n8\\. Participants anticipated to or undergoing enzymatic debridemen9","ALL",{"count":19,"type":20},280,"ESTIMATED","OBSERVATIONAL","The purpose of this Study is to help expand the use of the DeepView AI System so that it can assess burn injuries on the hands, head\u002Fface, and feet. To do this, the Study will collect new images of burns in these areas. Some of these images will be used to improve and retrain the AI system, while others will be used to test how well the updated system performs. The images for both purposes will be collected at the same time. The new images from the hands, head\u002Fface, and feet will then be combined with existing images from other body areas. This will allow researchers to determine whether the updated AI system performs as well as, or better than, previous versions of the technology. For participants with Study Burns requiring surgical excision, the Study site clinician will collect punch biopsies from the Study Burn according to a standardised burn wound punch biopsy collection.",[24,25,26],"Burns","Burn Injury","Diagnostic","NOT_YET_RECRUITING","2026-06-24",{"date":30,"type":31},"2026-07-01","ACTUAL",{"date":33,"type":20},"2026-09-01",{"date":35,"type":20},"2027-05-01",{"name":37,"class":38},"SpectralMD","INDUSTRY",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":48,"conditions":49,"keywords":50,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100644664","foreign-national-burn-patients-in-a-border-region-burn-center-100644664","NCT07673796","Foreign-National Burn Patients in a Border-Region Burn Center","Clinical Characteristics and In-Hospital Outcomes of Foreign-National Burn Patients in a Border-Region Burn Center: A Retrospective Cohort Study","Inclusion Criteria: Patients hospitalized and treated with a diagnosis of burn injury at the Burn Center of Gaziantep City Hospital between October 2023 and June 2026.\n\nPatients with a confirmed diagnosis of burn injury in patient files, discharge summaries, or hospital information management system records.\n\nPatients whose nationality status can be classified as Turkish citizen or foreign-national according to hospital records.\n\nPatients with available basic demographic, clinical, and in-hospital outcome data.\n\nPatients of all age groups and both sexes.\n\nExclusion Criteria: Patients treated outside the predefined study period. Patients without a confirmed diagnosis of burn injury. Patients evaluated only in the outpatient setting without hospitalization. Patients with missing nationality data. Patients with insufficient demographic or clinical outcome data for analysis. Duplicate records related to the same burn event; only the first hospitalization will be included.\n\nPatients evaluated only for consultation without hospitalization at the Burn Center of Gaziantep City Hospital.\n\n\\-",{"count":47,"type":20},1400,"This retrospective cohort study will evaluate burn patients hospitalized and treated at the Burn Center of Gaziantep City Hospital between October 2023 and June 2026. The study aims to compare demographic characteristics, burn severity, clinical course, and in-hospital outcomes between Turkish citizens and foreign-national burn patients.\n\nData will be obtained retrospectively from patient files, discharge summaries, intensive care records, operative notes, and the hospital information management system. Variables will include age, sex, nationality status, burn etiology, total body surface area burned, inhalation injury, sepsis, intensive care unit admission, mechanical ventilation requirement, surgical treatment requirement, number of operations, length of hospital stay, discharge status, transfer to another center, and in-hospital mortality.\n\nNo additional intervention, diagnostic test, treatment, or follow-up procedure will be performed as part of this study. All analyses will be conducted using anonymized or coded retrospective clinical data.",[25,24],[51,52,53,54,55,56,57,58,59,60,61,62,63,64,65],"Burn injury","Burn center","Foreign-national patients","Refugees","Border region","Retrospective cohort","Total body surface area","Inhalation injury","Intensive care","Mechanical ventilation","Sepsis","In-hospital mortality","ABSI score","Revised Baux score","Ryan-based modified clinical score","2026-06-23",{"date":68,"type":31},"2026-06-29",{"date":70,"type":20},"2026-07",{"date":72,"type":20},"2026-09",{"name":74,"class":75},"Gaziantep City Hospital","OTHER",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100642413","mitochondrial-energy-metabolism-in-burns-100642413","NCT07643545","Mitochondrial Energy Metabolism in Burns","The Role of the Mitochondrian in the Metabolic Stress Response to Burn Trauma","Mito Burn","Inclusion Criteria:\n\n* Male or Female\n* Ages 2 years to 80 years\n* Requiring hospital admission for burn care\n* All races\n* All ethnicities\n\nExclusion Criteria:\n\n* Age \\\u003C 2 years\n* Under 10 kg in body mass\n* Age \\> 80 years\n* Active pregnancy\n* Unable to provide informed consent and no legal authorized representative present\n* Patient is considered moribund at the time of admission by the treating physician.","2 Years","80 Years",{"count":87,"type":20},125,"The goal of this observational study is to assess the impact of burn injury on cellular energetics in patients that have been admitted to the burn center at Arkansas Children's Hospital for burn care and require one or more procedures to clean, debride, and repair burn wounds will be eligible to participate in this study.\n\nDuring the study, we will collect the following information:\n\n* General background information such as date of birth, height, weight, and other basic information.\n* Medical information, such as: basic medical information, details of burn injury, vital signs on the day of surgery, medicines you take during your stay, and some clinical tests.\n* Blood, urine, and tissue during surgeries you have during your stay.",[25],"RECRUITING","2026-06-09",{"date":93,"type":31},"2026-06-11",{"date":95,"type":31},"2023-04-20",{"date":97,"type":20},"2026-06",{"name":99,"class":75},"Arkansas Children's Hospital Research Institute",1,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":108,"sex":17,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":100},"100596806","the-effect-of-simulated-burn-injury-on-post-exercise-recovery-in-hot-environments-100596806","NCT07050264","The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments","HSR","Inclusion Criteria:\n\n* 18 and 65 years of age\n* free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram.\n\nExclusion Criteria:\n\n* Known heart disease\n* other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc. as well as serious abnormalities detected on routine screening.\n* Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test.\n* Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response.\n* Current smokers, as well as individuals who regularly smoked within the past 3 years.\n* body mass index is ≥ 31 kg\u002Fm2.",true,"18 Years","65 Years",{"count":112,"type":20},28,"INTERVENTIONAL",[115],"NA","Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise\u002Fenvironmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.",[25,118,119],"Body Temperature Regulation","Cardiovascular Physiology","2026-05-21",{"date":122,"type":31},"2026-05-26",{"date":124,"type":31},"2026-03-01",{"date":126,"type":20},"2028-08-01",{"name":128,"class":75},"University of Texas Southwestern Medical Center",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":110,"enrollmentInfo":136,"targetDuration":4,"studyType":113,"phases":138,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":100},"100639271","mesenchymal-stem-cells-in-the-treatment-of-burn-wounds-100639271","NCT07580755","Mesenchymal Stem Cells in the Treatment of Burn Wounds","A Randomized Controlled Study on the Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cells in the Treatment of Extensive Burns","Inclusion Criteria:\n\n1. Voluntary participation and signing of the informed consent form;\n2. Burn patients, subjects requiring autologous skin grafting;\n3. Age 18 to 65 years old, gender not restricted;\n4. During this clinical study, single person, single donor skin area (lateral thigh or trunk) treatment;\n5. Skin burn area \\\u003C 30% of total body surface area (TBSA);\n6. The donor skin area is the first time for donation, and the donor skin area is medium-thick skin (thickness approximately 0.4mm);\n7. The area of the excised skin flap ≥ 90 cm2;\n8. Able to cooperate with this study protocol and accept regular postoperative follow-up visits.\n\nExclusion Criteria:\n\n1. Those allergic to sodium alginate (gel component);\n2. Electric shock injuries, chemical burns, radiation injuries or combined with other traumas;\n3. Subjects with severe systemic diseases (judged by the researchers);\n4. Subjects with uncontrolled hypertension or diabetes (judged by the researchers);\n5. Pregnant or lactating women;\n6. Subjects whose condition may affect the study assessment or require the concurrent use of medical treatments that may affect the efficacy assessment;\n7. Subjects with acute or chronic kidney diseases, renal failure or serum creatinine level = 1.5 times the upper limit of normal value;\n8. Subjects with acute or chronic liver diseases, total bilirubin, alanine aminotransferase, aspartate aminotransferase = 2.0 times the upper limit of normal value;\n9. Subjects with a history of malignant tumors;\n10. Subjects who have participated in other clinical studies for less than 3 months;\n11. Subjects with mental disorders and without self-awareness, unable to express clearly;\n12. Subjects using immunosuppressants and those who have been using corticosteroids for a long time (more than 1 month) (excluding local application);\n13. Subjects with infectious diseases (any one of the four items positive in the test);\n14. Subjects with other severe systemic diseases;\n15. Other subjects that the researchers consider not eligible for inclusion.",{"count":137,"type":20},90,[115],"Burn patients were randomly divided into the low-dose stem cell gel group, the high-dose stem cell gel group, and the placebo group (with only the gel), and received the same treatment under the same conditions simultaneously.",[25,141],"Burn Patients","2026-05-05",{"date":144,"type":31},"2026-05-12",{"date":146,"type":20},"2026-04-27",{"date":148,"type":20},"2028-12-31",{"name":150,"class":75},"The First Affiliated Hospital of Xinxiang Medical College",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":113,"phases":161,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":173,"leadSponsor":175,"locationsCount":100},"100609316","phase-3-plasma-resuscitation-early-for-evaluating-volume-and-endotheliopathy-of-thermal-injury-preevent-trial-100609316","NCT07212998","Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) Trial","PREEVEnT","Inclusion Criteria:\n\n* Estimated ≥ 20% Total Body Surface Area burn\u002Fthermal injury with 2nd or 3rd degree depth\n* Anticipated admission to burn ICU\n\nExclusion Criteria:\n\n* Estimated rBaux score \\\u003C55\n* Not expected to survive \\>24 hours\n* Wearing NO PREEVENT opt-out bracelet\n* Age \\> 75 or \\\u003C 18 years of age\n* Concomitant traumatic injury with hemorrhagic shock\n* Isolated chemical burn\u002Finjury\n* Isolated deep electrical burn\u002Finjury\n* Known prisoner\n* Known pregnancy\n* Cardiac arrest with \\> 5 continuous minutes of CPR\n* Concern for anoxic injury\u002F fixed pupils bilaterally\n* Objection to study voiced by subject or family member at the scene or at the emergency department\u002Fburn center","75 Years",{"count":160,"type":20},750,[162],"PHASE3","The Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) trial will be a 6-year (4-year enrollment), open label, phase-3, multi-center, early in-hospital phase randomized trial utilizing burn centers from within the LITES network and will enroll approximately 750 injured adult patients who have suffered large 2nd or 3rd degree thermal burns on at least 20% of their body surface requiring burn resusciation. The objective is to determine if initiating plasma resuscitation as soon as possible upon arrival to an emergency department or burn unit is the most effective resuscitation for those who have experienced large thermal burns and significantly reduces the morbidity and mortality attributable to post-injury complications as compared to standard in-hospital resuscitation practice.",[25,165],"Thermal Burn",[167,168],"burn","plasma resuscitation","2026-05-01",{"date":171,"type":31},"2026-05-04",{"date":97,"type":20},{"date":174,"type":20},"2030-05",{"name":176,"class":75},"Jason Sperry",{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":113,"phases":187,"briefSummary":188,"conditions":189,"keywords":200,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":100},"100617334","vr-pmr-for-post-burn-symptoms-100617334","NCT07317271","VR-PMR for Post-Burn Symptoms","Virtual Reality-Enhanced Progressive Muscle Relaxation for Symptom Management in Burn Survivors","VIBE","Inclusion criteria are:\n\n* ≥18 years old;\n* sustained a burn injury in the last 6 months or longer;\n* Score high on at least one of the following: Insomnia severity index (ISI) score of ≥8, Brief Pain Inventory Short Form (BPI-SF) Pain severity score of ≥3, or PROMIS Itch Severity of ≥55;\n* own a smartphone or computer with reliable internet connection for online visits and survey completion;\n* able to comfortably wear goggles or headsets on face as determined by self-report.\n\nExclusion criteria:\n\n* Cognitive impairment (Mini Mental Status Exam (MMSE) \\\u003C 25);\n* history of motion sickness, photosensitivity, photoinduced seizures, and claustrophobia as determined by self-report;\n* uncorrected visual or hearing impairments as determined by self-report;\n* non-English speaker.",{"count":186,"type":20},34,[115],"The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep disturbances, and fatigue, in adult burn survivors.\n\nThe main questions it aims to answer are:\n\n* Does VR-enhanced PMR (VR-PMR) reduce chronic pain, anxiety, itch, sleep disturbances, and fatigue more effectively than standard PMR?\n* Is VR-PMR a feasible and acceptable self-administered home-based intervention for burn survivors?\n\nResearchers will compare two self-administered intervention conditions, VR-enhanced PMR and standard PMR, using a randomized to sequence crossover design to see if VR technology enhances the therapeutic effects of PMR on chronic symptom management in burn survivors.\n\nParticipants will:\n\n* Complete home-based sessions of VR-enhanced PMR\n* Complete home-based sessions of standard PMR\n* Report symptoms such as pain, itch, anxiety, sleep disturbances, and fatigue throughout the study\n* Use VR equipment provided for the intervention period (during the VR-PMR arm)",[190,191,192,193,194,195,196,197,198,25,199],"Burn","Chronic Pain Following Thermal Burn Injury","Non-Pharmacological Interventions","Virtual Reality","Sleep Disturbance","Anxiety","Depressive Symptoms","Fatigue Symptom","Pruritus","Progressive Muscle Relaxation",[193,201,199,202,203,204,205,206,24,25],"Burn Survivors","Chronic Symptom Management","Pain","Itch","Sleep","Fatigue","2026-03-03",{"date":209,"type":31},"2026-03-05",{"date":211,"type":31},"2026-02-27",{"date":213,"type":20},"2026-12",{"name":215,"class":75},"Johns Hopkins University",{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":85,"enrollmentInfo":222,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":224,"conditions":225,"keywords":229,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":248},"100612144","surgical-critical-care-initiative-sc2i-tissue-and-data-acquisition-protocol-tdap-in-burn-patients-improving-the-robustness-and-generalizability-of-post-burn-sepsis-prediction-with-the-post-burn-sepsis-digital-twin-group-1-100612144","NCT07249762","Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1","Inclusion Criteria:\n\n* Burn Injury \\>10% TBSA with who have a recognized concurrent or impending risk for clinical decompensation.\n* Male and female ages 18 years and older (maximum age of 80 years old) with burn injury or related illness requiring surgical care or treatment in a critical care or emergency setting who are being cared for at an SC2i-member clinical care facility (Emory\u002FGrady, USF and USAISR) will be considered for study.\n* Ability to understand the purposes and risks of the study and to provide informed consent, either through written documentation or in accordance with the IRB-approved Waiver of Documentation of Consent procedures. In the case of incapacitated patients, a willing Legally Authorized Representative (LAR) may provide informed consent in accordance with written documentation or under the provisions of the approved Waiver of Documentation of Consent.\n\nExclusion Criteria:\n\n* Any condition that, in the opinion of the attending physician, would place the patient or volunteer subject at undue risk by participating. Specific conditions include but are not limited to anemia prohibitive of phlebotomy, or technical considerations that would prevent acquisition of sufficient tissue for clinical use.\n* Pregnant patients\n* Minors \\\u003C 18 years of age\n* Prisoners",{"count":223,"type":20},40,"This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery. Researchers will collect small amounts of blood and tissue samples, along with information already recorded in the medical record, such as vital signs, lab results, and details of surgeries or complications. The goal is to identify patterns that may help predict who is at higher risk for infections or other problems after a burn injury. This information could lead to new tools, including computer-based models, to improve burn care and outcomes in the future. Participation involves providing samples and allowing researchers to review medical records during the hospital stay and up to one year after discharge.",[61,25,226,227,228],"Wound Healing","Critical Illness","Multiple Organ Dysfunction Syndrome",[230,61,227,231,232,233,234,226,235,236,237,238],"Burn Infection","Thermal Injury","Infection","Multiple Organ Dysfunction Syndrome (MODS)","Acute Respiratory Distress Syndrome (ARDS)","Biomarkers","Digital Twin Model","Predictive Analytics","Surgical Critical Care","2026-02-02",{"date":241,"type":31},"2026-02-04",{"date":243,"type":20},"2026-05-15",{"date":245,"type":20},"2027-12-15",{"name":247,"class":75},"Henry M. Jackson Foundation for the Advancement of Military Medicine",3,{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":85,"enrollmentInfo":256,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":224,"conditions":258,"keywords":259,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":260,"startDateStruct":261,"completionDateStruct":262,"leadSponsor":263,"locationsCount":248},"100610138","tdap-in-burn-patients-group-2-100610138","NCT07223684","TDAP in Burn Patients (Group 2)","Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-Burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin","Inclusion Criteria:\n\n* Male and female ages 18 years and older (maximum age of 80 years old) with burn injury or related illness requiring surgical care or treatment in a critical care or emergency setting who are being cared for at an SC2i-member clinical care facility (Emory\u002FGrady, USF and USAISR) will be considered for study.\n* Burn Injury \\>10% TBSA\n* Ability to understand the purposes and risks of the study and willingly give written informed consent, or in the case of incapacitated patients, a willing legally authorized representative (LAR) is able to give written informed consent.\n\nExclusion Criteria:\n\n* Any condition that, in the opinion of the attending physician, would place the patient or volunteer subject at undue risk by participating. Specific conditions include but are not limited to anemia prohibitive of phlebotomy, or technical considerations that would prevent acquisition of sufficient tissue for clinical use.\n* Pregnant patients\n* Minors \\\u003C 18 years of age\n* Prisoners",{"count":257,"type":20},80,[61,25,226,227,228],[230,61,227,231,232,233,234,226,235,236,237,238],{"date":241,"type":31},{"date":243,"type":20},{"date":245,"type":20},{"name":247,"class":75},{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":108,"sex":17,"minAge":109,"maxAge":110,"enrollmentInfo":270,"targetDuration":4,"studyType":113,"phases":271,"briefSummary":272,"conditions":273,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":100},"100556795","skin-wetting-in-burn-survivors-100556795","NCT06529757","Skin Wetting in Burn Survivors","Inclusion Criteria: Non-burn survivors\n\n* Healthy male and female subjects\n* 18-65 years of age.\n* Free of any underlying medical conditions\n\nExclusion Criteria (non-burned individuals):\n\n* Any burn-related injuries resulting in at least one night of hospitalization.\n* Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension.\n* Abnormalities detected on routine screening\n* Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.\n* Current smokers, as well as individuals who regularly smoked within the past 3 years.\n* Body mass index of greater than 30 kg\u002Fm\\^2.\n* Pregnant individuals\n\nInclusion Criteria (burn survivors):\n\n* Healthy male and female subjects\n* 18-65 years of age.\n* Free of any underlying medical conditions\n* Having a burn injury covering 20-40% or \\>40% of the participant's body surface area; at least 50% of those burn injuries must be full thickness that required skin grafting.\n* Participants must have been hospitalized due to the burn injury for a minimum of 15 days\n\nExclusion Criteria (burn survivors):\n\n* Any burn-related injuries resulting in at least one night of hospitalization.\n* Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension.\n* Abnormalities detected on routine screening\n* Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.\n* Current smokers, as well as individuals who regularly smoked within the past 3 years.\n* Body mass index of greater than 30 kg\u002Fm\\^2.\n* Pregnant individuals\n* Extensive unhealed injured skin",{"count":223,"type":20},[115],"This project will identify the efficacy of whole body skin wetting aimed to attenuate excessive elevations in internal body temperatures during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects, subjects who experienced burns covering \\~20% to 40% of their body surface area, and subject having burns \\>40% of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling or whole body skin wetting.",[25],"2025-10-20",{"date":276,"type":31},"2025-10-21",{"date":278,"type":31},"2024-07-31",{"date":280,"type":20},"2026-07-31",{"name":128,"class":75},{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":11,"sex":17,"minAge":288,"maxAge":158,"enrollmentInfo":289,"targetDuration":4,"studyType":113,"phases":291,"briefSummary":293,"conditions":294,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":100},"100505103","phase-1-clinical-assessment-of-protopic-ointment-in-deep-partial-thickness-burns-100505103","NCT05856994","Clinical Assessment of Protopic® Ointment in Deep Partial-Thickness Burns","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form by the subject or Legally Authorized Representative.\n* Stated willingness to comply with all study procedures and availability for the duration of the study.\n* Male or female aged 50 to 75 at time of screening visit.\n* For females of reproductive potential, confirmed negative urine pregnancy test at enrollment.\n* Presence of deep partial-thickness burns to one or both dorsal hands (burns may be present on other areas of the body, so long as all regions combined are ≤ 5% Total Body Surface Area \\[TBSA\\], using the Browder and Lund Chart).\n* Thermal burn (caused by fire, hot objects, steam or hot liquids \\[scalding\\]) etiology, located on one or both dorsal hands.\n* Ability to implement treatment within 24-48 hours days of the initial burn.\n\nExclusion Criteria:\n\n* Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study, if applicable.\n* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.\n* Allergy or hypersensitivity to tacrolimus or other components of the ointment (per subject report) or personal preference.\n* Allergy or hypersensitivity to bacitracin and\u002For any of its drug formulation components. Patients with known hypersensitivity to neomycin may also be sensitive to bacitracin.\n* Subject is incarcerated.\n* Friction, chemical or electric burn etiology.\n* Immunosuppression, as determined by the Principal Investigator.\n* Presence of a local and\u002For systemic infection that, in the Investigator's opinion, requires aggressive treatment which would warrant exclusion from participating in this study.\n* Subject is unwilling or unable to follow study related procedures and\u002For follow-up visits.\n* Prior treatment to the burn wound(s) on the hand(s) considered for this trial with another product (treatment failure).\n* Subject report of previous participation in another interventional burn wound study within 60 days prior to the Screening Visit.\n* Subject report of concurrent participation in another clinical trial that involves an investigational drug or device that would interfere with this study.\n* The subject has any physical or psychiatric condition that in the Investigator's opinion would warrant exclusion from the study or prevent the subject from completing the study.","50 Years",{"count":290,"type":20},18,[292],"PHASE1","There is currently no standard treatment to prevent burn depth conversion in partial-thickness burns. Conversion into deeper wounds is associated with higher complications and morbidity. The most common theory attributes this depth conversion to the prolonged inflammatory response that occurs after burn injury. Therefore, the investigators propose testing the safety and efficacy of tacrolimus ointment (an immunosuppressive agent) in patients with deep partial-thickness burns.",[25],"2025-10-16",{"date":274,"type":31},{"date":298,"type":31},"2024-09-19",{"date":300,"type":20},"2028-06-01",{"name":302,"class":75},"Vanderbilt University Medical Center",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":108,"sex":17,"minAge":109,"maxAge":110,"enrollmentInfo":309,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":311,"conditions":312,"keywords":314,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":100},"100590355","ieem--workrest-cycles-in-burn-survivors--humidity-100590355","NCT06966336","IEEM- Work:Rest Cycles in Burn Survivors- Humidity","Inclusion Criteria for Non-burned Individuals:\n\n* Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants must be between the ages of 18 and 65.\n\nExclusion Criteria for Non-burned Individuals:\n\n* Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg\u002Fm2 will likewise be excluded. Participants must not have had a serious burn injury requiring more than 1 night stay in the hospital.\n\nInclusion Criteria for Individuals with up to 40% of their body surface area burned (moderate burn group):\n\n\\- Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants who have sustained a burn injury must have a burn covering 20-40% of their body surface area and 50% of those burns must be full-thickness burns requiring skin grafts. Participants must be between the ages of 18 and 65.\n\nExclusion Criteria for Individuals with up to 40% of their body surface area burned (moderate burn group):\n\n\\- Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg\u002Fm2 will likewise be excluded.\n\nInclusion Criteria for Individuals with greater than 40% of their body surface area burned (large burn group):\n\n\\- Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants who have sustained a burn injury must have a burn covering more than 40% of their body surface area and 50% of those burns must be full-thickness burns requiring skin grafts. Participants must be between the ages of 18 and 65.\n\nExclusion Criteria for Individuals with greater than 40% of their body surface area burned (large burn group):\n\n\\- Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg\u002Fm2 will likewise be excluded.",{"count":310,"type":20},70,"The purpose of this project is to identify the effects of a severe burn injuries in humans on core temperature responses during work:rest cycles while in a heated environment.",[313,25],"Hyperthermia",[315,190,316,317,318,319,320],"Burn Survivor","humid","dry","core temperature","heat","body temperature","2025-08-19",{"date":323,"type":31},"2025-08-26",{"date":325,"type":31},"2025-08-15",{"date":327,"type":20},"2031-08-01",{"name":128,"class":75},{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":85,"enrollmentInfo":337,"targetDuration":4,"studyType":113,"phases":339,"briefSummary":340,"conditions":341,"keywords":345,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":100},"100596169","biphasic-positive-airway-pressure-ventilation-versus-flow-controlled-ventilation-in-burn-patients-100596169","NCT07041957","Biphasic Positive Airway Pressure Ventilation Versus Flow-Controlled Ventilation in Burn Patients","Biphasic Positive Airway Pressure Ventilation Versus Flow-Controlled Ventilation in Burn Patients: A Monocentric, Randomized Controlled, Parallel Group Trial","BIFLOWBURN","Inclusion Criteria:\n\n* Body weight ≥ 40 kg\n* Invasive ventilation time ≤ 24 hours before admission to the burn ICU or indication for intubation and invasive ventilation within 48 hours after admission to the burn ICU\n* Estimated (further) invasive ventilation time ≥ 24 hours\n* Intervention start within 48 hours after admission to the burn ICU\n* Establishment of a central venous line and invasive blood pressure monitoring as part of the intensive care therapy before the intervention start\n* Signed informed consent from the participant, legal guardian, next of kin in incompetent patients, or an intensivist in charge and independent from the Trial Management Committee in incompetent patients without a representative of the patients will\n\nExclusion Criteria:\n\n* Participation in another interventional trial\n* Duration of invasive ventilation \\> 24 hours at the time point of admission to the burn ICU\n* Estimated (further) invasive ventilation time \\\u003C 24 hours\n* Patients being treated in the burn ICU for (suspected) severe skin reactions such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN)\n* Lack of consent from the participant, legal guardian, next of kin, or intensivist in charge to participate in the study",{"count":338,"type":20},24,[115],"The goal of this clinical trial is to learn if the new ventilation mode flow-controlled ventilation (FCV) is a more protective mode of ventilation for adult patients after severe burn injury. The main question it aims to answer is:\n\nDoes FCV reduce the mechanical power (a key determinant of ventilator-induced lung injury) compared to conventional pressure-controlled ventilation (PCV) during ventilation of patients with burn injury?\n\nResearchers will compare FCV with PCV for up to 70 hours of ventilation to see if the mechanical power is reduced during ventilation of participants being in need of ventilation after severe burn injury.\n\nVentilation of participants will be controlled by either FCV or PCV. Group-specific ventilation will have the following characteristics:\n\n* FCV: Control of airway flows during inspiration and expiration, use of individualized lower and upper airway pressures and no fixed values for the volumes being inspired and expired (tidal volumes)\n* PCV: No control of airway flows during expiration, use of individualized lower airway pressures and upper airway pressures for a fixed tidal volume during each breath (6-8 ml\u002Fkg ideal body weight)\n\nIn total, at least 24 participants in need of ventilation after severe burn injury will be ventilated either with FCV (12 participants) or PCV (12 participants) for up to 70 hours.\n\nDuring ventilation mechanical power is computed according to certain ventilation parameters. Additionally, we evaluate organ functions of the cardiovascular systems, the lungs and other organs during and after the group-specific ventilation.",[25,342,343,344],"Inhalational Injury","Pulmonary Complications","Ventilator-induced Lung Injury (VILI)",[346,347,348,349,350],"Flow-controlled ventilation","Pressure-controlled ventilation","Mechanical Power","Dissipated Energy","Ventilator-induced lung injury","2025-06-18",{"date":353,"type":31},"2025-06-27",{"date":355,"type":20},"2025-07",{"date":357,"type":20},"2028-06",{"name":359,"class":75},"University Hospital Bergmannsheil Bochum",{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":4,"enrollmentInfo":367,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":369,"conditions":370,"keywords":371,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":379,"completionDateStruct":381,"leadSponsor":383,"locationsCount":100},"100586902","assessment-of-burn-severity-and-extent-spatial-frequency-domain-imaging-100586902","NCT06921421","Assessment Of Burn Severity and Extent Spatial Frequency Domain Imaging","Assessment Of Burn Severity and Extent Spatial Frequency Domain Imaging (SFDI): An Observational Pilot Study","Inclusion Criteria:\n\n1. Patients 18 years of age or older\n2. Thermal burns of any depth (superficial, deep partial thickness, or full thickness).\n\nExclusion Criteria:\n\n1. Patients less than 18 years of age\n2. Pregnant or breastfeeding women",{"count":368,"type":20},15,"The goal of this pilot clinical study is to evaluate the feasibility of collecting Spatial Frequency Domain Imaging (SFDI) data in patients with circulatory compromise due to thermal burns using the FDA-cleared Clarifi Imaging System and the next generation handheld m-Clarifi. Accurate assessment of burn depth and assessment at the point of care is an essential input for clinicians to plan proper treatment and management. SFDI has been shown to be a promising method to evaluate burn depth and extent within 24 hours in pre-clinical studies. The two feasibility goals of this study are as follows: 1) Do the values obtained with a commercial SFDI system provide utility in assessing burn depth in a clinical setting? And 2) Do Clarifi and m-Clarifi provide equivalent data when assessing subjects with burn injuries (biomarker imaging values, clinical workflow).",[190,25],[372,373,374,375],"SFDI","Spatial Frequency Domain Imaging","Burn depth","Burn injury assessment","2025-04-08",{"date":378,"type":31},"2025-04-10",{"date":380,"type":20},"2025-04",{"date":382,"type":20},"2025-12",{"name":384,"class":75},"The Metis Foundation",{"id":386,"slug":387,"hasResults":11,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":4,"eligibilityCriteria":391,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":4,"enrollmentInfo":392,"targetDuration":4,"studyType":113,"phases":394,"briefSummary":396,"conditions":397,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":404,"leadSponsor":406,"locationsCount":4},"100579769","phase-4-perioperative-lidocaine-infusions-for-the-management-of-pain-from-burn-injury-100579769","NCT06828601","Perioperative Lidocaine Infusions for the Management of Pain From Burn Injury","Perioperative Lidocaine Infusions for the Management of Pain From Burn Injury: A Pilot Study to Investigate Analgesic and Opioid Sparing Effects","Inclusion Criteria:\n\n* Acute burn patients\n* 18 years or older\n* \\\u003C20% Total Body Surface Area\n* Wound debridement surgery scheduled at Harborview Medical Center\n\nExclusion Criteria:\n\n* History of polysubstance use\n* Chronic opioid use (MED\\>40mg for more than 6 weeks)\n* Cases where the known clinical standard care would be to keep patient intubated postoperatively\n* Cases where the known clinical standard care would avoid IV Lidocaine infusion\n* Allergy to amide local anesthetics\n* Any elevated risk for local anesthetic systemic toxicity as determined by the study team\n* Cardiac arrythmias or cardiovascular instability (e.g. shock)\n* Severe renal or hepatic impairment\n* Pregnancy\n* Local anesthesia will be given by another route (e.g. nerve block)\n* Prisoners\n* Non-English Speaking\u002Freading",{"count":393,"type":20},20,[395],"PHASE4","The purpose of this study is to find out if IV lidocaine infusion decreases the need of opioids, improves pain management, and reduces the risks of developing complications from prolonged opioid use in burn injury participants undergoing wound debridement in the operating room.\n\nParticipants will:\n\n* be randomized to receive either an IV Lidocaine treatment or an IV Saline Placebo during their surgery. The IV treatment continues for 48 hours after surgery.\n* be asked about their pain and how they're feeling at 4 timepoints during the 48 hours.\n* be asked about their pain 2 weeks after surgery.\n\nThe participant and medical care providers will both be blinded to what IV treatment is being received.\n\nResearchers will compare the 2 groups to see if IV Lidocaine helps decrease the need of opioids, improves pain management, and reduces the risks of developing complications from prolonged opioid use (this includes opioid tolerance, opioid dependence, and opioid induced hyper-sensitivity to pain).",[398,25,399],"Pain Management","Lidocaine","2025-03-31",{"date":402,"type":31},"2025-04-04",{"date":380,"type":20},{"date":405,"type":20},"2026-01",{"name":407,"class":75},"University of Washington",{"id":409,"slug":410,"hasResults":11,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":4,"enrollmentInfo":415,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":416,"conditions":417,"keywords":420,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":100},"100574255","comparison-of-high-flow-nasal-oxygen-and-nasal-cannula-in-burn-patients-under-sedation-100574255","NCT06756906","Comparison of High Flow Nasal Oxygen and Nasal Cannula in Burn Patients Under Sedation","Comparison of the Effects of High Flow Nasal Oxygen and Standard Nasal Oxygen Therapy in Preventing Hypoxia in Minor and Moderate Burn Patients Treated Under Sedation","Inclusion Criteria : Voluntary patients over 18 years of age -ASA(American Society of Anaesthesiologists) I-III risk scores Exlusion Criteria\n\nExclusion Criteria:\n\n* Intubation\n* Tracheostomies\n* Need for oxygen therapy due to preexisting disease\n* Pregnancy",{"count":310,"type":20},"Burn-related pain is severe and often difficult to manage. Burn patients often require high doses of opioids and anxiolytics. Anesthetic agents used during sedation such as benzodiazepines, propofol and opioids can cause respiratory depression, predisposing patients to hypoventilation and hypoxemia due to airway obstruction. Oxygen is administered to patients with a standard nasal cannula during sedation. High Flow Nasal Oxygen (HFNO) helps to improve the oxygenation of patients with respiratory distress by delivering high flow humidified oxygen through the nasal cannula at a high rate of up to 40-70 liters per minute. The aim of this study was to compare the effects of HFNO and nasal oxygen therapy in preventing hypoxemia in deeply sedated burn patients.",[25,418,419],"Hypoxia","Sedation",[421,419,422],"HFNO","burn injury","2025-01-02",{"date":425,"type":31},"2025-01-03",{"date":427,"type":31},"2024-07-15",{"date":429,"type":20},"2025-02-10",{"name":431,"class":75},"Ankara City Hospital Bilkent"]