[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"burn-wound\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:burn-wound":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100578109","phase-2-post-operative-use-of-fs2-to-mitigate-scarring-in-burn-patients-100578109",false,"NCT06807021","Post-Operative Use of FS2 to Mitigate Scarring in Burn Patients","Post-operative Topical Administration of Fibrosis Inhibiting Compound FS2 in a Double- Blind, Randomized, Vehicle-controlled Study Evaluating the Safety and Mitigation of Cutaneous Scarring in Skin Graft and Donor Sites in Burn Patients","Inclusion Criteria:\n\n1. Medically able and willing to consent\u002Fassent to study requirements\n2. Male and female burn patients\n3. 12 to 65 years of age (inclusive)\n4. Able to understand the study requirements and consent without a translator. Where applicable, participant's legally authorized representative (LAR) is willing and able to agree to the requirements and restrictions of the study, be willing to give voluntary informed consent (or assent, if capable), be able to understand and read the questionnaires, carry out all study-related procedures, and communicate effectively with the study staff.\n5. Have a BMI between 15 and 35 kg\u002Fm2 (inclusive)\n6. Have clinically acceptable results in the safety laboratory tests as deemed by the investigator\n7. Have full thickness burn injury that required partial thickness skin graft (meshed or sheet) for any location other than the face and genitalia\n8. Skin graft size is between 50 cm2 and 800 cm2 (post-meshing, if a meshed graft)\n9. If skin graft is meshed, maximum skin graft expansion ratio is 1:1.5\n10. Able to apply the IPs as instructed, whether by the participants themselves or their accompanying caregivers\n\nExclusion Criteria:\n\n1. Medically unable to consent to study requirements\n2. Treatment site(s) (skin graft site) located on the face and genitalia\n3. Treatment site(s) (skin graft site and skin donor site) that has not reached complete re-epithelization at baseline, based on the investigator's assessment\n4. Expected to be medically unstable for the duration of the study period and an additional 1-month thereafter\n5. Pregnant, or attempting to become pregnant\n6. Subjects who had taken part in an interventional clinical trial within 3 months prior to admission to this trial or who are currently participating in a clinical trial, whether an investigational drug was used or not\n7. Subjects who had any clinical evidence of severe ongoing or prolonged depression or mental illness within the last year\n8. Subjects who smoke more than 20 cigarettes a day\n9. Subjects who have a history of heavy drinking in the past month, defined as more than 14 drinks per week for men or more than 7 drinks per week for women\n10. Subjects who have a history of substance abuse within the 12 months prior to screening (including having been hospitalized for such in an in-patient or out-patient intervention)\n11. Subjects with severe inhalation injury requiring FiO2 \\>50%, renal failure requiring dialysis or hemodynamic instability requiring vasopressor therapy at the time of initiation of study treatment\n12. Subjects who have scarring from previous interventions or evidence of thermal, electrical or radiation burn scars, tattoos, birthmarks or moles within 5 cm of the treatment sites\n13. Subjects with a history of abnormal keloid scarring\n14. Subjects with additional concurrent illnesses or conditions that may have interfered with wound healing like neoplastic, immune-mediated, or primary infectious disease (e.g. carcinoma, vasculitis, connective tissue disease, immune system disorders, uncontrolled HIV infection, rheumatoid arthritis, chronic renal impairment, significant hepatic impairment, inadequately or uncontrolled congestive heart failure or diabetes mellitus) or any clinically significant medical condition or history of any condition which may impair wound healing\n15. Subjects with a skin disorder that is chronic or currently active and which the investigator considers will adversely affect the healing of acute wounds or will involve the areas to be examined in this trial (including psoriasis, dermatitis, eczema)\n16. A history of radiotherapy to the study scar area\n17. Subjects who have known sensitivity to any components of the IPs\n18. Any other diagnosis, condition, physical or geographical limitation with the participant","ALL","12 Years","65 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","The goal of this study is to see how an ingredient called kynurenic acid (which we named \"FS2\") affects scar formation in people with burn injuries that need skin graft surgery. A cream with FS2 will be used on both the area where the skin graft was placed and the area where the skin was taken (donor site). The cream will be applied after the skin has healed. This study will help us understand if FS2 is safe and effective for mitigating skin scar formation in burn patients.",[28,29],"Burn Scar","Burn Wound",[31,32,33,34,35,36,37],"Scar","Burn","skin graft","Kynurenic acid","FS2","Skin grafted wound","Donor Wound","RECRUITING","2026-04-28",{"date":41,"type":42},"2026-05-04","ACTUAL",{"date":44,"type":21},"2026-05-15",{"date":46,"type":21},"2026-11-06",{"name":48,"class":49},"Birch BioMed Inc","INDUSTRY",2,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100588451","effect-of-solutions-used-in-burn-wound-irrigation-on-healing-pain-fear-and-anxiety-randomized-controlled-study-100588451","NCT06941571","Effect of Solutions Used in Burn Wound Irrigation on Healing, Pain, Fear and Anxiety: Randomized Controlled Study","Inclusion Criteria: The child must be between the ages of 5-10, be followed up in the burn clinic of the pediatric surgery service, be conscious, alert, and open to communication, be a child with 10% or 2nd degree superficial and deep burns who are being followed up as an outpatient, have burns on the arms, legs, and torso, have hot water (boiling water, etc.) burns, and the parent and child must agree to participate in the study.\n\nExclusion Criteria: The child must be younger than 5 years old or older than 10 years old, have a general condition disorder due to burns, have a change in consciousness, have genital area and facial burns, have a 10% or more second and third degree burn, have a burn that is an indication for hospitalization, the parent uses topical agents for burn healing at home, and the parent and child do not accept to participate in the study.","5 Years","10 Years",{"count":60,"type":21},69,[62],"NA","Burn, skin and\u002For subcutaneous tissues; It is an acute injury that causes traumatic lesions by exposure to thermal, chemical, mechanical or electrical agents. Among all traumatic injuries, burns are the most common type of injury and affect the entire body system. The World Health Organization reports that approximately 180,00 deaths per year are due to burns, making it the fifth most common type of childhood injury. It is also stated that 80% of burned children have hot water burns. Treatment is in two ways: surgical and non-surgical. The type of burn, its size, depth and the individual characteristics of the child affect the type of treatment.\n\nNon-surgical treatment is always the first choice in burn treatment. The primary method of this method is burn dressings. Before dressing, the burn surface must be cleaned\u002Firrigated with an appropriate antiseptic solution to remove metabolic wastes and tissue exudate. The aim here is to prepare a suitable environment for the burn wound to heal and to accelerate the healing process. In the literature, it is recommended to use various antiseptic solutions such as 0.9% NaCl, 0.5% chlorhexidine and hypochlorous acid for irrigation of burn wounds. Applying these solutions involves physical contact with the wound, and this contact may cause pain in the child. Additionally, the temperature and pH of the solution may cause discomfort. The pain that occurs during the irrigation process can further intensify anxiety and fear. However, it is not known which burn solutions used cause more pain, anxiety and fear. In this project, the effects of irrigation solutions used in the care of pediatric burn wounds on pain, fear, anxiety, infection development and healing will be examined. Child patients aged 5-10 years old with limb burns who present with hot water burns and do not have an indication for hospitalization will be included in the project. Children coming to burn dressing will be divided into three groups by simple randomization method. The burn wound of children in the first group will be irrigated with 0.09% NaCl, the children in the second group will be irrigated with 0.5% chlorhexidine, and the burn wound of children in the third group will be irrigated with hypochlorous acid solution. During irrigation of the burn wound, the child's anxiety, fear and pain status will be evaluated. At the same time, the effectiveness of the irrigation solutions used on the development of infection on the wound and its effectiveness on healing will be examined. For this reason, the burn wound will be monitored every three days. For this reason, children will be called to the burn clinic for dressing every three days. Before each dressing, a wound swab sample will be taken to determine the infection status in the burn wound. The Bates-Jensen wound assessment tool will be used to determine the healing status of the burn wound, and this tool will be evaluated by the burn nurse and two pediatric surgeons. In total, children will be monitored for 12 days. At the end of the project, the effect of the solutions used in burn irrigation on infection and healing will be determined. At the same time, the effects of the solutions on anxiety, fear and pain in children will be evaluated. It is thought that the data obtained as a result of the project will contribute to the development of a burn wound care protocol.",[32,29,65,66,67,68],"Healing","Pain","Anxiety","Fear","NOT_YET_RECRUITING","2025-07-24",{"date":72,"type":42},"2025-07-28",{"date":74,"type":21},"2025-09-30",{"date":76,"type":21},"2026-04-30",{"name":78,"class":79},"Nurdan AKCAY DİDİSEN","OTHER",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":18,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100586276","virtual-reality-adjunct-for-procedural-pain-and-anxiety-management-in-burn-wound-care-100586276","NCT06913270","Virtual Reality Adjunct for Procedural Pain and Anxiety Management in Burn Wound Care","Efficacy of Virtual Reality as an Adjunct for Procedural Pain and Anxiety Management in Burn Wound Care: A Single-Center, Randomized Controlled Trial","VR-Burn","Inclusion Criteria:\n\nAdult burn patients (18-65 years) with confirmed partial-thickness burns. Scheduled for routine dressing changes. Able to provide informed consent. Baseline pain score of ≥4\u002F10 during a dressing change session.\n\nExclusion Criteria:\n\nPatients with cognitive impairment preventing comprehension of the intervention.\n\nHistory of severe motion sickness or visual impairments that preclude the use of VR devices.\n\nPatients with contraindications to standard analgesic care.","18 Years",{"count":90,"type":21},100,[62],"This randomized controlled trial is designed to evaluate the efficacy of immersive virtual reality (VR) as an adjunct to standard analgesia during dressing changes in adult burn patients. The study compares an intervention group receiving standard care combined with an immersive VR distraction (using a head-mounted display displaying an engaging virtual environment) versus a control group receiving standard care plus non-VR distraction (watching a nature video on a tablet). The primary outcomes include procedural pain intensity measured by the Visual Analog Scale (VAS) and anxiety levels measured by the State-Trait Anxiety Inventory (STAI). Secondary outcomes include patient satisfaction and physiological parameters (heart rate and blood pressure) recorded during the procedure. This trial addresses the critical gap of heterogeneity and small sample sizes noted in previous VR studies for burn care pain management (Dascal et al., 2017).",[94,29,95,96],"Burns","Procedural Pain","Anxiety Acute","2025-03-30",{"date":99,"type":42},"2025-04-06",{"date":101,"type":21},"2025-04-12",{"date":103,"type":21},"2026-05-25",{"name":105,"class":79},"Al Hayah University In Cairo",1]